Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 8, 2001, Pages 3665-3674

  McKinnon, Timothy ^a   Chakraborty, Chandan ^a   Gleeson, Louise M ^a   Chidiac, Peter ^a   Lala, Peeyush K ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ADENYLATE CYCLASE; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; RECOMBINANT SOMATOMEDIN B; SOMATOMEDIN B RECEPTOR; SOMATOMEDIN BINDING PROTEIN;

ARTICLE; CELL INVASION; CELL MEMBRANE; CELL MIGRATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TROPHOBLAST; WESTERN BLOTTING;

EID: 0034885755     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.86.8.7711     Document Type: Article

References (62)

1. Mechanisms of placental invasion of the uterus and their control
2. Extravillous trophoblasts in the human placenta
3. A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies
4. The placental bed
5. Biochemical evidence of impaired trophoblastic invasion of decidual stroma in women destined to have preeclampsia
6. Growth factors, proteases and protease inhibitors in the fetal-maternal dialogue
7. Characterization of pure human first trimester cytotrophoblast cells in long-term culture: Growth pattern, markers and hormone production
8. Characteristics of trophoblast cells migrating from first trimester chorionic villus explants and propagated in culture
9. Normal metastatic human trophoblast cells share in vitro invasive properties of malignant cells
10. Mechanisms of trophoblast invasiveness and their control: The role of proteases and protease inhibitors
11. Interleukin 1β regulates human cytotrophoblast metalloprotenase activity and invasion in vitro
12. Role of growth factors and other placental signals in extravillous trophoblast cell function
13. Localization of transforming growth factor-β at the human fetal-maternal interface: Role in trophoblast growth and differentiation
14. Mechanisms of control of trophoblast invasion in situ
15. Molecular mechanisms controlling trophoblast invasion of the uterus
16. Effects of transforming growth factor β in the plasminogen activator system in cultural first trimester human cytotrophoblasts
17. Resistance of malignant trophoblast cells to both anti-proliferative and anti-invasive effects of TGFβ
18. Functional role of cell surface integrins on human trophoblast cell migration: Regulation by TGF-β, IGF-II and IGFBP-1
19. The expression of IGF and IGFBP genes in the human placenta and membranes: Evidence for IGF-IGFBP interactions at the feto-maternal interface
20. Autocrine-paracrine regulation of human trophoblast invasiveness by IGF-II and IGFBP-1
21. Insulin-like growth factors and their binding proteins; biological actions
22. Identification and characterization of IGF receptors on adult rat cardiac myocytes
23. Affinity for the IGF-II receptor inhibits autocrine activity in MCF-7 breast cancer cells
24. Molecular aspects of the endocytic pathway
25. The carboxy-terminal peptides of 46kDa and 300 kDa M6P receptors share partial sequence homology and contain information for sorting in the early endosomal pathway
26. Inhibition of IGF-II-induced redistribution of mannose-6-phosphate receptors by the phosphatidylinositol 3-kinase inhibitor, wortamannin
27. The rate of internalization of the M6P/IGF-II receptor is enhanced by multivalent ligand binding
28. The insulin-like growth factor II (IGF-II)/Mannose 6-phosphate receptor mediates IGF-II-induced motility in human rhabdomyosarcoma cells
29. Growth-factor-dependent migration of human lung cancer cells
30. Requirement for the insulin like growth factor II/mannose 6-ph-osphate receptor in proliferin-induced angiogenesis
31. Possible direct linkage of IGF-II receptor with guanine nucleotide-binding proteins
32. Distinctive regulation of the functional linkage between the human cation-independent M6P receptor and GTP-binding proteins by IGF-II and M6P
33. Analysis of stimulation-G protein subunit coupling by using active IGF-II receptor peptide
34. Regulation of cell motility by MAP kinase
35. Establishment and characterization of first trimester human trophoblast cells with extended lifespan
36. Susceptibility of MHC Class-I expressing EVT cell lines to killing by natural killer cells
37. 1 integrin via MAPK pathway
38. ECM and hypoxia regulate the expression of HLA-G and integrins in a human trophoblast cell line
39. Determination of adenylyl cyclase catalytic activity using single and double column procedures
40. Antibody to the phosphomannosyl receptor inhibits recycling of receptor in fibroblasts
41. Synthesis and characterization of IGF-II analogs: Applications in the evaluation of IGFR function and IGF-independent actions of IGFBPs
42. Insulin-like growth (IGF)-II binding to IGF-binding proteins and IGF receptors is modified by deletion of the N-terminal hexapeptide or substitution of arginine for glutamate-6 in IGF-II
43. PD098059 is a specific inhibitor of the activation of MAPKK in vitro and in vivo
44. Proliferin induces endothelial cell chemotaxis through a G protein-coupled, mitogen-activated protein kinase-dependent pathway
45. The M6P/IGF-II receptor is a nanomolar affinity receptor for glycosylated human LIF
46. M6P/IGF-II receptor mediates internalization and degradation of LIF but not signal transduction
47. Mastoparan, a peptide toxin from wasp venom, mimics receptor by activating GTP binding proteins (G proteins)
48. Regulation of Gi and Go by mastoparan, related amphiphilic peptides and hydrophobic amines, mechanisms and structural determinants of activity
49. A simple structure encodes G protein-activating function of the IGF-II/M6P receptor
50. In vivo coupling of the IGF-II/M6P receptor to heteromeric G proteins
51. Cyclic GMP- dependent protein kinase blocks pertussis toxin-sensitive hormone receptor signaling pathways in Chinese hamster ovary cells
52. IGF-II/M6P receptor is incapable of activating GTP-binding proteins in response to M6P, but capable in response to IGF-II
53. Conversion of G-protein specificity of IGF-II/M6P receptor by exchanging a short region with β-adrenergic receptor
54. Mannose 6-phosphate/insulin-like-growth factor II receptor fails to interact with G-proteins
55. Binding of G protein βγ-subunits to pleestrin homology domains
56. Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G βγ-mediated signaling
57. Mitogen-activated protein kinase activation mediates PDGF-directed migration of RPE cells
58. Erb2 is necessary for induction of carcinoma cell invasion by Erb2 family RTKs
59. Increasing cAMP attenuates activation of mitogen-activated protein kinase
60. Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate
61. Elevation of intracellular cAMP inhibits growth factor-mediated matrix metalloproteinase-9 induction and keratinocyte migration
62. c-Jun N-terminal kinase but not mitogen-activated protein kinase is sensitive to cAMP inhibition in T lymphocytes