gp49B1-αvβ3 interaction inhibits antigen-induced mast cell activation

Nature Immunology

Volumn 2, Issue 5, 2001, Pages 436-442

  Castells, Mariana C ^a   Klickstein, Lloyd B ^a   Hassani, Kevin ^a   Cumplido, Jose A ^a   Lacouture, Mario E ^a   Austen, K Frank ^a   Katz, Howard R ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GP49A PROTEIN, MOUSE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN RECEPTOR; INTEGRIN; LIGAND; LILRB4 PROTEIN, MOUSE; MEMBRANE ANTIGEN; MEMBRANE PROTEIN; RECOMBINANT PROTEIN; VITRONECTIN; VITRONECTIN RECEPTOR;

ANIMAL; ARTICLE; BINDING COMPETITION; BONE MARROW CELL; GENETICS; IMMUNOLOGY; MAST CELL; METABOLISM; MOUSE; PROTEIN BINDING;

ANIMALS; ANTIGENS, SURFACE; BINDING, COMPETITIVE; BONE MARROW CELLS; IMMUNOGLOBULIN E; INTEGRINS; LIGANDS; MAST CELLS; MEMBRANE GLYCOPROTEINS; MICE; PROTEIN BINDING; RECEPTORS, IMMUNOLOGIC; RECEPTORS, VITRONECTIN; RECOMBINANT PROTEINS; VITRONECTIN;

EID: 0035344083     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/87749     Document Type: Article

References (52)

1. Arm, J. P. et al. Molecular cloning of gp49, a cell surface antigen that is preferentially expressed by mouse mast cell progenitors and is a new member of the immunoglobulin superfamily. J. Biol. Chem. 266, 15966-15973 (1991).
2. Castells, M. C. et al. Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49. J. Biol. Chem. 269, 8393-8401 (1994).
3. Katz, H. R., Benson, A. C. & Austen, K. F. Activation- and phorbol ester-stimulated phosphorylation of a plasma membrane glycoprotein antigen expressed on mouse IL-3-dependent mast cells and serosal mast cells. J. Immunol. 142, 919-926 (1989).
4. Katz, H. R. et al. Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE. Proc. Natl. Acad. Sci. USA 93, 10809-10814 (1996).
5. LeBlanc, P. A., Russell, S. W. & Chang, S.-M. T. Mouse mononuclear phagocyte heterogeneity detected by monoclonal antibodies. J. Reticuloendothelial Soc. 32, 219-231 (1982).
6. Rojo, S., Burshtyn, D. N., Long, E. O. & Wagtmann, N. Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells. J. Immunol. 158, 9-12 (1997).
7. Wang, L. L. Mehta, I. K., LeBlanc, P. A. & Yokoyama, W. M. Mouse natural killer cells express gp49B1, a structural homolog of human killer inhibitory receptors. J. Immunol. 158, 13-17 (1997).
8. McCormick, M. J., Castells, M. C., Austen, K. F. & Katz, H. R. The gp49A gene has extensive sequence conservation with the gp49B gene and provides gp49A protein, a unique member of a large family of activating and inhibitory receptors of the immunoglobulin superfamily. Immunogenetics 50, 286-294 (1999).
9. Lu-Kuo, J. M., Joyal, D. M., Austen, K. F. & Katz, H. R. gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of the src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization. J. Biol. Chem. 274, 5791-5796 (1999).
10. Colonna, M. & Samaridis, J. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 268, 405-408 (1995).
11. D’Andrea, A. et al. Molecular cloning of NKB1.A natural killer cell receptor for HLA-B allotypes. J. Immunol. 155, 2306-2310 (1995).
12. Moretta, A. et al. P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities. J. Exp. Med. 178, 597-604 (1993).
13. Wagtmann, N. et al. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity 2, 439-449 (1995).
14. Muta, T. et al. A 13-amino-acid motif in the cytoplasmic domain of FrγRIIB modulates B-cell receptor signalling. Nature 368, 70-73 (1994).
15. Burshtyn, D. N. et al. Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. Immunity 4, 77-85 (1996).
16. Olcese, L. et al. Human and mouse killer-cell inhibitory receptors recruit PTPIC and PTPID protein tyrosine phosphatases. J. Immunol. 156, 4531-4534 (1996).
17. Binstadt, B. A. et al. Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity 5, 629-638 (1996).
18. Olcese, L. et al. Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by natural killer cells. J. Immunol. 158, 5083-5086 (1997).
19. Campbell, K. S. et al. Signaling through human killer cell activating receptors triggers tyrosine phosphorylation of an associated protein complex. Eur. J. Immunol. 28, 599-609 (1998).
20. Lanier, L. L. et al. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature 391, 703-707 (1998).
21. Lanier, L. L. NK cell receptors. Annu. Rev. Immunol. 16, 359-393 (1998).
22. Arm, J. P., Nwankwo, C. & Austen, K. F. Molecular identification of a novel family of human immunoglobulin superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. J. Immunol. 159, 2342-2349 (1997).
23. Borges, L. et al. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. J. Immunol. 159, 5192-5196 (1997).
24. Meyaard, L. et al. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. Immunity 7, 283-290 (1997).
25. Samaridis, J. & Colonna, M. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. Eur. J. Immunol. 27, 660-665 (1997).
26. Navarro, F. et al. The ILT2 (LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-GI and HLA-E molecules co-expressed on target cells. Eur. J. Immunol. 29, 277-283 (1999).
27. Lanier, L. L. Natural killer cells fertile with receptors for HLA-G? Proc. Natl. Acad. Sci. USA 96, 5343-5345 (1999).
28. Hayami, K. et al. Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors. J. Biol. Chem. 272, 7320-7337 (1997).
29. Kubagawa, H., Burrows, P. D. & Cooper, M. D. A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Proc. Natl. Acad. Sci. USA 94, 5261-5266 (1997).
30. Pierschbacher, M. D. & Ruoslahti, E. Influence of stereochemistry of the sequence arg-gly-asp-xaa on binding specificity in cell adhesion. J. Biol. Chem. 262, 17294-17298 (1987).
31. 1 mediate attachment of lyme disease spirochetes to human cells. Infect. Immun. 66, 1946-1952 (1998).
32. 1. J. Cell Biol. 127, 1129-1137 (1994).
33. 1 integrin genes by rodent mast cells. J. Immunol. 149, 1964-1972 (1992).
34. Colonna, M. et al. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 186, 1809-1818 (1997).
35. Felding-Habermann, B., Mueller, B. M., Romerdahl, C. A. & Cheresh, D. A. Involvement of integrin αv gene expression in human melanoma tumorigenicity. J. Clin. Invest. 89, 2018-2022 (1992).
36. 1 in promoting cellular attachment and spreading on fibronectin. J. Cell Biol. 111, 2795-2800 (1990).
37. Elices, M. J. et al. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 60, 577-584 (1990).
38. 1. Cell 60, 53-61 (1990).
39. 1. J. Biol. Chem. 269, 4005-4011 (1994).
40. 1: implications for integrin function and rational drug design. Ciba. Found. Symp. 189, 177-191 (1995).
41. Emini, E. A., Hughes, J. V., Perlow, D. S. & Boger, J. Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide. J. Virol. 55, 836-839 (1985).
42. Morton, H. C. et al. Immunoglobulin-binding sites of human FcαR1 (CD89) and bovine Fcγ2R are located in their membrane-distal extracellular domains. J. Exp. Med. 189, 1715-1722 (1999).
43. 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J. Biol. Chem. 270, 25570-25577 (1995).
44. 3. J. Biol. Chem. 270, 9917-9925 (1995).
45. Matsumoto, Y., Wang, L. L., Yokoyama, W. M. & Aso, T. Uterine macrophages express the gp49B inhibitory receptor in midgestation. J. Immunol. 166, 781-786 (2001).
46. Matsumoto, Y., Handa, S. & Taki, T. gp49B1, an inhibitory signaling receptor gene of hematopoietic cells, is induced by leukemia inhibitory factor in the uterine endometrium just before implantation. Dev. Growth Differ. 39, 591-597 (1997).
47. 3 integrin adversely affects implantation in the mouse. Biol. Reprod. 62, 1285-1290 (2000).
48. Van Kooyk, Y. & Figdor, C. G. Avidity regulation of integrins: the driving force in leukocyte adhesion. Curr. Opin. Cell Biol 12, 542-547 (2000).
49. Rojo, S. et al. Natural killer cells and mast cells from gp49B null mutant mice are functional. Mol. Cell. Biol. 20, 7178-7182 (2000).
50. Yatohgo, T., Izumi, M., Kashiwagi, H. & Hayashi, M. Novel purification of vitronectin from human plasma by heparin affinity chromatography. Cell Struct. Funct. 13, 281-292 (1988).
51. Cheng, Y. & Prusoff, W. H. Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (150) of an enzymatic reaction. Biochem. Pharmacol. 22, 3099-3108 (1973).
52. Johnston, S. C., Dustin, M. L., Hibbs, M. L. & Springer, T. A. On the species specificity of the interaction of LFA-1 with intercellular adhesion molecules. J. Immunol. 145, 1181-1187 (1990).