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Volumn 35, Issue 3, 2008, Pages 129-137

Recent progress in the study of Hedgehog signaling

Author keywords

Hedgehog; processing; signal transduction

Indexed keywords

PROTEIN PATCHED; PROTEOHEPARAN SULFATE; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN;

EID: 40749129601     PISSN: 16738527     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1673-8527(08)60019-3     Document Type: Article
Times cited : (12)

References (90)
  • 1
    • 34249007279 scopus 로고    scopus 로고
    • The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development
    • Allen B.L., Tenzen T., and McMahon A.P. The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev. 21 (2007) 1244-1257
    • (2007) Genes Dev. , vol.21 , pp. 1244-1257
    • Allen, B.L.1    Tenzen, T.2    McMahon, A.P.3
  • 2
  • 3
    • 0028329349 scopus 로고
    • Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein
    • Basler K., and Struhl G. Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein. Nature 368 (1994) 208-214
    • (1994) Nature , vol.368 , pp. 208-214
    • Basler, K.1    Struhl, G.2
  • 4
    • 0032474837 scopus 로고    scopus 로고
    • Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
    • Bellaiche Y., The I., and Perrimon N. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature 394 (1998) 85-88
    • (1998) Nature , vol.394 , pp. 85-88
    • Bellaiche, Y.1    The, I.2    Perrimon, N.3
  • 6
    • 0028837742 scopus 로고
    • Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
    • Bitgood M.J., and McMahon A.P. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev. Biol. 172 (1995) 126-138
    • (1995) Dev. Biol. , vol.172 , pp. 126-138
    • Bitgood, M.J.1    McMahon, A.P.2
  • 7
    • 0030111258 scopus 로고    scopus 로고
    • Sertoli cell signaling by Desert hedgehog regulates the male germline
    • Bitgood M.J., Shen L., and McMahon A.P. Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr. Biol. 6 (1996) 230-298
    • (1996) Curr. Biol. , vol.6 , pp. 230-298
    • Bitgood, M.J.1    Shen, L.2    McMahon, A.P.3
  • 8
    • 2542627320 scopus 로고    scopus 로고
    • Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways
    • Bornemann D.J., Duncan J.E., Staatz W., Selleck S., and Warrior R. Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways. Development 131 (2004) 1927-1938
    • (2004) Development , vol.131 , pp. 1927-1938
    • Bornemann, D.J.1    Duncan, J.E.2    Staatz, W.3    Selleck, S.4    Warrior, R.5
  • 9
    • 0034964445 scopus 로고    scopus 로고
    • A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube
    • Briscoe J., Chen Y., Jessell T.M., and Struhl G. A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube. Mol. Cell 7 (2001) 1279-1291
    • (2001) Mol. Cell , vol.7 , pp. 1279-1291
    • Briscoe, J.1    Chen, Y.2    Jessell, T.M.3    Struhl, G.4
  • 10
    • 0028966517 scopus 로고
    • Proteolytic processing yields two secreted forms of Sonic hedgehog
    • Bumcrot D.A., Takata R., and McMahon A.P. Proteolytic processing yields two secreted forms of Sonic hedgehog. Mol. Cell Biol. 15 (1995) 2294-2303
    • (1995) Mol. Cell Biol. , vol.15 , pp. 2294-2303
    • Bumcrot, D.A.1    Takata, R.2    McMahon, A.P.3
  • 11
    • 0033598964 scopus 로고    scopus 로고
    • Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified Hedgehog from signaling cells
    • Burke R., Nellen D., Bellotto M., Hafen E., Senti K.A., Dickson B.J., and Basler K. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified Hedgehog from signaling cells. Cell 99 (1999) 803-815
    • (1999) Cell , vol.99 , pp. 803-815
    • Burke, R.1    Nellen, D.2    Bellotto, M.3    Hafen, E.4    Senti, K.A.5    Dickson, B.J.6    Basler, K.7
  • 12
    • 0028032065 scopus 로고
    • The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development
    • Capdevila J., Estrada M.P., Sanchez-Herrero E., and Guerrero I. The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBO J. 13 (1994) 71-82
    • (1994) EMBO J. , vol.13 , pp. 71-82
    • Capdevila, J.1    Estrada, M.P.2    Sanchez-Herrero, E.3    Guerrero, I.4
  • 13
    • 0024584913 scopus 로고
    • Molecular modeling of protein glycosaminoglycan interactions
    • Cardin A.D., and Weintraub H.J. Molecular modeling of protein glycosaminoglycan interactions. Arteriosclerosis 9 (1989) 21-32
    • (1989) Arteriosclerosis , vol.9 , pp. 21-32
    • Cardin, A.D.1    Weintraub, H.J.2
  • 14
    • 27644523308 scopus 로고    scopus 로고
    • Heparan sulfate proteoglycans exert positive and negative effects in shh activity
    • Carrasco H., Olivares G.H., Faunes F., Oliva C., and Larrain J. Heparan sulfate proteoglycans exert positive and negative effects in shh activity. J. Cell Bio. 96 (2005) 831-838
    • (2005) J. Cell Bio. , vol.96 , pp. 831-838
    • Carrasco, H.1    Olivares, G.H.2    Faunes, F.3    Oliva, C.4    Larrain, J.5
  • 15
    • 0035860538 scopus 로고    scopus 로고
    • Skinny Hedgehog, an acyltransferase required for palmitoylation and activity of the Hedgehog signal
    • Chamoun Z., Mann R.K., Nellen D., von Kessler D.P., Bellotto M., Beachy P.A., and Basler K. Skinny Hedgehog, an acyltransferase required for palmitoylation and activity of the Hedgehog signal. Science 293 (2001) 2080-2084
    • (2001) Science , vol.293 , pp. 2080-2084
    • Chamoun, Z.1    Mann, R.K.2    Nellen, D.3    von Kessler, D.P.4    Bellotto, M.5    Beachy, P.A.6    Basler, K.7
  • 16
    • 0036829397 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling by direct binding of cyclopamine to smoothened
    • Chen J.K., Taipale J., Cooper M.K., and Beachy P.A. Inhibition of Hedgehog signaling by direct binding of cyclopamine to smoothened. Genes Dev. 16 (2002) 2743-2748
    • (2002) Genes Dev. , vol.16 , pp. 2743-2748
    • Chen, J.K.1    Taipale, J.2    Cooper, M.K.3    Beachy, P.A.4
  • 18
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing Hedgehog
    • Chen Y., and Struhl G. Dual roles for patched in sequestering and transducing Hedgehog. Cell 87 (1996) 553-563
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 19
  • 20
    • 0033580269 scopus 로고    scopus 로고
    • Vertebrate Hedgehog signaling modulated by induction of a Hedgehog binding protein
    • Chuang P.T., and McMahon A.P. Vertebrate Hedgehog signaling modulated by induction of a Hedgehog binding protein. Nature 397 (1999) 617-621
    • (1999) Nature , vol.397 , pp. 617-621
    • Chuang, P.T.1    McMahon, A.P.2
  • 22
    • 33744788672 scopus 로고    scopus 로고
    • Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
    • Corcoran R.B., and Scott M.P. Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proc. Natl. Acad. Sci. USA 103 (2006) 8408-8413
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 8408-8413
    • Corcoran, R.B.1    Scott, M.P.2
  • 23
    • 1542512393 scopus 로고    scopus 로고
    • Hedgehog interacting protein in the mature brain: membrane-associated and soluble forms
    • Coulombe J., Traiffort E., Loulier K., Faure H., and Ruat M. Hedgehog interacting protein in the mature brain: membrane-associated and soluble forms. Mol. Cell Neurosci. 25 (2004) 323-333
    • (2004) Mol. Cell Neurosci. , vol.25 , pp. 323-333
    • Coulombe, J.1    Traiffort, E.2    Loulier, K.3    Faure, H.4    Ruat, M.5
  • 24
    • 0034682719 scopus 로고    scopus 로고
    • Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
    • Denef N., Neubuser D., Perez L., and Cohen S.M. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 102 (2000) 521-531
    • (2000) Cell , vol.102 , pp. 521-531
    • Denef, N.1    Neubuser, D.2    Perez, L.3    Cohen, S.M.4
  • 25
    • 0036512117 scopus 로고    scopus 로고
    • Messenger-RNA-binding proteins and the messages they carry
    • Dreyfuss G., Kim V.N., and Kataoka N. Messenger-RNA-binding proteins and the messages they carry. Nat. Rev. Mol. Cell Biol. 3 3 (2002) 195-205
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , Issue.3 , pp. 195-205
    • Dreyfuss, G.1    Kim, V.N.2    Kataoka, N.3
  • 26
    • 0141989894 scopus 로고    scopus 로고
    • Self-enhanced ligand degradation underlies robustness of morphogen gradients
    • Eldar A., Rosin D., Shilo B.Z., and Barkai N. Self-enhanced ligand degradation underlies robustness of morphogen gradients. Dev. Cell 5 (2003) 635-646
    • (2003) Dev. Cell , vol.5 , pp. 635-646
    • Eldar, A.1    Rosin, D.2    Shilo, B.Z.3    Barkai, N.4
  • 27
    • 0029041177 scopus 로고
    • Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway
    • Fan C.M., Porter J.A., Chiang C., Chang D.T., Beachy P.A., and Tessier-Lavigne M. Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway. Cell 81 (1995) 457-465
    • (1995) Cell , vol.81 , pp. 457-465
    • Fan, C.M.1    Porter, J.A.2    Chiang, C.3    Chang, D.T.4    Beachy, P.A.5    Tessier-Lavigne, M.6
  • 28
    • 0029311316 scopus 로고
    • Secretion of the amino-terminal fragment of the hedgehog protein is necessary and sufficient for hedgheog signaling in Drosophila
    • Fietz M.J., Jacinto A., Taylor A.M., Alexandre C., and Ingham P.W. Secretion of the amino-terminal fragment of the hedgehog protein is necessary and sufficient for hedgheog signaling in Drosophila. Curr. Biol. 5 (1995) 643-650
    • (1995) Curr. Biol. , vol.5 , pp. 643-650
    • Fietz, M.J.1    Jacinto, A.2    Taylor, A.M.3    Alexandre, C.4    Ingham, P.W.5
  • 30
    • 16644398750 scopus 로고    scopus 로고
    • Answering a century old riddle: brachydactyly type A1
    • Gao B., and He L. Answering a century old riddle: brachydactyly type A1. Cell Res. 14 (2004) 179-187
    • (2004) Cell Res. , vol.14 , pp. 179-187
    • Gao, B.1    He, L.2
  • 31
    • 13244292984 scopus 로고    scopus 로고
    • Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog
    • Glise B., Miller C.A., Crotazier M., Halbisen M.A., Wise S., Olson D.J., Vincent A., and Blair S.S. Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog. Dev. Cell 8 (2005) 255-266
    • (2005) Dev. Cell , vol.8 , pp. 255-266
    • Glise, B.1    Miller, C.A.2    Crotazier, M.3    Halbisen, M.A.4    Wise, S.5    Olson, D.J.6    Vincent, A.7    Blair, S.S.8
  • 32
    • 33645228803 scopus 로고    scopus 로고
    • A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form
    • Goetz J.A., Singh S., Suber L.M., Kull F.J., and Robbins D.J. A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form. J. Biol. Chem. 281 (2006) 4087-4093
    • (2006) J. Biol. Chem. , vol.281 , pp. 4087-4093
    • Goetz, J.A.1    Singh, S.2    Suber, L.M.3    Kull, F.J.4    Robbins, D.J.5
  • 33
    • 0036008549 scopus 로고    scopus 로고
    • Sonic Hedgehog as a mediator of long-range signaling
    • Goetz J.A., Suber L.M., and Zeng X. Sonic Hedgehog as a mediator of long-range signaling. BioEssays 24 (2002) 157-165
    • (2002) BioEssays , vol.24 , pp. 157-165
    • Goetz, J.A.1    Suber, L.M.2    Zeng, X.3
  • 34
    • 0030027059 scopus 로고    scopus 로고
    • Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog
    • Goodrich L.V., Johnson R.L., Milenkovic L., McMahon J.A., and Scott M.P. Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev. 10 (1996) 301-312
    • (1996) Genes Dev. , vol.10 , pp. 301-312
    • Goodrich, L.V.1    Johnson, R.L.2    Milenkovic, L.3    McMahon, J.A.4    Scott, M.P.5
  • 35
    • 13244257603 scopus 로고    scopus 로고
    • The Drosophila ortholog of human Wnt inhibitory factor shifted controls the diffusion of lipid-modified Hedgehog
    • Gorfinkiel N., Sierra J., Callejo A., Ibanez C., and Guerrero I. The Drosophila ortholog of human Wnt inhibitory factor shifted controls the diffusion of lipid-modified Hedgehog. Dev. Cell 8 (2005) 241-253
    • (2005) Dev. Cell , vol.8 , pp. 241-253
    • Gorfinkiel, N.1    Sierra, J.2    Callejo, A.3    Ibanez, C.4    Guerrero, I.5
  • 36
    • 0012466695 scopus 로고    scopus 로고
    • Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation
    • Guy R.K. Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation. Proc. Natl. Acad. Sci. USA 97 (2000) 7307-7312
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7307-7312
    • Guy, R.K.1
  • 37
    • 2342440335 scopus 로고    scopus 로고
    • Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation
    • Han C., Belenkaya T.Y., Khodoun M., Tauchi M., and Lin X. Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation. Development 131 (2004) 1563-1575
    • (2004) Development , vol.131 , pp. 1563-1575
    • Han, C.1    Belenkaya, T.Y.2    Khodoun, M.3    Tauchi, M.4    Lin, X.5
  • 38
    • 1242329977 scopus 로고    scopus 로고
    • Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamic-independent process
    • Han C., Belenkaya T.Y., Wang B., and Lin X. Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamic-independent process. Development 131 (2003) 601-611
    • (2003) Development , vol.131 , pp. 601-611
    • Han, C.1    Belenkaya, T.Y.2    Wang, B.3    Lin, X.4
  • 39
    • 13244299160 scopus 로고    scopus 로고
    • Shifted from Wnt to Hedgehog signaling pathways
    • Han C., and Lin X. Shifted from Wnt to Hedgehog signaling pathways. Mol. Cell 17 (2005) 321-322
    • (2005) Mol. Cell , vol.17 , pp. 321-322
    • Han, C.1    Lin, X.2
  • 40
    • 40749144679 scopus 로고    scopus 로고
    • Yoder B.K. Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
    • Haycraft C.J., Banizs B., Aydin-Son Y., Zhang Q., and Michaud E.J. Yoder B.K. Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genetics 1 (2005) 480-488
    • (2005) PLoS Genetics , vol.1 , pp. 480-488
    • Haycraft, C.J.1    Banizs, B.2    Aydin-Son, Y.3    Zhang, Q.4    Michaud, E.J.5
  • 42
    • 23844485210 scopus 로고    scopus 로고
    • Cilia and Hedgehog responsiveness in the mouse
    • Huangfu D., and Anderson K.V. Cilia and Hedgehog responsiveness in the mouse. Proc. Natl. Acad. Sci. USA 102 (2005) 11325-11330
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 11325-11330
    • Huangfu, D.1    Anderson, K.V.2
  • 45
    • 13344275921 scopus 로고    scopus 로고
    • Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1
    • Jeong J., and McMahon A.P. Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development 132 (2005) 143-154
    • (2005) Development , vol.132 , pp. 143-154
    • Jeong, J.1    McMahon, A.P.2
  • 46
    • 11144237279 scopus 로고    scopus 로고
    • Hedgehog signaling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
    • Jia J., Tong C., Wang B., Luo L., and Jiang J. Hedgehog signaling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature 432 (2004) 1045-1050
    • (2004) Nature , vol.432 , pp. 1045-1050
    • Jia, J.1    Tong, C.2    Wang, B.3    Luo, L.4    Jiang, J.5
  • 47
    • 2942538442 scopus 로고    scopus 로고
    • Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification
    • Koziel L., Kunath M., Kelly O.G., and Vortkamp A. Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification. Dev. Cell 6 (2004) 801-813
    • (2004) Dev. Cell , vol.6 , pp. 801-813
    • Koziel, L.1    Kunath, M.2    Kelly, O.G.3    Vortkamp, A.4
  • 48
    • 0029028990 scopus 로고
    • Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage
    • Lai C.J., Ekker S.C., Beachy P.A., and Moon R.T. Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage. Development 121 (1995) 2349-2360
    • (1995) Development , vol.121 , pp. 2349-2360
    • Lai, C.J.1    Ekker, S.C.2    Beachy, P.A.3    Moon, R.T.4
  • 50
    • 0035942989 scopus 로고    scopus 로고
    • Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein
    • Lee J.D., and Treisman J.E. Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein. Curr. Biology 11 (2001) 1147-1152
    • (2001) Curr. Biology , vol.11 , pp. 1147-1152
    • Lee, J.D.1    Treisman, J.E.2
  • 52
    • 0026783674 scopus 로고
    • Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
    • Lee J.J., Von Kessler D.P., Parks S., and Beachy P.A. Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell 71 (1992) 33-50
    • (1992) Cell , vol.71 , pp. 33-50
    • Lee, J.J.1    Von Kessler, D.P.2    Parks, S.3    Beachy, P.A.4
  • 54
    • 0035368725 scopus 로고    scopus 로고
    • Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
    • Lewis P.M., Dunn M.P., McMahon J.A., Logan M., Martin J.F., Jacques B., and McMahon A.P. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 105 (2001) 599-612
    • (2001) Cell , vol.105 , pp. 599-612
    • Lewis, P.M.1    Dunn, M.P.2    McMahon, J.A.3    Logan, M.4    Martin, J.F.5    Jacques, B.6    McMahon, A.P.7
  • 55
    • 33646247878 scopus 로고    scopus 로고
    • Cholesterol modification restricts the spread of Shh gradient in the limb bud
    • Li Y., Zhang H., Litingtung Y., and Chiang C. Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc. Natl. Acad. Sci. USA 103 (2006) 6548-6553
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 6548-6553
    • Li, Y.1    Zhang, H.2    Litingtung, Y.3    Chiang, C.4
  • 56
    • 12344310615 scopus 로고    scopus 로고
    • Functions of heparan sulfate proteoglycans in cell signaling during development
    • Lin X. Functions of heparan sulfate proteoglycans in cell signaling during development. Development 131 (2004) 6009-6021
    • (2004) Development , vol.131 , pp. 6009-6021
    • Lin, X.1
  • 57
    • 23144466931 scopus 로고    scopus 로고
    • Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
    • Liu A., Wang B., and Niswander L.A. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132 (2005) 3103-3111
    • (2005) Development , vol.132 , pp. 3103-3111
    • Liu, A.1    Wang, B.2    Niswander, L.A.3
  • 58
    • 33748690784 scopus 로고    scopus 로고
    • The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover
    • Lu X.W., Liu S.M., and Kornberg T.B. The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover. Genes Dev. 20 (2006) 2539-2551
    • (2006) Genes Dev. , vol.20 , pp. 2539-2551
    • Lu, X.W.1    Liu, S.M.2    Kornberg, T.B.3
  • 59
    • 0029948270 scopus 로고    scopus 로고
    • Biochemical evidence that patched is the Hedgehog receptor
    • Marigo V., Davey R.A., Zuo Y., Cunningham J.M., and Tabin C.J. Biochemical evidence that patched is the Hedgehog receptor. Nature 384 (1996) 176-179
    • (1996) Nature , vol.384 , pp. 176-179
    • Marigo, V.1    Davey, R.A.2    Zuo, Y.3    Cunningham, J.M.4    Tabin, C.J.5
  • 60
    • 0029019627 scopus 로고
    • Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
    • Marti E., Bumcrot D.A., Takada R., and McMahon A.P. Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature 375 (1995) 322-325
    • (1995) Nature , vol.375 , pp. 322-325
    • Marti, E.1    Bumcrot, D.A.2    Takada, R.3    McMahon, A.P.4
  • 61
    • 34249011892 scopus 로고    scopus 로고
    • Gas1 extends the range of Hedgehog action by facilitating its signaling
    • Martinelli D.C., and Fan C.M. Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev. 21 (2007) 1231-1243
    • (2007) Genes Dev. , vol.21 , pp. 1231-1243
    • Martinelli, D.C.1    Fan, C.M.2
  • 62
    • 27744484694 scopus 로고    scopus 로고
    • Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
    • May S.R., Ashique A.M., Karlen M., Wang B., Shen Y., Zarbalis K., Reiter J., Ericson J., and Peterson A. Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev. Biol. 287 (2005) 378-389
    • (2005) Dev. Biol. , vol.287 , pp. 378-389
    • May, S.R.1    Ashique, A.M.2    Karlen, M.3    Wang, B.4    Shen, Y.5    Zarbalis, K.6    Reiter, J.7    Ericson, J.8    Peterson, A.9
  • 64
    • 0002452569 scopus 로고    scopus 로고
    • Developmental roles and clinical significance of hedgehog signaling
    • McMahon A.P., Ingham P.W., and Tabin C.J. Developmental roles and clinical significance of hedgehog signaling. Curr. Top. Dev. Biol. 53 (2003) 1-114
    • (2003) Curr. Top. Dev. Biol. , vol.53 , pp. 1-114
    • McMahon, A.P.1    Ingham, P.W.2    Tabin, C.J.3
  • 65
    • 0033554347 scopus 로고    scopus 로고
    • Schwann cell-derived desert hedgehog signals nerve sheath formation
    • Mirsky R., Parmantier E., McMahon A.P., and Jessen K.R. Schwann cell-derived desert hedgehog signals nerve sheath formation. Ann. NY. Acad. Sci. 883 (1999) 196-202
    • (1999) Ann. NY. Acad. Sci. , vol.883 , pp. 196-202
    • Mirsky, R.1    Parmantier, E.2    McMahon, A.P.3    Jessen, K.R.4
  • 66
    • 13144298531 scopus 로고    scopus 로고
    • Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors
    • Olsen C.L., Hsu P.P., Glienke J., Rubanyi G.M., and Brooks A.R. Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors. BMC Cancer 4 (2004) 43
    • (2004) BMC Cancer , vol.4 , pp. 43
    • Olsen, C.L.1    Hsu, P.P.2    Glienke, J.3    Rubanyi, G.M.4    Brooks, A.R.5
  • 70
    • 0028948811 scopus 로고
    • The product of hedgehog autoproteolytic cleavage active in local and long-range signaling
    • Porter J.A., VonKessler D.P., Ekker S.C., Young K.E., Lee J.J., Moses K., and Beachy P.A. The product of hedgehog autoproteolytic cleavage active in local and long-range signaling. Nature 374 (1995) 363-366
    • (1995) Nature , vol.374 , pp. 363-366
    • Porter, J.A.1    VonKessler, D.P.2    Ekker, S.C.3    Young, K.E.4    Lee, J.J.5    Moses, K.6    Beachy, P.A.7
  • 71
    • 0029844192 scopus 로고    scopus 로고
    • Cholesterol modification of hedgehog signaling proteins in animal development
    • Porter J.A., Young K.E., and Beachy P.A. Cholesterol modification of hedgehog signaling proteins in animal development. Science 274 (1996) 255-259
    • (1996) Science , vol.274 , pp. 255-259
    • Porter, J.A.1    Young, K.E.2    Beachy, P.A.3
  • 72
    • 0029004233 scopus 로고
    • Floor plate and motor neuron induction by different concentrations of the amino terminal cleavage product of Sonic hedgehog autoproteolysis
    • Roelink H., Porter J.A., Chiang C., Tanabe Y., Chang D.T., Beachy P.A., and Tessell T.M. Floor plate and motor neuron induction by different concentrations of the amino terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81 (1995) 445-455
    • (1995) Cell , vol.81 , pp. 445-455
    • Roelink, H.1    Porter, J.A.2    Chiang, C.3    Tanabe, Y.4    Chang, D.T.5    Beachy, P.A.6    Tessell, T.M.7
  • 73
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates Hedgehog signaling at the primary cilium
    • Rohatgi R., Milenkovic L., and Scott M.P. Patched1 regulates Hedgehog signaling at the primary cilium. Science 317 (2007) 372-376
    • (2007) Science , vol.317 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 74
    • 0036341998 scopus 로고    scopus 로고
    • Cerebellar proteoglycans regulate sonic hedgehog responses during development
    • Rubin J.B., Choi Y., and Segal R.A. Cerebellar proteoglycans regulate sonic hedgehog responses during development. Development 129 (2002) 2223-2232
    • (2002) Development , vol.129 , pp. 2223-2232
    • Rubin, J.B.1    Choi, Y.2    Segal, R.A.3
  • 76
    • 0030663064 scopus 로고    scopus 로고
    • A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
    • Strigini M., and Cohen S.M. A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development 124 (1997) 4697-4705
    • (1997) Development , vol.124 , pp. 4697-4705
    • Strigini, M.1    Cohen, S.M.2
  • 77
    • 0030795569 scopus 로고    scopus 로고
    • Hedgehog acts by distinct gradient and signal relay mechanisms to organize cell type and cell polarity in the Drosophila abdomen
    • Struhl G., Barbash D.A., and Lawrence P.A. Hedgehog acts by distinct gradient and signal relay mechanisms to organize cell type and cell polarity in the Drosophila abdomen. Development 124 (1997) 2155-2165
    • (1997) Development , vol.124 , pp. 2155-2165
    • Struhl, G.1    Barbash, D.A.2    Lawrence, P.A.3
  • 78
    • 0028178786 scopus 로고
    • Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
    • Tabata T., and Kornberg T.B. Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76 (1994) 89-102
    • (1994) Cell , vol.76 , pp. 89-102
    • Tabata, T.1    Kornberg, T.B.2
  • 79
    • 1342341864 scopus 로고    scopus 로고
    • Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans
    • Takei Y., Ozawa Y., Sato M., Watanabe A., and Tabata T. Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans. Development 131 (2004) 73-82
    • (2004) Development , vol.131 , pp. 73-82
    • Takei, Y.1    Ozawa, Y.2    Sato, M.3    Watanabe, A.4    Tabata, T.5
  • 80
    • 0028841677 scopus 로고
    • A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signaling domain of sonic hedgehog
    • Tanaka Hall T.M., Porter J.A., Beachy P.A., and Leahy D.J. A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signaling domain of sonic hedgehog. Nature 378 (1995) 212-216
    • (1995) Nature , vol.378 , pp. 212-216
    • Tanaka Hall, T.M.1    Porter, J.A.2    Beachy, P.A.3    Leahy, D.J.4
  • 82
    • 33646103902 scopus 로고    scopus 로고
    • The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice
    • Tenzen T., Allen B.L., Cole F., Kang J.S., Krauss R.S., and McMahon A.P. The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev. Cell 10 (2006) 647-656
    • (2006) Dev. Cell , vol.10 , pp. 647-656
    • Tenzen, T.1    Allen, B.L.2    Cole, F.3    Kang, J.S.4    Krauss, R.S.5    McMahon, A.P.6
  • 83
    • 0029961659 scopus 로고    scopus 로고
    • Phosphorylation of the fused protein kinase in response to signaling from hedgehog
    • Therond P.P., Knight J.D., Komberg T.B., and Bishop J.M. Phosphorylation of the fused protein kinase in response to signaling from hedgehog. Proc. Natl. Acad. Sci. USA 93 (1996) 4224-4228
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4224-4228
    • Therond, P.P.1    Knight, J.D.2    Komberg, T.B.3    Bishop, J.M.4
  • 84
    • 3042799334 scopus 로고    scopus 로고
    • Patched controls the Hedgehog gradient by endocytosis in a dynamindependent manner, but this internalization does not play a major role in signal transduction
    • Torroja C., Gorfinkiel N., and Guerrero I. Patched controls the Hedgehog gradient by endocytosis in a dynamindependent manner, but this internalization does not play a major role in signal transduction. Development 131 (2004) 2395-2408
    • (2004) Development , vol.131 , pp. 2395-2408
    • Torroja, C.1    Gorfinkiel, N.2    Guerrero, I.3
  • 87
    • 33646035770 scopus 로고    scopus 로고
    • The Ihog cell-surface proteins bind Hedgehog and mediate pathway activation
    • Yao S., Lum L., and Beachy P.A. The Ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell 125 (2006) 343-357
    • (2006) Cell , vol.125 , pp. 343-357
    • Yao, S.1    Lum, L.2    Beachy, P.A.3
  • 88
  • 89
    • 11144248964 scopus 로고    scopus 로고
    • Extensive phosphorylation of smoothened in Hedgehog pathway activation
    • Zhang C., Williams E.H., Guo Y., Lum L., and Beachy P.A. Extensive phosphorylation of smoothened in Hedgehog pathway activation. Proc. Natl. Acad. Sci. USA 101 (2004) 17900-17907
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 17900-17907
    • Zhang, C.1    Williams, E.H.2    Guo, Y.3    Lum, L.4    Beachy, P.A.5
  • 90
    • 33646120095 scopus 로고    scopus 로고
    • Cdo functions at multiple points short article in the sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
    • Zhang W., Kang J.S., Cole F., Yi M.J., and Krauss R.S. Cdo functions at multiple points short article in the sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev. Cell 10 (2006) 657-665
    • (2006) Dev. Cell , vol.10 , pp. 657-665
    • Zhang, W.1    Kang, J.S.2    Cole, F.3    Yi, M.J.4    Krauss, R.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.