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Volumn 8, Issue 2, 2008, Pages 199-207

Classification of genetic profiles of Crohn's disease: A focus on the ATG16L1 gene

Author keywords

ATG16L1; Autophagy related 16 like 1 gene; Crohn's disease; Genome wide association; Single nucleotide polymorphism

Indexed keywords

ALANINE; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CYTOKINE RECEPTOR; INTERLEUKIN 23 RECEPTOR; THREONINE; UNCLASSIFIED DRUG;

EID: 41549098375     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/14737159.8.2.199     Document Type: Review
Times cited : (11)

References (89)
  • 1
    • 33144459948 scopus 로고    scopus 로고
    • European evidence based consensus on the diagnosis and management of Crohn's disease: Current management
    • Travis SP, Stange EF, Lemann M et al. European evidence based consensus on the diagnosis and management of Crohn's disease: current management. Gut 55(Suppl. 1), I16-I35 (2006).
    • (2006) Gut , vol.55 , Issue.SUPPL. 1
    • Travis, S.P.1    Stange, E.F.2    Lemann, M.3
  • 2
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky DK. Inflammatory bowel disease. N. Engl. J. Med. 347(6), 417-429 (2002).
    • (2002) N. Engl. J. Med , vol.347 , Issue.6 , pp. 417-429
    • Podolsky, D.K.1
  • 3
    • 17744373329 scopus 로고    scopus 로고
    • Genetics of Crohn disease, an archetypal inflammatory barrier disease
    • Schreiber S, Rosenstiel P, Albrecht M, Hampe J, Krawczak M. Genetics of Crohn disease, an archetypal inflammatory barrier disease. Nat. Rev. 6(5), 376-388 (2005).
    • (2005) Nat. Rev , vol.6 , Issue.5 , pp. 376-388
    • Schreiber, S.1    Rosenstiel, P.2    Albrecht, M.3    Hampe, J.4    Krawczak, M.5
  • 4
    • 0142053206 scopus 로고    scopus 로고
    • The immunological and genetic basis of inflammatory bowel disease
    • Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat. Rev. Immunol. 3(7), 521-533 (2003).
    • (2003) Nat. Rev. Immunol , vol.3 , Issue.7 , pp. 521-533
    • Bouma, G.1    Strober, W.2
  • 5
    • 33745775434 scopus 로고    scopus 로고
    • Mechanisms of disease: Pathogenesis of Crohn's disease and ulcerative colitis
    • Sartor RB. Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat. Clin. Pract. 3(7), 390-407 (2006).
    • (2006) Nat. Clin. Pract , vol.3 , Issue.7 , pp. 390-407
    • Sartor, R.B.1
  • 6
    • 0000651358 scopus 로고
    • Family occurrences of ulcerative colitis, regional enteritis, and ileocolitis
    • Kirsner JB, Spencer JA. Family occurrences of ulcerative colitis, regional enteritis, and ileocolitis. Ann. Intern. Med. 59, 133-144 (1963).
    • (1963) Ann. Intern. Med , vol.59 , pp. 133-144
    • Kirsner, J.B.1    Spencer, J.A.2
  • 7
    • 33745473236 scopus 로고    scopus 로고
    • Family and twin studies in inflammatory bowel disease
    • Halme L, Paavola-Sakki P, Turunen U et al. Family and twin studies in inflammatory bowel disease. World J. Gastroenterol. 12(23), 3668-3672 (2006).
    • (2006) World J. Gastroenterol , vol.12 , Issue.23 , pp. 3668-3672
    • Halme, L.1    Paavola-Sakki, P.2    Turunen, U.3
  • 8
    • 0025966488 scopus 로고
    • Familial occurrence of inflammatory bowel disease
    • Orholm M, Munkholm P, Langholz E et al. Familial occurrence of inflammatory bowel disease. N. Engl. J. Med. 324(2), 84-88 (1991).
    • (1991) N. Engl. J. Med , vol.324 , Issue.2 , pp. 84-88
    • Orholm, M.1    Munkholm, P.2    Langholz, E.3
  • 9
    • 0029788997 scopus 로고    scopus 로고
    • Familial aggregation in Crohn's disease: Increased age-adjusted risk and concordance in clinical characteristics
    • Peeters M, Nevens H, Baert F et al. Familial aggregation in Crohn's disease: increased age-adjusted risk and concordance in clinical characteristics. Gastroenterology 111(3), 597-603 (1996).
    • (1996) Gastroenterology , vol.111 , Issue.3 , pp. 597-603
    • Peeters, M.1    Nevens, H.2    Baert, F.3
  • 10
    • 0027404560 scopus 로고
    • Familial empirical risks for inflammatory bowel disease: Differences between Jews and non-Jews
    • Yang H, McElree C, Roth MP et al. Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews. Gut 34(4), 517-524 (1993).
    • (1993) Gut , vol.34 , Issue.4 , pp. 517-524
    • Yang, H.1    McElree, C.2    Roth, M.P.3
  • 11
    • 0031011057 scopus 로고    scopus 로고
    • The genetics of inflammatory bowel disease
    • Satsangi J, Jewell DP, Bell JI. The genetics of inflammatory bowel disease. Gut 40(5), 572-574 (1997).
    • (1997) Gut , vol.40 , Issue.5 , pp. 572-574
    • Satsangi, J.1    Jewell, D.P.2    Bell, J.I.3
  • 12
    • 0029810041 scopus 로고    scopus 로고
    • Crohn's disease: Influence of age at diagnosis on site and clinical type of disease
    • Polito JM II, Childs B, Mellits ED et al. Crohn's disease: influence of age at diagnosis on site and clinical type of disease. Gastroenterology 111(3), 580-586 (1996).
    • (1996) Gastroenterology , vol.111 , Issue.3 , pp. 580-586
    • Polito II, J.M.1    Childs, B.2    Mellits, E.D.3
  • 13
    • 7144253128 scopus 로고    scopus 로고
    • Anticipation in familial Crohn's disease
    • Grandbastien B, Peeters M, Franchimont D et al. Anticipation in familial Crohn's disease. Gut 42(2), 170-174 (1998).
    • (1998) Gut , vol.42 , Issue.2 , pp. 170-174
    • Grandbastien, B.1    Peeters, M.2    Franchimont, D.3
  • 14
    • 0029788998 scopus 로고    scopus 로고
    • Clinical characteristics of Crohn's disease in 72 families
    • Colombel JF, Grandbastien B, Gower-Rousseau C et al. Clinical characteristics of Crohn's disease in 72 families. Gastroenterology 111(3), 604-607 (1996).
    • (1996) Gastroenterology , vol.111 , Issue.3 , pp. 604-607
    • Colombel, J.F.1    Grandbastien, B.2    Gower-Rousseau, C.3
  • 15
    • 0034885938 scopus 로고    scopus 로고
    • Familial expression of anti-Saccharomyces cerevisiae Mannan antibodies in Crohn's disease and ulcerative colitis: A GISC study
    • Annese V, Andreoli A, Andriulli A et al. Familial expression of anti-Saccharomyces cerevisiae Mannan antibodies in Crohn's disease and ulcerative colitis: a GISC study. Am. J. Gastroenterol. 96(8), 2407-2412 (2001).
    • (2001) Am. J. Gastroenterol , vol.96 , Issue.8 , pp. 2407-2412
    • Annese, V.1    Andreoli, A.2    Andriulli, A.3
  • 16
    • 0030031717 scopus 로고    scopus 로고
    • Maintenance therapy for Crohn's disease
    • Bayless TM. Maintenance therapy for Crohn's disease. Gastroenterology 110(1), 299-302 (1996).
    • (1996) Gastroenterology , vol.110 , Issue.1 , pp. 299-302
    • Bayless, T.M.1
  • 17
    • 0034326740 scopus 로고    scopus 로고
    • Familial and sporadic inflammatory bowel disease: Different entities?
    • Peeters M, Cortot A, Vermeire S, Colombel JF. Familial and sporadic inflammatory bowel disease: different entities? Inflamm. Bowel Dis. 6(4), 314-320 (2000).
    • (2000) Inflamm. Bowel Dis , vol.6 , Issue.4 , pp. 314-320
    • Peeters, M.1    Cortot, A.2    Vermeire, S.3    Colombel, J.F.4
  • 18
    • 0033773642 scopus 로고    scopus 로고
    • Concordance of inflammatory bowel disease among Danish twins. Results of a nationwide study
    • Orholm M, Binder V, Sorensen TI, Rasmussen LP, Kyvik KO. Concordance of inflammatory bowel disease among Danish twins. Results of a nationwide study. Scand. J. Gastroenterol. 35(10), 1075-1081 (2000).
    • (2000) Scand. J. Gastroenterol , vol.35 , Issue.10 , pp. 1075-1081
    • Orholm, M.1    Binder, V.2    Sorensen, T.I.3    Rasmussen, L.P.4    Kyvik, K.O.5
  • 19
    • 0037308263 scopus 로고    scopus 로고
    • The genetics of inflammatory bowel disease
    • Bonen DK, Cho JH. The genetics of inflammatory bowel disease. Gastroenterology 124(2), 521-536 (2003).
    • (2003) Gastroenterology , vol.124 , Issue.2 , pp. 521-536
    • Bonen, D.K.1    Cho, J.H.2
  • 20
    • 0142021798 scopus 로고    scopus 로고
    • Update on the genetics of inflammatory bowel disease
    • Duerr RH. Update on the genetics of inflammatory bowel disease. J. Clin. Gastroenterol. 37(5), 358-367 (2003).
    • (2003) J. Clin. Gastroenterol , vol.37 , Issue.5 , pp. 358-367
    • Duerr, R.H.1
  • 21
    • 16844366944 scopus 로고    scopus 로고
    • Genomics, genetic epidemiology, and genomic medicine
    • Lazaridis KN, Petersen GM. Genomics, genetic epidemiology, and genomic medicine. Clin. Gastroenterol. Hepatol. 3(4), 320-328 (2005).
    • (2005) Clin. Gastroenterol. Hepatol , vol.3 , Issue.4 , pp. 320-328
    • Lazaridis, K.N.1    Petersen, G.M.2
  • 22
    • 0030042271 scopus 로고    scopus 로고
    • Genetics versus environment in inflammatory bowel disease: Results of a British twin study
    • Thompson NP, Driscoll R, Pounder RE, Wakefield AJ. Genetics versus environment in inflammatory bowel disease: results of a British twin study. BMJ 312(7023), 95-96 (1996).
    • (1996) BMJ , vol.312 , Issue.7023 , pp. 95-96
    • Thompson, N.P.1    Driscoll, R.2    Pounder, R.E.3    Wakefield, A.J.4
  • 23
    • 0023713859 scopus 로고
    • Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking
    • Tysk C, Lindberg E, Jarnerot G, Floderus-Myrhed B. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 29(7), 990-996 (1988).
    • (1988) Gut , vol.29 , Issue.7 , pp. 990-996
    • Tysk, C.1    Lindberg, E.2    Jarnerot, G.3    Floderus-Myrhed, B.4
  • 24
    • 33646020997 scopus 로고    scopus 로고
    • New genes in inflammatory bowel disease: Lessons for complex diseases?
    • Gaya DR, Russell RK, Nimmo ER, Satsangi J. New genes in inflammatory bowel disease: lessons for complex diseases? Lancet 367(9518), 1271-1284 (2006).
    • (2006) Lancet , vol.367 , Issue.9518 , pp. 1271-1284
    • Gaya, D.R.1    Russell, R.K.2    Nimmo, E.R.3    Satsangi, J.4
  • 25
    • 0038620498 scopus 로고    scopus 로고
    • Inflammatory bowel disease in a Swedish twin cohort: A long-term follow-up of concordance and clinical characteristics
    • Halfvarson J, Bodin L, Tysk C, Lindberg E, Jarnerot G. Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics. Gastroenterology 124(7), 1767-1773 (2003).
    • (2003) Gastroenterology , vol.124 , Issue.7 , pp. 1767-1773
    • Halfvarson, J.1    Bodin, L.2    Tysk, C.3    Lindberg, E.4    Jarnerot, G.5
  • 26
    • 0030823714 scopus 로고    scopus 로고
    • Monozygotic twins with Crohn's disease and ulcerative colitis: A unique case report
    • Breslin NP, Todd A, Kilgallen C, O'Morain C. Monozygotic twins with Crohn's disease and ulcerative colitis: a unique case report. Gut 41(4), 557-560 (1997).
    • (1997) Gut , vol.41 , Issue.4 , pp. 557-560
    • Breslin, N.P.1    Todd, A.2    Kilgallen, C.3    O'Morain, C.4
  • 27
    • 0032433451 scopus 로고    scopus 로고
    • Genetic susceptibility in Crohn's disease - review of clinical studies
    • Tysk C. Genetic susceptibility in Crohn's disease - review of clinical studies. Eur. J. Surg. 164(12), 893-896 (1998).
    • (1998) Eur. J. Surg , vol.164 , Issue.12 , pp. 893-896
    • Tysk, C.1
  • 28
    • 1842455329 scopus 로고    scopus 로고
    • Genetics of inflammatory bowel disease: Progress and prospects
    • Mathew CG, Lewis CM. Genetics of inflammatory bowel disease: progress and prospects. Hum. Mol. Genet. 13(Spec. No 1), R161-R168 (2004).
    • (2004) Hum. Mol. Genet , vol.13 , Issue.SPEC. 1
    • Mathew, C.G.1    Lewis, C.M.2
  • 29
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP, Chamaillard M, Zouali H et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411(6837), 599-603 (2001).
    • (2001) Nature , vol.411 , Issue.6837 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 30
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411(6837), 603-606 (2001).
    • (2001) Nature , vol.411 , Issue.6837 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 31
    • 0035897904 scopus 로고    scopus 로고
    • Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
    • Hampe J, Cuthbert A, Croucher PJ et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet 357(9272), 1925-1928 (2001).
    • (2001) Lancet , vol.357 , Issue.9272 , pp. 1925-1928
    • Hampe, J.1    Cuthbert, A.2    Croucher, P.J.3
  • 32
    • 0034785352 scopus 로고    scopus 로고
    • Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease
    • Rioux JD, Daly MJ, Silverberg MS et al. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat. Genet. 29(2), 223-228 (2001).
    • (2001) Nat. Genet , vol.29 , Issue.2 , pp. 223-228
    • Rioux, J.D.1    Daly, M.J.2    Silverberg, M.S.3
  • 33
    • 0037383554 scopus 로고    scopus 로고
    • Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease
    • Mirza MM, Fisher SA, King K et al. Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease. Am. J. Hum. Genet. 72(4), 1018-1022 (2003).
    • (2003) Am. J. Hum. Genet , vol.72 , Issue.4 , pp. 1018-1022
    • Mirza, M.M.1    Fisher, S.A.2    King, K.3
  • 34
    • 2442585704 scopus 로고    scopus 로고
    • Functional variants of OCTN cation transporter genes are associated with Crohn disease
    • Peltekova VD, Wintle RF, Rubin LA et al. Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat. Genet. 36(5), 471-475 (2004).
    • (2004) Nat. Genet , vol.36 , Issue.5 , pp. 471-475
    • Peltekova, V.D.1    Wintle, R.F.2    Rubin, L.A.3
  • 35
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr RH, Taylor KD, Brant SR et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314(5804), 1461-1463 (2006).
    • (2006) Science , vol.314 , Issue.5804 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3
  • 36
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome, 4377063, 1299-1320
    • A haplotype map of the human genome. Nature 437(7063), 1299-1320 (2005).
    • (2005) Nature
  • 37
    • 2642583283 scopus 로고    scopus 로고
    • Mapping complex disease loci in whole-genome association studies
    • Carlson CS, Eberle MA, Kruglyak L, Nickerson DA. Mapping complex disease loci in whole-genome association studies. Nature 429(6990), 446-452 (2004).
    • (2004) Nature , vol.429 , Issue.6990 , pp. 446-452
    • Carlson, C.S.1    Eberle, M.A.2    Kruglyak, L.3    Nickerson, D.A.4
  • 38
    • 13144306071 scopus 로고    scopus 로고
    • Genome-wide association studies for common diseases and complex traits
    • Hirschhorn JN, Daly MJ. Genome-wide association studies for common diseases and complex traits. Nat. Rev. 6(2), 95-108 (2005).
    • (2005) Nat. Rev , vol.6 , Issue.2 , pp. 95-108
    • Hirschhorn, J.N.1    Daly, M.J.2
  • 39
    • 35348983887 scopus 로고    scopus 로고
    • A second generation human haplotype map of over 3.1 million SNPs
    • Frazer KA, Ballinger DG, Cox DR et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 449(7164), 851-861 (2007).
    • (2007) Nature , vol.449 , Issue.7164 , pp. 851-861
    • Frazer, K.A.1    Ballinger, D.G.2    Cox, D.R.3
  • 40
    • 33751329250 scopus 로고    scopus 로고
    • Global variation in copy number in the human genome
    • Redon R, Ishikawa S, Fitch KR et al. Global variation in copy number in the human genome. Nature 444(7118), 444-454 (2006).
    • (2006) Nature , vol.444 , Issue.7118 , pp. 444-454
    • Redon, R.1    Ishikawa, S.2    Fitch, K.R.3
  • 41
    • 27144472560 scopus 로고    scopus 로고
    • A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility
    • Reich D, Patterson N, De Jager PL et al. A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat. Genet. 37(10), 1113-1118 (2005).
    • (2005) Nat. Genet , vol.37 , Issue.10 , pp. 1113-1118
    • Reich, D.1    Patterson, N.2    De Jager, P.L.3
  • 42
    • 31344476038 scopus 로고    scopus 로고
    • Whole-genome genotyping with the single-base extension assay
    • Steemers FJ, Chang W, Lee G et al. Whole-genome genotyping with the single-base extension assay. Nat. Methods 3(1), 31-33 (2006).
    • (2006) Nat. Methods , vol.3 , Issue.1 , pp. 31-33
    • Steemers, F.J.1    Chang, W.2    Lee, G.3
  • 43
    • 18144425478 scopus 로고    scopus 로고
    • A genome-wide scalable SNP genotyping assay using microarray technology
    • Gunderson KL, Steemers FJ, Lee G, Mendoza LG, Chee MS. A genome-wide scalable SNP genotyping assay using microarray technology. Nat. Genet. 37(5), 549-554 (2005).
    • (2005) Nat. Genet , vol.37 , Issue.5 , pp. 549-554
    • Gunderson, K.L.1    Steemers, F.J.2    Lee, G.3    Mendoza, L.G.4    Chee, M.S.5
  • 44
    • 34547621758 scopus 로고    scopus 로고
    • A genome-wide association study identifies KIAA0350 as a Type 1 diabetes gene
    • Hakonarson H, Grant SF, Bradfield JP et al. A genome-wide association study identifies KIAA0350 as a Type 1 diabetes gene. Nature 448, 591-594 (2007).
    • (2007) Nature , vol.448 , pp. 591-594
    • Hakonarson, H.1    Grant, S.F.2    Bradfield, J.P.3
  • 45
    • 34347341846 scopus 로고    scopus 로고
    • Robust associations of four new chromosome regions from genome-wide analyses of Type 1 diabetes
    • Todd JA, Walker NM, Cooper JD et al. Robust associations of four new chromosome regions from genome-wide analyses of Type 1 diabetes. Nat. Genet. 39(7), 857-864 (2007).
    • (2007) Nat. Genet , vol.39 , Issue.7 , pp. 857-864
    • Todd, J.A.1    Walker, N.M.2    Cooper, J.D.3
  • 46
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145), 661-678 (2007).
    • (2007) Nature , vol.447 , Issue.7145 , pp. 661-678
  • 47
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for Type 2 diabetes
    • Sladek R, Rocheleau G, Rung J et al. A genome-wide association study identifies novel risk loci for Type 2 diabetes. Nature 445(7130), 881-885 (2007).
    • (2007) Nature , vol.445 , Issue.7130 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3
  • 48
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Saxena R, Voight BF, Lyssenko V et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316(5829), 1331-1336 (2007).
    • (2007) Science , vol.316 , Issue.5829 , pp. 1331-1336
    • Saxena, R.1    Voight, B.F.2    Lyssenko, V.3
  • 49
    • 34249895023 scopus 로고    scopus 로고
    • Replication of genome-wide association signals in UK samples reveals risk loci for Type 2 diabetes
    • Zeggini E, Weedon MN, Lindgren CM et al. Replication of genome-wide association signals in UK samples reveals risk loci for Type 2 diabetes. Science 316(5829), 1336-1341 (2007).
    • (2007) Science , vol.316 , Issue.5829 , pp. 1336-1341
    • Zeggini, E.1    Weedon, M.N.2    Lindgren, C.M.3
  • 50
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of Type 2 diabetes in Finns detects multiple susceptibility variants
    • Scott LJ, Mohlke KL, Bonnycastle LL et al. A genome-wide association study of Type 2 diabetes in Finns detects multiple susceptibility variants. Science 316(5829), 1341-1345 (2007).
    • (2007) Science , vol.316 , Issue.5829 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3
  • 51
    • 20244380171 scopus 로고    scopus 로고
    • Complement factor H polymorphism in age-related macular degeneration
    • Klein RJ, Zeiss C, Chew EY et al. Complement factor H polymorphism in age-related macular degeneration. Science 308(5720), 385-389 (2005).
    • (2005) Science , vol.308 , Issue.5720 , pp. 385-389
    • Klein, R.J.1    Zeiss, C.2    Chew, E.Y.3
  • 52
    • 34250010480 scopus 로고    scopus 로고
    • A common variant on chromosome 9p21 affects the risk of myocardial infarction
    • Helgadottir A, Thorleifsson G, Manolescu A et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 316(5830), 1491-1493 (2007).
    • (2007) Science , vol.316 , Issue.5830 , pp. 1491-1493
    • Helgadottir, A.1    Thorleifsson, G.2    Manolescu, A.3
  • 53
    • 34249996115 scopus 로고    scopus 로고
    • A common allele on chromosome 9 associated with coronary heart disease
    • McPherson R, Pertsemlidis A, Kavaslar N et al. A common allele on chromosome 9 associated with coronary heart disease. Science 316(5830), 1488-1491 (2007).
    • (2007) Science , vol.316 , Issue.5830 , pp. 1488-1491
    • McPherson, R.1    Pertsemlidis, A.2    Kavaslar, N.3
  • 54
    • 85172068588 scopus 로고    scopus 로고
    • Easton DF, Pooley KA, Dunning AM et al. Genome-wide association study identifies novel breast cancer susceptibility loci. 447(7148), 1087-1093 Nature (2007).
    • Easton DF, Pooley KA, Dunning AM et al. Genome-wide association study identifies novel breast cancer susceptibility loci. 447(7148), 1087-1093 Nature (2007).
  • 55
    • 34547436749 scopus 로고    scopus 로고
    • Association of variants of the interleukin-23 receptor (IL23R) gene with susceptibility to pediatric Crohn's disease
    • Baldassano RN, Bradfield JP, Monos DS et al. Association of variants of the interleukin-23 receptor (IL23R) gene with susceptibility to pediatric Crohn's disease. Clin. Gastroenterol. Hepatol. Clin. 5(8), 972-976 (2007).
    • (2007) Clin. Gastroenterol. Hepatol. Clin , vol.5 , Issue.8 , pp. 972-976
    • Baldassano, R.N.1    Bradfield, J.P.2    Monos, D.S.3
  • 56
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe J, Franke A, Rosenstiel P et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat. Genet. 39(2), 207-211 (2007).
    • (2007) Nat. Genet , vol.39 , Issue.2 , pp. 207-211
    • Hampe, J.1    Franke, A.2    Rosenstiel, P.3
  • 57
    • 0037265610 scopus 로고    scopus 로고
    • Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations
    • Croucher PJ, Mascheretti S, Hampe J et al. Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations. Eur. J. Hum. Genet. 11(1), 6-16 (2003).
    • (2003) Eur. J. Hum. Genet , vol.11 , Issue.1 , pp. 6-16
    • Croucher, P.J.1    Mascheretti, S.2    Hampe, J.3
  • 58
  • 59
    • 0142059667 scopus 로고    scopus 로고
    • Are we there yet?: Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits
    • Page GP, George V, Go RC, Page PZ, Allison DB. "Are we there yet?": deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits. Am. J. Hum. Genet. 73(4), 711-719 (2003).
    • (2003) Am. J. Hum. Genet , vol.73 , Issue.4 , pp. 711-719
    • Page, G.P.1    George, V.2    Go, R.C.3    Page, P.Z.4    Allison, D.B.5
  • 61
    • 34247554965 scopus 로고    scopus 로고
    • Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    • Rioux JD, Xavier RJ, Taylor KD et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat. Genet. 39(5), 596-604 (2007).
    • (2007) Nat. Genet , vol.39 , Issue.5 , pp. 596-604
    • Rioux, J.D.1    Xavier, R.J.2    Taylor, K.D.3
  • 62
    • 34247579326 scopus 로고    scopus 로고
    • Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4
    • Libioulle C, Louis E, Hansoul S et al. Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet. 3(4), E58 (2007).
    • (2007) PLoS Genet , vol.3 , Issue.4
    • Libioulle, C.1    Louis, E.2    Hansoul, S.3
  • 63
    • 33748506089 scopus 로고    scopus 로고
    • Human IRGM induces autophagy to eliminate intracellular mycobacteria
    • Singh SB, Davis AS, Taylor GA, Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313(5792), 1438-1441 (2006).
    • (2006) Science , vol.313 , Issue.5792 , pp. 1438-1441
    • Singh, S.B.1    Davis, A.S.2    Taylor, G.A.3    Deretic, V.4
  • 64
    • 34347338690 scopus 로고    scopus 로고
    • Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    • Parkes M, Barrett JC, Prescott NJ et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat. Genet. 39(7), 830-832 (2007).
    • (2007) Nat. Genet , vol.39 , Issue.7 , pp. 830-832
    • Parkes, M.1    Barrett, J.C.2    Prescott, N.J.3
  • 65
    • 36549062442 scopus 로고    scopus 로고
    • IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease
    • Roberts RL, Gearry RB, Hollis-Moffatt JE et al. IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease. Am. J. Gastroenterol. 102(12), 2754-2761 (2007).
    • (2007) Am. J. Gastroenterol , vol.102 , Issue.12 , pp. 2754-2761
    • Roberts, R.L.1    Gearry, R.B.2    Hollis-Moffatt, J.E.3
  • 66
    • 33645517833 scopus 로고    scopus 로고
    • Crohn's disease in adults: Observations in a multiracial Asian population
    • Hilmi I, Tan YM, Goh KL. Crohn's disease in adults: observations in a multiracial Asian population. World J. Gastroenterol. 12(9), 1435-1438 (2006).
    • (2006) World J. Gastroenterol , vol.12 , Issue.9 , pp. 1435-1438
    • Hilmi, I.1    Tan, Y.M.2    Goh, K.L.3
  • 67
    • 0031885567 scopus 로고    scopus 로고
    • Crohn's disease in the Singapore Chinese population
    • Law NM, Lim CC, Chong R, Ng HS. Crohn's disease in the Singapore Chinese population. J. Clin. Gastroenterol. 26(1), 27-29 (1998).
    • (1998) J. Clin. Gastroenterol , vol.26 , Issue.1 , pp. 27-29
    • Law, N.M.1    Lim, C.C.2    Chong, R.3    Ng, H.S.4
  • 68
    • 0033784182 scopus 로고
    • Incidence and prevalence of ulcerative colitis in the Songpa-Kangdong District, Seoul, Korea, 2000
    • Yang SK, Hong WS, Min YI et al. Incidence and prevalence of ulcerative colitis in the Songpa-Kangdong District, Seoul, Korea, 1986-1997. J. Gastroenterol. Hepatol. 15(9), 1037-1042 (2000).
    • (1986) J. Gastroenterol. Hepatol , vol.15 , Issue.9 , pp. 1037-1042
    • Yang, S.K.1    Hong, W.S.2    Min, Y.I.3
  • 69
    • 4644227888 scopus 로고    scopus 로고
    • The epidemiology and phenotype of Crohn's disease in the Chinese population
    • Leong RW, Lau JY, Sung JJ. The epidemiology and phenotype of Crohn's disease in the Chinese population. Inflamm. Bowel Dis. 10(5), 646-651 (2004).
    • (2004) Inflamm. Bowel Dis , vol.10 , Issue.5 , pp. 646-651
    • Leong, R.W.1    Lau, J.Y.2    Sung, J.J.3
  • 70
    • 2442563304 scopus 로고    scopus 로고
    • Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences
    • Loftus EV Jr. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 126(6), 1504-1517 (2004).
    • (2004) Gastroenterology , vol.126 , Issue.6 , pp. 1504-1517
    • Loftus Jr., E.V.1
  • 71
    • 34347357508 scopus 로고    scopus 로고
    • Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients
    • Yamazaki K, Onouchi Y, Takazoe M et al. Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients. J. Hum. Genet. 52(7), 575-583 (2007).
    • (2007) J. Hum. Genet , vol.52 , Issue.7 , pp. 575-583
    • Yamazaki, K.1    Onouchi, Y.2    Takazoe, M.3
  • 72
    • 34547211759 scopus 로고    scopus 로고
    • Association of the T300A nonsynonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease
    • Baldassano RN, Bradfield JP, Monos DS et al. Association of the T300A nonsynonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease. Gut 56(8), 1171-1173 (2007).
    • (2007) Gut , vol.56 , Issue.8 , pp. 1171-1173
    • Baldassano, R.N.1    Bradfield, J.P.2    Monos, D.S.3
  • 73
    • 34247566585 scopus 로고    scopus 로고
    • A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5
    • Prescott NJ, Fisher SA, Franke A et al. A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. Gastroenterology 132(5), 1665-1671 (2007).
    • (2007) Gastroenterology , vol.132 , Issue.5 , pp. 1665-1671
    • Prescott, N.J.1    Fisher, S.A.2    Franke, A.3
  • 74
    • 0033927387 scopus 로고    scopus 로고
    • High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12
    • Duerr RH, Barmada MM, Zhang L, Pfutzer R, Weeks DE. High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12. Am. J. Hum. Genet. 66(6), 1857-1862 (2000).
    • (2000) Am. J. Hum. Genet , vol.66 , Issue.6 , pp. 1857-1862
    • Duerr, R.H.1    Barmada, M.M.2    Zhang, L.3    Pfutzer, R.4    Weeks, D.E.5
  • 75
    • 0033358425 scopus 로고    scopus 로고
    • A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort
    • Hampe J, Schreiber S, Shaw SH et al. A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. Am. J. Hum. Genet. 64(3), 808-816 (1999).
    • (1999) Am. J. Hum. Genet , vol.64 , Issue.3 , pp. 808-816
    • Hampe, J.1    Schreiber, S.2    Shaw, S.H.3
  • 76
    • 0242606876 scopus 로고    scopus 로고
    • Stratification by CARD15 variant genotype in a genome-wide search for inflammatory bowel disease susceptibility loci
    • Shaw SH, Hampe J, White R et al. Stratification by CARD15 variant genotype in a genome-wide search for inflammatory bowel disease susceptibility loci. Hum. Genet. 113(6), 514-521 (2003).
    • (2003) Hum. Genet , vol.113 , Issue.6 , pp. 514-521
    • Shaw, S.H.1    Hampe, J.2    White, R.3
  • 77
    • 7444244288 scopus 로고    scopus 로고
    • Cloning and analysis of human Apg16L
    • Zheng H, Ji C, Li J et al. Cloning and analysis of human Apg16L. DNA Seq. 15(4), 303-305 (2004).
    • (2004) DNA Seq , vol.15 , Issue.4 , pp. 303-305
    • Zheng, H.1    Ji, C.2    Li, J.3
  • 78
    • 0038325675 scopus 로고    scopus 로고
    • Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
    • Mizushima N, Kuma A, Kobayashi Y et al. Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J. Cell Sci. 116(Pt 9), 1679-1688 (2003).
    • (2003) J. Cell Sci , vol.116 , Issue.PART 9 , pp. 1679-1688
    • Mizushima, N.1    Kuma, A.2    Kobayashi, Y.3
  • 79
    • 0037166241 scopus 로고    scopus 로고
    • Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast
    • Kuma A, Mizushima N, Ishihara N, Ohsumi Y. Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J. Biol. Chem. 277(21), 18619-18625 (2002).
    • (2002) J. Biol. Chem , vol.277 , Issue.21 , pp. 18619-18625
    • Kuma, A.1    Mizushima, N.2    Ishihara, N.3    Ohsumi, Y.4
  • 80
    • 33744958258 scopus 로고    scopus 로고
    • Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole
    • Birmingham CL, Smith AC, Bakowski MA, Yoshimori T, Brumell JH. Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole. J. Biol. Chem. 281(16), 11374-11383 (2006).
    • (2006) J. Biol. Chem , vol.281 , Issue.16 , pp. 11374-11383
    • Birmingham, C.L.1    Smith, A.C.2    Bakowski, M.A.3    Yoshimori, T.4    Brumell, J.H.5
  • 81
    • 32544451924 scopus 로고    scopus 로고
    • Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of Type 2 diabetes
    • Grant SF, Thorleifsson G, Reynisdottir I et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of Type 2 diabetes. Nat. Genet. 38(3), 320-323 (2006).
    • (2006) Nat. Genet , vol.38 , Issue.3 , pp. 320-323
    • Grant, S.F.1    Thorleifsson, G.2    Reynisdottir, I.3
  • 82
    • 33845939675 scopus 로고    scopus 로고
    • TCF7L2: The biggest story in diabetes genetics since HLA?
    • Zeggini E, McCarthy MI. TCF7L2: the biggest story in diabetes genetics since HLA? Diabetologia, 50(1), 1-4 (2007).
    • (2007) Diabetologia , vol.50 , Issue.1 , pp. 1-4
    • Zeggini, E.1    McCarthy, M.I.2
  • 83
    • 33344475671 scopus 로고    scopus 로고
    • Autophagy in innate and adaptive immunity against intracellular pathogens
    • Schmid D, Dengjel J, Schoor O, Stevanovic S, Munz C. Autophagy in innate and adaptive immunity against intracellular pathogens. J. Mol. Med. 84(3), 194-202 (2006).
    • (2006) J. Mol. Med , vol.84 , Issue.3 , pp. 194-202
    • Schmid, D.1    Dengjel, J.2    Schoor, O.3    Stevanovic, S.4    Munz, C.5
  • 84
    • 33745357459 scopus 로고    scopus 로고
    • Autophagy as an immune defense mechanism
    • Deretic V. Autophagy as an immune defense mechanism. Curr. Opin. Immunol. 18(4), 375-382 (2006).
    • (2006) Curr. Opin. Immunol , vol.18 , Issue.4 , pp. 375-382
    • Deretic, V.1
  • 85
    • 20344361954 scopus 로고    scopus 로고
    • Autophagy promotes MHC class II presentation of peptides from intracellular source proteins
    • Dengjel J, Schoor O, Fischer R et al. Autophagy promotes MHC class II presentation of peptides from intracellular source proteins. Proc. Natl Acad. Sci. USA 102(22), 7922-7927 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , Issue.22 , pp. 7922-7927
    • Dengjel, J.1    Schoor, O.2    Fischer, R.3
  • 86
    • 33745240931 scopus 로고    scopus 로고
    • A genome-wide association study of nonsynonymous SNPs identifies a Type 1 diabetes locus in the interferon-induced helicase (IFIH1) region
    • Smyth DJ, Cooper JD, Bailey R et al. A genome-wide association study of nonsynonymous SNPs identifies a Type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat. Genet. 38(6), 617-619 (2006).
    • (2006) Nat. Genet , vol.38 , Issue.6 , pp. 617-619
    • Smyth, D.J.1    Cooper, J.D.2    Bailey, R.3
  • 87
    • 24744463111 scopus 로고    scopus 로고
    • Autophagy in innate and adaptive immunity
    • Deretic V. Autophagy in innate and adaptive immunity. Trends Immunol. 26(10), 523-528 (2005).
    • (2005) Trends Immunol , vol.26 , Issue.10 , pp. 523-528
    • Deretic, V.1
  • 88
    • 19644388051 scopus 로고    scopus 로고
    • Macrophages rapidly transfer pathogens from lipid raft vacuoles to autophagosomes
    • Amer AO, Byrne BG, Swanson MS. Macrophages rapidly transfer pathogens from lipid raft vacuoles to autophagosomes. Autophagy 1(1), 53-58 (2005).
    • (2005) Autophagy , vol.1 , Issue.1 , pp. 53-58
    • Amer, A.O.1    Byrne, B.G.2    Swanson, M.S.3
  • 89
    • 8344247016 scopus 로고    scopus 로고
    • Autophagy defends cells against invading group A Streptococcus
    • Nakagawa I, Amano A, Mizushima N et al. Autophagy defends cells against invading group A Streptococcus. Science 306(5698), 1037-1040 (2004).
    • (2004) Science , vol.306 , Issue.5698 , pp. 1037-1040
    • Nakagawa, I.1    Amano, A.2    Mizushima, N.3


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