Single transmembrane spanning heterotrimeric G protein-coupled receptors and their signaling cascades

Pharmacological Reviews

Volumn 56, Issue 3, 2004, Pages 371-385

  Patel, Tarun B ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR; AMYLOID PRECURSOR PROTEIN; ATRIAL NATRIURETIC FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRIN; ION CHANNEL; NATRIURETIC PEPTIDE TYPE C; PLATELET DERIVED GROWTH FACTOR; PROTEIN TYROSINE KINASE; SERPENTINE; SOMATOMEDIN C; T LYMPHOCYTE RECEPTOR;

APOPTOSIS; AUTOCRINE EFFECT; COMPLEX FORMATION; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN METABOLISM; RECEPTOR UPREGULATION; REVIEW; SECOND MESSENGER; ZONA PELLUCIDA;

ANIMALS; CELL MEMBRANE; HETEROTRIMERIC GTP-BINDING PROTEINS; MODELS, BIOLOGICAL; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 4143085992     PISSN: 00316997     EISSN: None     Source Type: Journal    
DOI: 10.1124/pr.56.3.4     Document Type: Review

References (163)

1. Alderton F, Rakhit S, Kong KC, Palmer T, Sambi B, Pyne S, and Pyne NJ (2001) Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells. J Biol Chem 276:28578-28585.
2. Anand-Srivastava MB, Cantin M, and Genest J (1985a) Inhibition of pituitary adenylate cyclase by atrial natriuretic factor. Life Sci 36:1873-1879.
3. Anand-Srivastava MB, Franks DJ, Cantin M, and Genest J (1984) Atrial natriuretic factor inhibits adenylate cyclase activity. Biochem Biophys Res Commun 121:855-862.
4. Anand-Srivastava MB, Genest J, and Cantin M (1985b) Inhibitory effect of atrial natriuretic factor on adenylate cyclase activity in adrenal cortical membranes. FEBS Lett 181:199-202.
5. Anand-Srivastava MB, Sairam MR, and Cantin M (1990) Ring-deleted analogs of atrial natriuretic factor inhibit adenylate cyclase/cAMP system. Possible coupling of clearance atrial natriuretic factor receptors to adenylate cyclase/cAMP signal transduction system. J Biol Chem 265:8566-8572.
6. Anand-Srivastava MB, Sehl PD, and Lowe DG (1996) Cytoplasmic domain of natriuretic peptide receptor-C inhibits adenylyl cyclase. Involvement of a pertussis toxin-sensitive G protein. J Biol Chem 271:19324-19329.
7. Anand-Srivastava MB, Srivastava AK, and Cantin M (1987) Pertussis toxin attenuates atrial natriuretic factor-mediated inhibition of adenylate cyclase. Involvement of inhibitory guanine nucleotide regulatory protein. J Biol Chem 262:4931-4934.
8. Barbier AJ, Poppleton HM, Yigzaw Y, Mullenix JB, Wiepz GJ, Bertics PJ, and Patel TB (1999) Transmodulation of epidermal growth factor receptor function by cyclic AMP-dependent protein kinase. J Biol Chem 274:14067-14073.
9. Behrendt N, Ploug M, Patthy L, Houen G, Blasi F, and Dano K (1991) The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator. J Biol Chem 266:7842-7847.
10. Birnbaumer L (1990) G proteins in signal transduction. Anna Rev Pharmacol Toxicol 30:675-705.
11. Birnbaumer L (1992) Receptor-to-effector signaling through G proteins: roles for beta gamma dimers as well as alpha subunits. Cell 71:1069-1072.
12. Bosch F, Bouscarel B, Slaton J, Blackmore PF, and Exton JH (1986) Epidermal growth factor mimics insulin effects in rat hepatocytes. Biochem J 239:523-530.
13. Brazil DP and Hemmings BA (2001) Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci 26:657-664.
14. Brenner BM, Ballermann BJ, Gunning ME, and Zeidel ML (1990) Diverse biological actions of atrial natriuretic peptide. Physiol Rev 70:665-699.
15. Budnik LT and Mukhopadhyay AK (1991) Epidermal growth factor, a modulator of luteal adenylate cyclase. Characterization of epidermal growth factor receptors and its interaction with adenylate cyclase system in bovine luteal cell membrane. J Biol Chem 266:13908-13913.
16. Burchett SA (2000) Regulators of G protein signaling: a bestiary of modular protein binding domains. J Neurochem 75:1335-1351.
17. Carpenter G (1992) Receptor tyrosine kinase substrates: src homology domains and signal transduction. FASEB J 6:3283-3289.
18. Carpenter G (2000) The EGF receptor: a nexus for trafficking and signaling. Bioessays 22:697-707.
19. Cenciarelli C, Hohman RJ, Atkinson TP, Gusovsky F, and Weissman AM (1992) Evidence for GTP-binding protein involvement in the tyrosine phosphorylation of the T cell receptor zeta chain. J Biol Chem 267:14527-14530.
20. Chang MS, Lowe DG, Lewis M, Hellmiss R, Chen E, and Goeddel DV (1989) Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclases. Nature (Lond) 341:68-72.
21. Chen Z, Nield HS, Sun H, Barbier A, and Patel TB (1995) Expression of type V adenylyl cyclase is required for epidermal growth factor-mediated stimulation of cAMP accumulation. J Biol Chem 270:27525-27530.
22. Chinkers M, Garbers DL, Chang MS, Lowe DG, Chin HM, Goeddel DV, and Schulz S (1989) A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor. Nature (Lond) 338:78-83.
23. Chow JC, Condorelli G, and Smith RJ (1998) Insulin-like growth factor-I receptor internalization regulates signaling via the Shc/mitogen-activated protein kinase pathway, but not the insulin receptor substrate-1 pathway. J Biol Chem 273:4672-4680.
24. Ciaraldi TP and Maisel A (1989) Role of guanine nucleotide regulatory proteins in insulin stimulation of glucose transport in rat adipocytes. Influence of bacterial toxins. Biochem J 264:389-396.
25. Conway AM, Rakhit S, Pyne S, and Pyne NJ (1999) Platelet-derived-growth- factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase. Biochem J 337 (Pt 2):171-177.
26. Dalle S, Imamura T, Rose DW, Worrall DS, Ugi S, Hupfeld CJ, and Olefsky JM (2002) Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1. Mol Cell Biol 22:6272-6285.
27. Dalle S, Ricketts W, Imamura T, Vollenweider P, and Olefsky JM (2001) Insulin and insulin-like growth factor I receptors utilize different G protein signaling components. J Biol Chem 276:15688-15695.
28. Davis MM (2002) A new trigger for T cells. Cell 110:285-287.
29. de Bold AJ, Borenstein HB, Veress AT, and Sonnenberg H (1981) A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci 28:89-94.
30. Degryse B, Resnati M, Rabbani SA, Villa A, Fazioli F, and Blasi F (1999) Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells. Blood 94:649-662.
31. De Vries L and Gist Farquhar M (1999) RGS proteins: more than just GAPs for heterotrimeric G proteins. Trends Cell Biol 9:138-144.
32. Dewji NN and Singer SJ (1996) Genetic clues to Alzheimer's disease. Science (Wash DC) 271:159-160.
33. Erb L, Liu J, Ockerhausen J, Kong Q, Garrad RC, Griffin K, Neal C, Krugh B, Santiago-Perez LI, Gonzalez FA, et al. (2001) An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction. J Cell Biol 153:491-501.
34. Exton JH (1994) Phosphoinositide phospholipases and G proteins in hormone action. Annu Rev Physiol 56:349-369.
35. Fazioli F and Blasi F (1994) Urokinase-type plasminogen activator and its receptor: new targets for anti-metastatic therapy? Trends Pharmacol Sci 15:25-29.
36. Ferreira A, Caceres A, and Kosik KS (1993) Intraneuronal compartments of the amyloid precursor protein. J Neurosci 13:3112-3123.
37. Frazier WA, Gao AG, Dimitry J, Chung J, Brown EJ, Lindberg FP, and Linder ME (1999) The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi. J Biol Chem 274:8554-8560.
38. Fuller F, Porter JG, Arfsten AE, Miller J, Schilling JW, Scarborough RM, Lewicki JA, and Schenk DB (1988) Atrial natriuretic peptide clearance receptor. Complete sequence and functional expression of cDNA clones. J Biol Chem 263:9395-9401.
39. Gao AG, Lindberg FP, Dimitry JM, Brown EJ, and Frazier WA (1996a) Thrombospondin modulates alpha v beta 3 function through integrin-associated protein. J Cell Biol 135:533-544.
40. Gao AG, Lindberg FP, Finn MB, Blystone SD, Brown EJ, and Frazier WA (1996b) Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin. J Biol Chem 271:21-24.
41. Gao BN and Gilman AG (1991) Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proc Natl Acad Sci USA 88:10178-10182.
42. Giambarella U, Murayama Y, Ikezu T, Fujita T, and Nishimoto I (1997a) Potential CRE suppression by familial Alzheimer's mutants of APP independent of adenylyl cyclase regulation. FEBS Lett 412:97-101.
43. Giambarella U, Yamatsuji T, Okamoto T, Matsui T, Ikezu T, Murayama Y, Levine MA, Katz A, Gautam N, and Nishimoto I (1997b) G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. EMBO (Eur Mol Biol Organ) J 16:4897-4907.
44. Gilman AG (1987) G proteins: transducers of receptor-generated signals. Annu Rev Biochem 56:615-649.
45. Gong X, Dubois DH, Miller DJ, and Shur BD (1995) Activation of a G protein complex by aggregation of beta-1,4-galactosyltransferase on the surface of sperm. Science (Wash DC) 269:1718-1721.
46. Goren HJ, Northup JK, and Hollenberg MD (1985) Action of insulin modulated by pertussis toxin in rat adipocytes. Can J Physiol Pharmacol 63:1017-1022.
47. Griffiths EK and Penninger JM (2002a) ADAP-ting TCR signaling to integrins. Sci STKE:RE3.
48. Griffiths EK and Penninger JM (2002b) Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. Curr Opin Immunol 14:317-322.
49. Hallak H, Seiler AE, Green JS, Ross BN, and Rubin R (2000) Association of heterotrimeric G(i) with the insulin-like growth factor-I receptor. Release of G(beta-gamma) subunits upon receptor activation. J Biol Chem 275:2255-2258.
50. Hardy J (1992) Framing beta-amyloid. Nat Genet 1:233-234.
51. Hu RM, Levin ER, Pedram A, and Frank HJ (1992) Atrial natriuretic peptide inhibits the production and secretion of endothelin from cultured endothelial cells. Mediation through the C receptor. J Biol Chem 267:17384-17389.
52. Hupfeld CJ, Dalle S, and Olefsky JM (2003) Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes. Proc Natl Acad Sci USA 100:161-166.
53. Hurowitz EH, Melnyk JM, Chen YJ, Kouros-Mehr H, Simon MI, and Shizuya H (2000) Genomic characterization of the human heterotrimeric G protein alpha, beta and gamma subunit genes. DNA Res 7:111-120.
54. Ikezu T, Okamoto T, Giambarella U, Yokota T, and Nishimoto I (1995) In vivo coupling of insulin-like growth factor II/mannose 6-phosphate receptor to heteromeric G proteins. Distinct roles of cytoplasmic domains and signal sequestration by the receptor. J Biol Chem 270:29224-29228.
55. Ikezu T, Okamoto T, Komatsuzaki K, Matsui T, Martyn JA, and Nishimoto I (1996) Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP (Abstract). EMBO (Eur Mol Biol Organ) J 15:2468-2475.
56. Imamura T, Vollenweider P, Egawa K, Clodi M, Ishibashi K, Nakashima N, Ugi S, Adams JW, Brown JH, and Olefsky JM (1999) G alpha-q/11 protein plays a key role in insulin-induced glucose transport in 3T3-L1 adipocytes. Mol Cell Biol 19:6765-6774.
57. Imboden JB, Shoback DM, Pattison G, and Stobo JD (1986) Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium. Proc Natl Acad Sci USA 83:5673-5677.
58. Jo H, Byer S, and McDonald JM (1993) Insulin stimulates association of a 41kDa G-protein (GIR41) with the insulin receptor. Biochem Biophys Res Commun 196: 99-106.
59. Jo H, Cha BY, Davis HW, and McDonald JM (1992) Identification, partial purification and characterization of two guanosine triphosphate-binding proteins associated with insulin receptors. Endocrinology 131:2855-2862.
60. Johnson RM and Garrison JC (1987) Epidermal growth factor and angiotensin II stimulate formation of inositol 1,4,5- and inositol 1,3,4-trisphosphate in hepatocytes. Differential inhibition by pertussis toxin and phorbol 12-myristate 13-acetate. J Biol Chem 262:17285-17293.
61. Kajkowski EM, Lo CF, Ning X, Walker S, Sofia HJ, Wang W, Edris W, Chanda P, Wagner E, Vile S, et al. (2001) beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module. J Biol Chem 276: 18748-18756.
62. Kane LP, Lin J, and Weiss A (2002) It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation. Trends Immunol 23:413-420.
63. Kanzaki M, Lindorfer MA, Garrison JC, and Kojima I (1997) Activation of the calcium-permeable cation channel CD20 by alpha subunits of the Gi protein. J Biol Chem 272:14733-14739.
64. Kanzaki M, Watson RT, Artemyev NO, and Pessin JE (2000) The trimeric GTP-binding protein (G(q)/G(11)) alpha subunit is required for insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes. J Biol Chem 275:7167-7175.
65. Kiemer AK, Lehner MD, Hartung T, and Vollmar AM (2002) Inhibition of cyclooxygenase-2 by natriuretic peptides. Endocrinology 143:846-852.
66. Krieger-Brauer HI, Medda P, and Kather H (2000) Basic fibroblast growth factor utilizes both types of component subunits of Gs for dual signaling in human adipocytes. Stimulation of adenylyl cyclase via Galph(s) and inhibition of NADPH oxidase by Gbeta gamma(s). J Biol Chem 275:35920-35925.
67. Krupinski J, Rajaram R, Lakonishok M, Benovic JL, and Cerione RA (1988) Insulin-dependent phosphorylation of GTP-binding proteins in phospholipid vesicles. J Biol Chem 263:12333-12341.
68. Kuemmerle JF and Murthy KS (2001) Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma-dependent mitogen-activated protein kinase activation and growth. J Biol Chem 276:7187-7194.
69. LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild CC, and Jay G (1995) The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat Genet 9:21-30.
70. Lawler OA, Miggin SM, and Kinsella BT (2001) Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(S)-, to G(i)- and to G(q)-coupled effector signaling. J Biol Chem 276:33596-33607.
71. Levin ER and Frank HJ (1991) Natriuretic peptides inhibit rat astroglial proliferation: mediation by C receptor. Am J Physiol 261 (Pt 2):R453-R457.
72. Li J, Lin ML, Wiepz GJ, Guadarrama AG, and Bertics PJ (1999) Integrin-mediated migration of murine B82L fibroblasts is dependent on the expression of an intact epidermal growth factor receptor. J Biol Chem 274:11209-11219.
73. Liang M and Garrison JC (1992) Epidermal growth factor activates phospholipase C in rat hepatocytes via a different mechanism from that in A431 or rat1hER cells. Mol Pharmacol 42:743-752.
74. Liang MN and Garrison JC (1991) The epidermal growth factor receptor is coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rat hepatocytes. J Biol Chem 266:13342-13349.
75. Lin FT, Daaka Y, and Lefkowitz RJ (1998) beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. J Biol Chem 273:31640-31643.
76. Linder B, Harris S, Eisen A, and Nissley P (1994) Evidence against roles for pertussis toxin sensitive G proteins or diacylglycerol generation in insulin-like growth factor-1 stimulated DNA synthesis in MG-63 osteosarcoma cells. Mol Cell Endocrinol 105:111-118.
77. Lippert E, Jacques Y, and Hermouet S (2000) Positive regulation of human T cell activation by Gi2 proteins and interleukin-8. J Leukoc Biol 67:742-748.
78. Lorenzo A, Yuan M, Zhang Z, Paganetti PA, Sturchler-Pierrat C, Staufenbiel M, Mautino J, Vigo FS, Sommer B, and Yankner BA (2000) Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease. Nat Neurosci 3:460-464.
79. Luttrell LM (2002) Activation and targeting of mitogen-activated protein kinases by G-protein-coupled receptors. Can J Physiol Pharmacol 80:375-382.
80. Luttrell LM, van Biesen T, Hawes BE, Koch WJ, Touhara K, and Lefkowitz RJ (1995) G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. J Biol Chem 270:16495-16498.
81. Matsunaga H, Nishimoto I, Kojima I, Yamashita N, Kurokawa K, and Ogata E (1988) Activation of a calcium-permeable cation channel by insulin-like growth factor II in BALB/c 3T3 cells. Am J Physiol 255 (Pt 1):C442-C446.
82. McKinnon T, Chakraborty C, Gleeson LM, Chidiac P, and Lala PK (2001) Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK. J Clin Endocrinol Metab 86:3665-3674.
83. Meyer CJ, Alenghat FJ, Rim P, Fong JH, Fabry B, and Ingber DE (2000) Mechanical control of cyclic AMP signalling and gene transcription through integrins. Nat Cell Biol 2:666-668.
84. Moxham CM and Malbon CC (1996) Insulin action impaired by deficiency of the G-protein subunit G ialpha2. Nature (Lond) 379:840-844.
85. Murayama Y, Okamoto T, Ogata E, Asano T, Iiri T, Katada T, Ui M, Grubb JH, Sly WS, and Nishimoto I (1990) Distinctive regulation of the functional linkage between the human cation-independent mannose 6-phosphate receptor and GTP-binding proteins by insulin-like growth factor II and mannose 6-phosphate. J Biol Chem 265:17456-17462.
86. Nair BG, Parikh B, Milligan G, and Patel TB (1990) Gs alpha mediates epidermal growth factor-elicited stimulation of rat cardiac adenylate cyclase. J Biol Chem 265:21317-21322.
87. Nair BG and Patel TB (1993) Regulation of cardiac adenylyl cyclase by epidermal growth factor (EGF). Role of EGF receptor protein tyrosine kinase activity. Biochem Pharmacol 46:1239-1245.
88. Nair BG, Rashed HM, and Patel TB (1989) Epidermal growth factor stimulates rat cardiac adenylate cyclase through a GTP-binding regulatory protein. Biochem J 264:563-571.
89. Nair BG, Rashed HM, and Patel TB (1993) Epidermal growth factor produces inotropic and chronotropic effects in rat hearts by increasing cyclic AMP accumulation. Growth Factors 8:41-48.
90. Nakagawa Y, Gammichia J, Purushotham KR, Schneyer CA, and Humphreys-Beher MG (1991) Epidermal growth factor activation of rat parotid gland adenylate cyclase and mediation by a GTP-binding regulatory protein. Biochem Pharmacol 42:2333-2340.
91. Nel AE, Vandenplas M, Wooten MM, Cooper R, Vandenplas S, Rheeder A, and Daniels J (1988) Cholera toxin partially inhibits the T-cell response to phytohaemagglutinin through the ADP-ribosylation of a 45 kDa membrane protein. Biochem J 256:383-390.
92. Neves SR, Ram PT, and Iyengar R (2002) G protein pathways. Science (Wash DC) 296:1636-1639.
93. Nishimoto I, Hata Y, Ogata E, and Kojima I (1987a) Insulin-like growth factor II stimulates calcium influx in competent BALB/c 3T3 cells primed with epidermal growth factor. Characteristics of calcium influx and involvement of GTP-binding protein. J Biol Chem 262:12120-12126.
94. Nishimoto I, Murayama Y, Katada T, Ui M, and Ogata E (1989) Possible direct linkage of insulin-like growth factor-II receptor with guanine nucleotide-binding proteins. J Biol Chem 264:14029-14038.
95. Nishimoto I, Ogata E, and Kojima I (1987b) Pertussis toxin inhibits the action of insulin-like growth factor-I. Biochem Biophys Res Commun 148:403-411.
96. Nishimoto I, Okamoto T, Matsuura Y, Takahashi S, Murayama Y, and Ogata E (1993) Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(O). Nature (Lond) 362:75-79.
97. O'Brien RM, Houslay MD, Milligan G, and Siddle K (1987) The insulin receptor tyrosyl kinase phosphorylates holomeric forms of the guanine nucleotide regulatory proteins Gi and Go. FEBS Lett 212:281-288.
98. Ohmura T, Sakata A, and Onoue K (1992) A 68-kD GTP-binding protein associated with the T cell receptor complex. J Exp Med 176:887-891.
99. Okamoto T, Asano T, Harada S, Ogata E, and Nishimoto I (1991a) Regulation of transmembrane signal transduction of insulin-like growth factor II by competence type growth factors or viral ras p21. J Biol Chem 266:1085-1091.
100. Okamoto T, Katada T, Murayama Y, Ui M, Ogata E, and Nishimoto I (1990a) A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor. Cell 62:709-717.
101. Okamoto T, Murayama Y, Hayashi Y, Inagaki M, Ogata E, and Nishimoto I (1991b) Identification of a Gs activator region of the beta 2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation. Cell 67:723-730.
102. Okamoto T, Murayama Y, Hayashi Y, Ogata E, and Nishimoto I (1993) GTP-binding protein-activator sequences in the insulin receptor. FEBS Lett 334:143-148.
103. Okamoto T and Nishimoto I (1991) Analysis of stimulation-G protein subunit coupling by using active insulin-like growth factor II receptor peptide. Proc Natl Acad Sci USA 8:8020-8023.
104. Okamoto T, Nishimoto I, Murayama Y, Ohkuni Y, and Ogata E (199Ob) Insulin-like growth factor-II/mannose 6-phosphate receptor is incapable of activating GTP-binding proteins in response to mannose 6-phosphate, but capable in response to insulin-like growth factor-II. Biochem Biophys Res Commun 168:1201-1210.
105. Okamoto T, Takeda S, Giambarella U, Murayama Y, Matsui T, Katada T, Matsuura Y, and Nishimoto I (1996) Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease (Abstract). EMBO (Eur Mol Biol Organ) J 15:3769-3777.
106. Okamoto T, Takeda S, Murayama Y, Ogata E, and Nishimoto I (1995) Ligand-dependent G protein coupling function of amyloid transmembrane precursor. J Biol Chem 270:4205-4208.
107. Pagano M and Anand-Srivastava MB (2001) Cytoplasmic domain of natriuretic peptide receptor C constitutes Gi activator sequences that inhibit adenylyl cyclase activity. J Biol Chem 276:22064-22070.
108. Patel TB, Du Z, Pierre S, Cartin L, and Scholich K (2001) Molecular biological approaches to unravel adenylyl cyclase signaling and function. Gene 269:13-25.
109. Peter ME, Hall C, Ruhlmann A, Sancho J, and Terhorst C (1992) The T-cell receptor zeta chain contains a GTP/GDP binding site. EMBO (Eur Mol Biol Organ) J 11:933-941.
110. Poiraudeau S, Lieberherr M, Kergosie N, and Corvol MT (1997) Different mechanisms are involved in intracellular calcium increase by insulin-like growth factors 1 and 2 in articular chondrocytes: voltage-gated calcium channels and/or phospholipase C coupled to a pertussis-sensitive G-protein. J Cell Biochem 64:414-422.
111. Poppleton H, Sun H, Fulgham D, Bertics P, and Patel TB (1996) Activation of Gsalpha by the epidermal growth factor receptor involves phosphorylation. J Biol Chem 271:6947-6951.
112. Poppleton HM, Sun H, Mullenix JB, Wiepz GJ, Bertics PJ, and Patel TB (2000) The juxtamembrane region of the epidermal growth factor receptor is required for phosphorylation of Galpha(s). Arch Biochem Biophys 383:309-317.
113. Porter JG, Wang Y, Schwartz K, Arfsten A, Loffredo A, Spratt K, Schenk DB, Fuller F, Scarborough RM, and Lewicki JA (1988) Characterization of the atrial natriuretic peptide clearance receptor using a vaccinia virus expression vector. J Biol Chem 263:18827-18833.
114. Premont RT, Chen J, Ma HW, Ponnapalli M, and Iyengar R (1992) Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases. Proc Natl Acad Sci USA 89:9809-9813.
115. Prenzel N, Zwick E, Leserer M, and Ullrich A (2000) Tyrosine kinase signalling in breast cancer. Epidermal growth factor receptor: convergence point for signal integration and diversification. Breast Cancer Res 2:184-190.
116. Pyne NJ, Waters C, Moughal NA, Sambi BS, and Pyne S (2003) Receptor tyrosine kinase-GPCR signal complexes. Biochem Soc Trans 31 (Pt 6):1220-1225.
117. Rakhit S, Pyne S, and Pyne NJ (2000) The platelet-derived growth factor receptor stimulation of p42/p44 mitogen-activated protein kinase in airway smooth muscle involves a G-protein-mediated tyrosine phosphorylation of Gab1. Mol Pharmacol 58:413-420.
118. Hashed SM and Patel TB (1991) Regulation of hepatic energy metabolism by epidermal growth factor. Eur J Biochem 197:805-813.
119. Rothenberg PL and Kahn CR (1988) Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins. J Biol Chem 263:15546-15552.
120. Ruskoaho H (1992) Atrial natriuretic peptide: synthesis, release, and metabolism. Pharmacol Rev 44:479-602.
121. Rymer DL and Good TA (2001) The role of G protein activation in the toxicity of amyloidogenic Abeta-(1-40), Abeta-(25-35), and bovine calcitonin. J Biol Chem 276:2523-2530.
122. Sarbassov DD, Jones LG, and Peterson CA (1997) Extracellular signal-regulated kinase-1 and -2 respond differently to mitogenic and differentiative signaling pathways in myoblasts. Mol Endocrinol 11:2038-2047.
123. Schlessinger J (2000) Cell signaling by receptor tyrosine kinases. Cell 103:211-225.
124. Schlessinger J and Ullrich A (1992) Growth factor signaling by receptor tyrosine kinases. Neuron 9:383-391.
125. Schubert W, Prior R, Weidemann A, Dircksen H, Multhaup G, Masters CL, and Beyreuther K (1991) Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites. Brain Res 563:184-194.
126. Schulz S, Chinkers M, and Garbers DL (1989a) The guanylate cyclase/receptor family of proteins. FASEB J 3:2026-2035.
127. Schulz S, Singh S, Bellet RA, Singh G, Tubb DJ, Chin H, and Garbers DL (1989b) The primary structure of a plasma membrane guanylate cyclase demonstrates diversity within this new receptor family. Cell 58:1155-1162.
128. Selkoe DJ (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81:741-766.
129. Shi X, Amindari S, Paruchuru K, Skalla D, Burkin H, Shur BD, and Miller DJ (2001) Cell surface beta-1,4-galactosyltransferase-I activates G protein-dependent exocytotic signaling. Development 128:645-654.
130. Shiojima I and Walsh K (2002) Role of akt signaling in vascular homeostasis and angiogenesis. Circ Res 90:1243-1250.
131. Smit MJ and Iyengar R (1998) Mammalian adenylyl cyclases. Adv Second Messenger Phosphoprotein Res 32:1-21.
132. Sommermeyer H, Schwinzer R, Kaever V, Behl B, and Resch K (1990) The G protein coupling T cell antigen receptor/CDS-complex and phospholipase C in the human T cell lymphoma Jurkat is not a target for cholera toxin. Eur J Immunol 20:1881-1886.
133. Song X, Zheng X, Malbon CC, and Wang H (2001) Galpha i2 enhances in vivo activation of and insulin signaling to GLUT4. J Biol Chem 276:34651-34658.
134. Stanners J, Kabouridis PS, McGuire KL, and Tsoukas CD (1995) Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling. J Biol Chem 270:30635-30642.
135. Stork PJ and Schmitt JM (2002) Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol 12:258-266.
136. Stracke ML, Kohn EC, Aznavoorian SA, Wilson LL, Salomon D, Krutzsch HC, Liotta LA, and Schiffmann E (1988) Insulin-like growth factors stimulate chemotaxis in human melanoma cells. Biochem Biophys Res Commun 153:1076-1083.
137. Stryjek-Kaminska D, Piiper A, and Zeuzem S (1995) EGF inhibits secretagogue-induced cAMP production and amylase secretion by Gi proteins in pancreatic acini. Am J Physiol 269 (Pt 1):G676-G682.
138. Sudoh T, Maekawa K, Kojima M, Minamino N, Kangawa K, and Matsuo H (1989) Cloning and sequence analysis of cDNA encoding a precursor for human brain natriuretic peptide. Biochem Biophys Res Commun 159:1427-1434.
139. Sudoh T, Minamino N, Kangawa K, and Matsuo H (1988) Brain natriuretic peptide-32: N-terminal six amino acid extended form of brain natriuretic peptide identified in porcine brain. Biochem Biophys Res Commun 155:726-732.
140. Sun H, Chen Z, Poppleton H, Scholich K, Mullenix J, Weipz GJ, Fulgham DL, Bertics PJ, and Patel TB (1997) The juxtamembrane, cytosolic region of the epidermal growth factor receptor is involved in association with alpha-subunit of Gs. J Biol Chem 272:5413-5420.
141. Sun H, Seyer JM, and Patel TB (1995) A region in the cytosolic domain of the epidermal growth factor receptor antithetically regulates the stimulatory and inhibitory guanine nucleotide-binding regulatory proteins of adenylyl cyclase. Proc Natl Acad Sci USA 92:2229-2233.
142. Sunahara RK, Dessauer CW, and Gilman AG (1996) Complexity and diversity of mammalian adenylyl cyclases. Annu Rev Pharmacol Toxicol 36:461-480.
143. Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos L Jr, Eckman C, Golde TE, and Younkin SG (1994) An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science (Wash DC) 264:1336-1340.
144. Takahashi K, Murayama Y, Okamoto T, Yokota T, Ikezu T, Takahashi S, Giambarella U, Ogata E, and Nishimoto I (1993) Conversion of G-protein specificity of insulin-like growth factor II/mannose 6-phosphate receptor by exchanging of a short region with beta-adrenergic receptor. Proc Natl Acad Sci USA 90:11772-11776.
145. Tao J, Malbon CC, and Wang HY (2001) Galpha(i2) enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B. J Biol Chem 276:39705-39712.
146. Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, and Luttrell LM (2003) The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. J Biol Chem 278:6258-6267.
147. Uehara T, Tokumitsu Y, and Nomura Y (1999) Pertussis toxin-sensitive and insensitive intracellular signalling pathways in undifferentiated 3T3-L1 cells stimulated by insulin converge with phosphatidylinositol 3-kinase upstream of the Ras mitogen-activated protein kinase cascade. Eur J Biochem 259:801-808.
148. van Leeuwen JE and Samelson LE (1999) T cell antigen-receptor signal transduction. Curr Opin Immunol 11:242-248.
149. Walther T, Schultheiss HP, Tschope C, and Stepan H (2002) Natriuretic peptide system in fetal heart and circulation. J Hypertens 20:785-791.
150. Wang XQ and Frazier WA (1998) The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells. Mol Biol Cell 9:865-874.
151. Wang XQ, Lindberg FP, and Frazier WA (1999) Integrin-associated protein stimulates alpha2beta1-dependent chemotaxis via Gi-mediated inhibition of adenylate cyclase and extracellular-regulated kinases. J Cell Biol 147:389-400.
152. Wassarman PM (1999) Mammalian fertilization: molecular aspects of gamete adhesion, exocytosis and fusion. Cell 96:175-183.
153. Wei W, Wang X, and Kusiak JW (2002) Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection. J Biol Chem 277:17649-17656.
154. Wei Y, Lukashev M, Simon DI, Bodary SC, Rosenberg S, Doyle MV, and Chapman HA (1996) Regulation of integrin function by the urokinase receptor. Science (Wash DC) 273:1551-1555.
155. Wolozin B, Iwasaki K, Vito P, Ganjei JK, Lacana E, Sunderland T, Zhao B, Kusiak JW, Wasco W, and D'Adamio L (1996) Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science (Wash DC) 274:1710-1713.
156. Yaar M, Zhai S, Fine RE, Eisenhauer PB, Arble BL, Stewart KB, and Gilchrest BA (2002) Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling. J Biol Chem 277:7720-7725.
157. Yaar M, Zhai S, Pilch PF, Doyle SM, Eisenhauer PB, Fine RE, and Gilchrest BA (1997) Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease. J Clin Investig 100:2333-2340.
158. Yamada KM and Even-Ram S (2002) Integrin regulation of growth factor receptors. Nat Cell Biol 4:E75-E76.
159. Yamatsuji T, Matsui T, Okamoto T, Komatsuzaki K, Takeda S, Fukumoto H, Iwatsubo T, Suzuki N, Asami-Odaka A, Ireland S, et al. (1996a) G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP. Science (Wash DC) 272:1349-1352.
160. Yamatsuji T, Okamoto T, Takeda S, Murayama Y, Tanaka N, and Nishimoto I (1996b) Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype (Abstract). EMBO (Eur Mol Biol Organ) J 15:498-509.
161. Yu Y, Nair BG, and Patel TB (1992) Epidermal growth factor stimulates cAMP accumulation in cultured rat cardiac myocytes. J Cell Physiol 150:559-567.
162. Zamah AM, Delahunty M, Luttrell LM, and Lefkowitz RJ (2002) Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi: Demonstration in a reconstituted system. J Biol Chem 277: 31249-31256.
163. Zheng XL, Guo J, Wang H, and Malbon CC (1998) Expression of constitutively activated Gialpha2 in vivo ameliorates streptozotocin-induced diabetes. J Biol Chem 273:23649-23651.