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Volumn 27, Issue 9, 2008, Pages 715-723

Review article: RNA interference - Potential therapeutic applications for the gastroenterologist

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; SMALL INTERFERING RNA;

EID: 41749124773     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2008.03634.x     Document Type: Review
Times cited : (13)

References (51)
  • 1
    • 0001359591 scopus 로고
    • Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous gene in trans
    • Napoli C, Lemieux C, Jorgensen R. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous gene in trans. Plant Cell 1990 2 : 279 89.
    • (1990) Plant Cell , vol.2 , pp. 279-89
    • Napoli, C.1    Lemieux, C.2    Jorgensen, R.3
  • 2
    • 0025405838 scopus 로고
    • Flavonoid genes in petunia: Addition of a limited number of gene copies may lead to a suppression of gene expression
    • van der Krol AR, Mur LA, Beld M. Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression. Plant Cell 1990 2 : 291 9.
    • (1990) Plant Cell , vol.2 , pp. 291-9
    • Van Der Krol, A.R.1    Mur, L.A.2    Beld, M.3
  • 3
    • 0037123639 scopus 로고    scopus 로고
    • RNA-dependent RNA polymerases, viruses, and RNA silencing
    • Ahlquist P. RNA-dependent RNA polymerases, viruses, and RNA silencing. Science 2002 296 : 1270 3.
    • (2002) Science , vol.296 , pp. 1270-3
    • Ahlquist, P.1
  • 4
    • 0029024475 scopus 로고
    • Par-1 a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
    • Guo S, Kemphues KJ. par-1 a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell 1995 81 : 611 20.
    • (1995) Cell , vol.81 , pp. 611-20
    • Guo, S.1    Kemphues, K.J.2
  • 5
    • 0033883114 scopus 로고    scopus 로고
    • Heritable gene silencing in Drosophila using double-stranded RNA
    • Kennerdell JR, Carthew RW. Heritable gene silencing in Drosophila using double-stranded RNA. Nat Biotechnol 2000 18 : 896 8.
    • (2000) Nat Biotechnol , vol.18 , pp. 896-8
    • Kennerdell, J.R.1    Carthew, R.W.2
  • 6
    • 0035859929 scopus 로고    scopus 로고
    • Specific inhibition of gene expression by small double-stranded RNAs in invertebrates and vertebrate systems
    • Caplen NJ, Parrish S, Imani F, et al. Specific inhibition of gene expression by small double-stranded RNAs in invertebrates and vertebrate systems. Proc Natl Acad Sci U S A 2001 98 : 9742 7.
    • (2001) Proc Natl Acad Sci U S a , vol.98 , pp. 9742-7
    • Caplen, N.J.1    Parrish, S.2    Imani, F.3
  • 7
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998 391 : 806 11.
    • (1998) Nature , vol.391 , pp. 806-11
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3
  • 8
    • 0037370498 scopus 로고    scopus 로고
    • A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
    • Rubinson DA, Dillon CP, Kwiatkowski AV, et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 2003 33 : 401 6.
    • (2003) Nat Genet , vol.33 , pp. 401-6
    • Rubinson, D.A.1    Dillon, C.P.2    Kwiatkowski, A.V.3
  • 9
    • 0034683099 scopus 로고    scopus 로고
    • Sensitive assay of RNA interference in Drosophila and Chinese hamster cultured cells using firefly luciferase gene as target
    • Ui-Tei K, Zenna S, Miyata Y, et al. Sensitive assay of RNA interference in Drosophila and Chinese hamster cultured cells using firefly luciferase gene as target. FEBS Lett 2000 479 : 79 82.
    • (2000) FEBS Lett , vol.479 , pp. 79-82
    • Ui-Tei, K.1    Zenna, S.2    Miyata, Y.3
  • 10
    • 0033789992 scopus 로고    scopus 로고
    • Specific interference with gene function by double-stranded RNA in early mouse development
    • Wianny F, Zernicka-Goetz M. Specific interference with gene function by double-stranded RNA in early mouse development. Nat Cell Biol 2000 2 : 70 5.
    • (2000) Nat Cell Biol , vol.2 , pp. 70-5
    • Wianny, F.1    Zernicka-Goetz, M.2
  • 11
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001 411 : 494 8.
    • (2001) Nature , vol.411 , pp. 494-8
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3
  • 12
    • 0005227608 scopus 로고    scopus 로고
    • Small interfering RNAs: A revolutionary tool for the analysis of gene function and gene therapy
    • Tuschl T, Borkhardt A. Small interfering RNAs: a revolutionary tool for the analysis of gene function and gene therapy. Mol Interv 2002 2 : 158 67.
    • (2002) Mol Interv , vol.2 , pp. 158-67
    • Tuschl, T.1    Borkhardt, A.2
  • 13
    • 10044284093 scopus 로고    scopus 로고
    • Killing the messenger: Antisense DNA and siRNA
    • Nesterova M, Cho-Chung YS. Killing the messenger: antisense DNA and siRNA. Curr Drug Targets 2004 5 : 683 9.
    • (2004) Curr Drug Targets , vol.5 , pp. 683-9
    • Nesterova, M.1    Cho-Chung, Y.S.2
  • 14
    • 38549147453 scopus 로고    scopus 로고
    • RNA-bound: The future of antisense drugs
    • McCullagh K. RNA-bound: the future of antisense drugs. CancerWorld 2006 13 : 26 30.
    • (2006) CancerWorld , vol.13 , pp. 26-30
    • McCullagh, K.1
  • 15
    • 1842589494 scopus 로고    scopus 로고
    • PlantRNAi: How a viral silencing suppressor inactivates siRNA
    • Zamore PD. PlantRNAi: how a viral silencing suppressor inactivates siRNA. Curr Biol 2004 14 : R198 200.
    • (2004) Curr Biol , vol.14
    • Zamore, P.D.1
  • 16
    • 18744407284 scopus 로고    scopus 로고
    • Purified argonaute2 and an siRNA form recombinant human RISC
    • Rivas FV, Tolia NH, Song JJ, et al. Purified argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol 2005 12 : 340 9.
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 340-9
    • Rivas, F.V.1    Tolia, N.H.2    Song, J.J.3
  • 18
    • 22144436236 scopus 로고    scopus 로고
    • The role of the RNAi machinery in heterochromatin formation
    • Wassenegger M. The role of the RNAi machinery in heterochromatin formation. Cell 2005 122 : 13 6.
    • (2005) Cell , vol.122 , pp. 13-6
    • Wassenegger, M.1
  • 19
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: Small RNAs with a big role in gene regulation
    • Lin H, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004 5 : 522 31.
    • (2004) Nat Rev Genet , vol.5 , pp. 522-31
    • Lin, H.1    Hannon, G.J.2
  • 20
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism and function. Cell 2004 116 : 281 97.
    • (2004) Cell , vol.116 , pp. 281-97
    • Bartel, D.P.1
  • 21
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - MicroRNAs with a role in cancer
    • Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006 6 : 259 69.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-69
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 22
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature 2005 435 : 834 8.
    • (2005) Nature , vol.435 , pp. 834-8
    • Lu, J.1    Getz, G.2    Miska, E.A.3
  • 23
    • 34247862190 scopus 로고    scopus 로고
    • MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis
    • Bloomston M, Frankel WL, Petrocca F, et al. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA 2007 297 : 1901 8.
    • (2007) JAMA , vol.297 , pp. 1901-8
    • Bloomston, M.1    Frankel, W.L.2    Petrocca, F.3
  • 24
    • 33645136607 scopus 로고    scopus 로고
    • Therapeutic short hairpin RNA expression in liver: Viral targets and vectors
    • Grimm D, Kay MA. Therapeutic short hairpin RNA expression in liver: viral targets and vectors. Gene Ther 2006 13 : 563 75.
    • (2006) Gene Ther , vol.13 , pp. 563-75
    • Grimm, D.1    Kay, M.A.2
  • 25
    • 0037348329 scopus 로고    scopus 로고
    • RNA interference targeting Fas protects mice from fulminant hepatitis
    • Song E, Lee SK, Wang J, et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 2003 9 : 347 51.
    • (2003) Nat Med , vol.9 , pp. 347-51
    • Song, E.1    Lee, S.K.2    Wang, J.3
  • 26
    • 33748286741 scopus 로고    scopus 로고
    • Review article: Biological drugs in Crohn's disease
    • Kamm MA. Review article: biological drugs in Crohn's disease. Aliment Pharmacol Ther 2006 24 : 80 9.
    • (2006) Aliment Pharmacol Ther , vol.24 , pp. 80-9
    • Kamm, M.A.1
  • 27
    • 33746913567 scopus 로고    scopus 로고
    • Engineering mucosal RNA interference in vivo
    • Zhang Y, Cristofaro P, Silbermann R, et al. Engineering mucosal RNA interference in vivo. Mol Ther 2006 14 : 336 42.
    • (2006) Mol Ther , vol.14 , pp. 336-42
    • Zhang, Y.1    Cristofaro, P.2    Silbermann, R.3
  • 28
    • 14644389336 scopus 로고    scopus 로고
    • From colonic polyps to colon cancer: Pathophysiology, clinical presentation, and diagnosis
    • Cappell MS. From colonic polyps to colon cancer: pathophysiology, clinical presentation, and diagnosis. Clin Lab Med 2005 25 : 135 77.
    • (2005) Clin Lab Med , vol.25 , pp. 135-77
    • Cappell, M.S.1
  • 29
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic PI3K deregulates transcription and translation
    • Bader AG, Kang S, Zhao L, et al. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 2005 5 : 921 9.
    • (2005) Nat Rev Cancer , vol.5 , pp. 921-9
    • Bader, A.G.1    Kang, S.2    Zhao, L.3
  • 30
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutation of the PIK3CA gene in human cancers
    • Samuels Y, Wang A, Bardelli A, et al. High frequency of mutation of the PIK3CA gene in human cancers. Science 2004 304 : 554.
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, A.2    Bardelli, A.3
  • 31
    • 33745325973 scopus 로고    scopus 로고
    • Targeted molecular therapy of the PI3K pathway: Therapeutic significance of PI3K subunit targeting in colorectal carcinoma
    • Rychahou PG, Jackson LN, Silva SR, et al. Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma. Ann Surg 2006 243 : 833 42.
    • (2006) Ann Surg , vol.243 , pp. 833-42
    • Rychahou, P.G.1    Jackson, L.N.2    Silva, S.R.3
  • 32
    • 36348971520 scopus 로고    scopus 로고
    • Cyclooxygenase-2 knockdown by RNA interference in colon cancer
    • Charames GS, Bapat B. Cyclooxygenase-2 knockdown by RNA interference in colon cancer. Int J Oncol 2006 28 : 543 9.
    • (2006) Int J Oncol , vol.28 , pp. 543-9
    • Charames, G.S.1    Bapat, B.2
  • 33
    • 33644822482 scopus 로고    scopus 로고
    • In vitro inhibition of matriptase prevents invasive growth of cell lines of prostate and colon carcinoma
    • Forbs D, Thiel S, Stella MC, et al. In vitro inhibition of matriptase prevents invasive growth of cell lines of prostate and colon carcinoma. Int J Oncol 2005 27 : 1061 70.
    • (2005) Int J Oncol , vol.27 , pp. 1061-70
    • Forbs, D.1    Thiel, S.2    Stella, M.C.3
  • 34
    • 34447118186 scopus 로고    scopus 로고
    • Radiochemotherapy of esophageal cancer
    • Liao Z, Cox JD, Komaki R. Radiochemotherapy of esophageal cancer. J Thorac Oncol 2007 2 : 553 68.
    • (2007) J Thorac Oncol , vol.2 , pp. 553-68
    • Liao, Z.1    Cox, J.D.2    Komaki, R.3
  • 35
    • 33845879856 scopus 로고    scopus 로고
    • Down-regulation of Bcl-XL by RNA interference suppresses cell growth and induces apoptosis in human esophageal cancer cells
    • Xie Y, Tang E, Zhang D, et al. Down-regulation of Bcl-XL by RNA interference suppresses cell growth and induces apoptosis in human esophageal cancer cells. World J Gastroenterol 2006 12 : 7472 7.
    • (2006) World J Gastroenterol , vol.12 , pp. 7472-7
    • Xie, Y.1    Tang, E.2    Zhang, D.3
  • 36
    • 33645746620 scopus 로고    scopus 로고
    • Targeting the RNA splicing machinery as a novel treatment strategy for pancreatic carcinoma
    • Hayes GM, Carrigan PE, Beck AM, et al. Targeting the RNA splicing machinery as a novel treatment strategy for pancreatic carcinoma. Cancer Res 2006 66 : 3819 27.
    • (2006) Cancer Res , vol.66 , pp. 3819-27
    • Hayes, G.M.1    Carrigan, P.E.2    Beck, A.M.3
  • 37
    • 33745493934 scopus 로고    scopus 로고
    • Recent advances in coeliac disease
    • van Heel DA, West J. Recent advances in coeliac disease. Gut 2006 55 : 1037 46.
    • (2006) Gut , vol.55 , pp. 1037-46
    • Van Heel, D.A.1    West, J.2
  • 38
    • 33745755214 scopus 로고    scopus 로고
    • Transglutaminase-catalyzed reactions responsible for the pathogenesis of coeliac disease and neurodegenerative diseases: From basic biochemistry to clinic
    • Martin A, Romito G, Pepe I. Transglutaminase-catalyzed reactions responsible for the pathogenesis of coeliac disease and neurodegenerative diseases: from basic biochemistry to clinic. Curr Med Chem 2006 13 : 1895 902.
    • (2006) Curr Med Chem , vol.13 , pp. 1895-902
    • Martin, A.1    Romito, G.2    Pepe, I.3
  • 40
    • 0034956340 scopus 로고    scopus 로고
    • Recurrent Clostridium difficile diarrhoea
    • Kyne L, Kelly CP. Recurrent Clostridium difficile diarrhoea. Gut 2001 49 : 152 3.
    • (2001) Gut , vol.49 , pp. 152-3
    • Kyne, L.1    Kelly, C.P.2
  • 41
    • 28844442756 scopus 로고    scopus 로고
    • Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase
    • Kim H, Kokkotou E, Na X, et al. Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase. Gastroenterology 2005 129 : 1875 88.
    • (2005) Gastroenterology , vol.129 , pp. 1875-88
    • Kim, H.1    Kokkotou, E.2    Na, X.3
  • 42
    • 33748117817 scopus 로고    scopus 로고
    • Inhibition of choroidal neovascularization by adenovirus-mediated delivery of short hairpin RNAs targeting VEGF as a potential therapy for AMD
    • Cashman SM, Bowman L, Christofferson J, et al. Inhibition of choroidal neovascularization by adenovirus-mediated delivery of short hairpin RNAs targeting VEGF as a potential therapy for AMD. Invest Ophthalmol Vis Sci 2006 47 : 3496 504.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 3496-504
    • Cashman, S.M.1    Bowman, L.2    Christofferson, J.3
  • 43
    • 30144434185 scopus 로고    scopus 로고
    • An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infections
    • Palliser D, Chowdhury D, Wang QY, et al. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infections. Nature 2006 439 : 89 94.
    • (2006) Nature , vol.439 , pp. 89-94
    • Palliser, D.1    Chowdhury, D.2    Wang, Q.Y.3
  • 44
    • 13444262170 scopus 로고    scopus 로고
    • Inhibition of respiratory viruses by nasally administered siRNA
    • Bitko V, Musiyenko A, Shulyayeva O, et al. Inhibition of respiratory viruses by nasally administered siRNA. Nat Med 2005 11 : 50 5.
    • (2005) Nat Med , vol.11 , pp. 50-5
    • Bitko, V.1    Musiyenko, A.2    Shulyayeva, O.3
  • 45
    • 34447559636 scopus 로고    scopus 로고
    • Interfering with disease: A progress report on siRNA-based therapeutics
    • de Fougerolles A, Vornlocher H, Maraganore J, et al. Interfering with disease: a progress report on siRNA-based therapeutics. Nat Rev Drug Discov 2007 6 : 443 53.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 443-53
    • De Fougerolles, A.1    Vornlocher, H.2    Maraganore, J.3
  • 46
    • 36849087968 scopus 로고    scopus 로고
    • Therapeutic application of RNAi: Is mRNA targeting finally ready for prime time?
    • Grimm D, Kay MA. Therapeutic application of RNAi: is mRNA targeting finally ready for prime time? J Clin Invest 2007 117 : 3633 41.
    • (2007) J Clin Invest , vol.117 , pp. 3633-41
    • Grimm, D.1    Kay, M.A.2
  • 47
    • 34547582307 scopus 로고    scopus 로고
    • Effectiveness of siRNA uptake in target tissues by various delivery methods
    • Larson SD, Jackson LN, Chen LA, et al. Effectiveness of siRNA uptake in target tissues by various delivery methods. Surgery 2007 142 : 262 9.
    • (2007) Surgery , vol.142 , pp. 262-9
    • Larson, S.D.1    Jackson, L.N.2    Chen, L.A.3
  • 48
    • 34548779028 scopus 로고    scopus 로고
    • Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates
    • An DS, Donahue RE, Kamata M, et al. Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates. Proc Natl Acad Sci U S A 2007 104 : 13110 5.
    • (2007) Proc Natl Acad Sci U S a , vol.104 , pp. 13110-5
    • An, D.S.1    Donahue, R.E.2    Kamata, M.3
  • 49
    • 34250618419 scopus 로고    scopus 로고
    • Off-targeting and other non-specific effects of RNAi experiments in mammalian cells
    • Svoboda P. Off-targeting and other non-specific effects of RNAi experiments in mammalian cells. Curr Opin Mol Ther 2006 9 : 248 57.
    • (2006) Curr Opin Mol Ther , vol.9 , pp. 248-57
    • Svoboda, P.1
  • 50
    • 33745299723 scopus 로고    scopus 로고
    • Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
    • Grimm D, Streetz KL, Jopling CL, et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 2006 441 : 537 41.
    • (2006) Nature , vol.441 , pp. 537-41
    • Grimm, D.1    Streetz, K.L.2    Jopling, C.L.3
  • 51
    • 35549005821 scopus 로고    scopus 로고
    • Chemical modification resolves the asymmetry of siRNA strand degradation in human blood serum
    • Hoerter JA, Walter NG. Chemical modification resolves the asymmetry of siRNA strand degradation in human blood serum. RNA 2007 13 : 1887 93.
    • (2007) RNA , vol.13 , pp. 1887-93
    • Hoerter, J.A.1    Walter, N.G.2


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