Gadofullerenes as nanoscale magnetic labels for cellular MRI

Contrast Media and Molecular Imaging

Volumn 2, Issue 3, 2007, Pages 139-146

  Sitharaman, Balaji ^a,b,c   Tran, Lesa A ^a   Pham, Quynh P ^b   Bolskar, Robert D ^d   Muthupillai, Raja ^e,f,g   Flamm, Scott D ^f,g   Mikos, Antonios G ^b,c   Wilson, Lon J ^a,c  

^a RICE UNIVERSITY   (United States)

^b Rice University   (United States)

^c RICE UNIVERSITY   (United States)

^d TDA RESEARCH INC   (United States)

^e PHILIPS HEALTHCARE   (United States)

^f ST LUKE S EPISCOPAL HOSPITAL   (United States)

^g BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cellular MRI; Gadofullerenes; Magnetic label

Indexed keywords

ANION; CONTRAST MEDIUM; DIAGNOSTIC AGENT; GADOFULLERENE; GADOFULLERENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LABELING; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; DRUG UPTAKE; EX VIVO STUDY; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; MAMMAL CELL; MOUSE; NANOIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; THROMBOCYTE;

ANIMALS; ANIONS; CELL SURVIVAL; CONTRAST MEDIA; CRYOELECTRON MICROSCOPY; FULLERENES; GADOLINIUM DTPA; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETICS; MICE; MOLECULAR CONFORMATION; NANOPARTICLES; NIH 3T3 CELLS; TOMOGRAPHY;

EID: 34547500345     PISSN: 15554309     EISSN: 15554317     Source Type: Journal    
DOI: 10.1002/cmmi.140     Document Type: Article

References (24)

1. Wickline SA, Lanza GM. Molecular imaging, targeted therapeutics, and nanoscience. J. Cell Biochem. 2002; 39: 90-97.
2. Heath JR, Phelps ME, Hood L. Nanosystems biology. Mol. Imag. Biol. 2003; 5: 312-325.
3. Caravan P, Elllison JJ, McMurry TJ, Lanffer RB. Gadolinium(III) chelates as MRI contrast agents: structure, dynamics, and applications. Chem. Rev. 1999; 99: 2293-2352.
4. Brücher E. Kinetic stabilities of gadolinium(III) chelates used as MRI contrast agents in contrast agents I. Magn. Reson. Imag. 2002; 221: 103.
5. 10 as a MRI contrast agent. J. Am. Chem. Soc. 2003; 125(18): 5471-5478.
6. Kato H, Kanazawa Y, Okumura M, Taninaka A, Yokawa T, Shinohara H. Lanthanoid endohedral metallofullerenols for MRI contrast agents. J. Am. Chem. Soc. 2003; 125(14): 4391-4397.
7. Fatouros PP, Frank FD, Chen Z, Broaddus WC, Tatum JL, Kettenmann B, Ge Z, Gibson HW, Russ JL, Leonard AP, Duchamp JC, Dora HC. In vitro and in vivo imaging studies of a new endohedral metallofullerene nanoparticle radiology. Radiology 2006; 240: 756-764.
8. Toth E, Bolskar RD, Borel A, Gonzalez G, Helm LM, Merbach AE, Sitharaman B, Wilson LJ. Water-soluble gadofullerenes: toward high-relaxivity, pH-responsive MRI contrast agents. J. Am. Chem. Soc. 2005; 127(2): 799-805.
9. Datta N, Holtorf HL, Sikavitsas VI, Jansen JA, Mikos AG. Effect of bone extracellular matrix synthesized in vitro on the osteoblastic differentiation of marrow stromal cells. Biomaterials 2005; 26: 971-977.
10. Wiley HS, Herbst JJ, Walsh B J, Lauffenburger DA, Rosenfeld MG, Gill GN. The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor. J. Biol. Chem. 1991; 266: 11083-11094.
11. Ludtke SJ, Chiu W. Focal pair merging for contrast enhancement of single particles. J. Struct. Biol. 2003; 144: 73-78.
12. Look DC, Locker DR. Nuclear spin-lattice relaxation measurements by tone-burst modulation. Phys. Rev. Lett. 1968; 20: 987-989.
13. Dugan LL, Turetsky DM, Du C, Lobner D, Wheeler M, Almli CR, Shen C, Luh T, Choi D, Lin T. Carboxyfullerenes as neuroprotective antioxidants. Proc. Natl Acad. Sci. USA 1997; 94: 9434-9439.
14. Porter AE, Muller K, Skepper J, Midgley P, Welland M. Uptake of C60 by human monocyte macrophages, its localization and implications for toxicity: studied by high resolution electron microscopy and electron tomography. Acta Biomaterialia 2006; 2: 409-419.
15. Beveridge TJ, Popkin TJ, Cole RM. Electron microscopy. In Methods for General Molecular Bacteriology, Gerhardt P, Murray RGE, Wood WA, Krieg NR (eds). American Society for Microbiology: Washington, DC, 1994; 42-71.
16. McIntosh JR. Electron microscopy of cells: a new beginning for a new century. J. Cell Biol. 2001; 153: F25-F32.
17. McIntosh JR, Daniela Nicastro D, Mastronarde D. New views of cells in 3D:an introduction to electron tomography. Trends Cell Biol. 2005; 15(1): 43-51.
18. Anderson SA, Lee KK, Frank JA. Gadolinium-fullerenol as a paramagnetic contrast agent for cellular imaging. Invest. Radiol. 2006; 41: 332-338.
19. Daldrup-Link HE, Rudelius M, Metz S, Piontek G, Pichler B, Settles M, Heinzmann U, Schlegel J, Oostendorp RAJ, Rummeny EJ. Cell tracking with gadophrin-2: a bifunctional contrast agent for MR imaging, optical imaging, and fluorescence microscopy. Eur. J. Nucl. Med. Mol. Imag. 2004; 31: 1312-1321.
20. Allen MJ, MacRenads KW, Venkatasubramanian PN, Meade TJ. Cellular delivery of MRI contrast agents. Chem. Biol. 2004; 11: 301-307.
21. Josephson L, Tung CH, Moore A, Weissleder R. High-effciency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjug. Chem. 1999; 32: 889-899.
22. Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R: Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat. Biotechnol. 2000; 18: 410-414.
23. Bulte JW, Douglas T, Witwer B, Zhang SC, Strable E, Lewis BK, Zywicke H, Miller B, van Gelderen P, Moskowitz BM, Duncan ID, Frank JA. Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem ceils. Nat. Biotechnol. 2001; 19: 1141-1147.
24. Wilhem C, Billotey C, Roger J, Pons JN, Bacri JC, Gazeau F. Intracellular uptake of anionic superparamagnetic nanoparticles as a function of their surface coating. Biomaterials 2003; 24: 1001-1011.