Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice

Journal of Experimental Medicine

Volumn 194, Issue 2, 2001, Pages 227-233

  Daheshia, Massoud ^a,c   Friend, Daniel S ^a,c   Grusby, Michael J ^a,b   Austen, K Frank ^a,c   Katz, Howard R ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Active cutaneous anaphylaxis; Active systemic anaphylaxis; Immunoreceptor tyrosine based inhibitory motif; Mast cells; Passive cutaneous anaphylaxis

Indexed keywords

ANTIBODY; GLYCOPROTEIN GP 49B1; IMMUNOGLOBULIN; UNCLASSIFIED DRUG;

ALLERGIC DISEASE; ANAPHYLAXIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DISEASE SEVERITY; EDEMA; GENE DISRUPTION; HYPERSENSITIVITY; MAST CELL; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN ANAPHYLAXIS;

ANAPHYLAXIS; ANIMALS; ANTIGENS, SURFACE; EDEMA; FEMALE; MALE; MAST CELLS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; OVALBUMIN; PASSIVE CUTANEOUS ANAPHYLAXIS; RECEPTORS, IMMUNOLOGIC;

EID: 0035898442     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.2.227     Document Type: Article

References (29)

1. Molecular cloning of gp49, a cell surface antigen that is preferentially expressed by mouse mast cell progenitors and is a new member of the immunoglobulin superfamily
2. Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49
3. Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE
4. Activation- and phorbol ester-stimulated phosphorylation of a plasma membrane glycoprotein antigen expressed on mouse IL-3-dependent mast cells and serosal mast cells
5. Mononuclear phagocyte maturation: A cytotoxic monoclonal antibody reactive with postmonoblast stages
6. Uterine macrophages express the gp49B inhibitory receptor in midgestation
7. Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells
8. Mouse natural killer cells express gp49B1, a structural homolog of human killer inhibitory receptors
9. Inducible expression of the gp49B inhibitory receptor on NK cells
10. The gp49A gene has extensive sequence conservation with the gp49B gene and provides gp49A protein, a unique member of a large family of activating and inhibitory receptors of the immunoglobulin superfamily
11. gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of the src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization
12. A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling
13. The same tyrosine-based inhibition motif, in the intracytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation
14. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB
15. Augmented humoral and anaphylactic responses in FcγRII-deficient mice
16. Modulation of immunoglobulin (Ig) E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG
17. Identification of the low affinity receptor for immunoglobulin E on mouse mast cells and macrophages as FcγRII and FcγRIII
18. Activating and inhibitory, NK cell receptors
19. A family of inhibitory and activating Ig-like receptors that modulate function of lymphoid and myeloid cells
20. Paired immunoglobulin-like receptors of activating and inhibitory types
21. gp49B1-αvβ3 interaction inhibits antigen-induced mast cell activation
22. Vitronectin and its receptors
23. Natural killer cells and mast cells from gp49B null mutant mice are functional
24. 125I-fibrin deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin. Demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells
25. 4 synthase
26. Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor α chain gene
27. Differences in the expression of the cardiopulmonary alterations associated with anti-immunoglobulin E-induced or active anaphylaxis in mast cell-deficient and normal mice. Mast cells are not required for the cardiopulmonary changes associated with certain fatal anaphylactic responses
28. Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and FcγRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis
29. Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice