Integrin-associated protein stimulates α2β1-dependent chemotaxis via Gi-mediated inhibition of adenylate cyclase and extracellular-regulated kinases

Journal of Cell Biology

Volumn 147, Issue 2, 1999, Pages 389-399

  Wang, Xue Qing ^a   Lindberg, Frederik P ^a   Frazier, William A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chemotaxis; Cyclic AMP; Heterotrimeric G proteins; Integrin associated protein; MAP kinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 8 BROMO CYCLIC AMP; ADENYLATE CYCLASE; ANTISENSE OLIGONUCLEOTIDE; COLLAGEN; CYCLIC AMP; FORSKOLIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE; PERTUSSIS TOXIN; PHOSPHATASE; THROMBOSPONDIN 1;

ANIMAL CELL; AORTA MEDIA; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD47; CARRIER PROTEINS; CELLS, CULTURED; CHEMOTAXIS; CYCLIC AMP; GTP-BINDING PROTEINS; HUMANS; INTEGRINS; MAP KINASE SIGNALING SYSTEM; MICE; MUSCLE, SMOOTH, VASCULAR; OLIGOPEPTIDES; RECEPTORS, COLLAGEN; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0032746029     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.147.2.389     Document Type: Article

References (62)

1. Arroyo, A.G., A. Garcia-Pardo, and F. Sanchez-Madrid. 1993. A high affinity conformational state on VAL integrin heterodimers induced by an anti-β1 chain monoclonal antibody. J. Biol. Chem. 268:9863-9868.
2. Blystone, S.D., F.P. Lindberg, S.E. LaFlamme, and E.J. brown. 1995. Integrin β3 cytoplasmic tail is necessary and sufficient for regulation of α5β1 phagocytosis by αvβ3 and integrin-associated protein. J. Cell Biol. 130:745-754.
3. Brown, E.J., L. Hooper, T. Ho, and H. Gresham. 1990. Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins. J. Cell Biol. 111:2785-2794.
4. Carlos, T.M., and J.M. Harlan. 1994. Leukocyte-endothelial adhesion molecules. Blood. 84:2068-2101.
5. Casscells, W. 1992. Endothelial and smooth muscle cell migration: critical factors in restenosis. Circulation. 86:723-729.
6. Chan, B.M.C, and M.E. Hemler. 1993. Multiple functional forms of the integrin VLA-2 can be derived a single α2 cDNA clone: interconversion of forms induced by an anti-β1 antibody. J. Cell Biol. 120:537-543.
7. Chen, D., T. Asahara, K. Krasinski, B. Witzenbichler, J. Yang, M. Magner, M. Kearney, W. A. Frazier, J.M. Isner, and V. Andres. 1999. Antibody blockade of thrombospondin-1 accelerates reendothelialization and reduces neointima formation in balloon-injured rat carotid artery. Circulation. 100:849-854.
8. Chen, Q., M.S. Kinch, T.H. Lin, K. Burridge, and R.L. Juliano. 1994. Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J. Biol. Chem. 269:26602-26605.
9. 3. J. Biol. Chem. 272:14740-14746.
10. Chung, J., X.-Q. Wang, F.F. Lindberg, and W.A. Frazier. 1999. Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in α2β1-mediated platelet activation. Blood. 94:642-648.
11. Cooper, D., F.P. Lindberg, G.R. Gamble, E.J. Brown, and M.A. Vadas. 1995. Transendothelial migration of neutrophils involves integrin-associated protein (CD47). Proc. Natl. Acad. Sci. USA. 92:3978-3982.
12. Dimilla, P.A., K. Barbee, and D.A. Lauffenburger. 1991. Mathematical model for the effects of adhesion and mechanics on cell migration speed. Biophys. J. 120:15-37.
13. Dobrina, A., R. Menegazzi, T.M. Carlos, E. Nardon, R. Cramer, T. Zacchi, J.M. Harlan, and P. Patriarca. 1991. Mechanisms of eosinophil adherence to cultured vascular endothelial cells. J. Clin. Invest. 88:20-26.
14. Dubey, R.K., E.K. Jackson, and T.F. Luscher. 1995. Nitric oxide inhibits angiotensin II-induced migration of rat aortic smooth muscle cells: role of cyclic nucleotides and angiotensin receptors. J. Clin. Invest. 96:141-149.
15. Frazier, W.A., A.-G. Gao, J. Dimitry, J. Chung, F.P. Lindberg, E.J. Brown, and M.E. Linder. 1999. The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi. J. Biol. Chem. 274: 8554-8560.
16. 3 function through integrin associated protein. J. Cell Biol. 135:533-544.
17. Gao, A.-G., F.P. Lindberg, M.B. Finn, S.D. Blystone, E.J. Brown, and W.A. Frazier. 1996b. Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin. J. Biol. Chem. 271:21-24.
18. Giasson, E., M.J. Servant, and S. Meloche. 1997. Cyclic AMP-mediated inhibition of angiotension II-induced protein synthesis is associated with suppression of tyrosine phosphorylation signaling in vascular smooth muscle cells. J. Biol. Chem. 272:26879-26888.
19. Graves, L.M., K.E. Bornfeldt, J.S. Sidhu, G.M. Argas, E.W. Raines, R. Ross, C.C. Leslie, and E.G. Krebs. 1996. Platelet-derived growth factor stimulates protein kinase A through a mitogen-activated protein kinase-dependent pathway in human arterial smooth muscle cells. J. Biol. Chem. 271:505-511.
20. Hawes, B.E., T.V. Biesen, W.J. Koch, L.M. Luttrell, and R.J. Lefkowitz. 1995. Distinct pathways of Gi-and Gq-mediated mitogen-activated protein kinase activation. J. Biol. Chem. 270:17148-17153.
21. Hughes, P.E., and M. Pfaff. 1998. Integrin affinity modulation. Trends Cell Biol. 8:359-364.
22. Hughes, P.E., M.W. Renshaw, M. Pfaff, J. Forsyth, V.M. Keivens, M.A. Schwartz, and M.H. Ginsberg. 1997. Suppression of integrin activation: a novel function of a ras/raf-initiated MAP kinase pathway. Cell. 88:521-530.
23. Huttenlocher, A., R.R. Sandborg, and A.F. Horwitz. 1995. Adhesion in cell migration. Curr. Opin. Cell Biol. 7:697-706.
24. Hynes, R.O. 1992. Integrins: versatility, modulation and signaling in cell adhesion. Cell. 69:11-25.
25. Iaccarino, G., L.A. Smithwick, R.J. Lefkowitz, and W.J. Koch. 1999. Targeting Gβγ signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis. Proc. Natl. Acad. Sci. USA. 96:3945-3950.
26. Janat, M.F., and G. Liau. 1992. Transforming growth factor β1 is a powerful modulator of platelet-derived growth factor action in vascular smooth muscle cells. J. Cell Physiol. 150:232-242.
27. Keyse, S.M. 1998. Protein phosphatases and the regulation of MAP kinase activity. Semin. Cell. Devel. Biol. 9:143-152.
28. Klemke, R.L., S. Cai, A.L. Gianninni, P.J. Gallagher, P. Lanerolle, and D.A. Cheresh. 1997. Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol. 137:481-492.
29. Kosfeld, M.D., and W.A. Frazier. 1992. Identification of active peptide sequences in the carboxyl-terminal cell binding domain of human thrombospondin-1. J. Biol. Chem. 267:16230-16236.
30. Kovach, N.L., T.M. Carlos, E. Yee, and J.M. Harlan. 1992. A monoclonal antibody to β1 integrin (CD 29) stimulates VLA-dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components. J. Cell Biol. 116:499-509.
31. Laudanna, C., J.J. Campbell, and E.C. Butcher. 1997. Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants. J. Biol. Chem. 272:24141-24144.
32. Lauffenburger, D.A., and A.F. Horwitz. 1996. Cell migration: a physically integrated molecular process. Cell. 84:359-369.
33. Lefkowitz, R.J. 1998. G protein coupled receptors: III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization. J. Biol. Chem. 273:18677-18680.
34. Lindberg, F.P., D.C. Bullard, T.E. Caver, H.D. Gresham, A.L. Beaudet, and E.J. Brown. 1996. Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Science. 274:795-798.
35. Majack, R.A., S.C. Cook, and P. Bornstein. 1986. Control of smooth muscle cell growth by components of the extracellular matrix: autocrine role for thrombospondin. Proc. Natl. Acad. Sci. USA. 83:9050-9054.
36. Majack, R.A., L.V. Goodman, and V.M. Dixit. 1988. Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation. J. Cell. Biol. 106:415-422.
37. Nadal, F., S. Levy-Toledano, F. Grelac, J.P. Caen, J.-P. Rosa, and M. Bryckaert. 1997. Negative regulation of mitogen-activated protein kinase activation by integrin αIIbβ3 in platelets. J. Biol. Chem. 272:22381-22384.
38. Neer, E.J. 1995. Heterotrimeric G proteins: organizers of transmembrane signals. Cell. 80:249-257.
39. Nelson, P.R., S. Yamamura, and K.C. Kent. 1996. Extracellular matrix proteins are potent agonists of human smooth muscle cell migration. J. Vasc. Surg. 24:25-33.
40. Palmer, D., K. Tsoi, and D.H. Maurice. 1998. Synergistic inhibition of vascular smooth muscle cell migration by phosphodiesterase 3 and phosphodiesterase 4 inhibitors. Circ. Res. 82:852-861.
41. Parkos, C.A., S.P. Colgen, T.W. Liang, A. Nusrat, A.E. Bacarra, D.K. Carnes, and J.L. Madara. 1996. CD47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia. J. Cell Biol. 132: 437-450.
42. Patel, M.K., J.S. Lymn, G.F. Clunn, and A.D. Hughes. 1997. Thrombospondin-1 is a potent mitogen and chemoattractant for human vascular smooth cells. Arterio. Thromb. Vas. Biol. 17:2107-2114.
43. Pickering, J.G., S. Uniyal, C.M. Ford, T. Chau, M.A. Laurin, L.H. Chow, C.G. Ellis, J. Fish, and B.M.C. Chan. 1997. Fibroblast growth factor-2 potentiates vascular smooth muscle cell migration to platelet-derived growth factor. Upregulation of α2β1 integrin and disassembly of actin filaments. Circ. Res. 80: 627-637.
44. Ross, R., and B. Kariya. 1980. Circulation, vascular smooth muscle. In Handbook of Physiology. The Cardiovascular System. D.F. Bohr, A.P. Somlyo, and V. Sparks, editors. American Physiological Society, Bethesda, MD. 69-91.
45. Ross, R. 1993. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362:801-809.
46. Santoro, S.A., and W.A. Frazier. 1987. Isolation and characterization of thrombospondin-1. Methods Enzymol. 144:438-446.
47. Santoro, S.A., and M.M. Zutter. 1995. The alpha 2 beta 1 integrin: a collagen receptor on platelets and other cells. Thromb. Haemostasis. 74:813-821.
48. Schwartz, M.A., E.J. Brown, and B. Fazeli. 1993. A 50-kDa integrin-associated protein is required for integrin-regulated calcium entry in endothelial cells. J. Biol. Chem. 268:19931-19934.
49. Sevetson, B.R., X. Kong, and J.C. Lawrence. 1993. Increasing cAMP attenuates activation of mitogen-activated protein kinase. Proc. Natl. Acad. Sci. USA. 90:10305-10309.
50. Shattil, S.J., M.H. Ginsberg, and J.S. Brugge. 1994. Adhesive signaling in platelets. Curr. Opin. Cell Biol. 6:695-704.
51. Shattil, S.J., H. Kashiwagi, and N. Pampori. 1998. Integrin signaling: the platelet paradigm. Blood. 91:2645-2657.
52. Shimizu, Y., G.A. Seventer, S. Stewart, and S. Caixia. 1991. Regulated expression and binding of three VLA (β1) integrin receptors on T-cells. Nature. 345:250-253.
53. Skinner, M.P., E.W. Raines, and R. Ross. 1994. Dynamic expression of α1β1 and α2β1 integrin receptors by human vascular smooth muscle cells. α2β1 integrin is required for chemotaxis across type I collagen-coated membranes. Am. J. Pathol. 145:1070-1081.
54. Springer, T.A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 76:301-314.
55. Stupack, D.G., C. Shen, and J.A. Wilkins. 1994. Control of lymphocyte integrin function: evidence for multiple contributing factors. Cell. Immunol. 155: 237-245.
56. Sun, H., C. Charles, L.F. Lau, and N.K. Tonks. 1993. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell. 75:487-493.
57. Tan, J.L., S. Ravid, and J.A. Spudich. 1992. Control of nonmuscle myosins by phosphorylation. Annu. Rev. Biochem. 61:721-759.
58. Wang, X.Q., and W.A. Frazier. 1998. The thrombospondin receptor CD47 (IAP) modulates and associates with α2β1 integrin in vascular smooth muscle cells. Mol. Biol Cell. 9:865-874.
59. Wight, T.N., G.J. Raugi, S.M. Mumby, and P. Bornstein. 1985. Light microscopic immunolocalization of thrombospondin in human tissues. J. Histohem. Cytochem. 33:295-302.
60. Wilkins, J.T., D. Stupack, S. Stewart, and S. Caixia. 1991. β1-integrin-mediated lymphocyte adherence to extracellular matrix is enhanced by phorbol ester treatment. Eur. J. Immunol. 21:517-522.
61. Yabkowitz, R., P.J. Mansfield, U.S. Ryan, and S.J. Suchard. 1993. Thrombospondin mediates migration and potentiates platelet-derived growth factor-dependent migration of calf pulmonary artery smooth muscle cells. J. Cell. Physiol. 157:24-32.
62. Yue, T.-L., P.J. McKenna, E.H. Ohlstein, M.C. Farah-Carson, W.T. Butler, K. Johanson, P. McDevitt, G.Z. Feuerstein, and J.M. Stadel. 1994. Osteopontin-stimulated vascular smooth muscle cell migration is mediated by β3 integrin. Exp. Cell Res. 214:459-464.