Ci proteolysis: Regulation by a constellation of phosphorylation sites

Current Biology

Volumn 12, Issue 12, 2002, Pages R422-R423

  Lefers, Mark A ^a   Holmgren, Robert ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE; CI PROTEIN, DROSOPHILA; DNA BINDING PROTEIN; DROSOPHILA PROTEIN; GLYCOGEN SYNTHASE KINASE 3; PROTEIN KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN SERINE THREONINE KINASE; SHAGGY PROTEIN, DROSOPHILA; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BINDING SITE; DROSOPHILA; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CASEIN KINASES; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; GLYCOGEN SYNTHASE KINASE 3; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 0037173126     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00914-4     Document Type: Review

References (18)

1. Hedgehog signaling in animal development: Paradigms and principles
2. Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
3. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus
4. The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels
5. Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
6. Regulation of the Hedgehog and Wingless signalling pathways by the F- box/WD40-repeat protein Slimb
7. Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus
8. Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A
9. Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
10. Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by glycogen synthase kinase 3 and casein kinase 1
11. Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
12. Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation
13. Identification of a tetrameric hedgehog signaling complex
14. Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway
15. Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
16. Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
17. Gli proteins and Hedgehog signaling: Development and cancer
18. Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism