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Volumn 15, Issue 3, 1996, Pages 498-509

Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype

Author keywords

Amyloid precursor protein; Apoptosis; bcl 2; Familial Alzheimer's disease; G proteins

Indexed keywords

AMYLOID PRECURSOR PROTEIN; DNA FRAGMENT; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN BCL 2;

EID: 0030042249     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00382.x     Document Type: Article
Times cited : (109)

References (58)
  • 1
    • 0028237885 scopus 로고
    • G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts
    • Baffy, G., Yang, L., Raj, S., Manning, D.R. and Williamson, J.R. (1994) G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts. J. Biol. Chem., 269, 8483-8487.
    • (1994) J. Biol. Chem. , vol.269 , pp. 8483-8487
    • Baffy, G.1    Yang, L.2    Raj, S.3    Manning, D.R.4    Williamson, J.R.5
  • 2
    • 0022485548 scopus 로고
    • Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185
    • Bargmann, C.I., Hung, M.C. and Weinberg, R.A. (1986) Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Cell. 45, 649-657.
    • (1986) Cell. , vol.45 , pp. 649-657
    • Bargmann, C.I.1    Hung, M.C.2    Weinberg, R.A.3
  • 3
    • 0025819896 scopus 로고
    • Expression of 'Alzheimer antigens' in cultured skin fibroblasts
    • Blass, J.P., Baker, A.C., Ko, L.-W., Sheu, R.K.-F. and Black, R.S. (1991) Expression of 'Alzheimer antigens' in cultured skin fibroblasts. Arch. Neurol., 48, 709-717.
    • (1991) Arch. Neurol. , vol.48 , pp. 709-717
    • Blass, J.P.1    Baker, A.C.2    Ko, L.-W.3    Sheu, R.K.-F.4    Black, R.S.5
  • 4
    • 0001630994 scopus 로고
    • Neuronal apoptosis: Genetic and biochemical modulation
    • Tomei, L.D. and Frederick, F.O. (eds), Cold Spring Harbor Laboratory Press. Cold Spring Harbor, NY
    • Bredesen, D.E. (1994) Neuronal apoptosis: genetic and biochemical modulation. In Tomei, L.D. and Frederick, F.O. (eds), Apoptosis II. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, NY, pp. 397-421.
    • (1994) Apoptosis II , pp. 397-421
    • Bredesen, D.E.1
  • 5
    • 0027526419 scopus 로고
    • Release of excess amyloid β protein from a mutant amyloid β protein precursor
    • Cai, X.-D., Golde, T.E. and Younkin, S.G. (1993) Release of excess amyloid β protein from a mutant amyloid β protein precursor. Science, 259, 514-516.
    • (1993) Science , vol.259 , pp. 514-516
    • Cai, X.-D.1    Golde, T.E.2    Younkin, S.G.3
  • 7
    • 0022844766 scopus 로고
    • Purification of the major GTP-binding proteins from human placental membranes
    • Evans, T., Brown, M.L., Fraser, E.D. and Northup, J.K. (1986) Purification of the major GTP-binding proteins from human placental membranes. J. Biol. Chem., 261, 7052-7059.
    • (1986) J. Biol. Chem. , vol.261 , pp. 7052-7059
    • Evans, T.1    Brown, M.L.2    Fraser, E.D.3    Northup, J.K.4
  • 8
    • 0028985574 scopus 로고
    • Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
    • Games, D. et al. (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature, 373, 523-527.
    • (1995) Nature , vol.373 , pp. 523-527
    • Games, D.1
  • 9
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli, Y., Sherman, Y. and Ben-Sasson, S.A. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol., 119, 493-501.
    • (1992) J. Cell Biol. , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 10
    • 0026609129 scopus 로고
    • Cytosolic free calcium in lymphoblasts from young, aged and Alzheimer subjects
    • Gibson, G.E. and Toral-Barza, L. (1992) Cytosolic free calcium in lymphoblasts from young, aged and Alzheimer subjects. Mech. Ageing Dev., 63, 1-9.
    • (1992) Mech. Ageing Dev. , vol.63 , pp. 1-9
    • Gibson, G.E.1    Toral-Barza, L.2
  • 11
    • 0026088977 scopus 로고
    • Segregation of amissense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • Goate, A. et al. (1991) Segregation of amissense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature, 349, 704-706.
    • (1991) Nature , vol.349 , pp. 704-706
    • Goate, A.1
  • 12
    • 0024413593 scopus 로고
    • A pertussis toxin-sensitive G protein in hippocampal long-term potentiation
    • Goh, J.W. and Pennefather, P.S. (1989) A pertussis toxin-sensitive G protein in hippocampal long-term potentiation. Science, 244, 980-983.
    • (1989) Science , vol.244 , pp. 980-983
    • Goh, J.W.1    Pennefather, P.S.2
  • 13
    • 0025195871 scopus 로고
    • o in neuronal cultures from rat mesencephalon and hypothalamus
    • o in neuronal cultures from rat mesencephalon and hypothalamus. J. Neurochem., 54, 1995-2001.
    • (1990) J. Neurochem. , vol.54 , pp. 1995-2001
    • Granneman, J.G.1    Kapatos, G.2
  • 15
    • 0026894414 scopus 로고
    • Framing β-amyloid
    • Hardy, J. (1992) Framing β-amyloid. Nature Genet., 1, 233-234.
    • (1992) Nature Genet. , vol.1 , pp. 233-234
    • Hardy, J.1
  • 16
    • 0026699985 scopus 로고
    • Protease inhibitors generate cytotoxic fragments from Alzheimer amyloid protein precursor in cDNA-transfected glioma cells
    • Hayashi, Y., Kashiwagi, K. and Yoshikawa, K. (1992) Protease inhibitors generate cytotoxic fragments from Alzheimer amyloid protein precursor in cDNA-transfected glioma cells. Biochem. Biophys. Res. Commun., 187, 1249-1255.
    • (1992) Biochem. Biophys. Res. Commun. , vol.187 , pp. 1249-1255
    • Hayashi, Y.1    Kashiwagi, K.2    Yoshikawa, K.3
  • 19
    • 0022183734 scopus 로고
    • Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex
    • Huff, R.M., Axton, J.M. and Neer, E. (1985) Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex. J. Biol. Chem., 260, 10864-10871.
    • (1985) J. Biol. Chem. , vol.260 , pp. 10864-10871
    • Huff, R.M.1    Axton, J.M.2    Neer, E.3
  • 20
    • 0024467607 scopus 로고
    • Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts
    • Huynh, V.T., Cole, G., Katzman, R., Huang, K.-P. and Saitoh, T. (1989) Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts. Arch. Neurol., 46, 1195-1199.
    • (1989) Arch. Neurol. , vol.46 , pp. 1195-1199
    • Huynh, V.T.1    Cole, G.2    Katzman, R.3    Huang, K.-P.4    Saitoh, T.5
  • 21
    • 0027392384 scopus 로고
    • Mediation by G proteins of signals that cause collapse of growth cones
    • Igarashi, M., Strittmatter, S.M., Vartanian, T. and Fishman, M.C. (1993) Mediation by G proteins of signals that cause collapse of growth cones. Science, 259, 77-79.
    • (1993) Science , vol.259 , pp. 77-79
    • Igarashi, M.1    Strittmatter, S.M.2    Vartanian, T.3    Fishman, M.C.4
  • 23
    • 0023907869 scopus 로고
    • Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses
    • Ito, I., Okada, D. and Sugiyama, H. (1988) Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses. Neurosci. Lett., 90, 181-185.
    • (1988) Neurosci. Lett. , vol.90 , pp. 181-185
    • Ito, I.1    Okada, D.2    Sugiyama, H.3
  • 24
    • 0028169925 scopus 로고
    • Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)
    • Iwatsubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, N. and Ihara, Y. (1994) Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: evidence that an initially deposited species is Aβ42(43). Neuron, 13, 45-53.
    • (1994) Neuron , vol.13 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, N.5    Ihara, Y.6
  • 27
    • 0026686822 scopus 로고
    • Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the β-amyloid precursor protein gene
    • Karlinsky, H. et al. (1992) Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the β-amyloid precursor protein gene. Neurology, 42, 1445-1453.
    • (1992) Neurology , vol.42 , pp. 1445-1453
    • Karlinsky, H.1
  • 28
    • 0002204915 scopus 로고
    • Definition and incidence of apoptosis: An historical perspective
    • Tomei, L.D. and Cope, F.O. (eds), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Kerr, J.F.R. and Harmon, B.V. (1991) Definition and incidence of apoptosis: an historical perspective. In Tomei, L.D. and Cope, F.O. (eds), Apoptosis, The Molecular Basis of Cell Death. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 5-29.
    • (1991) Apoptosis, The Molecular Basis of Cell Death , pp. 5-29
    • Kerr, J.F.R.1    Harmon, B.V.2
  • 31
    • 0026663993 scopus 로고
    • The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth
    • Milward, E.A., Papadopoulos, R., Fuller, S.J., Moir, R.D., Small, D., Beyreuther, K. and Masters, C.L. (1992) The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron, 9, 129-137.
    • (1992) Neuron , vol.9 , pp. 129-137
    • Milward, E.A.1    Papadopoulos, R.2    Fuller, S.J.3    Moir, R.D.4    Small, D.5    Beyreuther, K.6    Masters, C.L.7
  • 32
    • 0027449187 scopus 로고
    • Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3
    • Miura, M., Zhu, H., Rotello, R., Hartwieg, E.A. and Yuan, J. (1993) Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell, 75, 653-660.
    • (1993) Cell , vol.75 , pp. 653-660
    • Miura, M.1    Zhu, H.2    Rotello, R.3    Hartwieg, E.A.4    Yuan, J.5
  • 33
    • 0027453433 scopus 로고
    • Effects of chronic lithium treatment on platelet PKC isoenzymes in Alzheimer's and elderly control subjects
    • Molchan, S.E., Manji, H., Chen, G., Dou, L., Little, J., Potter, W.Z. and Sunderland, T. (1993) Effects of chronic lithium treatment on platelet PKC isoenzymes in Alzheimer's and elderly control subjects. Neurosci. Lett., 162, 187-191.
    • (1993) Neurosci. Lett. , vol.162 , pp. 187-191
    • Molchan, S.E.1    Manji, H.2    Chen, G.3    Dou, L.4    Little, J.5    Potter, W.Z.6    Sunderland, T.7
  • 38
    • 0028935717 scopus 로고
    • Ligand-dependent G protein coupling function of amyloid transmembrane precursor
    • Okamoto, T., Takeda, S., Murayama, Y., Ogata, E. and Nishimoto, I. (1995) Ligand-dependent G protein coupling function of amyloid transmembrane precursor. J. Biol. Chem., 270, 4205-4208.
    • (1995) J. Biol. Chem. , vol.270 , pp. 4205-4208
    • Okamoto, T.1    Takeda, S.2    Murayama, Y.3    Ogata, E.4    Nishimoto, I.5
  • 40
    • 0343050763 scopus 로고
    • Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors
    • Peterson, C. and Goldman, J.E. (1986) Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors. Proc. Natl Acad. Sci. USA. 83, 2758-2762.
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 2758-2762
    • Peterson, C.1    Goldman, J.E.2
  • 41
    • 0039154020 scopus 로고
    • Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells
    • Platika, D., Boulos, M.H., Baizer, L. and Fishman, M.C. (1985) Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells. Proc. Natl Acad. Sci. USA. 82, 3499-3503.
    • (1985) Proc. Natl Acad. Sci. USA , vol.82 , pp. 3499-3503
    • Platika, D.1    Boulos, M.H.2    Baizer, L.3    Fishman, M.C.4
  • 42
    • 0026698135 scopus 로고
    • A simple and rapid method for detection of apoptosis in human cells
    • Rösl, F. (1992) A simple and rapid method for detection of apoptosis in human cells. Nucleic Acids Res., 20, 5243.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 5243
    • Rösl, F.1
  • 43
    • 0028174106 scopus 로고
    • βA4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons
    • Sandbrink, R., Masters, C.L. and Beyreuther, K. (1994) βA4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons. J. Biol. Chem., 269, 1510-1517.
    • (1994) J. Biol. Chem. , vol.269 , pp. 1510-1517
    • Sandbrink, R.1    Masters, C.L.2    Beyreuther, K.3
  • 45
    • 0024693393 scopus 로고
    • Neural cell adhesion molecules influence second messenger systems
    • Schuch, U., Lohse, M.J. and Schachner, M. (1989) Neural cell adhesion molecules influence second messenger systems. Neuron, 3, 13-20.
    • (1989) Neuron , vol.3 , pp. 13-20
    • Schuch, U.1    Lohse, M.J.2    Schachner, M.3
  • 47
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington, R. et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature, 375, 754-760.
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1
  • 49
    • 0028213567 scopus 로고
    • A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth
    • Small, D.H., Nurcombe, V., Reed, G., Clarris, H., Moir, R., Beyreuther, K. and Masters, C.L. (1994) A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J. Neurosci., 14, 2117-2127.
    • (1994) J. Neurosci. , vol.14 , pp. 2117-2127
    • Small, D.H.1    Nurcombe, V.2    Reed, G.3    Clarris, H.4    Moir, R.5    Beyreuther, K.6    Masters, C.L.7
  • 54
    • 0028587336 scopus 로고
    • APP717 missense mutation affects the ratio of amyloid β protein species (Aβ1-42/43 and Aβ1-40) in familial Alzheimer's disease brain
    • Tamaoka, A. et al. (1994) APP717 missense mutation affects the ratio of amyloid β protein species (Aβ1-42/43 and Aβ1-40) in familial Alzheimer's disease brain. J. Biol. Chem., 269, 32721-32724.
    • (1994) J. Biol. Chem. , vol.269 , pp. 32721-32724
    • Tamaoka, A.1
  • 56
    • 0024582224 scopus 로고
    • Decreased adhesiveness of Alzheimer's disease fibroblasts: Is amyloid β-protein precursor involved?
    • Ueda, K., Cole, G., Sundsmo, M., Katzman, R. and Saitoh, T. (1989) Decreased adhesiveness of Alzheimer's disease fibroblasts: is amyloid β-protein precursor involved? Ann. Neurol., 25, 246-251.
    • (1989) Ann. Neurol. , vol.25 , pp. 246-251
    • Ueda, K.1    Cole, G.2    Sundsmo, M.3    Katzman, R.4    Saitoh, T.5
  • 57
    • 0026779680 scopus 로고
    • Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor
    • Yoshikawa, K., Aizawa, T. and Hayashi, Y. (1992) Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor. Nature, 359, 64-67.
    • (1992) Nature , vol.359 , pp. 64-67
    • Yoshikawa, K.1    Aizawa, T.2    Hayashi, Y.3
  • 58
    • 0028988801 scopus 로고
    • β-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
    • Zheng, H. et al. (1995) β-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell, 81, 525-531.
    • (1995) Cell , vol.81 , pp. 525-531
    • Zheng, H.1


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