Airway remodeling in asthma: New insights

Journal of Allergy and Clinical Immunology

Volumn 111, Issue 2, 2003, Pages 215-226

  Davies, Donna E ^a   Wicks, James ^a   Powell, Robert M ^a   Puddicombe, Sarah M ^a   Holgate, Stephen T ^a,b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

ADAM33; Airway epithelium; Airway mesenchyme; Asthma; Remodeling

Indexed keywords

MUSCLE PROTEIN; PROTEIN ADAM33; UNCLASSIFIED DRUG;

AIRWAY; ASTHMA; BREATHING MUSCLE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC PREDISPOSITION; HISTORY OF MEDICINE; HUMAN; INFLAMMATORY CELL; LUNG FIBROBLAST; MESENCHYME; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; REVIEW; SMOOTH MUSCLE; T LYMPHOCYTE;

EID: 0037328988     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2003.128     Document Type: Article

References (90)

1. Salter HH. The pathology of asthma - its absolute nature. In: Brewis RAL, editor. Classic papers in asthma. London: Science Press Limited; 1990. p. 106-42.
2. Hilman B. NHLBI guidelines for diagnosis and management of asthma. Bethesda, Md: National Heart, Lung, and Blood Institute; 1997. NIH publication no. 97-4051.
3. Djukanovic R. Bronchoscopy as a research tool for the study of asthma pathogenesis and effects of antiasthma drugs. J Allergy Clin Immunol 1996;98(suppl):S41-5.
4. Djukanovie R, Dahl R, Jarjour N, Aalbers R. Safety of biopsies and bronchoalveolar lavage. Eur Respir J Suppl 1998;26:39S-41S.
5. Howarth PH, Wilson J, Djukanovie R, Wilson S, Britten K, Walls A, et al. Airway inflammation and atopie asthma: a comparative bronehoscopie investigation. Int Arch Allergy Appl Immunol 1991;94:266-9.
6. Djukanovie R. Airway inflammation in asthma and its consequences: implications for treatment in children and adults. J Allergy Clin Immunol 2002;109(suppl 6):S539-48.
7. The Global Initiative for Asthma. Global strategy for asthma management and prevention; a six part asthma management program. Bethesda, Md: National Institutes of Health; 2002. NHLBI publication no. 023659:93-172.
8. Van Ganse E, Laforest L, Pietri G, Boissel JP, Gormand F, Ben Joseph R, et al. Persistent asthma: disease control, resource utilisation and direct costs. Eur Respir J 2002;20:260-7.
9. Holgate ST. Asthma: more than an inflammatory disease. Curr Opin Allergy Clin Immunol 2002;2:27-9.
10. Bryan SA, Kanabar V, Matti S, Leckie MJ, Khan J, Rolfe L, et al. Effect of recombinant human interleukin-12 on cosinophils, airway hyperresponsiveness and the late asthmatic response. Lancet 2000;356:2149-53.
11. Leckie MJ, Brinke AT, Khan J, Diamant Z, O'Connor B. Walls CM, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airways hyper-responsiveness, and the late asthmatic response. Lancet 2000;356:2144-8.
12. Flood-Page M, Menzies-Gow S, Phipps S, Compton C, Walls C, Barnes N, et al. Reduction of tissue eosinophils in mild atopic asthmatics by an ant-IL-5 monoclonal antibody (mepolizumab) is associated with inhibition of tenascin deposition within the bronchial epithelial basement membrane [abstract]. Am J Respir Crit Care Med 2002;165:B42.
13. Skadhuage LR, Christensen K, Kyvik KO, Sigsgaard T. Genetic and environmental influence on asthma: a population based study of 11,688 Danish twin pairs. Eur Respir J 1999;13:8-14.
14. Holgate ST. Genetic and environmental interaction in allergy and asthma. J Allergy Clin Immunol 1999;104:1139-46.
15. Rahman I, MacNee W. Oxidative stress and regulation of glutathione in lung inflammation. Eur Respir J 2000;16:534-54.
16. COMEAP (Committee on the Medical Effects of Air Pollution). Asthma and outdoor air pollution. London: Her Majesty's Stationery Office; 1995.
17. Soutar A, Seaton A, Brown K. Bronchial reactivity and dietary antioxidants. Thorax 1997;52:166-70.
18. Message SD, Johnston SL. Viruses in asthma. Br Med Bull 2002;61:29-43.
19. Dunnill MS. The pathology of asthma. Ciba Foundation Study Group. 1971;38:35-46.
20. Carroll N, Elliot J, Morton A, James A. The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis 1993;147:405-10.
21. Jeffery P. Structural alterations and inflammation of bronchi in asthma. Int J Clin Pract Suppl 1998;96:5-14.
22. Busse WW, Banks-Schlegel S, Wenzel SE. Pathophysiology of severe asthma. J Allergy Clin Immunol 2000;106:1033-42.
23. Wiggs BR, Moreno R, Hogg JC, Hilliam C, Pare PD. A model of the mechanics of airway narrowing. J Appl Physiol 1990;69:849-60.
24. Wiggs BR, Bosken C, Pare PD, James A, Hogg JC. A model of airway narrowing in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1992;145:1251-8.
25. Sont JK, Willems LN, Bel EH, van Krieken JH, Vandenbroucke JP, Sterk PJ. Clinical control and histopathologic outcome of asthma when using airway hyperresponsivencss as an additional guide to long-term treatment. The AMPUL Study Group. Am J Respir Crit Care Med 1999;159:1043-51.
26. Lauge P, Parner J, Vestbo J, Schnohr P, Jensen G. A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med 1998;339:1194-200.
27. The Childhood Asthma Management Program Research Group. Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 2000;343:1054-63.
28. Cokugras H, Akcakaya N, Scekin, Camcioglu Y, Sarimurat N, Aksoy F. Ultrastructural examination of bronchial biopsy specimens from children with moderate asthma. Thorax 2001;56:25-9.
29. Pohunek P, Roche WR, Tarzikova J, Kurdmann J, Warner JO. Eosinophilic inflammation in the bronchial mucosa in children with bronchial asthma [abstract]. Eur Respir J 2000;11(suppl 25):160s.
30. Holgate ST, Davies DE, Lackie PM, Wilson SJ, Puddicombe SM, Lordan JL. Epithelial-mesenchymal interactions in the pathogenesis of asthma. J Allergy Clin Immunol 2000;105:193-204.
31. Davies DE. The bronchial epithelium in chronic and severe asthma. Curr Allergy Asthma Rep 2001;1:127-33.
32. Stein RT, Sherrill D, Morgan WJ, Holberg CJ, Halonen M,Taussig LM, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 1999;354:541-5.
33. Stein RT, Holberg CJ, Sherrill D, Wright AL, Morgan WJ, Taussig L, et al. Influence of parental smoking on respiratory symptoms during the first decade of life: the Tucson Children's Respiratory Study. Am J Epidemiol 1999;149:1030-7.
34. Nicolai T. Environmental air pollution and lung disease in children. Monaldi Arch Chest Dis 1999;54:475-8.
35. Bucchieri F, Puddicombe SM, Lordan JL, Richter A, Buchanan D, Wilson SJ, et al. Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis. Am J Respir Cell Mol Biol 2002;27:179-85.
36. Bayram H, Rusznak C, Khair OA, Sapstord RJ, Abdelaziz MM. Effect of ozone and nitrogen dioxide on the permeability of bronchial epithelial cell cultures of non-asthmatic and asthmatic subjects. Clin Exp Allergy 2002;32:1285-92.
37. Bayram H, Devalia JL, Sapsford RJ, Ohtoshi T, Miyabara Y, Sagai M, et al. The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro. Am J Respir Cell Mol Biol 1998;18:441-8.
38. Montefort S, Roche WR, Holgate ST. Bronchial epithelial shedding in asthmatics and non-asthmatics. Respir Med 1993;87 (suppl B):9-11.
39. Montefort S, Djukanovic R, Holgate ST, Roche WR. Ciliated cell damage in the bronchial epithelium of asthmatics and non-asthmatics. Clin Exp Allergy 1993;23:185-9.
40. Ordonez C, Ferrando R, Hyde DM, Wong HH, Fahy JV. Epithelial desquamation in asthma: artifact or pathology? Am J Respir Crit Care Med 2000;162:2324-9.
41. Puddicombe SM, Polosa R, Richter A, Krishna MT, Howarth PH, Holgate ST, et al. Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J 2000;14:1362-74.
42. Demoly P, Simony-Lafontaine J, Chanez P, Pujol JL, Lequeux N, Michel FB, et al. Cell proliferation in the bronchial mucosa of asthmatics and chronic bronchitics. Am J Respir Crit Care Med 1994;150:214-7.
43. Puddicomhe SM, Torres-Lozano C, Richter A, Bucchieri F, Lordan JL, Howarth P, et al. Increased expression of the cyclin dependent kinase inhibitor, p21waf, in asthmatic bronchial epithelium. Am J Respir Cell Mol Biol 2003;28:61-8.
44. Redington AE, Roche WR, Holgate ST, Howarth PH. Co-localization of immunoreactive transforming growth factor-beta I and decorin in bronchial biopsies from asthmatic and normal subjects. J Pathol 1998;186:410-5.
45. Redington AE, Madden J, Frew AJ, Djukanovic R, Roche WR, Holgate ST, et al. Transforming growth factor-beta I in asthma. Measurement in bronchoalveolar lavage fluid. Am J Respir Crit Care Med 1997;156:642-7.
46. Hamilton LM, Torres-Lozano C, Puddicombe SM, Richter A, Kimber I, Dearman RJ, et al. The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma. Clin Exp Allergy 2003. In press.
47. Rosendahl A, Pardali E, Speletas M, Ten Dijke P, Heldin CH, Sideras P. Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am J Respir Cell Mol Biol 2002;27:160-9.
48. Zhang S, Smartt H, Holgate ST, Roche WR. Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: an in vitro co-culture model of airway remodeling in asthma. Lab Invest 1999;79:395-405.
49. Richter A, Puddicombe SM, Lordan JL, Buechieri F, Wilson SJ, Djukanovic R, et al. The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am J Respir Cell Mol Biol 2001;25:385-91.
50. Warburton D, Schwarz M, Tefft D, Flores-Delgado G, Anderson KD, Cardoso WV. The molecular basis of lung morphogenesis. Mech Dev 2000;92:55-81.
51. Holgate ST, Davies DE. Airway inflammation and remodelling in asthma - cause and effect? Immunologist 2001;8:131-5.
52. Mullings RE, Wilson SJ, Puddicombe SM, Lordan JL, Buechieri F, Djukanovic R, et al. Signal transduction and activator of transcription-6 (STAT-6) expression and function in asthmatic bronchial epithelium. J Allergy Clin Immunol 2001;108:832-8.
53. Lordan JL, Bucchieri F, Richler A, Konslantinidis AK, Holloway JW, Puddicombe SM, et al. Co-operative effects of Th-2 cytokines and allergen on normal and asthmatic bronchial epithelial cells. J Immunol 2002;169:407-14.
54. Kohri K, Ueki IF, Nadel JA. Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation. Am J Physiol Lung Cell Mol Physiol 2002;283:L531-40.
55. Stick S. The contribution of airway development to paediatric and adult lung disease. Thorax 2000;55:587-94.
56. Fanucchi MV, Wong VJ, Hinds D, Tarkingtou BK, Van Winkle LS, Plopper CG. Repeated episodes of exposure to ozone alters postnatal development of distal conducting airways in infant rhesus monkeys [abstract]. Am J Respir Crit Care Med 2000;161:A615.
57. Sekhon HS, Jia Y, Raab R, Kuryatov A, Pankow JF, Whitsett JA, et al. Prenatal nicotine increases pulmonary alpha7 nicotinic receptor expression and alters fetal lung development in monkeys. J Clin Invest 1999;103:637-47.
58. Gizycki MJ, Adelroth E, Rogers AV, O'Byrne PM, Jeffery PK. Myofibroblast involvement in the allergen-induced late response in mild atopic asthma. Am J Respir Cell Mol Biol 1997;16:664-73.
59. Hinz B, Mastrangelo D, Iselin CE, Chaponnier C, Gabbiani G. Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation. Am J Pathol 2001;159:1009-20.
60. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 2002;3:349-63.
61. Qian J, Kumar A, Szucsik JC, Lessard JL. Tissue and developmental specific expression of murine smooth muscle gamma-actin fusion genes in transgenic mice. Dev Dyn 1996;207:135-44.
62. Billington CK, Penn RB. m3 muscarinic acetylcholine receptor regulation in the airway. Am J Respir Cell Mol Biol 2002;26:269-72.
63. Sappino AP, Schurch W, Gabbiani G. Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations. Lab Invest 1990;63:144-61.
64. Darby I, Skalli O, Gabbiani G. Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Invest 1990;63:21-9.
65. Chamley JH, Campbell GR, MeConnell JD, Groschel-Stewart U. Comparison of vascular smooth muscle cells from adult human, monkey and rabbit in primary culture and in subculture. Cell Tissue Res 1977;177:503-22.
66. Buoro S, Ferrarese P, Chiavegato A, Roelofs M, Scatena M, Pauletto P, et al. Myofibroblast-derived smooth muscle cells during remodelling of rabbit urinary bladder wall induced by partial outflow obstruction. Lab Invest 1993;69:589-602.
67. Zhang HY, Phan SH. Inhibition of myofibroblast apoplosis by transforming growth factor beta(1). Am J Respir Cell Mol Biol 1999;21:658-65.
68. Mochitate K, Pawelek P, Grinnell F. Stress relaxation of contracted collagen gels: disruption of actin filament bundles, release of cell surface fibronectin, and down- regulation of DNA and protein synthesis. Exp Cell Res 1991;193:198-207.
69. Yang Y, Beqaj S, Kemp P, Ariel I, Schuger L. Stretch-induced alternative splicing of serum response factor promotes bronchial myogenesis and is defective in lung hypoplasia. J Clin Invest 2000;106:1321-30.
70. Camoretti-Mercado B, Liu HW, Halayko AJ, Forsythe SM, Kyle JW, Li B, et al. Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor. J Biol Chem 2000;275:30387-93.
71. Swartz MA, Tsehumperlin DJ, Kamm RD, Drazen JM. Mechanical stress is communicated between different cell types to elicit matrix remodeling. Proc Natl Acad Sci U S A 2001;98:6180-5.
72. Tsehumperlin DJ, Drazen JM. Mechanical stimuli to airway remodeling. Am J Respir Crit Care Mud 2001;164(suppl):S90-4.
73. Freyer AM, Johnson SR, Hall IP. Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cells. Am J Respir Cell Mol Biol 2001;25:569-76.
74. Hayward IP, Bridle KR, Campbell GR, Underwood PA, Campbell JH. Effect of extracellular matrix proteins on vascular smooth muscle cell phenotype. Cell Biol Int 1995;19:839-46.
75. Zhang J, O'Shea S, Liu J, Schuger L. Bronchial smooth muscle bypoplasia in mouse embryonic lungs exposed to a laminin beta1 chain antisense oligonucleotide. Mech Dev 1999;89:15-23.
76. Beqaj S, Jakkaraju S, Mattingly RR, Pan D, Schuger L. High RhoA activity maintains the undifferentiated mesenehymal cell phenotype, whereas RhoA down-regulation by laminin-2 induces smooth muscle myogenesis. J Cell Biol 2002;156:893-903.
77. Scaffidi AK, Moodley YP, Weichselbaum M, Thompson PJ, Knight DA. Regulation of human lung fibroblast phenotype and function by vitronectin and vitronectin integrins. J Cell Sci 2001;114:3507-16.
78. Chaudhary N, Richter A, Collins JE, Roche WR, Davies DE, Holgate ST. Phenotype comparison of asthmatic and nonasthmatic (myo)fibroblasts [abstract]. Am J Respir Crit Care Med 2001;163:A473.
79. Johnson PR, Roth M, Tamm M, Hughes M, Ge Q, King G, et al. Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med 2001;164:474-7.
80. Yamashita J, Itoh H, Hirashima M, Ogawa M, Nishikawa S, Yurugi T, et al. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 2000;408:92-6.
81. Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, et al. Association of the ADAM-33 gene with asthma and bronchial hyper-responsiveness. Nature 2002;418:426-30.
82. De Sanctis GT, Merchant M, Beier DR, Dredge RD, Grobholz JK, Martin TR, et al. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet 1995;11:150-4.
83. Primakoff P, Myles DG. The ADAM gene family: surface proteins with adhesion and protease activity. Trends Genet 2000;16:83-7.
84. Black RA, White JM. ADAMs: focus on the protease domain. Curr Opin Cell Biol 1998;10:654-9.
85. Blobel CP. Remarkable roles of proteolysis on and beyond the cell surface. Curr Opin Cell Biol 2000;12:606-12.
86. Nath D, Sloeombe PM, Stephens PE, Warn A, Hutchinson GR, Yamada KM, et al. Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells. J Cell Sci 1999;112(suppl):579-87.
87. Nath D, Sloeombe PM, Webster A, Stephens PE, Doeherty AJ, Murphy G. Meltrin gamma(ADAM-9) mediates cellular adhesion through alpha(6)beta(1)integrin, leading to a marked induction of fibroblast cell motility. J Cell Sci 2000;113(suppl):2319-28.
88. Evans JP. Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization. Bioessays 2001;23:628-39.
89. Asakura M, Kitakaze M, Takashima S, Liao Y, Ishikura F, Yoshinaka T, et al. Cardiac hypertrophy is inhibited by antagonism of ADAM 12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nat Med 2002;8:35-40.
90. Gilpin BJ, Loechel F, Mattei MG, Engvall E, Albrechtsen R, Wewer UM. A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo. J Biol Chem 1998;273:157-66.