Altered conformation of recombinant frontotemporal dementia-17 mutant tau proteins

Neuroscience Letters

Volumn 260, Issue 3, 1999, Pages 153-156

  Jicha, Gregory A ^a   Rockwood, Julia M ^a   Berenfeld, Benjamin ^a   Hutton, Mike ^b   Davies, Peter ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Conformation; Frontotemporal dementia; Tau

Indexed keywords

MUTANT PROTEIN; RECOMBINANT PROTEIN; TAU PROTEIN;

ARTICLE; CIRCULAR DICHROISM; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; GENETIC LINKAGE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; DEMENTIA; FRONTAL LOBE; HUMANS; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; TAU PROTEINS; TEMPORAL LOBE;

EID: 0033525221     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00980-X     Document Type: Article

References (9)

1. Butner K.A., Kirschner M.W. Tau protein binds to microtubules through a flexible array of distributed weak sites. J. Cell Biol. 115:1991;717-730.
2. Goedert M., Jakes R. Expression of separate isoforms of human tau protein: correlation with tau pattern in brain and effects on tubulin polymerization. Eur. Mol. Biol. Organ. J. 8:1990;4225-4230.
3. Harada A., Oguchi K., Okabe S., Kuno J., Terada S., Ohshima T., Sato-Yoshitake R., Takel Y., Noda T., Hirokawa N. Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature. 369:1994;488-491.
4. Hutton M., Lendon C.L., Rizzu P., Baker M., Froelich S., Houlden H., Pickering-Brown S., Chakraverty S., Isaacs A., Grover A., Hackett J., Adamson J., Lincoln S., Dickson D., Davies P., Petersen R.C., Stevens M., De Graaff E., Wauters E., Van Baren J., Hillebrand M., Joose M., Kwon J.M., Nowotny P., Che L.K., Norton J., Morris J.C., Reed L.A., Trojanowski J., Basun H., Lannfelt L., Neystat M., Fahn S., Dark F., Tannenberg T., Dodd P.R., Hayward N., Kwok J.B.J., Schofield P.R., Andreadis A., Snowden J., Craufurd D., Neary D., Owen F., Oostra B.A., Hardy J., Goate A., Van Swueten J., Mann D., Lynch T., Heutink P. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Lett. Nature. 393:1998;702-705.
5. Jicha G.A., Bowser R., Kazam I.G., Davies P. Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau. J. Neurosci. Res. 48:1997;128-132.
6. Jicha G.A., Lane E., Vincent I., Otvos L. Jr., Hoffmann R., Davies P. A conformation- and phosphorylation-dependent antibody recognizing the paired helical filaments of Alzheimer's disease. J. Neurochem. 69:1997;2087-2095.
7. Poorkaj P., Bird T.D., Wijsman E., Nemens E., Garruto R.M., Anderson L., Andreadis A., Wiederholt W.C., Raskind M., Schellenberg G.D. Tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann. Neurol. 43:1998;815-825.
8. Spillantini M.G., Bird T.D., Ghetti B. Frontotemporal dementia and parkinsonism linked to chromosome 17: a new group of tauopathies. Brain Pathol. 8:1998;387-402.
9. Yanagawa H., Chung S.-H., Ogawa Y., Sato K., Shibata-Seki T., Masai J., Ishiguro K. Protein anatomy: C-tail region of human tau protein as a crucial structural element in Alzheimer's paired helical filament formation in vitro. Biochemistry. 37:1998;1979-1988.