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Volumn 124, Issue 11, 1997, Pages 2155-2165

Hedgehog acts by distinct gradient and signal relay mechanisms to organise cell type and cell polarity in the Drosophila abdomen

Author keywords

Drosophila; Gradient; Hedgehog; Protein kinase A; Segmentation; Smoothened

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; SECRETORY PROTEIN;

EID: 0030795569     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (80)

References (52)
  • 1
    • 0030602796 scopus 로고    scopus 로고
    • The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
    • Alcedo, J., Ayzenzon, M., Von Ohlen, T., Noll, M. and Hooper, J. E. (1996). The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 86, 221-232.
    • (1996) Cell , vol.86 , pp. 221-232
    • Alcedo, J.1    Ayzenzon, M.2    Von Ohlen, T.3    Noll, M.4    Hooper, J.E.5
  • 2
    • 0029858774 scopus 로고    scopus 로고
    • Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins
    • Alexandre, C., Jacinto, A. and Ingham, P. W. (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev. 10, 2003-2013.
    • (1996) Genes Dev. , vol.10 , pp. 2003-2013
    • Alexandre, C.1    Jacinto, A.2    Ingham, P.W.3
  • 3
    • 0028329349 scopus 로고
    • Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein
    • Basler, K. and Struhl, G. (1994). Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368, 208-214.
    • (1994) Nature , vol.368 , pp. 208-214
    • Basler, K.1    Struhl, G.2
  • 5
    • 15844390388 scopus 로고    scopus 로고
    • The roles of hedgehog, wingless and lines in patterning the dorsal epidermis in Drosophila
    • Bokor, P. and DiNardo, S. (1996). The roles of hedgehog, wingless and lines in patterning the dorsal epidermis in Drosophila. Development 122, 1083-1092.
    • (1996) Development , vol.122 , pp. 1083-1092
    • Bokor, P.1    DiNardo, S.2
  • 6
    • 0029795757 scopus 로고    scopus 로고
    • Antagonistic interactions between wingless and decapentaplegic responsible for dorsal-ventral pattern in the Drosophila leg
    • Brook, W. J. and Cohen, S. M. (1996). Antagonistic interactions between wingless and decapentaplegic responsible for dorsal-ventral pattern in the Drosophila leg. Science 273, 1373-1377.
    • (1996) Science , vol.273 , pp. 1373-1377
    • Brook, W.J.1    Cohen, S.M.2
  • 7
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for Patched in sequestering and transducing Hedgehog
    • Chen, Y. and Struhl, G. (1996). Dual roles for Patched in sequestering and transducing Hedgehog. Cell 87, 553-563.
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 8
    • 0026695342 scopus 로고
    • Use of a yeast site-specific recombinase to produce female gennline chimeras in Drosophila
    • Chou, T. B. and Perrimon, N. (1992). Use of a yeast site-specific recombinase to produce female gennline chimeras in Drosophila. Genetics 131, 643-653.
    • (1992) Genetics , vol.131 , pp. 643-653
    • Chou, T.B.1    Perrimon, N.2
  • 9
    • 0029896212 scopus 로고    scopus 로고
    • Sending and receiving the hedgehog signal: Control by the Drosophila Gli protein cubitus interruptus
    • Dominguez, M., Brunner, M., Hafen, E. and Basler, K. (1996). Sending and receiving the hedgehog signal: Control by the Drosophila Gli protein cubitus interruptus. Science 272, 1621-1625.
    • (1996) Science , vol.272 , pp. 1621-1625
    • Dominguez, M.1    Brunner, M.2    Hafen, E.3    Basler, K.4
  • 10
    • 0030584081 scopus 로고    scopus 로고
    • Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity
    • Ericson, J., Morton, S., Kawakami, A., Roelink, H. and Jessell, T. M. (1996). Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell 87, 661-673.
    • (1996) Cell , vol.87 , pp. 661-673
    • Ericson, J.1    Morton, S.2    Kawakami, A.3    Roelink, H.4    Jessell, T.M.5
  • 11
    • 0029311316 scopus 로고
    • Secretion of the amino-terminal fragment of the hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila
    • Fietz, M. J., Jacinto, A., Taylor, A. M., Alexandre, C. and Ingham, P. W. (1995). Secretion of the amino-terminal fragment of the hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila. Curr. Biol. 5, 643-650.
    • (1995) Curr. Biol. , vol.5 , pp. 643-650
    • Fietz, M.J.1    Jacinto, A.2    Taylor, A.M.3    Alexandre, C.4    Ingham, P.W.5
  • 12
    • 0025907542 scopus 로고
    • Site-specific recombination between homologous chromosomes in Drosophila
    • Golic, K. G. (1991). Site-specific recombination between homologous chromosomes in Drosophila. Science 252, 958-961.
    • (1991) Science , vol.252 , pp. 958-961
    • Golic, K.G.1
  • 13
    • 0029809523 scopus 로고    scopus 로고
    • Araucan and caupolican provide a link between compartment subdivisions and patterning of sensory organs and veins in the Drosophila wing
    • Gómez-Skarmeta, J. L. and Modolell, J. (1996). araucan and caupolican provide a link between compartment subdivisions and patterning of sensory organs and veins in the Drosophila wing. Genes Dev. 10, 2935-2945.
    • (1996) Genes Dev. , vol.10 , pp. 2935-2945
    • Gómez-Skarmeta, J.L.1    Modolell, J.2
  • 14
    • 0020004250 scopus 로고
    • A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster
    • Gubb, D. and Garcia-Bellido, A. (1982). A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster. J. Embryol. Exp. Morphol. 68, 37-57.
    • (1982) J. Embryol. Exp. Morphol. , vol.68 , pp. 37-57
    • Gubb, D.1    Garcia-Bellido, A.2
  • 15
    • 0025282638 scopus 로고
    • Region-specific recombination and expression are directed by portions of the Drosophila engrailed promoter
    • Hama, C., Ali, Z. and Kornberg, T. B. (1990). Region-specific recombination and expression are directed by portions of the Drosophila engrailed promoter. Genes Dev. 4, 1079-1093.
    • (1990) Genes Dev. , vol.4 , pp. 1079-1093
    • Hama, C.1    Ali, Z.2    Kornberg, T.B.3
  • 16
    • 0028910516 scopus 로고
    • Growth and differentiation in the Drosophila eye coordinated by hedgehog
    • Heberlein, U., Singh, C. M., Luk, A. Y. and Donohoe, T. J. (1995). Growth and differentiation in the Drosophila eye coordinated by hedgehog. Nature 373, 709-711.
    • (1995) Nature , vol.373 , pp. 709-711
    • Heberlein, U.1    Singh, C.M.2    Luk, A.Y.3    Donohoe, T.J.4
  • 17
    • 0028008784 scopus 로고
    • Drosophila hedgehog acts as a morphogen in cellular patterning
    • Heemskerk, J. and DiNardo, S. (1994). Drosophila hedgehog acts as a morphogen in cellular patterning. Cell 76, 449-460.
    • (1994) Cell , vol.76 , pp. 449-460
    • Heemskerk, J.1    DiNardo, S.2
  • 18
    • 0031040287 scopus 로고    scopus 로고
    • Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes
    • Hepker, J., Wang, Q.-T., Motzny, C. K., Holmgren, R. and Orenic, T. V. (1997). Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes. Development 124, 549-558.
    • (1997) Development , vol.124 , pp. 549-558
    • Hepker, J.1    Wang, Q.-T.2    Motzny, C.K.3    Holmgren, R.4    Orenic, T.V.5
  • 19
    • 0028077841 scopus 로고
    • Distinct pathways for autocrine and paracrine wingless signalling in Drosophila embryos
    • Hooper, J. E. (1994). Distinct pathways for autocrine and paracrine wingless signalling in Drosophila embryos. Nature 372, 461-464.
    • (1994) Nature , vol.372 , pp. 461-464
    • Hooper, J.E.1
  • 20
    • 0029278749 scopus 로고
    • Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing
    • Ingham, P. W. and Fietz, M. J. (1995). Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing. Curr. Biol. 5, 432-440.
    • (1995) Curr. Biol. , vol.5 , pp. 432-440
    • Ingham, P.W.1    Fietz, M.J.2
  • 21
    • 0028918468 scopus 로고
    • Protein kinase a and hedgehog signaling in Drosophila limb development
    • Jiang, J. and Struhl, G. (1995). Protein kinase A and hedgehog signaling in Drosophila limb development. Cell 80, 563-572.
    • (1995) Cell , vol.80 , pp. 563-572
    • Jiang, J.1    Struhl, G.2
  • 22
    • 0030576535 scopus 로고    scopus 로고
    • Complementary and mutually exclusive activities of decapentaplegic and wingless organize axial patterning during Drosophila leg development
    • Jiang, J. and Struhl, G. (1996). Complementary and mutually exclusive activities of decapentaplegic and wingless organize axial patterning during Drosophila leg development. Cell 86, 401-409.
    • (1996) Cell , vol.86 , pp. 401-409
    • Jiang, J.1    Struhl, G.2
  • 23
    • 0019613704 scopus 로고
    • Compartments in the abdomen of Drosophila and the role of the engrailed locus
    • Kornberg, T. (1981). Compartments in the abdomen of Drosophila and the role of the engrailed locus. Dev. Biol. 86, 363-372.
    • (1981) Dev. Biol. , vol.86 , pp. 363-372
    • Kornberg, T.1
  • 24
    • 0000995797 scopus 로고
    • Gradients in the insect segment: The orientation of hairs in the milkweed bug
    • Lawrence, P. A. (1966). Gradients in the insect segment: the orientation of hairs in the milkweed bug. J. Exp. Biol. 44, 607-620.
    • (1966) J. Exp. Biol. , vol.44 , pp. 607-620
    • Lawrence, P.A.1
  • 26
    • 0030604688 scopus 로고    scopus 로고
    • Morphogens, compartments, and pattern: Lessons from Drosophila?
    • Lawrence, P. A. and Struhl, G. (1996). Morphogens, compartments, and pattern: Lessons from Drosophila? Cell 85, 951-961.
    • (1996) Cell , vol.85 , pp. 951-961
    • Lawrence, P.A.1    Struhl, G.2
  • 27
    • 0029967209 scopus 로고    scopus 로고
    • Two distinct mechanisms for long-range patterning by decapentaplegic in the Drosophila wing
    • Lecuit, T., Brook, W. J., Ng, M., Calleja, M., Sun, H. and Cohen, S. M. (1996). Two distinct mechanisms for long-range patterning by decapentaplegic in the Drosophila wing. Nature 381, 387-393.
    • (1996) Nature , vol.381 , pp. 387-393
    • Lecuit, T.1    Brook, W.J.2    Ng, M.3    Calleja, M.4    Sun, H.5    Cohen, S.M.6
  • 28
    • 0028952718 scopus 로고
    • Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning
    • Lepage, T., Cohen, S. M., Diaz-Benjumea, F. J. and Parkhurst, S. M. (1995). Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature 373, 711-715.
    • (1995) Nature , vol.373 , pp. 711-715
    • Lepage, T.1    Cohen, S.M.2    Diaz-Benjumea, F.J.3    Parkhurst, S.M.4
  • 29
    • 0028897883 scopus 로고
    • Function of protein kinase a in hedgehog signal transduction and Drosophila imaginal disc development
    • Li, W., Ohlmeyer, J. T., Lane, M. E. and Kalderon, D. (1995). Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell 80, 553-562.
    • (1995) Cell , vol.80 , pp. 553-562
    • Li, W.1    Ohlmeyer, J.T.2    Lane, M.E.3    Kalderon, D.4
  • 30
    • 0019225646 scopus 로고
    • Morphogenesis of the epidermis of the adult abdomen of Drosophila
    • Madhavan, M. M. and Madhavan, K. (1980). Morphogenesis of the epidermis of the adult abdomen of Drosophila. J. Embryol, exp. Morphol. 60, 1-31.
    • (1980) J. Embryol, Exp. Morphol. , vol.60 , pp. 1-31
    • Madhavan, M.M.1    Madhavan, K.2
  • 31
    • 0029948270 scopus 로고    scopus 로고
    • Biochemical evidence that patched is the hedgehog receptor
    • Marigo, V., Davey, R. A., Zuo, Y., Cunningham, J. M. and Tabin, C. J. (1996). Biochemical evidence that patched is the hedgehog receptor. Nature 384, 176-179.
    • (1996) Nature , vol.384 , pp. 176-179
    • Marigo, V.1    Davey, R.A.2    Zuo, Y.3    Cunningham, J.M.4    Tabin, C.J.5
  • 32
    • 0030970025 scopus 로고    scopus 로고
    • Hedgehog activity, independent of Decapentaplegic, participates in wing disc patterning
    • Mullor, J. L., Calleja, M., Capdevila, J. and Guerrero, I. (1997). Hedgehog activity, independent of Decapentaplegic, participates in wing disc patterning. Development 124, 1227-1237.
    • (1997) Development , vol.124 , pp. 1227-1237
    • Mullor, J.L.1    Calleja, M.2    Capdevila, J.3    Guerrero, I.4
  • 33
    • 0029894568 scopus 로고    scopus 로고
    • Direct and graded long-range signalling by Dpp
    • Nellen, D., Burke, R., Basler, K. and Struhl, G. (1996). Direct and graded long-range signalling by Dpp. Cell 85, 357-368.
    • (1996) Cell , vol.85 , pp. 357-368
    • Nellen, D.1    Burke, R.2    Basler, K.3    Struhl, G.4
  • 34
    • 0028176875 scopus 로고
    • Dishevelled and armadillo act in the Wingless signalling pathway in Drosophila
    • Noordermeer, J., Klingensmith, J., Perrimon, N. and Nusse, R. (1994). dishevelled and armadillo act in the Wingless signalling pathway in Drosophila. Nature 367, 80-83.
    • (1994) Nature , vol.367 , pp. 80-83
    • Noordermeer, J.1    Klingensmith, J.2    Perrimon, N.3    Nusse, R.4
  • 35
    • 0028911915 scopus 로고
    • cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs
    • Pan, D. and Rubin, G. M. (1995). cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 80, 543-552.
    • (1995) Cell , vol.80 , pp. 543-552
    • Pan, D.1    Rubin, G.M.2
  • 36
    • 0029004233 scopus 로고
    • Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis
    • Roelink, H., Porter, J. A., Chiang, C., Tanabe, Y., Chang, D. T., Beachy, P. A. and Jessell, T. M. (1995). Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81, 445-455.
    • (1995) Cell , vol.81 , pp. 445-455
    • Roelink, H.1    Porter, J.A.2    Chiang, C.3    Tanabe, Y.4    Chang, D.T.5    Beachy, P.A.6    Jessell, T.M.7
  • 37
    • 0029870645 scopus 로고    scopus 로고
    • Cell fates in the adult abdomen of Drosophila are determined by wingless during pupal development
    • Shirras, A. D. and Couso, J. P. (1996). Cell fates in the adult abdomen of Drosophila are determined by wingless during pupal development. Dev. Biol. 175, 24-36.
    • (1996) Dev. Biol. , vol.175 , pp. 24-36
    • Shirras, A.D.1    Couso, J.P.2
  • 39
    • 0030740551 scopus 로고    scopus 로고
    • Hedgehog organizes the pattern and polarity of epidermal cells in the Drosophila abdomen
    • in press
    • Struhl, G., Barbash, D. A. and Lawrence, P. (1997). Hedgehog organizes the pattern and polarity of epidermal cells in the Drosophila abdomen. Development, in press.
    • (1997) Development
    • Struhl, G.1    Barbash, D.A.2    Lawrence, P.3
  • 40
    • 0027479044 scopus 로고
    • Organising activity of wingless protein in Drosophila
    • Struhl, G. and Basler, K. (1993). Organising activity of wingless protein in Drosophila. Cell 72, 527-540.
    • (1993) Cell , vol.72 , pp. 527-540
    • Struhl, G.1    Basler, K.2
  • 41
    • 0014025194 scopus 로고
    • Mechanisms by which cells measure their position within the body
    • Stumpf, H. F. (1966). Mechanisms by which cells measure their position within the body. Nature 212, 430-431.
    • (1966) Nature , vol.212 , pp. 430-431
    • Stumpf, H.F.1
  • 42
    • 0002021299 scopus 로고
    • Further studies on gradient-dependent diversification in the pupal cuticle of Galleria mellonella
    • Stumpf, H. F. (1968). Further studies on gradient-dependent diversification in the pupal cuticle of Galleria mellonella. J. Exp. Biol. 49, 49-60.
    • (1968) J. Exp. Biol. , vol.49 , pp. 49-60
    • Stumpf, H.F.1
  • 43
    • 0028178786 scopus 로고
    • Hedgehog is a signaling protein with a key role in patterning Drosophila imaginai discs
    • Tabata, T. and Kornberg, T. B. (1994). Hedgehog is a signaling protein with a key role in patterning Drosophila imaginai discs. Cell 76, 89-102.
    • (1994) Cell , vol.76 , pp. 89-102
    • Tabata, T.1    Kornberg, T.B.2
  • 44
    • 0030455147 scopus 로고    scopus 로고
    • Developmental territories created by mutual antagonism between Wingless and Decapentaplegic
    • Theisen, H., Haerry, T. E., O'Connor, M. B. and Marsh, J. L. (1996). Developmental territories created by mutual antagonism between Wingless and Decapentaplegic. Development 122, 3939-3948.
    • (1996) Development , vol.122 , pp. 3939-3948
    • Theisen, H.1    Haerry, T.E.2    O'Connor, M.B.3    Marsh, J.L.4
  • 45
    • 0028178391 scopus 로고
    • Dishevelled is required during wingless signaling to establish both cell polarity and cell identity
    • Theisen, H., Purcell, J., Bennett, M., Kansagara, D., Syed, A. and Marsh, J. L. (1994). dishevelled is required during wingless signaling to establish both cell polarity and cell identity. Development 120, 347-360.
    • (1994) Development , vol.120 , pp. 347-360
    • Theisen, H.1    Purcell, J.2    Bennett, M.3    Kansagara, D.4    Syed, A.5    Marsh, J.L.6
  • 46
    • 0029784223 scopus 로고    scopus 로고
    • Smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
    • van den Heuvel, M. and Ingham, P. W. (1996). smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 382, 547-551.
    • (1996) Nature , vol.382 , pp. 547-551
    • Van Den Heuvel, M.1    Ingham, P.W.2
  • 47
    • 0029027102 scopus 로고
    • Epithelial planar polarity in the developing Drosophila eye
    • Wehrli, M. and Tomlinson, A. (1995). Epithelial planar polarity in the developing Drosophila eye. Development 121, 2451-2459.
    • (1995) Development , vol.121 , pp. 2451-2459
    • Wehrli, M.1    Tomlinson, A.2
  • 48
    • 0014593403 scopus 로고
    • Positional information and the spatial pattern of cellular differentiation
    • Wolpert, L. (1969). Positional information and the spatial pattern of cellular differentiation. J. Theor. Biol. 25, 1-47.
    • (1969) J. Theor. Biol. , vol.25 , pp. 1-47
    • Wolpert, L.1
  • 49
    • 0019891303 scopus 로고
    • Regeneration of the segment boundary in Oncopeltus
    • Wright, D. A. and Lawrence, P. A. (1981). Regeneration of the segment boundary in Oncopeltus. Developmental Biology 85, 317-327.
    • (1981) Developmental Biology , vol.85 , pp. 317-327
    • Wright, D.A.1    Lawrence, P.A.2
  • 50
    • 0027267041 scopus 로고
    • Analysis of genetic mosaics in developing and adult Drosophila tissues
    • Xu, T. and Rubin, G. M. (1993). Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223-1237.
    • (1993) Development , vol.117 , pp. 1223-1237
    • Xu, T.1    Rubin, G.M.2
  • 51
    • 0029079881 scopus 로고
    • Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing
    • Zecca, M., Basler, K. and Struhl, G. (1995). Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. Development 121, 2265-2278.
    • (1995) Development , vol.121 , pp. 2265-2278
    • Zecca, M.1    Basler, K.2    Struhl, G.3
  • 52
    • 0030606264 scopus 로고    scopus 로고
    • Direct and long-range action of a wingless morphogen gradient
    • Zecca, M., Basler, K. and Struhl, G. (1996). Direct and long-range action of a wingless morphogen gradient. Cell 87, 833-844.
    • (1996) Cell , vol.87 , pp. 833-844
    • Zecca, M.1    Basler, K.2    Struhl, G.3


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