Modulating leukocyte recruitment in inflammation

Journal of Allergy and Clinical Immunology

Volumn 120, Issue 1, 2007, Pages 3-10

  Kelly, Margaret ^a   Hwang, John M ^b   Kubes, Paul ^c  

^a Departments of Pathology

^b Surgery

^c Institute of Infection Immunity and Inflammation   (Canada)

Author keywords

asthma; contact sensitivity; endothelium; inflammation; integrins; leukocytes; microcirculation; recruitment; Selectins

Indexed keywords

CHEMOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; EOTAXIN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 4; L SELECTIN; PADGEM PROTEIN; SELECTIN; VASCULAR CELL ADHESION MOLECULE 1;

ASTHMA; CELL ADHESION; HUMAN; INFLAMMATION; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SKIN ALLERGY;

ANIMALS; ASTHMA; CELL ADHESION; CHEMOTAXIS, LEUKOCYTE; HUMANS; HYPERSENSITIVITY; INFLAMMATION; LEUKOCYTE ROLLING; LEUKOCYTES;

EID: 34250807106     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2007.05.017     Document Type: Review

References (88)

1. Kansas G.S. Selectins and their ligands: current concepts and controversies. Blood 88 (1996) 3259-3287
2. Patel K.D., Nollert M.U., and McEver R.P. P-selectin must extend a sufficient length from the plasma membrane to mediate rolling of neutrophils. J Cell Biol 131 suppl (1995) 1893-1902
3. Erlandsen S.L., Hasslen S.R., and Nelson R.D. Detection and spatial distribution of the beta 2 integrin (Mac-1) and L-selectin (LECAM-1) adherence receptors on human neutrophils by high-resolution field emission SEM. J Histochem Cytochem 41 (1993) 327-333
4. Geng J.G., Bevilacqua M.P., Moore K.L., McIntyre T.M., Prescott S.M., Kim J.M., et al. Rapid neutrophil adhesion to activated endothelium mediated by GMP-140. Nature 343 (1990) 757-760
5. Mayadas T.N., Johnson R.C., Rayburn H., Hynes R.O., and Wagner D.D. Leukocyte rolling and extravasation are severely compromised in P-selectin-deficient mice. Cell 74 (1993) 541-554
6. Yao L., Pan J., Setiadi H., Patel K.D., and McEver R.P. Interleukin 4 or oncostatin M induces a prolonged increase in P-selectin mRNA and protein in human endothelial cells. J Exp Med 184 (1996) 81-92
7. Woltmann G., McNulty C.A., Dewson G., Symon F.A., and Wardlaw A.J. Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flow. Blood 95 (2000) 3146-3152
8. Pan J., Xia L., and McEver R.P. Comparison of promoters for the murine and human P-selectin genes suggests species-specific and conserved mechanisms for transcriptional regulation in endothelial cells. J Biol Chem 273 (1998) 10058-10067
9. Hickey M.J., Kanwar S., McCafferty D.-M., Granger D.N., Eppihimer M.J., and Kubes P. Varying roles of E-selectin and P-selectin in different microvascular beds in response to antigen. J Immunol 162 (1999) 1137-1143
10. Frenette P.S., Mayadas T.N., Rayburn H., Hynes R.O., and Wagner D.D. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell 84 (1996) 563-574
11. Kunkel E.J., and Ley K. Distinct phenotype of E-selectin-deficient mice. E-selectin is required for slow leukocyte rolling in vivo. Circ Res 79 (1996) 1196-1204
12. x-dependent alterations in leukocyte kinetics in vivo. Circ Res 77 (1995) 879-887
13. Gallatin W.M., Weissman I.L., and Butcher E.C. A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature 304 (1983) 30-34
14. Steeber D.A., Tang M.L., Green N.E., Zhang X.Q., Sloane J.E., and Tedder T.F. Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways. J Immunol 163 (1999) 2176-2186
15. Jung U., and Ley K. Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectin. J Immunol 162 (1999) 6755-6762
16. Jung T.M., and Dailey M.O. Rapid modulation of homing receptors (gp90MEL-14) induced by activators of protein kinase C. Receptor shedding due to accelerated proteolytic cleavage at the cell surface. J Immunol 144 (1990) 3130-3136
17. Moore K.L., Patel K.D., Brehl R.E., Johnson D.A., Lichenstein H.S., Cummings R.D., et al. P-selectin glycoprotein ligand mediates rolling of human neutrophils on P-selectin. J Cell Biol 128 (1995) 661-671
18. Yang J., Hirata T., Croce K., Merrill-Skoloff G., Tchernychev B., Williams E., et al. Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E- selectin-mediated neutrophil rolling and migration. J Exp Med 190 (1999) 1769-1782
19. Asa D., Raycroft L., Ma L., Aeed P.A., Kaytes P.S., Elhammer A.P., et al. The P-selectin glycoprotein ligand functions as a common human leukocyte ligand for P- and E-selectins. J Biol Chem 270 (1995) 11662-11670
20. Zanardo R.C., Bonder C.S., Hwang J.M., Andonegui G., Liu L., Vestweber D., et al. A down-regulatable E-selectin ligand is functionally important for PSGL-1-independent leukocyte-endothelial cell interactions. Blood 104 (2004) 3766-3773
21. Xia L., Sperandio M., Yago T., McDaniel J.M., Cummings R.D., Pearson-White S., et al. P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. J Clin Invest 109 (2002) 939-950
22. Hwang J., Yamanouchi J., Santamaria P., and Kubes P. A critical temporal window for selectin-dependent CD4+ lymphocyte homing and initiation of late phase inflammation in contact sensitivity. J Exp Med 199 (2004) 1223-1234
23. Zollner O., Lenter M.C., Blanks J.E., Borges E., Steegmaier M., Zerwes H.G., et al. L-selectin from human, but not from mouse neutrophils binds directly to E-selectin. J Cell Biol 136 (1997) 707-716
24. Fuhlbrigge R.C., King S.L., Sackstein R., and Kupper T.S. CD43 is a ligand for E-selectin on CLA+ human T cells. Blood 107 (2006) 1421-1426
25. Hidalgo A., Peired A.J., Wild M.K., Vestweber D., and Frenette P.S. Complete Identification of E-Selectin Ligands on Neutrophils Reveals Distinct Functions of PSGL-1, ESL-1, and CD44. Immunity 26 (2007) 477-489
26. Steegmaier M., Levinovitz A., Isenmann S., Borges E., Lenter M., Kocher H.P., et al. The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor. Nature 373 (1995) 615-620
27. Austrup F., Vestweber D., Borges E., Lohning M., Brauer R., Herz U., et al. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues. Nature 385 (1997) 81-83
28. Campbell D.J., and Butcher E.C. Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues. J Exp Med 195 (2002) 135-141
29. Bonder C.S., Norman M.U., Macrae T., Mangan P.R., Weaver C.T., Bullard D.C., et al. P-selectin can support both Th1 and Th2 lymphocyte rolling in the intestinal microvasculature. Am J Pathol 167 (2005) 1647-1660
30. Mangan P.R., O'Quinn D., Harrington L., Bonder C.S., Kubes P., Kucik D.F., et al. Both Th1 and Th2 cells require P-selectin glycoprotein ligand-1 for optimal rolling on inflamed endothelium. Am J Pathol 167 (2005) 1661-1675
31. Rosen S.D. Ligands for L-selectin: homing, inflammation, and beyond. Annu Rev Immunol 22 (2004) 129-156
32. Alon R., Fuhlbrigge R.C., Finger E.B., and Springer T.A. Interactions through L-selectin between leukocytes and adherent leukocytes nucleate rolling adhesions on selectins and VCAM-1 in shear flow. J Cell Biol 135 (1996) 849-865
33. Mitchell D.J., Li P., Reinhardt P.H., and Kubes P. Importance of L-selectin-dependent leukocyte-leukocyte interactions in human whole blood. Blood 95 (2000) 2954-2959
34. Kunkel E.J., Chomas J.E., and Ley K. Role of primary and secondary capture for leukocyte accumulation in vivo. Circ Res 82 (1998) 30-38
35. Alon R., Kassner P.D., Carr M.W., Finger E.B., Hemler M.E., and Springer T.A. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol 128 (1995) 1243-1253
36. 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo. J Exp Med 181 (1996) 1995-2006
37. Issekutz A.C., and Issekutz T.B. The role of E-selectin, P-selectin, and very late activation antigen-4 in T lymphocyte migration to dermal inflammation. J Immunol 168 (2002) 1934-1939
38. Johnston B., and Butcher E.C. Chemokines in rapid leukocyte adhesin triggering and migration. Semin Immunol 14 (2002) 83-92
39. Miller M.D., and Krangel M.S. Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines. Crit Rev Immunol 12 (1992) 17-46
40. Baggiolini M., Dewald B., and Moser B. Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv Immunol 55 (1992) 96-179
41. Proudfoot A.E., Handel T.M., Johnson Z., Lau E.K., LiWang P., Clark-Lewis I., et al. Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines. Proc Natl Acad Sci U S A 100 (2003) 1885-1890
42. Middleton J., Neil S., Wintle J., Clark-Lewis I., Moore H., Lam C., et al. Transcytosis and surface presentation of IL-8 by venular endothelial cells. Cell 91 (1997) 385-395
43. Luo B.H., Carman C.V., and Springer T.A. Structural basis of integrin regulation and signaling. Annu Rev Immunol 25 (2007) 619-647
44. Gallin J.I., and Snyderman R. Basic principles and clinical correlates. In: Gallin J.I., and Snyderman R. (Eds). Inflammation (1999), Lippincott Williams and Wilkins, Philadelphia (PA)
45. Grabbe S., Varga G., Beissert S., Steinert M., Pendl G., Seeliger S., et al. Beta2 integrins are required for skin homing of primed T cells but not for priming naive T cells. J Clin Invest 109 (2002) 183-192
46. Springer T.A. Traffic signals of lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 76 (1994) 301-314
47. Bochner B.S., Luscinskas F.W., Gimbrone Jr. M.A., Newman W., Sterbinsky S.A., Derse-Anthony C.P., et al. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. J Exp Med 173 (1991) 1553-1557
48. Bowden R.A., Ding Z.M., Donnachie E.M., Petersen T.K., Michael L.H., Ballantyne C.M., et al. Role of alpha4 integrin and VCAM-1 in CD18-independent neutrophil migration across mouse cardiac endothelium. Circ Res 90 (2002) 562-569
49. Kubes P., Niu X.-F., Smith C.W., Kehrli Jr. M.E., Reinhardt P.H., and Woodman R.C. A novel b1-dependent adhesion pathway on neutrophils: A mechanism invoked by dihydrocytochalasin B or endothelial transmigration. FASEB J 9 (1995) 1103-1111
50. Johnston B., and Kubes P. The alpha4-integrin: an alternative pathway for neutrophil recruitment?. Immunol Today 20 (1999) 545-550
51. O'Connor P. Natalizumab and the role of alpha 4-integrin antagonism in the treatment of multiple sclerosis. Expert Opin Biol Ther 7 (2007) 123-136
52. Hyams J.S., Wilson D.C., Thomas A., Heuschkel R., Mitton S., Mitchell B., et al. Natalizumab therapy for moderate to severe Crohn disease in adolescents. J Pediatr Gastroenterol Nutr 44 (2007) 185-191
53. Baker D.E. Natalizumab: overview of its pharmacology and safety. Rev Gastroenterol Disord 7 (2007) 38-46
54. Norman MU, Van De Velde NC, Timoshanko JR, Issekutz A, Hickey MJ. Overlapping roles of endothelial selectins and vascular cell adhesion molecule-1 in immune complex-induced leukocyte recruitment in the cremasteric microvasculature. Am J Pathol 2003;163:1491-503.
55. Johnston B., Chee A., Issekutz T.B., Ugarova T., Fox-Robichaud A., Hickey M.J., et al. Alpha 4 integrin-dependent leukocyte recruitment does not require VCAM-1 in a chronic model of inflammation. J Immunol 164 (2000) 3337-3344
56. Picarella D., Hurlbut P., Rottman J., Shi X., Butcher E., and Ringler D.J. Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of SCID mice reconstituted with CD45RBhigh CD4+ T cells. J Immunol 158 (1997) 2099-2106
57. Briskin M., Winsor-Hines D., Shyjan A., Cochran N., Bloom S., Wilson J., et al. Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Am J Pathol 151 (1997) 97-110
58. Schenkel A.R., Mamdouh Z., and Muller W.A. Locomotion of monocytes on endothelium is a critical step during extravasation. Nat Immunol 5 (2004) 393-400
59. Phillipson M., Heit B., Colarusso P., Liu L., Ballantyne C.M., and Kubes P. Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade. J Exp Med 203 (2006) 2569-2575
60. Engelhardt B., and Wolburg H. Mini-review: transendothelial migration of leukocytes: through the front door or around the side of the house?. Eur J Immunol 34 (2004) 2955-2963
61. Feng D., Nagy J.A., Pyne K., Dvorak H.F., and Dvorak A.M. Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP. J Exp Med 187 (1998) 903-915
62. Shaw S.K., Bamba P.S., Perkins B.N., and Luscinskas F.W. Real-time imaging of vascular endothelial-cadherin during leukocyte transmigration across endothelium. J Immunol 167 (2001) 2323-2330
63. Carman C.V., and Springer T.A. A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J Cell Biol 167 (2004) 377-388
64. Jeffery P.K. Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc 1 (2004) 176-183
65. Bousquet J., Jeffery P.K., Busse W.W., Johnson M., and Vignola A.M. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 161 (2000) 1720-1745
66. Broide D., and Sriramarao P. Eosinophil trafficking to sites of allergic inflammation. Immunol Rev 179 (2001) 163-172
67. Kitayama J., Fuhlbrigge R.C., Puri K.D., and Springer T.A. P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions. J Immunol 159 (1997) 3929-3939
68. Symon F.A., Lawrence M.B., Williamson M.L., Walsh G.M., Watson S.R., and Wardlaw A.J. Functional and structural characterization of the eosinophil P-selectin ligand. J Immunol 157 (1996) 1711-1719
69. Broide D.H., Sullivan S., Gifford T., and Sriramarao P. Inhibition of pulmonary eosinophilia in P-selectin- and ICAM-1-deficient mice. Am J Respir Cell Mol Biol 18 (1998) 218-225
70. Dang B., Wiehler S., and Patel K.D. Increased PSGL-1 expression on granulocytes from allergic-asthmatic subjects results in enhanced leukocyte recruitment under flow conditions. J Leukoc Biol 72 (2002) 702-710
71. Grayson MH, van der Vieren M, Sterbinsky SA, Michael GW, Hoffman PA, Staunton DE, et al. alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1). J Exp Med 1998;188:2187-91.
72. Henderson Jr. W.R., Chi E.Y., Albert R.K., Chu S.J., Lamm W.J., Rochon Y., et al. Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. J Clin Invest 100 (1997) 3083-3092
73. Nakajima H., Sano H., Nishimura T., Yoshida S., and Iwamoto I. Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue. J Exp Med 179 (1994) 1145-1154
74. Ten Hacken N.H., Postma D.S., Bosma F., Drok G., Rutgers B., Kraan J., et al. Vascular adhesion molecules in nocturnal asthma: a possible role for VCAM-1 in ongoing airway wall inflammation. Clin Exp Allergy 28 (1998) 1518-1525
75. Ohkawara Y., Yamauchi K., Maruyama N., Hoshi H., Ohno I., Honma M., et al. In situ expression of the cell adhesion molecules in bronchial tissues from asthmatics with air flow limitation: in vivo evidence of VCAM-1/VLA-4 interaction in selective eosinophil infiltration. Am J Respir Cell Mol Biol 12 (1995) 4-12
76. Jose P.J., Griffiths-Johnson D.A., Collins P.D., Walsh D.T., Moqbel R., Totty N.F., et al. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J Exp Med 179 (1994) 881-887
77. Rothenberg M.E., and Hogan S.P. The eosinophil. Annu Rev Immunol 24 (2006) 147-174
78. Fulkerson P.C., Fischetti C.A., and Rothenberg M.E. Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling. Am J Pathol 169 (2006) 2117-2126
79. Zimmermann N., Hershey G.K., Foster P.S., and Rothenberg M.E. Chemokines in asthma: cooperative interaction between chemokines and IL-13. J Allergy Clin Immunol 111 (2003) 227-242
80. Nakamura H., Luster A.D., Nakamura T., In K.H., Sonna L.A., Deykin A., et al. Variant eotaxin: its effects on the asthma phenotype. J Allergy Clin Immunol 108 (2001) 946-953
81. Askenase P.W., Szczepanik M., Itakura A., Kiener C., and Campos R.A. Extravascular T-cell recruitment requires initiation begun by Valpha14+ NKT cells and B-1 B cells. Trends Immunol 25 (2004) 441-449
82. Tsuji R.F., Kawikova I., Ramabhadran R., kahira-Azuma M., Taub D., Hugli T.E., et al. Early local generation of C5a initiates the elicitation of contact sensitivity by leading to early T cell recruitment. J Immunol 165 (2000) 1588-1598
83. Yu B., Koga T., Urabe K., Moroi Y., Maeda S., Yanagihara Y., et al. Differential regulation of thymus- and activation-regulated chemokine induced by IL-4, IL-13, TNF-alpha and IFN-gamma in human keratinocyte and fibroblast. J Dermatol Sci 30 (2002) 29-36
84. Rottman J.B., Smith T.L., Ganley K.G., Kikuchi T., and Krueger J.G. Potential role of the chemokine receptors CXCR3, CCR4, and the integrin alphaEbeta7 in the pathogenesis of psoriasis vulgaris. Lab Invest 81 (2001) 335-347
85. Homey B., Alenius H., Muller A., Soto H., Bowman E.P., Yuan W., et al. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med 8 (2002) 157-165
86. Staite N.D., Justen J.M., Sly L.M., Beaudet A.L., and Bullard D.C. Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin. Blood 88 (1996) 2973-2979
87. McHale J.F., Harari O.A., Marshall D., and Haskard D.O. Vascular endothelial cell expression of ICAM-1 and VCAM-1 at the onset of eliciting contact hypersensitivity in mice: evidence for a dominant role of TNF-alpha. J Immunol 162 (1999) 1648-1655
88. Chishom P.L., Williams C.A., and Lobb R.R. Monoclonal antibodies to the integrin a-4 subunit inhibit the murine contact hypersensitivity response. Eur J Immunol 23 (1993) 682-688