T cells from patients with hodgkin's disease have a defective T-cell receptor ζ chain expression that is reversible by T-cell stimulation with CD3 and CD28

Blood

Volumn 88, Issue 1, 1996, Pages 236-241

  Renner, Christoph ^a   Ohnesorge, Sascha ^a   Held, Gerhard ^a   Bauer, Stefan ^a   Jung, Wolfram ^a   Pfitzenmeier, Jan Peter ^a   Pfreundschuh, Michael ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; INTERLEUKIN 2; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; CYTOLYSIS; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; HODGKIN DISEASE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; RECEPTOR DOWN REGULATION; T LYMPHOCYTE ACTIVATION;

EID: 0029902054     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.1.236.bloodjournal881236     Document Type: Article

References (31)

1. Han T, Minowada J: Impairment of cell mediated immunity in untreated Hodgkin's disease. N Y State J Med 2:216, 978
2. Hersh EM, Oppenheim JJ: Impaired in vitro lymphocyte transformation with Hodgkin's disease. N Engl J Med 273:1006, 1965
3. Twomey JJ, Laughter AH, Lazar S, Douglass CC: Reactivity of lymphocytes from primary neoplasms of lymphoid tissues. Cancer 38:740, 1976
4. Miller DG, Lizardo JG: Homologous and heterologous skin transplantation in patients with lymphomatous disease. J Natl Cancer Inst 26:569, 1961
5. Sibbitt WL, Bankhurst AD, Williams RC: Studies of cell subpopulations mediating mitogen hyporesponsiveness in patients with Hodgkin's disease. J Clin Oncol 61:55, 1978
6. Faguet GB, Davis HC: Survival in Hodgkin's disease: The role of immunocompetence and other major risk factors. Blood 59:938, 1982
7. Fröland SS: Binding of sheep erythrocytes to human lymphocytes: A probable marker of T-lymphocytes. Scand J Hematol 1:269, 1972
8. Andersen E: Depletion of thymus dependent lymphocytes in Hodgkin's disease. Scand J Hematol 12:263, 1974
9. Dorreen MS, Habeshaw JA, Wrigley PFM, Lister TA: Distribution of T lymphocyte subsets in Hodgkin disease characterized by monoclonal antibodies. Br J Cancer 45:491, 1982
10. Posner MR, Reinherz EL, Breard J, Nadler LM, Rosenthal DS, Schlossman SF: Lymphoid subpopulations of peripheral blood and spleen in untreated Hodgkin's disease. Cancer 48:1170, 1981
11. Soulillou JP, Douillard JY, Vie H, Harousseau JL, Guenel J, Le Mevel-Le Pourhiet A, Le Mevel B: Defect in lectin-induced interleukin 2(IL2) production by peripheral blood lymphocytes of patients with Hodgkin's disease. Eur J Cancer Clin Oncol 21:935, 1985
12. Twomey JJ, Laughter AH, Farrow S, Douglass CC: Hodgkin's disease: An immunodepleting and immunosuppressive disorder. J Clin Invest 56:467, 1975
13. Murray JL, Perez-Soler R, Bywaters D, Hersh EM: Decreased adenosine deaminase (ADA) and 5′nucleotidase (5NT) in peripheral blood T cells in Hodgkin disease. Am J Hematol 21:57, 1986
14. Raz A, Collard JG, Inbar M: Decrease in 5′nucleotidase activity in malignant transformed normal stimulated cells. Cancer Res 38:1258, 1978
15. Renner C, Jung W, Sahin U, Denfeld R, Pohl C, Trümper L, Hartmann F, Diehl V van Lier R, Pfreundschuh M: Cure of xenografted human tumors by bispecific monoclonal antibodies and human T-cells. Science 264:833, 1994
16. Renner C, Bauer St, Sahin U, Jung W, van Lier R, Jacobs G, Held G, Diehl V, Pfreundschuh M: Cure of disseminated xenografted human Hodgkin's tumors by bispecific monoclonal antibodies and human T cells: The role of human T cell subsets in a preclinical model. Blood 87:2930, 1996
17. Romeo C, Amiot M, Seed B: Sequence requirements for induction of cytolysis by the T cell antigen/Fc receptor z chain. Cell 69:889, 1992
18. Sussman JJ, Bonifacino JS, Lippincott-Schwartz J, Weissman AM, Saito T, Klausner RD, Ashwell JD: Failure to synthesize the T cell CD3 ζ chain: Structure and function of a partial T cell receptor complex. Cell 52:85, 1988
19. Finke JH, Zea AH, Stanley J, Longo DL, Mizoguichi H, Tubbs RR, Wiltrout RH, O'Shea JJ, Kudoh S, Klein E, Bukowski RM, Ochoa AC: Loss of T-cell receptor ζ chain and p56 lck in T-cells infiltrating human renal cell carcinoma. Cancer Res 53:5613, 1993
20. Nakagomi H, Petersson M, Magnusson M, Jublin C, Matsuda M, Mellstedt H, Taupin JL, Vivier E, Anderson P, Kiessling R: Decreased expression of the signal-transducing z chains in tumor infiltrating T-cells and NK cells of patients with colorectal carcinoma. Cancer Res 53:5610, 1993
21. Renner C, Jung W, van Lier R, Sahin U, Pfreundschuh M: The role of lymphocyte subsets and adhesion molecules in T-cell dependent cytotoxicity mediated by CD3 and CD28 bispecific monoclonal antibodies. Eur J Immunol 25:2027, 1995
22. Diehl V, Kirchner HH, Schaadt M, Fonatsch C, Stein H, Gerdes J, Boie C: Hodgkin's disease: Establishment and characterization of four in vitro cell lines. J Cancer Res Clin Oncol 101:111, 1984
23. Assenmacher M, Schmitz J, Radbruch A: Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin-10 in interferon-γ and in interleukin-4 expressing cells. Eur J Immunol 24:1097, 1994
24. Massaia MC, Attisano E, Beggiato A, Bianchi A, Pileri A: Correlation between disease activity and T-cell CD3 ζ chain expression in a B-cell lymphoma. Br J Cancer 88:886, 1994
25. Mizoguchi H, O'Shea JJ, Longo DL, Loeffler CM, McVicar DW, Ochoa AC: Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science 258:1795, 1992
26. Hwu P, Rosenberg SA: The genetic modification of T cells for cancer therapy: An overview of laboratory and clinical trials. Cancer Detect Prev 18:43, 1994
27. Correa M, Sica A, Melamed P, Longo DL, Ochoa AC: TCR cloning stimulation as in vitro model to study anergy in human cells. 9th International Congress of Immunology, San Francisco, CA, July 23-29, 1995, vol 1, p 157, 1995
28. Sloan-Lancaster J, Shaw AS, Rothbard JB, Allen PM: Partial T cell signalling: Altered phospho-ζ and lack of ZAP 70 recruitment in APL-induced T cell anergy. Cell 79:913, 1994
29. Brocker T, Karjalainen K: Signals through T cell receptor-ζ chain alone are insufficient to prime resting T lymphocytes. J Exp Med 181:1653, 1995
30. Pardoll DM: Cancer vaccines. Immunol Today 14:310, 1993
31. Renner C, Pfreundschuh M: Tumor therapy by immune recruitment with bispecific antibodies. Immunol Rev 145:179, 1995