Recent advances in coeliac disease

Gut

Volumn 55, Issue 7, 2006, Pages 1037-1046

  Van Heel, D A ^a   West, J ^b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; GLUTEN; HLA ANTIGEN CLASS 2; HORMONE; INTERLEUKIN 15; PEPTIDE;

AUTOIMMUNE DISEASE; BONE DENSITY; CELIAC DISEASE; CLINICAL FEATURE; CRYSTAL STRUCTURE; DENDRITIC CELL; DIARRHEA; DUAL ENERGY X RAY ABSORPTIOMETRY; ENDOSCOPIC BIOPSY; ENDOSCOPY; FERTILITY; FRACTURE; HORMONE SUBSTITUTION; HUMAN; INTESTINE CELL; MORTALITY; OSTEOPOROSIS; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SCREENING; SEROLOGY; STEATORRHEA; SYMPTOMATOLOGY; UNITED KINGDOM; WEIGHT REDUCTION;

CELIAC DISEASE; DIAGNOSTIC ERRORS; FERTILITY; HUMANS; INCIDENCE; PREVALENCE; RISK;

EID: 33745493934     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2005.075119     Document Type: Review

References (129)

1. Fasano A, Berti I, Gerarduzzi T, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med 2003;163:286-92.
2. Catassi C, Ratsch IM, Fabiani E, et al. Coeliac disease in the year 2000: exploring the iceberg. Lancet 1994;343:200-3.
3. Meloni G, Dore A, Fanciulli G, et al. Subclinicol coeliac disease in schoolchildren from northern Sardinia. Lancet 1999;353:37.
4. Bingley PJ, Williams AJ, Norcross AJ, et al. Undiagnosed coeliac disease at age seven: population based prospective birth cohort study. BMJ 2004;328:322-3.
5. Maki M, Mustalahti K, Kokkonen J, et al. Prevalence of celiac disease among children in Finland. N Engl J Med 2003;348:2517-24.
6. Catassi C, Ratsch IM, Gandolfi L, et al. Why is coeliac disease endemic in the people of the Sahara? Lancet 1999;354:647-8.
7. Johnston SD, Watson RG, McMillan SA, et al. Prevalence of coeliac disease in Northern Ireland, Lancet 1997;350:1370.
8. Ivarsson A, Persson LA, Juto P, et al. High prevalence of undiagnosed coeliac disease in adults: a Swedish population-based study. J Intern Med 1999;245:63-8.
9. Couignoux S, Ocmant A, Cottel D, et al. Prevalence of adult coeliac disease in Northern France. Gut 2000;47:A196.
10. West J, Logan RF, Hill PG, et al. Seroprevalence, correlates, and characteristics of undetected coeliac disease in England. Gut 2003;52:960-5.
11. Collin P, Reunala T, Rasmussen M, et al. High incidence and prevalence of adult coeliac disease. Augmented diagnostic approach. Scand J Gastroenterol 1997;32:1129-33.
12. Bode S, Gudmand-Hoyer E. Incidence and prevalence of adult coeliac disease within a defined geographic area in Denmark. Scand J Gastroenterol 1996;31:694-9.
13. Murray JA, van Dyke C, Plevak MF, et al. Trends in the identification and clinical features of celiac disease in a North American Community, 1950-2001. Clin Gastroenterol Hepatol 2003;1:19-27.
14. Logan RF, Rifkind EA, Busuttil A, et al. Prevalence and "incidence" of celiac disease in Edinburgh and the Lothian region of Scotland. Gastroenterology 1986;90:334-42.
15. West J, Palmer BP, et al. Trends in clinical presentation of adult coeliac disease: a 25 year prospective study. Gut 2001;48(suppl I):A78.
16. Stevens FM, Egan-Mitchell B, Cryan E, et al. Decreasing incidence of coeliac disease. Arch Dis Child 1987;62:465-8.
17. Dossetor JF, Gibson AA, McNeish AS. Childhood coeliac disease is disappearing. Lancet 1981;1:322-3.
18. Littlewood JM, Crollick AJ, Richards IDG. Childhood coeliac disease is disappearing. Lancet 1980;ii:1359.
19. Maki M, Kallonen K, Lahdeaho ML, et al. Changing pattern of childhood coeliac disease in Finland. Acta Paediatr Scand 1988;77:408-12.
20. Dahan S, Slater PE, Cooper M, et al. Coeliac disease in the Rehovot-Ashdod region of Israel: incidence and ethnic distribution. J Epidemiol Comm Health 1984;38:58-60.
21. Ivarsson A, Persson LA, Nystrom L, et al. Epidemic of coeliac disease in Swedish children. Acta Paediatr 2000;89:165-71.
22. Ivarsson A. The Swedish epidemic of coeliac disease explored using an epidemiological approach-some lessons to be learnt. Best Pract Res Clin Gastroenterol 2005;19:425-40.
23. George EK, Mearin ML, Franken HC, et al. Twenty years of childhood coeliac disease in The Netherlands: a rapidly increasing incidence? Gut 1997;40:61-6.
24. Hawkes ND, Swift GL, Smith PM, et al. Incidence and presentation of coeliac disease in South Glamorgan. Eur J Gastroenterol Hepatol 2000;12:345-9.
25. American Gastroenterological Association medical position statement: celiac sprue. Gastroenterology 2001;120:1522-5.
26. Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology 2001;120:636-51.
27. Feighery C. Fortnightly review: coeliac disease. BMJ 1999;319:236-9.
28. Ciclitira PJ, King AL, Fraser JS. AGA technical review on celiac sprue. American Gastroenterological Association. Gastroenterology 2001;120:1526-40.
29. Maki M, Collin P. Coeliac disease. Lancet 1997;349:1755-9.
30. Bode S, Gudmand-Hoyer E. Symptoms and haematologic features in consecutive adult coeliac patients. Scand J Gastroenterol 1996;31:54-60.
31. Logan RF, Tucker G, Rifkind EA, et al. Changes in clinical features of coeliac disease in adults in Edinburgh and the Lothians 1960-79. BMJ (Clin Res Ed) 1983;286:95-7.
32. Sanders DS, Hurlstone DP, Stokes RO, et al. Changing face of adult coeliac disease: experience of a single university hospital in South Yorkshire. Postgrad Med J 2002;78:31-3.
33. Lo W, Sano K, Lebwohl B, et al. Changing presentation of adult celiac disease. Dig Dis Sci 2003;48:395-8.
34. Hin H, Bird G, Fisher P, et al. Coeliac disease in primary care: case finding study. BMJ 1999;318:164-7.
35. Corazza GR, Di Sario A, Cecchetti L, et al. Influence of pattern of clinical presentation and of gluten-free diet on bone mass and metabolism in adult coeliac disease. Bone 1996;18:525-30.
36. Corazza GR, Di Sario A, Sacco G, et al. Subclinical coeliac disease: an anthropometric assessment. J Intern Med 1994;236:183-7.
37. Mustalahti K, Collin P, Sievanen H, et al. Osteopenia in patients with clinically silent coeliac disease warrants screening. Lancet 1999;354:744-5.
38. Scott EM, Gaywood I, Scott BB. Guidelines for osteoporosis in coeliac disease and inflammatory bowel disease. British Society of Gastroenterology. Gut 2000;46(suppl 1):i1-8.
39. Bernstein CN, Leslie WD. The pathophysiology of bone disease in gastrointestinal disease. Eur J Gastroenterol Hepatol 2003;15:857-64.
40. Vasqgez H, Mazure R, Gonzalez D, et al. Risk of fractures in celiac disease patients: a cross-sectional, case-control study. Am J Gastroenterol 2000;95:183-9.
41. Moreno ML, Vazquez H, Mazure R, et al. Stratification of bone fracture risk in patients with celiac disease. Clin Gastroenterol Hepatol 2004;2:127-34.
42. Fickling WE, McFarlane XA, Bhalla AK, et al. The clinical impact of metabolic bone disease in coeliac disease. Postgrad Med J 2001;77:33-6.
43. Thomason K, West J, Logan RF, et al. Fracture experience of patients with coeliac disease: a population based survey. Gut 2003;52:518-22.
44. Vestergaard P, Mosekilde L. Fracture risk in patients with celiac disease, Crohn's disease, and ulcerative colitis: a nationwide follow-up study of 16,416 patients in Denmark. Am J Epidemiol 2002;156:1-10.
45. West J, Logan RF, Card TR, et al. Fracture risk in people with celiac disease: a population-based cohort study. Gastroenterology 2003;125:429-36.
46. Corrao G, Corazza GR, Bagnardi V, et al. Mortality in patients with coeliac disease and their relatives: a cohort study. Lancet 2001;358:356-61.
47. Holmes GK, Prior P, Lane MR, et al. Malignancy in coeliac disease-effect of a gluten free diet. Gut 1989;30:333-8.
48. Cooper BT, Holmes GK, Ferguson R, et al. Celiac disease and malignancy. Medicine (Baltimore) 1980;59:249-61.
49. Logan RF, Rifkind EA, Turner ID, et al. Mortality in celiac disease. Gastroenterology 1989;97:265-71.
50. Cottone M, Termini A, Oliva L, et al. Mortality and causes of death in celiac disease in a Mediterranean area. Dig Dis Sci 1999;44:2538-41.
51. Peters U, Askling J, Gridley G, et al. Causes of death in patients with celiac disease in a population-based Swedish cohort. Arch Intern Med 2003;163:1566-72.
52. Askling J, Linet M, Gridley G, et al. Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis. Gastroenterology 2002;123:1428-35.
53. Card TR, West J, Holmes GK. Risk of malignancy in diagnosed coeliac disease: a 24-year prospective, population-based, cohort study. Aliment Pharmacol Ther 2004;20:769-75.
54. West J, Logan RF, Smith CI, et al. Malignancy and mortality in people with coeliac disease: population based cohort study. BMJ 2004;329:716-19.
55. Alstead EM, Nelson-Piercy C. Inflammatory bowel disease in pregnancy. Gut 2003;52:159-61.
56. Buchel E, Van Steenbergen W, Nevens F, et al. Improvement of autoimmune hepatitis during pregnancy followed by flare-up after delivery. Am J Gastroenterol 2002;97:3160-5.
57. Dominitz JA, Young JC, Boyko FJ. Outcomes of infants born to mothers with inflammatory bowel disease: a population-based cohort study. Am J Gastroenterol 2002;97:641-8.
58. Rostami K, Steegers EA, Wong WY, et al. Coeliac disease and reproductive disorders: a neglected association. Eur J Obstet Gynecol Reprod Biol 2001;96:146-9.
59. Wood SL, Jick H, Sauve R. The risk of stillbirth in pregnancies before and after the onset of diabetes. Diabet Med 2003;20:703-7.
60. Green PH, Jabri B. Coeliac disease. Lancet 2003;362:383-91.
61. Smecuol E, Maurino E, Vazquez H, et al. Gynaecological and obstetric disorders in coeliac disease: frequent clinical onset during pregnancy or the puerperium. Eur J Gastroenterol Hepatol 1996;8:63-89.
62. Norgard B, Fonager K, Sorensen HT, et al. Birth outcomes of women with celiac disease: a nationwide historical cohort study. Am J Gastroenterol 1999;94:2435-40.
63. Ciacci C, Cirillo M, Auriemma G, et al. Celiac disease and pregnancy outcome. Am J Gastroenterol 1996;91:718-22.
64. Sher KS, Mayberry JF. Female fertility, obstetric and gynaecological history in coeliac disease: a case control study. Acta Paediatr Suppl 1996;412:76-7.
65. Martinelli P, Troncone R, Paparo F, et al. Coeliac disease and unfavourable outcome of pregnancy. Gut 2000;46:332-5.
66. Tata LJ, Card TR, Logan RF, et al. Fertility and pregnancy-related events in women with celiac disease: a population-based cohort study. Gastroenterology 2005;128:849-55.
67. Ludvigsson JF, Montgomery SM, Ekbom A. Celiac disease and risk of adverse fetal outcome: a population-based cohort study. Gastroenterology 2005;129:454-63.
68. Arentz-Hansen H, McAdam SN, Molberg O, et al. Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues. Gastroenterology 2002;123:803-9.
69. Hausch F, Shan L, Santiago NA, et al. Intestinal digestive resistance of immunodominant gliadin peptides. Am J Physiol Gastrointest Liver Physiol 2002;283:G996-1003.
70. Shan L, Molberg O, Parrot I, et al. Structural basis for gluten intolerance in celiac sprue. Science 2002;297:2275-9.
71. Sturgess R, Day P, Ellis HJ, et al. Wheat peptide challenge in coeliac disease. Lancet 1994;343:758-61.
72. Maiuri L, Ciacci C, Ricciardelli I, et al. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet 2003;362:30-7.
73. Hue S, Mention JJ, Monteiro RC, et al. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity 2004;21:367-77.
74. Meresse B, Chen Z, Ciszewski C, et al. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 2004;21:357-66.
75. Clemente MG, De Virgiliis S, Kang JS, et al. Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut 2003;52:218-23.
76. Maiuri L, Ciacci C, Ricciardelli I, et al. Unexpected role of surface transglutaminase type II in celiac disease. Gastroenterology 2005;129:1400-13.
77. Sollid IM, Markussen G, Ek J, et al. Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. J Exp Med 1989;169:345-50.
78. Karell K, Louka AS, Moodie SJ, et al. HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. Hum Immunol 2003;64:469-77.
79. van Heel DA, Hunt K, Greco L, et al. Genetics in coeliac disease. Best Pract Res Clin Gastroenterol 2005;19:323-39.
80. Kim CY, Quarsten H, Bergseng E, et al. Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Proc Natl Acad Sci USA 2004;101:4175-9.
81. Xia J, Sollid LM, Khosla C. Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2. Biochemistry 2005;44:4442-9.
82. Lundin KE, Scott H, Hansen T, et al. Gliadin-specific, HLA-DQ (alpha 1*0501,beta1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 1993;178:187-96.
83. Molberg O, McAdam SN, Korner R, et al. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med 1998;4:713-17.
84. Voder LW, de Ru A, van der Wal Y, et al. Specificity of tissue transglutaminase explains cereal toxicity in celiac disease. J Exp Med 2002;195:643-9.
85. Fleckenstein B, Qiao SW, Larsen MR, et al. Molecular characterization of covalent complexes between tissue transglutaminase and gliadin peptides. J Biol Chem 2004;279:17607-16.
86. Vader W, Kooy Y, Van Veelen P, et al. The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides. Gastroenterology 2002;122:1729-37.
87. Arentz-Hansen H, Korner R, Molberg O, et al. The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase. J Exp Med 2000;191:603-12.
88. Sjostrom H, Lundin KE, Molberg O, et al. Identification of a gliadin T-cell epitope in coeliac disease: general importance of gliadin deamidation for intestinal T-cell recognition. Scand J Immunol 1998;48:111-15.
89. Vader LW, Stepniak DT, Bunnik EM, et al. Characterization of cereal toxicity for celiac disease patients based on protein homology in grains. Gastroenterology 2003;125:1105-13.
90. Arentz-Hansen H, Fleckenstein B, Molberg O, et al. The molecular basis for oat intolerance in patients with celiac disease. PLoS Med 2004;1:e1.
91. Anderson RP, Degano P, Godkin AJ, et al. In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope. Nat Med 2000;6:337-42.
92. Anderson RP, van Heel DA, Tye-Din JA, et al. T cells in peripheral blood after gluten challenge in coeliac disease. Gut 2005;54:1217-23.
93. Beissbarth T, Tye-Din JA, Smyth GK, et al. A systematic approach for comprehensive T-cell epitope discovery using peptide libraries. Bioinformatics 2005;21:i29-37.
94. Fraser JS, Engel W, Ellis HJ, et al. Coeliac disease: in vivo toxicity of the putative immunodominant epitope. Gut 2003;52:1698-702.
95. Chorzelski TP, Beutner EH, Sulej J, et al. IgA anti-endomysium antibody. A new immunological marker of dermatitis herpetiformis and coeliac disease. Br J Dermatol 1984;111:395-402.
96. James MW, Scott BB. Endomysial antibody in the diagnosis and management of coeliac disease. Postgrad Med J 2000;76:466-8.
97. Burgin-Wolff A, Dahlbom I, Hadziselimovic F, et al. Antibodies against human tissue transglutaminase and endomysium in diagnosing and monitoring coeliac disease. Scand J Gastraenterol 2002;37:685-91.
98. Horvath K, Hill ID. Anti-tissue transglutaminase antibody as the first line screening for celiac disease: good-bye antigliadin tests? Am J Gastroenterol 2002;97:2702-4.
99. Dieterich W, Laag E, Schopper H, et al. Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology 1998;115:1317-21.
100. Sulkanen S, Halltunen T, Laurila K, et al. Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Gastroenterology 1998;115:1322-8.
101. Hill PG, Thompson SP, Holmes GK. IgA anti-gliadin antibodies in adult celiac disease. Clin Chem 1991;37:647-50.
102. West J, Lloyd CA, Hill PG, et al. IgA-antitissue transglutaminase: validation of a commercial assay for diagnosing coeliac disease. Clin Lab 2002;48:241-6.
103. Wong RC, Wilson RJ, Steele RH, et al. A comparison of 13 guinea pig and human anti-tissue transglutaminase antibody ELISA kits. J Clin Pathol 2002;55:488-94.
104. Cataldo F, Marino V, Bottaro G, et al. Celiac disease and selective immunoglobulin A deficiency. J Pediatr 1997;131:306-8.
105. Hill PG, Forsyth JM, Semeraro D, et al. IgA antibodies to human tissue transglutaminase: audit of routine practice confirms high diagnostic accuracy. Scand J Gastroenterol 2004;39:1078-82.
106. Green PH, Rostami K, Marsh MN. Diagnosis of coeliac disease. Best Pract Res Clin Gastroenterol 2005;19:389-400.
107. Janatuinen EK, Pikkarainen PH, Kemppainen TA, et al. A comparison of diets with and without oats in adults with celiac disease. N Engl J Med 1995;333:1033-7.
108. Hoffenberg EJ, Haas J, Drescher A, et al. A trial of oats in children with newly diagnosed celiac disease. J Pediatr 2000;137:361-6.
109. Hogberg L, Laurin P, Falth-Magnusson K, et al. Oats to children with newly diagnosed coeliac disease: a randomised double blind study. Gut 2004;53:649-54.
110. Picarelli A, Di Tola M, Sabbatella L, et al. Immunologic evidence of no harmful effect of oats in celiac disease. Am J Clin Nutr 2001;74:137-40.
111. Janaluinen EK, Kemppainen TA, Julkunen RJ, et al. No harm from five year ingestion of oats in coeliac disease. Gut 2002;50:332-5.
112. Kupper C. Dietary guidelines and implementation for celiac disease. Gastroenterology 2005;128:S121-7.
113. Thompson T. Gluten contamination of commercial oat products in the United States. N Engl J Med 2004;351:2021-2.
114. Lundin KE, Nilsen EM, Scott HG, et al. Oats induced villous atrophy in coeliac disease. Gut 2003;52:1649-52.
115. Shan L, Mathews II, Khosla C. Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity. Proc Natl Acad Sci U S A 2005;102:3599-604.
116. Matysiak-Budnik T, Candalh C, Cellier C, et al. Limited efficiency of prolylendopeptidase in the detoxification of gliadin peptides in celiac disease. Gastroenterology 2005;129:786-96.
117. Belghith M, Bluestone JA, Barriot S, et al. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med 2003;9:1202-8.
118. Keymeulen B, Vandemeulebroucke E, Ziegler AG, et al. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med 2005;352:2598-608.
119. Harlan DM, von Herrath M. Immune intervention with anti-CD3 in diabetes. Nat Med 2005;11:716-18.
120. Molberg O, Uhlen AK, Jensen T, et al. Mapping of gluten T-cell epitopes in the bread wheat ancestors: implications for celiac disease. Gastroenterology 2005;128:393-401.
121. Spaenij-Dekking I, Kooy-Winkelaar Y, van Veelen P, et al. Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients. Gastroenterology 2005;129:797-806.
122. Spaenij-Dekking EH, Kooy-Winkelaar EM, Nieuwenhuizen WF, et al. A novel and sensitive method for the detection of T cell stimulatory epitopes of alpha/beta- and gamma-gliadin. Gut 2004;53:1267-73.
123. WGO-OMGE practice guideline: celiac disease. 2005 www. worldgastroenterorogy.org/globalguidelines (accessed 10 April 2006).
124. NIH consensus development conference on celiac disease: final statement. 2004 http://consensus.nih.gov/2004/2004CeliacDisease118html.htm (accessed 10 April 2006).
125. Corazza GR, Andreani ML, Biagi F, et al. The smaller size of the 'coeliac iceberg' in adults. Scand J Gastroenterol 1997;32: 917-19.
126. Riestra S, Fernandez E, Rodrigo L, et al. Prevalence of Coeliac disease in the general population of northern Spain. Strategies of serologic screening. Scand J Gastroenterol 2000;35:398-402.
127. Volta U, Bellentani S, Bianchi FB, et al. High prevalence of celiac disease in Italian general population. Dig Dis Sci 2001;46:1500-5.
128. Gomez JC, Selvaggio GS, Viola M, et al. Prevalence of celiac disease in Argentina: screening of an adult population in the La Plata area. Am J Gastroenterol 2001;96:2700-4.
129. Hovell G, Collett JA, Vautier G, et al. High prevalence of coeliac disease in a population-based study from Western Australia: a case for screening? Med J Aust 2001;175:247-50.