Detecting and treating cancer with nanotechnology

Molecular Diagnosis and Therapy

Volumn 12, Issue 1, 2008, Pages 1-14

  Hartman, Keith B ^a   Wilson, Lon J ^a,c   Rosenblum, Michael G ^b  

^a RICE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c RICE UNIVERSITY   (United States)

Author keywords

Cancer, general; Diagnostics; Imaging agents, diagnostic use; Nanoparticles

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; FULLERENE DERIVATIVE; GADOLINIUM PENTETATE; GEMTUZUMAB OZOGAMICIN; IRON OXIDE; NANOPARTICLE; NANOSHELL; NANOTUBE; QUANTUM DOT; RENILLA LUCIFERIN 2 MONOOXYGENASE; RITUXIMAB; SINGLE WALLED NANOTUBE;

BRAIN CANCER; CLINICAL TRIAL; COLLOID; DRUG DELIVERY SYSTEM; FLUORESCENCE MICROSCOPY; FLUOROSCOPY; GLIOBLASTOMA; HUMAN; HYPERTHERMIA; IRIDOTOMY; LIVER CELL CARCINOMA; MAGNETIC FIELD; NANOTECHNOLOGY; NEAR INFRARED SPECTROSCOPY; NEOPLASM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; PROSTATE CANCER; REVIEW; SURFACE PLASMON RESONANCE; UTERINE CERVIX CANCER;

EID: 39549115661     PISSN: 11771062     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03256264     Document Type: Review

References (172)

1. NCI Nanotechnology Initiative. Cancer nanotechnology plan: a strategic initiative to transform clinical oncology and basic research through the directed application of nanotechnology. 2004 Jul [online]. Available from URL: http://nano.cancer.gov/about_alliance/cancer_nanotechnology_plan.pdf [Accessed 2008 Jan 23]
2. Agrawal A, Xing Y, Gao X, et al. Quantum dots. In: Vo-Dinh T, editor. Nanotechnology in biology: methods, devices, and applications. Boca Raton (FL): CRC Press, 2007: 1-15
3. Klostranec JM, Chan WCW. Quantum dots in biological and biomedical research: recent progress and present challenges. Adv Mater 2006; 18 (15): 1953-64
4. Caruthers SD, Wickline SA, Lanza GM. Nanotechnological applications in medicine. Curr Opin Biotechnol 2007; 18 (1): 26-30
5. Hirsch LR, Gobin AM, Lowery AR, et al. Metal nanoshells. Ann Biomed Eng 2006; 34 (1): 15-22
6. Sonvico F, Dubernet C, Colombo P, et al. Metallic colloid nanotechnology, applications in diagnosis and therapeutics. Curr Pharm Design 2005; 11 (16): 2091-105
7. Wang H, Brandl DW, Nordlander P, et al. Plasmonic nanostructures: artificial molecules. Acc Chem Res 2007; 40 (1): 53-62
8. Duguet E, Vasseur S, Mornet S, et al. Magnetic nanoparticles and their applications in medicine. Nanomed 2006; 1 (2): 157-68
9. Corot C, Robert P, Idee J-M, et al. Recent advances in iron oxide nanocrystal technology for medical imaging. Adv Drug Deliv Rev 2006; 58 (14): 1471-504
10. Tasis D, Tagmatarchis N, Bianco A, et al. Chemistry of carbon nanotubes. Chem Rev 2006; 106 (3): 1105-36
11. Guldi DM, Rahman GMA, Sgobba V, et al. Multifunctional molecular carbon materials: from fullerenes to carbon nanotubes. Chem Soc Rev 2006; 35 (5): 471-87
12. Hartschuh A, Pedrosa HN, Peterson J, et al. Single carbon nanotube optical spectroscopy. Chem Phys Chem 2005; 6 (4): 577-82
13. Green M. Organometallic based strategies for metal nanocrystal synthesis. Chem Commun 2005; 24: 3002-11
14. Brus L. Electronic wave functions in semiconductor clusters: experiment and theory. J Phys Chem 1986; 90 (12): 2555-60
15. Brus LE. Electron-electron and electron-hole interactions in small semiconductor crystallites: the size dependence of the lowest excited electronic state. J Phys Chem 1984; 80 (9): 4403-9
16. Bruchez Jr M, Moronne M, Gin P, et al. Semiconductor nanocrystals as fluorescent biological labels. Science 1998; 281 (5385): 2013-6
17. Jaiswal JK, Mattoussi H, Mauro JM, et al. Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat Biotechnol 2003; 21 (1): 47-51
18. Shepard JRE. Polychromatic microarrays: simultaneous multicolor array hybridization of eight samples. Anal Chem 2006; 78 (8): 2478-86
19. Levy M, Cater SF, Ellington AD. Quantum-dot aptamer beacons for the detection of proteins. Chem Bio Chem 2005; 6 (12): 2163-6
20. Chan P, Yuen T, Ruf F, et al. Method for multiplex cellular detection of mRNAs using quantum dot fluorescent in situ hybridization. Nucleic Acids Res 2005; 33 (18): e161/1-8
21. Ho Y-P, Kung MC, Yang S, et al. Multiplexed hybridization detection with multicolor colocalization of quantum dot nanoprobes. Nano Lett 2005; 5 (9): 1693-7
22. Kobayashi H, Hama Y, Koyama Y, et al. Simultaneous multicolor imaging of five different lymphatic basins using quantum dots. Nano Lett 2007; 7 (6): 1711-6
23. So M-K, Xu C, Loening AM, et al. Self-illuminating quantum dot conjugates for in vivo imaging. Nat Biotechnol 2006; 24 (3): 339-43
24. Cai W, Shin D-W, Chen K, et al. Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. Nano Lett 2006; 6 (4): 669-76
25. Tada H, Higuchi H, Wanatabe TM, et al. In vivo real-time tracking of single quantum dots conjugated with monoclonal Anti-HER2 antibody in tumors of mice. Cancer Res 2007; 67 (3): 1138-44
26. Yu X, Chen L, Li K, et al. Immunofluorescence detection with quantum dot bioconjugates for hepatoma in vivo. J Biomed Opt 2007; 12 (1): 014008/1-5
27. Gao X, Chung LWK, Nie S. Quantum dots for in vivo molecular and cellular imaging. Meth Mol Biol 2007; 374 (Quantum Dots): 135-45
28. Toms SA, Daneshvar H, Muhammad O, et al. Optical detection of brain tumors using quantum dots. Proceedings of the SPIE; 2005 Nov. In: Analoui M, Dunn DA, editors. Optical methods in drug discovery and development. Bellingham (WA): SPIE, 2005 [online]. Available from URL: http://adsabs.harvard.edu/abs/ 2005SPIE.6009..125T [Accessed 2008 Feb 6]
29. Chan WC, Nie S. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 1998; 281 (5385): 2016-8
30. Ballou B, Lagerholm BC, Ernst LA, et al. Noninvasive imaging of quantum dots in mice. Bioconj Chem 2004; 15 (1): 79-86
31. Akerman ME, Chan WCW, Laakkonen P, et al. Nanocrystal targeting in vivo. Proc Natl Acad Sci U S A 2002; 99 (20): 12617-21
32. Grecco HE, Lidke KA, Heintzmann R, et al. Ensemble and single particle photophysical properties (two-photon excitation, anisotropy, FRET, lifetime, spectral conversion) of commercial quantum dots in solution and in live cells. Micro Res Tech 2004; 65 (4/5): 169-79
33. Howarth M, Takao K, Hayashi Y, et al. Targeting quantum dots to surface proteins in living cells with biotin ligase. Proc Natl Acad Sci U S A 2005; 102 (21): 7583-8
34. Pinaud F, King D, Moore H-P, et al. Bioactivation and cell targeting of semiconductor CdSe/ZnS Nanocrystals with phytochelatin-related peptides. J Am Chem Soc 2004; 126 (19): 6115-23
35. Babu P, Sinha S, Surolia A. Sugar-quantum dot conjugates for a selective and sensitive detection of lectins. Bioconj Chem 2007; 18 (1): 146-51
36. Sun X-L, Cui W, Haller C, et al. Site-specific multivalent carbohydrate labeling of quantum dots and magnetic beads. Chem Bio Chem 2004; 5 (11): 1593-6
37. Gao X, Cui Y, Levenson RM, et al. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 2004; 22 (8): 969-76
38. Goldman ER, Clapp AR, Anderson GP, et al. Multiplexed toxin analysis using four colors of quantum dot fluororeagents. Anal Chem 2004; 76 (3): 684-8
39. Wu X, Liu H, Liu J, et al. Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat Biotechnol 2003; 21 (1): 41-6
40. Zhu L, Ang S, Liu W-T. Quantum dots as a novel immunofluorescent detection system for Cryptosporidium parvum and Giardia lamblia. Appl Environ Microbiol 2004; 70 (1): 597-8
41. Soo Choi H, Liu W, Misra P, et al. Renal clearance of quantum dots. Nat Biotechnol 2007 Oct; 25 (10): 1165-70
42. Jackson JB, Halas NJ. Silver nanoshells: variations in morphologies and optical properties. J Phys Chem B 2001; 105 (14): 2743-6
43. Luo Y, Lee SK, Hofmeister H, et al. Pt nanoshell tubes by template wetting. Nano Lett 2004; 4 (1): 143-7
44. Wang J, Zhu Y, Wu Y, et al. Fabrication, assembly and magnetic properties of nickel hollow nanoballs. Mod Phys Lett B 2006; 20 (10): 549-55
45. Sershen SR, Westcott SL, Halas NJ, et al. Independent optically addressable nanoparticle-polymer optomechanical composites. Appl Phys Lett 2002; 80 (24): 4609-11
46. Oldenburg SJ, Averitt RD, Westcott SL, et al. Nanoengineering of optical resonances. Chem Phys Lett 1998; 288 (2,3,4): 243-7
47. Mohamed MB, Ismail KZ, Link S, et al. Thermal reshaping of gold nanorods in micelles. J Phys Chem B 1998; 102 (47): 9370-4
48. Durr NJ, Larson T, Smith DK, et al. Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods. Nano Lett 2007; 7 (4): 941-5
49. Huang C-J, Wang Y-H, Chiu P-H, et al. Electrochemical synthesis of gold nanocubes. Mater Lett 2006; 60 (15): 1896-900
50. Chen J, Saeki F, Wiley BJ, et al. Gold nanocages: bioconjugation and their potential use as optical imaging contrast agents. Nano Lett 2005; 5 (3): 473-7
51. Hao F, Nehl CL, Hafner JH, et al. Plasmon resonances of a gold nanostar. Nano Lett 2007; 7 (3): 729-32
52. Jain PK, Lee KS, El-Sayed IH, et al. Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. J Phys Chem B 2006; 110 (14): 7238-48
53. Gobin AM, Lee MH, Halas NJ, et al. Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy. Nano Lett 2007 Jul; 7 (7): 1929-34
54. Copland JA, Eghtedari M, Popov VL, et al. Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography. Mol Imaging Biol 2004; 6 (5): 341-9
55. Fu K, Sun J, Lin AWH, et al. Polarized angular dependent light scattering properties of bare and PEGylated gold nanoshells. Curr Nanosci 2007; 3 (2): 167-70
56. Loo C, Hirsch L, Lee M-H, et al. Gold nanoshell bioconjugates for molecular imaging in living cells. Optics Lett 2005; 30 (9): 1012-4
57. Hirsch LR, Stafford RJ, Bankson JA, et al. Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc Natl Acad Sci U S A 2003; 100 (23): 13549-54
58. Overgaard K, Overgaard J. Investigations on the possibility of a thermic tumour therapy: I. Short-wave treatment of a transplanted isologous mouse mammary carcinoma. Eur J Cancer 1972; 8 (1): 65-78
59. Pankhurst QA, Connolly J, Jones SK, et al. Applications of magnetic nanoparticles in biomedicine. J Phys D Appl Phys 2003; 36 (13): R167-81
60. Sershen SR, Westcott SL, Halas NJ, et al. Temperature-sensitive polymer-nanoshell composites for photothermally modulated drug delivery. J Biomed Mater Res 2000; 51 (3): 293-8
61. Tartaj P, Morales MdP, Veintemillas-Verdaguer S, et al. The preparation of magnetic nanoparticles for applications in biomedicine. J Phys D Appl Phys 2003; 36 (13): R182-97
62. Gupta AK, Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterial 2005; 26 (18): 3995-4021
63. 4 particles by precipitation in the presence of PVA at high pH. J Coll Inter Sci 1996; 177 (2): 490-4
64. Massart R, Cabuil V. Effect of some parameters on the formation of colloidal magnetite in alkaline medium: yield and particle size control. J Chimie Physique Phys Chimie Biol 1987; 84 (7-8): 967-73
65. Pileni MP. Reverse micelles as microreactors. J Phys Chem 1993; 97 (27): 6961-73
66. Zarur AJ, Ying JY. Reverse microemulsion synthesis of nanostructured complex oxides for catalytic combustion. Nature 2000; 403 (6765): 65-7
67. Zhang Y, Kohler N, Zhang M. Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake. Biomaterials 2002; 23 (7): 1553-61
68. Pileni M-P. The role of soft colloidal templates in controlling the size and shape of inorganic nanocrystals. Nat Mater 2003; 2 (3): 145-50
69. Reimer P, Balzer T. Ferucarbotran (Resovist): a new clinically approved RES-specific contrast agent for contrast-enhanced MRI of the liver: properties, clinical development, and applications. Eur Radiol 2003; 13 (6): 1266-76
70. Gruttner C, Teller J. New types of silica-fortified magnetic nanoparticles as tools for molecular biology applications. J Magn Magn Mater 1999; 194 (1-3): 8-15
71. Berry CC, Curtis ASG. Functionalisation of magnetic nanoparticles for applications in biomedicine. J Phys D Appl Phys 2003; 36 (13): R198-206
72. Ji X, Shao R, Elliott AM, et al. Bifunctional gold nanoshells with a superparamagnetic iron oxide-silica core suitable for both mr imaging and photothermal therapy. J Phys Chem C 2007; 111 (17): 6245-51
73. Merbach AE, Toth E, editors. The chemistry of contrast agents in medical magnetic resonance imaging. New York: Wiley, 2001
74. Mornet S, Vasseur S, Grasset F, et al. Magnetic nanoparticle design for medical diagnosis and therapy. J Mater Chem 2004; 14 (14): 2161-75
75. Taupitz M, Wagner S, Schnorr J, et al. Phase I clinical evaluation of citrate-coated monocrystalline very small superparamagnetic iron oxide particles as a new contrast medium for magnetic resonance imaging. Invest Radiol 2004; 39 (7): 394-405
76. Clement O, Siauve N, Cuenod CA, et al. Liver imaging with ferumoxides (Feridex): fundamentals, controversies, and practical aspects. Top Magn Reson Imaging 1998; 9 (3): 167-82
77. Reimer P, Marx C, Rummeny EJ, et al. SPIO-enhanced 2D-TOF MR angiography of the portal venous system: results of an intraindividual comparison. J Magn Reson Imaging 1997; 7 (6): 945-9
78. McLachlan SJ, Morris MR, Lucas MA, et al. Phase I clinical evaluation of a new iron oxide MR contrast agent. J Magn Reson Imaging 1994; 4 (3): 301-7
79. Li W, Tutton S, Vu AT, et al. First-pass contrast-enhanced magnetic resonance angiography in humans using ferumoxytol, a novel ultrasmall superparamagnetic iron oxide (USPIO)-based blood pool agent. J Magn Reson Imaging 2005; 21 (1): 46-52
80. Reimer P, Tombach B. Hepatic MRI with SPIO: detection and characterization of focal liver lesions. Eur Radiol 1998; 8 (7): 1198-204
81. Schulze E, Ferrucci Jr JT, Poss K, et al. Cellular uptake and trafficking of a prototypical magnetic iron oxide label in vitro. Invest Radiol 1995; 30 (10): 604-10
82. Toma A, Otsuji E, Kuriu Y, et al. Monoclonal antibody A7-superparamagnetic iron oxide as contrast agent of MR imaging of rectal carcinoma. Br J Cancer 2005; 93 (1): 131-6
83. Funovics MA, Kapeller B, Hoeller C, et al. MR imaging of the her2/neu and 9.2.27 tumor antigens using immunospecific contrast agents. Magn Reson Imaging 2004; 22 (6): 843-50
84. Tsourkas A, Shinde-Patil VR, Kelly KA, et al. In vivo imaging of activated endothelium using an anti-VCAM-1 magnetooptical probe. Bioconj Chem 2005; 16 (3): 576-81
85. Josephson L, Tung C-H, Moore A, et al. High-efficiency intracellular magnetic labeling with novel superparamagnetic-tat peptide conjugates. Bioconj Chem 1999; 10 (2): 186-91
86. Zhao M, Kircher Moritz F, Josephson L, et al. Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconj Chem 2002; 13 (4): 840-4
87. Sun C, Sze R, Zhang M. Folic acid-PEG conjugated superparamagnetic nanoparticles for targeted cellular uptake and detection by MRI. J Biomed Mater Res A 2006; 78 (3): 550-7
88. Bos C, Delmas Y, Desmouliere A, et al. In vivo MR imaging of intravascularly injected magnetically labeled mesenchymal stem cells in rat kidney and liver. Radiology 2004; 233 (3): 781-9
89. Frank JA, Miller BR, Arbab AS, et al. Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology 2003; 228 (2): 480-7
90. Leuschner C, Kumar CSSR, Hansel W, et al. LHRH-conjugated magnetic iron oxide nanoparticles for detection of breast cancer metastases. Breast Cancer Res Treat 2006; 99 (2): 163-76
91. Rosensweig RE. Heating magnetic fluid with alternating magnetic field. J Magn Magn Mater 2002; 252 (1-3): 370-4
92. Jordan A, Rheinlaender T, Waldoefner N, et al. Increase of the specific absorption rate (SAR) by magnetic fractionation of magnetic fluids. J Nanopart Res 2003; 5 (5-6): 597-600
93. Johannsen M, Gneveckow U, Taymoorian K, et al. Morbidity and quality of life during thermotherapy using magnetic nanoparticles in locally recurrent prostate cancer: results of a prospective phase I trial. Int J Hyperthermia 2007; 23 (3): 315-23
94. 60: buckminsterfullerene. Nature 1985; 318 (6042): 162-3
95. Haddon RC. Carbon nanotubes. Acc Chem Res 2002; 35 (12): 997
96. Dai H. Carbon nanotubes: synthesis, integration, and properties. Acc Chem Res 2002; 35 (12): 1035-44
97. Cognet L, Tsyboulski DA, Rocha J-DR, et al. Stepwise quenching of exciton fluorescence in carbon nanotubes by single-molecule reactions. Science 2007; 316 (5830): 1465-8
98. Cherukuri P, Bachilo SM, Litovsky SH, et al. Near-infrared fluorescence microscopy of single-walled carbon nanotubes in phagocytic cells. J Am Chem Soc 2004; 126 (48): 15638-9
99. Cherukuri P, Gannon CJ, Leeuw TK, et al. Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence. Proc Natl Acad Sci U S A 2006; 103 (50): 18882-6
100. Leeuw TK, Reith RM, Simonette RA, et al. Single-walled carbon nanotubes in the intact organism: near-IR imaging and biocompatibility studies in drosophila. Nano Lett 2007; 7 (9): 2650-4
101. Kam NWS, O'Connell M, Wisdom JA, et al. Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proc Natl Acad Sci U S A 2005; 102 (33): 11600-5
102. Gannon CJ, Cherukuri P, Yakobson BI, et al. Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field. Cancer 2007; 110 (12): 2654-65
103. 60 based MRI contrast enhancing agents [abstract no. 0986]. Proceedings of the Electrochem-istry Society; 2002 Mar 12-17; Philadelphia (PA) [online]. Available from URL: http://www.electrochem.org/dl/ma/201/pdfs/0986.pdf [Accessed 2008 Jan 22]
104. 10 as a MRI contrast agent. J Am Chem Soc 2003; 125 (18): 5471-8
105. 10. J Am Chem Soc 2005; 127 (26): 9368-9
106. Laus S, Sitharaman B, Toth E, et al. Understanding paramagnetic relaxation phenomena for water-soluble gadofullerenes. J Phys Chem C 2007; 111 (15): 5633-9
107. x: nanoscale aggregation studies of two metallofullerene MRI contrast agents in aqueous solution. Nano Lett 2004; 4 (12): 2373-8
108. Toth E, Bolskar RD, Borel A, et al. Water-soluble gadofullerenes: toward high-relaxivity, pH-responsive MRI contrast agents. J Am Chem Soc 2005; 127 (2): 799-805
109. Sitharaman B, Tran LA, Pham QP, et al. Gadofullerenes as nanoscale magnetic labels for cellular MRI. Contrast Media Molec Imag 2007; 2 (3): 139-46
110. Fatouros PP, Corwin FD, Chen Z-J, et al. In vitro and in vivo imaging studies of a new endohedral metallofullerene nanoparticle. Radiology 2006; 240 (3): 756-64
111. Rancan F, Helmreich M, Moelich A, et al. Synthesis and in vitro testing of a pyropheophorbide-a-fullerene hexakis adduct immunoconjugate for photodynamic therapy. Bioconj Chem 2007; 18 (4): 1078-86
112. 60 derivatives with the murine anti-gp240 melanoma antibody. Chem Commun 2006; 28: 3004-6
113. Sitharaman B, Kissell KR, Hartman KB, et al. Superparamagnetic gadonanotubes are high-performance MRI contrast agents. Chem Commun 2005; 31: 3915-7
114. Sitharaman B, Wilson LJ. Gadonanotubes as new high-performance MRI contrast agents. Int J Nanomed 2006; 1 (3): 291-5
115. Hartman KB, Wilson LJ. Carbon nanostructures as a new, high-performance platform for MR molecular imaging. In: Chan WCW, editor. Bio-applications of nanoparticles. Austin (TX): Landes Biosciences, 2007
116. Gu Z, Peng H, Hauge RH, et al. Cutting single-wall carbon nanotubes through fluorination. Nano Lett. 2002; 2 (9): 1009-13
117. Hartman KB, Laus S, Bolskar RD, et al. Gadonanotubes as ultrasensitive pH-smart probes for magnetic resonance imaging. Nano Lett. Epub 2008 Jan 24
118. Baselga J. The EGFR as a target for anticancer therapy-focus on cetuximab. Eur J Cancer 2001; 37 Suppl. 4: S16-22
119. Crombet T, Torres O, Rodriguez V, et al. Phase I clinical evaluation of a neutralizing monoclonal antibody against epidermal growth factor receptor in advanced brain tumor patients: preliminary study. Hybridoma 2001; 20 (2): 131-6
120. Labianca R, La Verde N, Garassino MC. Development and clinical indications of cetuximab. Int J Biol Markers 2007; 22 (1 Suppl. 4): S40-6
121. Morgillo F, Bareschino MA, Bianco R, et al. Primary and acquired resistance to anti-EGFR targeted drugs in cancer therapy. Differentiation 2007 Nov; 75 (9): 788-99
122. Yang XD, Jia XC, Corvalan JR, et al. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit Rev Oncol Hematol 2001; 38 (1): 17-23
123. Hudis CA. Trastuzumab: mechanism of action and use in clinical practice. N Engl J Med 2007; 357 (1): 39-51
124. Meric-Bernstam F, Hung M-C. Advances in targeting human epidermal growth factor receptor-2 signaling for cancer therapy. Clin Cancer Res 2006; 12 (21): 6326-30
125. Moasser MM. Targeting the function of the HER2 oncogene in human cancer therapeutics. Oncogene 2007 Oct 11; 26 (46): 6577-92
126. Simonds HM, Miles D. Adjuvant treatment of breast cancer: impact of monoclonal antibody therapy directed against the HER2 receptor. Expert Opin Biol Ther 2007; 7 (4): 487-91
127. Inwards DJ, Cilley JC, Winter JN. Radioimmunotherapeutic strategies in autologous hematopoietic stem-cell transplantation for malignant lymphoma. Best Pract Res Clin Haematol 2006; 19 (4): 669-84
128. Liebenguth P, Vogt Temple S. Radioimmunotherapy for non-Hodgkin's lymphoma. Semin Oncol Nurs 2006; 22 (4): 257-66
129. Schaefer-Cutillo J, Friedberg JW, Fisher RI. Novel concepts in radioimmunotherapy for non-Hodgkin's lymphoma. Oncology 2007; 21 (2): 203-12; discussion 214, 217, 221
130. Witzig TE. Radioimmunotherapy for B-cell non-Hodgkin lymphoma. Best Pract Res Clin Haematol 2006; 19 (4): 655-68
131. Fenton C, Perry CM. Gemtuzumab ozogamicin: a review of its use in acute myeloid leukaemia. Drugs 2005; 65 (16): 2405-27
132. Maslak PG, Jurcic JG, Scheinberg DA. Monoclonal antibody therapy of APL. Curr Top Microbiol Immun 2007; 313: 205-19
133. O'Brien S, Albitar M, Giles FJ. Monoclonal antibodies in the treatment of leukemia. Curr Molec Med 2005; 5 (7): 663-75
134. O'Mahony D, Bishop MR. Monoclonal antibody therapy. Front Biosci 2006; 11 (2): 1620-35
135. Pagano L, Fianchi L, Caira M, et al. The role of gemtuzumab ozogamicin in the treatment of acute myeloid leukemia patients. Oncogene 2007; 26 (25): 3679-90
136. Tallman MS. New strategies for the treatment of acute myeloid leukemia including antibodies and other novel agents. Hematology Am Soc Hematol Educ Program 2005: 143-50
137. Tsimberidou A-M, Giles FJ, Estey E, et al. The role of gemtuzumab ozogamicin in acute leukaemia therapy. Br J Haematol 2006; 132 (4): 398-409
138. Wu AM, Senter PD. Arming antibodies: prospects and challenges for immunoconjugates. Nat Biotechnol 2005; 23 (9): 1137-46
139. McDevitt MR, Chattopadhyay D, Kappel BJ, et al. Tumor targeting with antibody functionalized, radiolabeled carbon nanotubes. J Nucl Med 2007; 48 (7): 1180-9
140. Mackeyev YA, Marks JW, Rosenblum MG, et al. Stable containment of radionuclides on the nanoscale by cut single-wall carbon nanotubes. J Phys Chem B 2005; 109 (12): 5482-4
141. 211AtCl@US-tube nanocapsules: a new concept in radiotherapeutic-agent design. Small 2007; 3 (9): 1496-9
142. Liu Z, Winters M, Holodniy M, et al. siRNA delivery into human T cells and primary cells with carbon-nanotube transporters. Angewandte Chem Int Ed 2007; 46 (12): 2023-7
143. Jiang H, Zhang T, Sun X. Vascular endothelial growth factor gene delivery by magnetic DNA nanospheres ameliorates limb ischemia in rabbits. J Surg Res 2005; 126 (1): 48-54
144. Dobson J. Gene therapy progress and prospects: magnetic nanoparticle-based gene delivery. Gene Ther 2006; 13 (4): 283-7
145. Everts M, Saini V, Leddon JL, et al. Covalently linked Au nanoparticles to a viral vector: potential for combined photothermal and gene cancer therapy. Nano Lett 2006; 6 (4): 587-91
146. Morishita N, Nakagami H, Morishita R, et al. Magnetic nanoparticles with surface modification enhanced gene delivery of HVJ-E vector. Biochem Biophys Res Commun 2005; 334 (4): 1121-6
147. Portney NG, Ozkan M. Nano-oncology: drug delivery, imaging, and sensing. Anal Bioanal Chem 2006; 384 (3): 620-30
148. Park JH, Kwon S, Nam J-O, et al. Self-assembled nanoparticles based on glycol chitosan bearing 5b-cholanic acid for RGD peptide delivery. J Control Release 2004; 95 (3): 579-88
149. Chalasani KB, Russell-Jones GJ, Yandrapu SK, et al. A novel vitamin B12-nanosphere conjugate carrier system for peroral delivery of insulin. J Control Release 2007; 117 (3): 421-9
150. Cherian AK, Rana AC, Jain SK. Self-assembled carbohydrate-stabilized ceramic nanoparticles for the parenteral delivery of insulin. Drug Dev Ind Pharm 2000; 26 (4): 459-63
151. Cui F-D, Tao A-J, Cun D-M, et al. Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery. J Pharm Sci 2007; 96 (2): 421-7
152. Fernandez-Urrusuno R, Calvo P, Remunan-Lopez C, et al. Enhancement of nasal absorption of insulin using chitosan nanoparticles. Pharm Res 1999; 16 (10): 1576-81
153. Gupta AK, Berry C, Gupta M, et al. Receptor-mediated targeting of magnetic nanoparticles using insulin as a surface ligand to prevent endocytosis. IEEE Trans Nanobiosci 2003; 2 (4): 255-61
154. Leobandung W, Ichikawa H, Fukumori Y, et al. Preparation of stable insulin-loaded nanospheres of poly(ethylene glycol) macromers and N-isopropyl acrylamide. J Control Release 2002; 80 (1-3): 357-63
155. Ma Z, Lim TM, Lim L-Y. Pharmacological activity of peroral chitosan-insulin nanoparticles in diabetic rats. Int J Pharm 2005; 293 (1-2): 271-80
156. Ma Z, Yeoh HH, Lim L-Y. Formulation pH modulates the interaction of insulin with chitosan nanoparticles. J Pharm Sci 2002; 91 (6): 1396-404
157. Mesiha MS, Sidhom MB, Fasipe B. Oral and subcutaneous absorption of insulin poly(isobutylcyanoacrylate) nanoparticles. Int J Pharm 2005; 288 (2): 289-93
158. Pan Y, Li Y-J, Zhao H-Y, et al. Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm 2002; 249 (1-2): 139-47
159. Reis CP, Ribeiro AJ, Houng S, et al. Nanoparticulate delivery system for insulin: design, characterization and in vitro/in vivo bioactivity. Eur J Pharm Sci 2007; 30 (5): 392-7
160. Sajeesh S, Sharma CP. Cyclodextrin-insulin complex encapsulated polymethacrylic acid based nanoparticles for oral insulin delivery. Int J Pharm 2006; 325 (1-2): 147-54
161. Zhang Q, Shen Z, Nagai T. Prolonged hypoglycemic effect of insulin-loaded polybutylcyanoacrylate nanoparticles after pulmonary administration to normal rats. Int J Pharm 2001; 218 (1-2): 75-80
162. Pan Y-L, Cai J-Y, Qin L, et al. Atomic force microscopy-based cell nanostructure for ligand-conjugated quantum dot endocytosis. Acta Biochim Biophys Sin 2006; 38 (9): 646-52
163. Alexiou C, Jurgons R, Seliger C, et al. Delivery of superparamagnetic nanoparticles for local chemotherapy after intraarterial infusion and magnetic drug targeting. Anticancer Res 2007; 27 (4A): 2019-22
164. Fahmy TM, Fong PM, Park J, et al. Nanosystems for simultaneous imaging and drug delivery to T cells. AAPS J 2007; 9 (2): E171-80
165. Gan ZF, Jiang JS, Yang Y, et al. Immobilization of homing peptide on magnetite nanoparticles and its specificity in vitro. J Biomed Mater Res A 2008 Jan; 84 (1): 10-8
166. Gupta AK, Naregalkar RR, Vaidya VD, et al. Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications. Nanomed 2007; 2 (1): 23-39
167. McCarthy JR, Kelly KA, Sun EY, et al. Targeted delivery of multifunctional magnetic nanoparticles. Nanomed 2007; 2 (2): 153-67
168. Reddy GR, Bhojani MS, McConville P, et al. Vascular targeted nanoparticles for imaging and treatment of brain tumors. Clin Cancer Res 2006; 12 (22): 6677-86
169. Serda RE, Adolphi NL, Bisoffi M, et al. Targeting and cellular trafficking of magnetic nanoparticles for prostate cancer imaging. Mol Imaging 2007; 6 (4): 277-88
170. Wang J-M, Xiao B-L, Zheng J-W, et al. Effect of targeted magnetic nanoparticles containing 5-FU on expression of bcl-2, bax and caspase 3 in nude mice with transplanted human liver cancer. World J Gastroenterol 2007; 13 (23): 3171-5
171. Zhang J, Misra RD. Magnetic drug-targeting carrier encapsulated with thermosensitive smart polymer: core-shell nanoparticle carrier and drug release response. Acta Biomater 2007; 3 (6): 838-50
172. Xie H-Y, Zuo C, Liu Y, et al. Cell-targeting multifunctional nanospheres with both fluorescence and magnetism. Small 2005; 1 (5): 506-9