Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 32, 2007, Pages 13110-13115

  Dong, Sung An ^a   Donahue, Robert E ^b   Kamata, Masakazu ^a   Poon, Betty ^a   Metzger, Mark ^b   Mao, Si Hua ^a   Bonifacino, Aylin ^b   Krouse, Allen E ^b   Darlix, Jean Luc ^d   Baltimore, David ^c   Qin, F Xiao Feng ^e   Chen, Irvin S Y ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITÉ DE LYON   (France)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Gene therapy; Rhesus macaque; Short hairpin RNA; siRNA

Indexed keywords

CHEMOKINE RECEPTOR CCR5; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; INFECTION SENSITIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROVIRUS INFECTION; RHESUS MONKEY; RNA INTERFERENCE; SIMIAN IMMUNODEFICIENCY VIRUS; ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL; DRUG ANTAGONISM; GENE THERAPY; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPHOCYTE; MACACA; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; PRIMATES; SIMIAN IMMUNODEFICIENCY VIRUS;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; GENE THERAPY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HIV-1; LYMPHOCYTES; MACACA MULATTA; RECEPTORS, CCR5; RNA INTERFERENCE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 34548779028     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0705474104     Document Type: Article

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