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Volumn 25, Issue 1, 2000, Pages 107-120

Multiple forms of phosphatase from human brain: Isolation and partial characterization of affi-gel blue binding phosphatases

Author keywords

Alzheimer's disease; Calcineurin; Human brain; Microtubule assembly; Microtubule associated protein tau; Phosphatases

Indexed keywords

AGAROSE; BRAIN ENZYME; CALMODULIN; PHOSPHATASE; PHOSPHOPROTEIN; POLYLYSINE; SEPHAROSE; SODIUM CHLORIDE; TAU PROTEIN;

EID: 0342948840     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007547701518     Document Type: Article
Times cited : (17)

References (44)
  • 1
    • 0011563425 scopus 로고
    • Phosphoprotein phosphatases
    • P. D. Boyer and E. G. Krebs (eds.), Academic Press, New York
    • Ballou, L. M., and Fischer, E. H. 1987. Phosphoprotein phosphatases. pp. 311-361, in P. D. Boyer and E. G. Krebs (eds.), The Enzymes, Vol. XVII, Academic Press, New York.
    • (1987) The Enzymes , vol.17 , pp. 311-361
    • Ballou, L.M.1    Fischer, E.H.2
  • 2
    • 0024397415 scopus 로고
    • The structure and regulation of protein phosphatases
    • Cohen, P. 1989. The structure and regulation of protein phosphatases, Annu. Rev. Biochem. 58:453-508.
    • (1989) Annu. Rev. Biochem. , vol.58 , pp. 453-508
    • Cohen, P.1
  • 4
    • 0028170809 scopus 로고
    • Protein serine/threonine phosphatases - New avenues for cell regulation
    • Shenolikar, S. 1994. Protein serine/threonine phosphatases - new avenues for cell regulation. Annu Rev Cell Biol. 10:55-86.
    • (1994) Annu Rev Cell Biol. , vol.10 , pp. 55-86
    • Shenolikar, S.1
  • 5
    • 0028155865 scopus 로고
    • Protein tyrosine phosphatases: Mechanism of catalysis and substrate specificity
    • Zhang, Z. Y., and Dixon, J. E. 1994. Protein tyrosine phosphatases: mechanism of catalysis and substrate specificity. Adv Enzymol Relat Areas Mol Biol. 68:1-36.
    • (1994) Adv Enzymol Relat Areas Mol Biol. , vol.68 , pp. 1-36
    • Zhang, Z.Y.1    Dixon, J.E.2
  • 8
    • 0024312664 scopus 로고
    • Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease
    • Iqbal, K., Grundke-Iqbal, I., Smith, A. J., George, L., Tung, Y.-C., and Zaidi, T. 1989. Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease. Proc. Natl. Acad. Sci. USA 86:5646-5650.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 5646-5650
    • Iqbal, K.1    Grundke-Iqbal, I.2    Smith, A.J.3    George, L.4    Tung, Y.-C.5    Zaidi, T.6
  • 9
    • 0025904444 scopus 로고
    • A68: A major subunit of paired helical filaments and derivatized forms of normal τ
    • Lee V. M.-Y., Balin B. J., Otvos Jr. L., and Trojanowski J. Q. 1991. A68: A major subunit of paired helical filaments and derivatized forms of normal τ. Science 251:675-678.
    • (1991) Science , vol.251 , pp. 675-678
    • Lee, V.M.-Y.1    Balin, B.J.2    Otvos L., Jr.3    Trojanowski, J.Q.4
  • 10
    • 0028361538 scopus 로고
    • Alzheimer paired helical filaments: Restoration of the biological activity by dephosphorylation
    • Iqbal, K., Zaidi, T., Bancher, C., and Grundke-Iqbal, I. 1994. Alzheimer paired helical filaments: Restoration of the biological activity by dephosphorylation. FEBS Lett 349:104-108.
    • (1994) FEBS Lett , vol.349 , pp. 104-108
    • Iqbal, K.1    Zaidi, T.2    Bancher, C.3    Grundke-Iqbal, I.4
  • 11
    • 0027308924 scopus 로고
    • Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
    • Bramblett, G. T., Goedert, M., Jakes, R., Merrick, S. E., Trojanowski, J. Q., and Lee, V. M.-Y. 1993. Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 10:1089-1099.
    • (1993) Neuron , vol.10 , pp. 1089-1099
    • Bramblett, G.T.1    Goedert, M.2    Jakes, R.3    Merrick, S.E.4    Trojanowski, J.Q.5    Lee, V.M.-Y.6
  • 12
    • 0028227962 scopus 로고
    • Role of abnormally phosphorylated τ in the breakdown of microtubules in Alzheimer disease
    • Alonso, A. del C., Zaidi, T., Grundke-Iqbal, I., and Iqbal, K. 1994. Role of abnormally phosphorylated τ in the breakdown of microtubules in Alzheimer disease. Proc. Natl. Acad. Sci. 91:5562-5566.
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 5562-5566
    • Del Alonso, A.C.1    Zaidi, T.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 13
    • 0029999787 scopus 로고    scopus 로고
    • Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
    • Alonso, A. C., Grundke-Iqbal, I., and Iqbal, K. 1996. Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nature Med. 2:783-787.
    • (1996) Nature Med. , vol.2 , pp. 783-787
    • Alonso, A.C.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 14
    • 0031012497 scopus 로고    scopus 로고
    • Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau
    • Alonso, A. D., Grundke-Iqbal, I., Barra, H. S., and Iqbal, K. 1997. Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc. Natl. Acad. Sci. USA 94:298-303.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 298-303
    • Alonso, A.D.1    Grundke-Iqbal, I.2    Barra, H.S.3    Iqbal, K.4
  • 15
    • 0027214404 scopus 로고
    • Phosphoprotein phosphatase activities in Alzheimer disease
    • Gong, C.-X., Singh, T. J., Grundke-Iqbal, I., and Iqbal, K. 1993. Phosphoprotein phosphatase activities in Alzheimer disease. J. Neurochem. 61:921-927.
    • (1993) J. Neurochem. , vol.61 , pp. 921-927
    • Gong, C.-X.1    Singh, T.J.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 16
    • 0027978340 scopus 로고
    • cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals
    • cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals. Brain Res. 655:70-76.
    • (1994) Brain Res. , vol.655 , pp. 70-76
    • Pei, J.-J.1    Sersen, E.2    Iqbal, K.3    Grundke-Iqbal, I.4
  • 17
    • 0029113874 scopus 로고
    • Phosphatase activity toward abnormally phosphorylated τ: Decrease in Alzheimer disease brain
    • Gong, C.-X., Shaikh, S., Wang, J.-Z., Zaidi, T., Grundke-Iqbal, I., and Iqbal, K. 1995. Phosphatase activity toward abnormally phosphorylated τ: decrease in Alzheimer disease brain. J Neurochem. 65:732-738.
    • (1995) J Neurochem. , vol.65 , pp. 732-738
    • Gong, C.-X.1    Shaikh, S.2    Wang, J.-Z.3    Zaidi, T.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 18
    • 0029798880 scopus 로고    scopus 로고
    • Reduction of calcineurin enzymatic activity in Alzheimer's disease: Correlation with neuropathologic changes
    • Ladner, C. J., Czech, J., Maurice, J., Lorens, S. A., and Lee, J. M. 1996. Reduction of calcineurin enzymatic activity in Alzheimer's disease: correlation with neuropathologic changes. Neuropathol. Exp. Neurol. 55:924-931.
    • (1996) Neuropathol. Exp. Neurol. , vol.55 , pp. 924-931
    • Ladner, C.J.1    Czech, J.2    Maurice, J.3    Lorens, S.A.4    Lee, J.M.5
  • 19
    • 0000547361 scopus 로고
    • Regional brain protein phosphatase 2A (PP2A) activiy and Alzheimer's disease (AD) neuropathology
    • Speciale, S. G., White, C. A., Bigio, E. H., Mumby, M. C., and Sontag, E. 1995. Regional brain protein phosphatase 2A (PP2A) activiy and Alzheimer's disease (AD) neuropathology. Soc. Neurosci. Abst. 21:744.
    • (1995) Soc. Neurosci. Abst. , vol.21 , pp. 744
    • Speciale, S.G.1    White, C.A.2    Bigio, E.H.3    Mumby, M.C.4    Sontag, E.5
  • 20
    • 0028172239 scopus 로고
    • The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases
    • Mawal-Dewan, M., Henley, J., van de Voorde, A., Trojanowski, J. Q., and Lee, V. M.-Y. 1994. The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases. J. Biol. Chem. 269:30981-30987.
    • (1994) J. Biol. Chem. , vol.269 , pp. 30981-30987
    • Mawal-Dewan, M.1    Henley, J.2    Van De Voorde, A.3    Trojanowski, J.Q.4    Lee, V.M.-Y.5
  • 21
    • 0028044722 scopus 로고
    • Alzheimer disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase 2B (calcineurin)
    • Gong, C.-X., Singh, T. J., Grundke-Iqbal, I., and Iqbal, K. 1994. Alzheimer disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase 2B (calcineurin). J. Neurochem. 62:803-806.
    • (1994) J. Neurochem. , vol.62 , pp. 803-806
    • Gong, C.-X.1    Singh, T.J.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 22
    • 0028350740 scopus 로고
    • Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease
    • Gong, C.-X., Grundke-Iqbal, I., Damuni, Z., and Iqbal, K. 1994. Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease. FEBS Lett. 341:94-98.
    • (1994) FEBS Lett. , vol.341 , pp. 94-98
    • Gong, C.-X.1    Grundke-Iqbal, I.2    Damuni, Z.3    Iqbal, K.4
  • 23
    • 0028064431 scopus 로고
    • Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A
    • Gong, C.-X., Grundke-Iqbal, I., and Iqbal, K. 1994. Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A. Neurosci. 61:765-772.
    • (1994) Neurosci. , vol.61 , pp. 765-772
    • Gong, C.-X.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 24
    • 0026595846 scopus 로고
    • Tau proteins of Alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms
    • Goedert, M., Spillantini, M. G., Cairns, N. J., and Crowther, R. A. 1992. Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms. Neuron 8:159-168.
    • (1992) Neuron , vol.8 , pp. 159-168
    • Goedert, M.1    Spillantini, M.G.2    Cairns, N.J.3    Crowther, R.A.4
  • 26
    • 0027753055 scopus 로고
    • Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcineurin and phosphatase-2A
    • Drewes, G., Mandelkow, E.-M., Baumann, K., Goris, J., Merlevede, W., and Mandelkow, E. 1993. Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcineurin and phosphatase-2A. FEBS Lett 336:425-432.
    • (1993) FEBS Lett , vol.336 , pp. 425-432
    • Drewes, G.1    Mandelkow, E.-M.2    Baumann, K.3    Goris, J.4    Merlevede, W.5    Mandelkow, E.6
  • 27
    • 0029995590 scopus 로고    scopus 로고
    • Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1
    • Wang, J. Z., Grundke-Iqbal, I., and Iqbal, K. 1996. Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1. Brain Res. Mol. Brain Res. 38:200-2008.
    • (1996) Brain Res. Mol. Brain Res. , vol.38 , pp. 200-2008
    • Wang, J.Z.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 28
    • 0022365608 scopus 로고
    • The distribution of tau in the mammalian central nervous system
    • Binder, L. I., Frankfurter, A., and Rebhun, L. I. 1985. The distribution of tau in the mammalian central nervous system. J. Biol. Chem. 101:1371-1378.
    • (1985) J. Biol. Chem. , vol.101 , pp. 1371-1378
    • Binder, L.I.1    Frankfurter, A.2    Rebhun, L.I.3
  • 30
    • 0031911959 scopus 로고    scopus 로고
    • Subcellular distribution of protein phosphatases and abnormally phosphorylated tau in the temporal cortex from Alzheimer's disease and control brains
    • Pei, J. J., Gong, C. X., Iqbal, K., Grundke-Iqbal, I., Wu, Q. L., Winblad, B., and Cowburn, R. F. 1998. Subcellular distribution of protein phosphatases and abnormally phosphorylated tau in the temporal cortex from Alzheimer's disease and control brains. J Neural Transm 105:69-83.
    • (1998) J Neural Transm , vol.105 , pp. 69-83
    • Pei, J.J.1    Gong, C.X.2    Iqbal, K.3    Grundke-Iqbal, I.4    Wu, Q.L.5    Winblad, B.6    Cowburn, R.F.7
  • 31
    • 0027361281 scopus 로고
    • Microbutule associated protein tau: Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease
    • Köpke, E., Tung, Y.-C., Shaikh, S., Alonso, A. del C., Iqbal, K., and Grundke-Iqbal, I. 1993. Microbutule associated protein tau: abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J. Biol. Chem. 268:24374-24384.
    • (1993) J. Biol. Chem. , vol.268 , pp. 24374-24384
    • Köpke, E.1    Tung, Y.-C.2    Shaikh, S.3    Del Alonso, A.C.4    Iqbal, K.5    Grundke-Iqbal, I.6
  • 33
    • 0018380690 scopus 로고
    • Decoration and stabilization of intact, smooth-walled microtubules with microtubule-associated proteins
    • Sloboda, R. D., and Rosenbaum, J. L. 1979. Decoration and stabilization of intact, smooth-walled microtubules with microtubule-associated proteins. Biochem. 18:48-55.
    • (1979) Biochem. , vol.18 , pp. 48-55
    • Sloboda, R.D.1    Rosenbaum, J.L.2
  • 34
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 35
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T
    • Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T. Nature 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 36
    • 0027534625 scopus 로고
    • Application of synthetic phospho- And unphospho-peptides to identify phosphorylation sites in a subregion of the tau molecule, which is modified in Alzheimer's disease
    • Liu, W.-K., Moore, W. T., Williams, R. T., Hall, F. L., and Yen, S.-H. 1993. Application of synthetic phospho- and unphospho-peptides to identify phosphorylation sites in a subregion of the tau molecule, which is modified in Alzheimer's disease. J Neurosci. Res. 34:371-376.
    • (1993) J Neurosci. Res. , vol.34 , pp. 371-376
    • Liu, W.-K.1    Moore, W.T.2    Williams, R.T.3    Hall, F.L.4    Yen, S.-H.5
  • 37
    • 0028593606 scopus 로고
    • Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residue 396 and residue 404
    • Otvos, L., Feiner, L., Lang, E., Szendrei, G., Goedert, M., and Lee, V. M. Y. 1994. Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residue 396 and residue 404. J. Neurosci. Res. 39:669-673.
    • (1994) J. Neurosci. Res. , vol.39 , pp. 669-673
    • Otvos, L.1    Feiner, L.2    Lang, E.3    Szendrei, G.4    Goedert, M.5    Lee, V.M.Y.6
  • 38
    • 0023833792 scopus 로고
    • Electron microscope studies of free and protease-bound duck ovostatins (ovomacroglubins): Model of ovostatin structure and its transformation upon proteolysis
    • Ruben, G. C., Harris, Jr., E. D., and Nagase, H. 1988. Electron microscope studies of free and protease-bound duck ovostatins (ovomacroglubins): Model of ovostatin structure and its transformation upon proteolysis. J. Biol. Chem. 263:2861-2869.
    • (1988) J. Biol. Chem. , vol.263 , pp. 2861-2869
    • Ruben, G.C.1    Harris E.D., Jr.2    Nagase, H.3
  • 39
    • 0020993936 scopus 로고
    • Use of calmodulin affinity chromatography for purification of specific calmodulin-dependent enzymes
    • Sharma, R. K., Taylor, W. A., and Wang, J. H. 1983. Use of calmodulin affinity chromatography for purification of specific calmodulin-dependent enzymes. Meth. Enzymol. 102:210-219.
    • (1983) Meth. Enzymol. , vol.102 , pp. 210-219
    • Sharma, R.K.1    Taylor, W.A.2    Wang, J.H.3
  • 41
    • 0001018554 scopus 로고
    • Calcineurin: A calcium- And calmodulin-binding protein of the nervous system
    • Klee, C. B., Crouch, T. H., and Krinks, M. H. 1979. Calcineurin: a calcium- and calmodulin-binding protein of the nervous system. Proc. Natl. Acad. Sci. USA 76:6270-6273.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 6270-6273
    • Klee, C.B.1    Crouch, T.H.2    Krinks, M.H.3
  • 42
    • 0020003589 scopus 로고
    • Discovery of a Ca2+- and calmodulin-dependent protein phosphatase: Probable identity with calcineurin (CaM-BP80)
    • Stewart, A. A., Ingebritsen, T. S., Manalan, A, Klee, C. B., and Cohen, P. 1982. Discovery of a Ca2+- and calmodulin-dependent protein phosphatase: probable identity with calcineurin (CaM-BP80). FEBS Lett. 137:80-84.
    • (1982) FEBS Lett. , vol.137 , pp. 80-84
    • Stewart, A.A.1    Ingebritsen, T.S.2    Manalan, A.3    Klee, C.B.4    Cohen, P.5
  • 44
    • 0028902487 scopus 로고
    • Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B
    • Wang, J.-Z., Gong, C.-X., Zaidi, T., Grundke-Iqbal, I., and Iqbal, K. 1995. Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B. J. Biol. Chem. 270:4854-4860.
    • (1995) J. Biol. Chem. , vol.270 , pp. 4854-4860
    • Wang, J.-Z.1    Gong, C.-X.2    Zaidi, T.3    Grundke-Iqbal, I.4    Iqbal, K.5


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