Effects of Nitric Oxide on Red Blood Cell Development and Phenotype

Current Topics in Developmental Biology

Volumn 82, Issue , 2008, Pages 169-215

  Čokić, Vladan P ^a   Schechter, Alan N ^b  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; NITRIC OXIDE;

ANIMAL; CYTOLOGY; ERYTHROCYTE; ERYTHROPOIESIS; GENETICS; HUMAN; MALARIA; METABOLISM; PHENOTYPE; REVIEW;

ANIMALS; ERYTHROCYTES; ERYTHROPOIESIS; HEMOGLOBINS; HUMANS; MALARIA; NITRIC OXIDE; PHENOTYPE;

EID: 39049099076     PISSN: 00702153     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0070-2153(07)00007-5     Document Type: Review

References (258)

1. Aaronson P.I., McKinnon W., and Poston L. Mechanism of butyrate-induced vasorelaxation of rat mesenteric resistance artery. Br. J. Pharmacol. 117 (1996) 365-371
2. Abboud C.N., Duerst R.E., Frantz C.N., Ryan D.H., Liesveld J.L., and Brennan J.K. Lysis of human fibroblast colony-forming cells and endothelial cells by monoclonal antibody (6-19) and complement. Blood 68 (1986) 1196-1200
3. Abramson S., Miller R.G., and Phillips R.A. The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems. J. Exp. Med. 145 (1977) 1567-1579
4. Aicher A., Heeschen C., Mildner-Rihm C., Urbich C., Ihling C., Technau-Ihling K., Zeiher A.M., and Dimmeler S. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat. Med. 9 (2003) 1370-1376
5. Albina J.E., Cui S., Mateo R.B., and Reichner J.S. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J. Immunol. 150 (1993) 5080-5085
6. Allison A.C. Protection afforded by sickle-cell trait against subtertian malarial infection. Br. Med. J. 1 (1954) 290-294
7. Ambs S., Bennett W.P., Merriam W.G., Ogunfusika M.O., Oser S.M., Khan M.A., Jones R.T., and Harris C.C. Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53. Br. J. Cancer 78 (1998) 233-239
8. Ambs S., Merriam W.G., Bennett W.P., Felley-Bosco E., Ogunfusika M.O., Oser S.M., Klein S., Shields P.G., Billiar T.R., and Harris C.C. Frequent nitric oxide synthase-2 expression in human colon adenomas: Implication for tumor angiogenesis and colon cancer progression. Cancer Res. 58 (1998) 334-341
9. Anstey N.M., Weinberg J.B., Hassanali M.Y., Mwaikambo E.D., Manyenga D., Misukonis M.A., Arnelle D.R., Hollis D., McDonald M.I., and Granger D.L. Nitric oxide in Tanzanian children with malaria: Inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J. Exp. Med. 184 (1996) 557-567
10. Asano K., Chee C.B., Gaston B., Lilly C.M., Gerard C., Drazen J.M., and Stamler J.S. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc. Natl. Acad. Sci. USA 91 (1994) 10089-10093
11. Assefa Z., Vantieghem A., Garmyn M., Declercq W., Vandenabeele P., Vandenheede J.R., Bouillon R., Merlevede W., and Agostinis P. p38 mitogen-activated protein kinase regulates a novel, caspase-independent pathway for the mitochondrial cytochrome c release in ultraviolet B radiation induced apoptosis. J. Biol. Chem. 275 (2000) 21416-21421
12. Bae S.W., Kim H.S., Cha Y.N., Park Y.S., Jo S.A., and Jo I. Rapid increase in endothelial nitric oxide production by bradykinin is mediated by protein kinase A signaling pathway. Biochem. Biophys. Res. Commun. 306 (2003) 981-987
13. Ballas S.K., Marcolina M.J., Dover G.J., and Barton F.B. Erythropoietic activity in patients with sickle cell anaemia before and after treatment with hydroxyurea. Br. J. Haematol. 105 (1999) 491-496
14. Barreiro Arcos M.L., Gorelik G., Klecha A., Goren N., Cerquetti C., and Cremaschi G.A. Inducible nitric oxide synthase-mediated proliferation of a Tl ymphoma cell line. Nitric Oxide 8 (2003) 111-118
15. Beauvais F., Michel L., and Dubertret L. The nitric oxide donors, azide and hydroxylamine, inhibit the programmed cell death of cytokine-deprived human eosinophils. FEBS Lett. 361 (1995) 229-232
16. Beleslin-Cokic B.B., Cokic V.P., Yu X., Weksler B.B., Schechter A.N., and Noguchi C.T. Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells. Blood 104 (2004) 2073-2080
17. Bender A.T., Demady D.R., and Osawa Y. Ubiquitination of neuronal nitric-oxide synthase in vitro and in vivo. J. Biol. Chem. 275 (2000) 17407-17411
18. Blaise G.A., Gauvin D., Gangal M., and Authier S. Nitric oxide, cell signaling and cell death. Toxicology 208 (2005) 177-192
19. Bonfoco E., Krainc D., Ankarcrona M., Nicotera P., and Lipton S.A. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. USA 92 (1995) 7162-7166
20. Boo Y.C., Sorescu G., Boyd N., Shiojima I., Walsh K., Du J., and Jo H. Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: Role of protein kinase A. J. Biol. Chem. 277 (2002) 3388-3396
21. Bor-Kucukatay M., Wenby R.B., Meiselman H.J., and Baskurt O.K. Effects of nitric oxide on red blood cell deformability. Am. J. Physiol. Heart Circ. Physiol. 284 (2003) H1577-H1584
22. Borst P., and Rottenberg S. Cancer cell death by programmed necrosis?. Drug Resist. Update 7 (2004) 321-324
23. Brandish P.E., Buechler W., and Marletta M.A. Regeneration of the ferrous heme of soluble guanylate cyclase from the nitric oxide complex: Acceleration by thiols and oxyhemoglobin. Biochemistry 37 (1998) 16898-16907
24. Bredt D.S., and Snyder S.H. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc. Natl. Acad. Sci. USA 87 (1990) 682-685
25. Brenman J.E., Chao D.S., Gee S.H., McGee A.W., Craven S.E., Santillano D.R., Wu Z., Huang F., Xia H., Peters M.F., Froehner S.C., and Bredt D.S. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell 84 (1996) 757-767
26. Brooks J. The action of nitrite on haemoglobin in the absence of oxygen. Proc. R. Soc. Lond. B Biol. Sci. 123 (1937) 368-382
27. Brown G.C., and Borutaite V. Nitric oxide, cytochrome c and mitochondria. Biochem. Soc. Symp. 66 (1999) 17-25
28. Browning D.D., Windes N.D., and Ye R.D. Activation of p38 mitogen-activated protein kinase by lipopolysaccharide in human neutrophils requires nitric oxide-dependent cGMP accumulation. J. Biol. Chem. 274 (1999) 537-542
29. Browning D.D., McShane M.P., Marty C., and Ye R.D. Nitric oxide activation of p38 mitogen-activated protein kinase in 293T fibroblasts requires cGMP-dependent protein kinase. J. Biol. Chem. 275 (2000) 2811-2816
30. Budworth J., Meillerais S., Charles I., and Powell K. Tissue distribution of the human soluble guanylate cyclases. Biochem. Biophys. Res. Commun. 263 (1999) 696-701
31. Bussolino F., Wang J.M., Defilippi P., Turrini F., Sanavio F., Edgell C.J., Aglietta M., Arese P., and Mantovani A. Granulocyte- and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate. Nature 337 (1989) 471-473
32. Bussolino F., Ziche M., Wang J.M., Alessi D., Morbidelli L., Cremona O., Bosia A., Marchisio P.C., and Mantovani A. In vitro and in vivo activation of endothelial cells by colony-stimulating factors. J. Clin. Invest. 87 (1991) 986-995
33. Calatayud S., Beltran B., Brines J., Moncada S., and Esplugues J.V. Foetal erythrocytes exhibit an increased ability to scavenge for nitric oxide. Eur. J. Pharmacol. 347 (1998) 363-366
34. Cassoly R., and Gibson Q. Conformation, co-operativity and ligand binding in human hemoglobin. J. Mol. Biol. 91 (1975) 301-313
35. Chalupsky K., Lobysheva I., Nepveu F., Gadea I., Beranova P., Entlicher G., Stoclet J.C., and Muller B. Relaxant effect of oxime derivatives in isolated rat aorta: Role of nitric oxide (NO) formation in smooth muscle. Biochem. Pharmacol. 67 (2004) 1203-1214
36. Chan Y., Fish J.E., D'Abreo C., Lin S., Robb G.B., Teichert A.M., Karantzoulis-Fegaras F., Keightley A., Steer B.M., and Marsden P.A. The cell-specific expression of endothelial nitric-oxide synthase: A role for DNA methylation. J. Biol. Chem. 279 (2004) 35087-35100
37. Charache S., Dover G.J., Moyer M.A., and Moore J.W. Hydroxyurea-induced augmentation of fetal hemoglobin production in patients with sickle cell anemia. Blood 69 (1987) 109-116
38. Charles I.G., Palmer R.M., Hickery M.S., Bayliss M.T., Chubb A.P., Hall V.S., Moss D.W., and Moncada S. Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc. Natl. Acad. Sci. USA 90 (1993) 11419-11423
39. Chartrain N.A., Geller D.A., Koty P.P., Sitrin N.F., Nussler A.K., Hoffman E.P., Billiar T.R., Hutchinson N.I., and Mudgett J.S. Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene. J. Biol. Chem. 269 (1994) 6765-6772
40. Chen L.Y., and Mehta J.L. Evidence for the presence of l-arginine-nitric oxide pathway in human red blood cells: Relevance in the effects of red blood cells on platelet function. J. Cardiovasc. Pharmacol. 32 (1998) 57-61
41. Chenais B., Molle I., and Jeannesson P. Inhibitory effect of nitric oxide on chemically induced differentiation of human leukemic K562 cells. Biochem. Pharmacol. 58 (1999) 773-778
42. Chiwakata C.B., Hemmer C.J., and Dietrich M. High levels of inducible nitric oxide synthase mRNA are associated with increased monocyte counts in blood and have a beneficial role in Plasmodium falciparum malaria. Infect. Immun. 68 (2000) 394-399
43. Chrisman T.D., Garbers D.L., Parks M.A., and Hardman J.G. Characterization of particulate and soluble guanylate cyclases from rat lung. J. Biol. Chem. 250 (1975) 374-381
44. Chun S.Y., Eisenhauer K.M., Kubo M., and Hsueh A.J. Interleukin-1 beta suppresses apoptosis in rat ovarian follicles by increasing nitric oxide production. Endocrinology 136 (1995) 3120-3127
45. Clark I.A., and Cowden W.B. The pathophysiology of falciparum malaria. Pharmacol.Ther. 99 (2003) 221-260
46. Cobb R.R., Felts K.A., Parry G.C., and Mackman N. Proteasome inhibitors block VCAM-1 and ICAM-1 gene expression in endothelial cells without affecting nuclear translocation of nuclear factor-kappa B. Eur. J. Immunol. 26 (1996) 839-845
47. Cobbs C.S., Brenman J.E., Aldape K.D., Bredt D.S., and Israel M.A. Expression of nitric oxide synthase in human central nervous system tumors. Cancer Res. 55 (1995) 727-730
48. Cokic V.P., Smith R.D., Beleslin-Cokic B.B., Njoroge J.M., Miller J.L., Gladwin M.T., and Schechter A.N. Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase. J. Clin. Invest. 111 (2003) 231-239
49. Cokic V.P., Beleslin-Cokic B.B., Tomic M., Stojilkovic S.S., Noguchi C.T., and Schechter A.N. Hydroxyurea induces the eNOS-cGMP pathway in endothelial cells. Blood 108 (2006) 184-191
50. Cokic V.P., Andric S.A., Stojilkovic S.S., Noguchi C.T., and Schechter A.N. Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells (2007) Blood. Prepublished Novembar 9; DOI 10.1182/blood-2007-05-088732
51. Cokic V.P., Beleslin-Cokic B.B., Noguchi C.T., and Schechter A.N. Hydroxyurea increases eNOS protein levels through inhibition of proteasome activity. Nitric Oxide 16 (2007) 371-378
52. Conran N., Oresco-Santos C., Acosta H.C., Fattori A., Saad S.T., and Costa F.F. Increased soluble guanylate cyclase activity in the red blood cells of sickle cell patients. Br. J. Haematol. 124 (2004) 547-554
53. Constantinescu J.N., Keren T., Socolovsky M., Nam H., Henis Y.I., and Lodish H.F. Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain. Proc. Natl. Acad. Sci. USA 98 (2001) 4379-4384
54. Contestabile A., and Ciani E. Role of nitric oxide in the regulation of neuronal proliferation, survival and differentiation. Neurochem. Int. 45 (2004) 903-914
55. Cosby K., Partovi K.S., Crawford J.H., Patel R.P., Reiter C.D., Martyr S., Yang B.K., Waclawiw M.A., Zalos G., Xu X., Huang K.T., Shields H., et al. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat. Med. 9 (2003) 1498-1505
56. Cui S., Reichner J.S., Mateo R.B., and Albina J.E. Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms. Cancer Res. 54 (1994) 2462-2467
57. De Caterina R., Libby P., Peng H.B., Thannickal V.J., Rajavashisth Jr. T.B., Gimbrone M.A., Shin W.S., and Liao J.K. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J. Clin. Invest. 96 (1995) 60-68
58. Dejam A., Hunter C.J., Pelletier M.M., Hsu L.L., Machado R.F., Shiva S., Power G.G., Kelm M., Gladwin M.T., and Schechter A.N. Erythrocytes are the major intravascular storage sites of nitrite in human blood. Blood 106 (2005) 734-739
59. Dexter T.M., Spooncer E., Schofield R., Lord B.I., and Simmons P. Haemopoietic stem cells and the problem of self-renewal. Blood Cells 10 (1984) 315-339
60. Dimmelder S., Haendeler J., Nehls M., and Zeiher A.M. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. J. Exp. Med. 185 (1997) 601-607
61. Dimmeler S., Fleming I., Fisslthaler B., Hermann C., Busse R., and Zeiher A.M. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399 (1999) 601-605
62. Doyle M.P., Pickering R.A., Deweert T.M., Hoekstra J.W., and Pater D. Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites. J. Biol. Chem. 256 (1981) 2393-2398
63. Duranski M.R., Greer J.J.M., Dejam A., Jaganmohan S., Hogg N., Langston W., Patel R.P., Yet S.F., Wang X.D., Kevil C.G., Gladwin M.T., and Lefer D.J. Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J. Clin. Invest. 115 (2005) 1232-1240
64. Eckardt K.U., Pugh C.W., Meier M., Tan C.C., Ratcliffe P.J., and Kurtz A. Production of erythropoietin by liver cells in vivo and in vitro. Ann. N. Y. Acad. Sci. 718 (1994) 50-60
65. Eich R.F., Li T., Lemon D.D., Doherty D.H., Curry S.R., Aitken J.F., Mathews A.J., Johnson K.A., Smith R.D., Phillips G.N., and Olson J.S. Mechanism of NO-induced oxidation of myoglobin and hemoglobin. Biochemistry 35 (1996) 6976-6983
66. Estevez A.G., Spear N., Thompson J.A., Cornwell T.L., Radi R., Barbeito L., and Beckman J.S. Nitric oxide dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor. J. Neurosci. 18 (1998) 3708-3714
67. Fehsel K., Kroncke K.D., Meyer K.L., Huber H., Wahn V., and Kolb-Bachofen V. Nitric oxide induces apoptosis in mouse thymocytes. J. Immunol. 155 (1995) 2858-2865
68. Ferro A., Queen L.R., Priest R.M., Xu B., Ritter J.M., Poston L., and Ward J.P. Activation of nitric oxide synthase by beta 2-adrenoceptors in human umbilical vein endothelium in vitro. Br. J. Pharmacol. 126 (1999) 1872-1880
69. Fisher J.W., Koury S., Ducey T., and Mendel S. Erythropoietin (Epo) production by interstitial cells of hypoxic monkey kidneys. Br. J. Haematol. 95 (1996) 27-32
70. Fischer K.D., Haese A., and Nowock J. Cooperation of GATA-1 and Sp1 can result in synergistic transcriptional activation or interference. J. Biol. Chem. 268 (1993) 23915-23923
71. Forstermann U., Pollock J.S., Schmidt H.H., Heller M., and Murad F. Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. Proc. Natl. Acad. Sci. USA 88 (1991) 1788-1792
72. Furchgott R.F., and Zawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288 (1980) 373-376
73. Furuyama T., Inagaki S., and Takagi H. Localizations of α1 and β1 subunits of soluble guanylate cyclase in the rat brain. Brain Res. Mol. Brain Res. 20 (1993) 335-344
74. Galbiati F., Volonte D., Gil O., Zanazzi G., Salzer J.L., Sargiacomos M., Scherer P.E., Engelman J.A., Schlegel A., Parenti M., Okamoto T., and Lisanti M.P. Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: Caveolin-2 is up-regulated in response to cell injury. Proc. Natl. Acad. Sci. USA 95 (1998) 10257-10262
75. Garcia-Gardena G., Fan R., Stern D.F., Liu J., and Sessa W.C. Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. J. Biol. Chem. 271 (1996) 27237-27240
76. Garthwaite J., Charles S.L., and Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 336 (1988) 385-388
77. Geller D.A., Lowenstein C.J., Shapiro R.A., Nussler A.K., Di Silvio M., Wang S.C., Nakayama D.K., Simmons R.L., Snyder S.H., and Billiar T.R. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc. Natl. Acad. Sci. USA 90 (1993) 3491-3495
78. Genaro A.M., Hortelano S., Alvarez A., Martinez C., and Bosca L. Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels. J. Clin. Invest. 95 (1995) 1884-1890
79. Geng Y.J., Hellstrand K., Wennmalm A., and Hansson G.K. Apoptotic death of human leukemic cells induced by vascular cells expressing nitric oxide synthase in response to gamma-interferon and tumor necrosis factor-alpha. Cancer Res. 56 (1996) 866-874
80. Gerzer R., Böhme E., Hofmann F., and Schultz G. Soluble guanylate cyclase purified from bovine lung contains heme and copper. FEBS Lett. 132 (1981) 71-74
81. Gibb B.J., and Garthwaite J. Subunits of the nitric oxide receptor, soluble guanylyl cyclase, expressed in rat brain. Eur. J. Neurosci. 13 (2001) 539-544
82. Giulivi C. Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolism. Biochem. J. 332 (1998) 673-679
83. Gladwin M.T., Schechter A.N., Shelhamer J.H., Pannell L.K., Conway D.A., Hrinczenko B.W., Nichols J.S., Pease-Fye M.E., Noguchi C.T., Rodgers G.P., and Ognibene F.P. Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity. J. Clin. Invest. 104 (1999) 937-945
84. Gladwin M.T., Ognibene F.P., Pannell L.K., Nichols J.S., Pease-Fye M.E., Shelhamer J.H., and Schechter A.N. Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation. Proc. Natl. Acad. Sci. USA 97 (2000) 9943-9948
85. Gladwin M.T., Shelhamer J.H., Schechter A.N., Pease-Fye M.E., Waclawiw M.A., Panza J.A., Ognibene F.P., and Cannon R.O. Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans. Proc. Natl. Acad. Sci. USA 97 (2000) 11482-11487
86. Gladwin M.T., Wang X.D., Reiter C.D., Yang B.K., Vivas E.X., Bonaventura C., and Schechter A.N. S-nitrosohemoglobin is unstable in the reductive erythrocyte environment and lacks O-2/NO-linked allosteric function. J. Biol. Chem. 277 (2002) 27818-27828
87. Glockzin S., von Knethen A., Scheffner M., and Brune B. Activation of the cell death program by nitric oxide involves inhibition of the proteasome. J. Biol. Chem. 274 (1999) 19581-19586
88. Gordon M.Y., Kearney L., and Hibbin J.A. Effects of human marrow stromal cells on proliferation by human granulocytic (GM-CFC), erythroid (BFU-E) and mixed (Mix-CFC) colony-forming cells. Br. J. Haematol. 53 (1983) 317-325
89. Govers R., van der Sluijs P., van Donselaar E., Slot J.W., and Rabelink T.J. Endothelial nitric oxide synthase and its negative regulator caveolin-1 localize to distinct perinuclear organelles. J. Histochem. Cytochem. 50 (2002) 779-788
90. Gow A.J., and Stamler J.S. Reactions between nitric oxide and haemoglobin under physiological conditions. Nature 391 (1998) 169-173
91. Gregory C.J., and Eaves A.C. Human marrow cells capable of erythropoietic differentiation in vitro: Definition of three erythroid colony responses. Blood 49 (1974) 855-864
92. Grubina R., Huang Z., Shiva S., Joshi M.S., Azarov I., Basu S., Ringwood L.A., Jiang A., Hogg N., Kim-Shapiro D.B., and Gladwin M.T. Concerted nitric oxide formation and release from the simultaneous reactions of nitrite with deoxy- and oxyhemoglobin. J. Biol. Chem. 282 (2007) 12916-12927
93. Haby C., Lisovoski F., Aunis D., and Zwiller J. Stimulation of the cyclic GMP pathway by NO induces expression of the immediate early genes c-fos and junB in PC12 cells. J. Neurochem. 62 (1994) 496-501
94. Hajri A., Metzger E., Vallat F., Coffy S., Flatter E., Evrard S., Marescaux J., and Aprahamian M. Role of nitric oxide in pancreatic tumour growth: In vivo and in vitro studies. Br. J. Cancer 78 (1998) 841-849
95. Hall A.V., Antoniou H., Wang Y., Cheung A.H., Arbus A.M., Olson S.L., Lu W.C., Kau C.L., and Marsden P.A. Structural organization of the human neuronal nitric oxide synthase gene (NOS1). J. Biol. Chem. 269 (1994) 33082-33090
96. Hamilton A.L., Eder J.P., Pavlick A.C., Clark J.W., Liebes L., Garcia-Carbonero R., Chachoua A., Ryan D.P., Soma V., Farrell K., Kinchla N., Boyden J., et al. Proteasome inhibition with bortezomib (PS-341): A phase I study with pharmacodynamic end points using a day 1 and day 4 schedule in a 14-day cycle. J. Clin. Oncol. 23 (2005) 6107-6116
97. Hardman J.G., and Sutherland E.W. Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3′,5′-monophosphate from guanosine triphosphate. J. Biol. Chem. 244 (1969) 6363-6370
98. Harrison D.E., and Zhong R.K. The same exhaustible multilineage precursor produces both myeloid and lymphoid cells as early as 3-4 weeks after marrow transplantation. Proc. Natl. Acad. Sci. USA 89 (1992) 10134-10138
99. Harteneck C., Koesling D., Söling A., Schultz G., and Böhme E. Expression of soluble guanylate cyclase: Catalytic activity requires two subunits. FEBS Lett. 272 (1990) 221-223
100. Harteneck C., Wedel B., Koesling D., Malkewitz J., Böhme E., and Schultz G. Molecular cloning and expression of a new α-subunit of soluble guanylyl cyclase. Interchangeability of the α-subunits of the enzyme. FEBS Lett. 292 (1991) 217-222
101. Haynes Jr. J., Baliga B.S., Obiako B., Ofori-Acquah S., and Pace B. Zileuton induces hemoglobin F synthesis in erythroid progenitors: Role of the l-arginine-nitric oxide signaling pathway. Blood 103 (2004) 3945-3950
102. Head C.A., Brugnara C., Martinez-Ruiz R., Kacmarek R.M., Bridges K.R., Kuter D., Bloch K.D., and Zapol W.M. Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo. J. Clin. Invest. 100 (1997) 1193-1198
103. Hecker M., Mülsch A., and Busse R. Subcellular localization and characterization of neuronal nitric oxide synthase. J. Neurochem. 62 (1994) 1524-1529
104. Heneka M.T., Loschmann P.A., Gleichmann M., Weller M., Schulz J.B., Wullner U., and Klockgether T. Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide. J. Neurochem. 71 (1998) 88-94
105. Hickey M.J., Granger D.N., and Kubes P. Inducible nitric oxide synthase (iNOS) and regulation of leucocyte/endothelial cell interactions: Studies in iNOS-deficient mice. Acta Physiol. Scand. 173 (2001) 119-126
106. Hideshima T., Richardson P., Chauhan D., Palombella V.J., Elliott P.J., Adams J., and Anderson K.C. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 61 (2001) 3071-3076
107. Hikiji H., Shin W.S., Oida S., Takato T., Koizumi T., and Toyo-oka T. Direct action of nitric oxide on osteoblastic differentiation. FEBS Lett. 30 (1997) 238-242
108. Huang F.P., Niedbala W., Wei X.Q., Feng G.J., Robinson J.H., Lam C., and Liew F.Y. Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages. Eur. J. Immunol. 28 (1998) 4062-4070
109. Huang K.T., Huang Z., and Kim-Shapiro D.B. Nitric oxide red blood cell membrane permeability at high and low oxygen tension. Nitric Oxide 16 (2007) 209-216
110. Hunter C.J., Dejam A., Blood A.B., Shields H., Kim-Shapiro D., Machado R.F., Tarekegn S., Mulla N., Hopper A.O., Schechter A.N., Power G.G., and Gladwin M.T. Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator. Nat. Med. 10 (2004) 1122-1127
111. Huot A.E., Kruszyna H., Kruszyna R., Smith R.P., and Hacker M.P. Formation of nitric oxide hemoglobin in erythrocytes co-cultured with alveolar macrophages taken from bleomycin treated rats. Biochem. Biophys. Res. Commun. 182 (1992) 151-157
112. Idriss S.D., Gudi T., Casteel D.E., Kharitonov V.G., Pilz R.B., and Boss G.R. Nitric oxide regulation of gene transcription via soluble guanylate cyclase and type I cGMP-dependent protein kinase. J. Biol. Chem. 274 (1999) 9489-9493
113. Ignarro L.J., Wood K.S., and Wolin M.S. Activation of purified soluble guanylate cyclase by protoporphyrin IX. Proc. Natl. Acad. Sci. USA 79 (1982) 2870-2873
114. Ignarro L.J., Fukoto J.M., Griscavage J.M., Rogers N.E., and Burns R.E. Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: Comparison with enzymatically formed nitric oxide from l-arginine. Proc. Natl. Acad. Sci. USA 90 (1993) 8103-8107
115. Ikuta T., Ausenda S., and Cappellini M.D. Mechanism for fetal globin gene expression: Role of the soluble guanylate cyclase-cGMP-dependent protein kinase pathway. Proc. Natl. Acad. Sci. USA 98 (2001) 1847-1852
116. Inoue A., Kuroyanagi Y., Terui K., Moi P., and Ikuta T. Negative regulation of gamma-globin gene expression by cyclic AMP-dependent pathway in erythroid cells. Exp. Hematol. 32 (2004) 244-253
117. Iyamu E.W., Cecil R., Parkin L., Woods G., Ohene-Frempong K., and Asakura T. Modulation of erythrocyte arginase activity in sickle cell disease patients during hydroxyurea therapy. Br. J. Haematol. 131 (2005) 389-394
118. Jacobs-Helber S.M., Abutin R.M., Tian C., Bondurant M., Wickrema A., and Sawyer S.T. Role of JunB in erythroid differentiation. J. Biol. Chem. 277 (2002) 4859-4866
119. Jadeski L.C., Chakraborty C., and Lala P.K. Nitric oxide-mediated promotion of mammary tumour cell migration requires sequential activation of nitric oxide synthase, guanylate cyclase and mitogen activated protein kinase. Int. J. Cancer 106 (2003) 496-504
120. Jenkins D.C., Charles I.G., Baylis S.A., Lelchuk R., Radomski M.W., and Moncada S. Human colon cancer cell lines show a diverse pattern of nitric oxide synthase gene expression and nitric oxide generation. Br. J. Cancer 70 (1994) 847-849
121. Jenkins D.C., Charles I.G., Thomsen L.L., Moss D.W., Holmes L.S., Baylis S.A., Rhodes P., Westmore K., Emson P.C., and Moncada S. Roles of nitric oxide in tumor growth. Proc. Natl. Acad. Sci. USA 92 (1995) 4392-4396
122. Jia L., Bonaventura C., Bonaventura J., and Stamler J.S. S-nitrosohaemoglobin: A dynamic activity of blood involved in vascular control. Nature 380 (1996) 221-226
123. Jubelin B.C., and Gierman J.L. Erythrocytes may synthesize their own nitric oxide. Am. J. Hypertens. 9 (1996) 1214-1219
124. Jung Y.D., Fan F., McConkey D.J., Jean M.E., Liu W., Reinmuth N., Stoeltzing O., Ahmad S.A., Parikh A.A., Mukaida N., and Ellis L.M. Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells. Cytokine 18 (2002) 206-213
125. Kamisaki Y., Saheki S., Nakane M., Palmieri J.A., Kuno T., Chang B.Y., Waldman S.A., and Murad F. Soluble guanylate cyclase from rat lung exists as a heterodimer. J. Biol. Chem. 261 (1986) 7236-7241
126. Kang E.S., Ford K., Grokulsky G., Wang Y.B., Chiang T.M., and Acchiardo S.R. Normal circulating adult human red blood cells contain inactive NOS proteins. J. Lab. Clin. Med. 135 (2000) 444-451
127. Kaufmann J.E., Iezzi M., and Vischer U.M. Desmopressin (DDAVP) induces NO production in human endothelial cells via V2 receptor- and cAMP-mediated signaling. J. Thromb. Haemost. 1 (2003) 821-828
128. + cells. Exp. Hematol. 34 (2006) 1151-1161
129. Keller C.C., Kremsner P.G., Hittner J.B., Misukonis M.A., Weinberg J.B., and Perkins D.J. Elevated nitric oxide production in children with malarial anemia: Hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells. Infect. Immun. 72 (2004) 4868-4873
130. Kharitonov V.G., Sharma V.S., Magde D., and Koesling D. Kinetics of nitric oxide dissociation from five- and six-coordinate nitrosyl hemes and heme proteins, including soluble guanylate cyclase. Biochemistry 36 (1997) 6814-6818
131. Kibbe M.R., Nie S., Seol D.W., Kovesdi I., Lizonova A., Makaroun M., Billiar T.R., and Tzeng E. Nitric oxide prevents p21 degradation with the ubiquitin-proteasome pathway in vascular smooth muscle cells. J. Vasc. Surg. 31 (2000) 364-374
132. Kim S.O., Xu Y., Katz S., and Pelech S. Cyclic GMP-dependent and-independent regulation of MAP kinases by sodium nitroprusside in isolated cardiomyocytes. Biochim. Biophys. Acta 1496 (2000) 277-284
133. Kim Y.M., de Vera M.E., Watkins S.C., and Billiar T.R. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression. J. Biol. Chem. 272 (1997) 1402-1411
134. Kim Y.M., Talanian R.V., and Billiar T.R. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J. Biol. Chem. 272 (1997) 31138-31148
135. Kim Y.M., Chung H.T., Simmons R.L., and Billiar T.R. Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and caspase inhibition. J. Biol. Chem. 275 (2000) 10954-10961
136. Kleinbongard P., Schulz R., Rassaf T., Lauer T., Dejam A., Jax T., Kumara I., Gharini P., Kabanova S., Ozuyaman B., Schnurch H.G., Godecke A., et al. Red blood cells express a functional endothelial nitric oxide synthase. Blood 107 (2006) 2943-2951
137. Klessig D.F., Durner J., Noad R., Navarre D.A., Wendehenne D., Kumar D., Zhou J.M., Shah J., Zhang S., Kachroo P., Trifa Y., Pontier D., et al. Nitric oxide and salicylic acid signaling in plant defense. Proc. Natl. Acad. Sci. USA 97 (2000) 8849-8855
138. Klotz T., Bloch W., Volberg C., Engelmann U., and Addicks K. Selective expression of inducible nitric oxide synthase in human prostate carcinoma. Cancer 82 (1998) 1897-1903
139. Koesling D., Herz J., Gausepohl H., Niroomand F., Hinsch K.D., Mülsch A., Böhme E., Schultz G., and Frank R. The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclase. FEBS Lett. 239 (1988) 29-34
140. Koury M.J., and Bondurant M.C. Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells. Science 248 (1990) 378-381
141. Kucukkaya B., Ozturk G., and Yalcintepe L. Nitric oxide levels during erythroid differentiation in K562 cell line. Indian J. Biochem. Biophys. 43 (2006) 251-253
142. Kumar A., Knox A.J., and Boriek A.M. CCAAT/enhancer-binding protein and activator protein-1 transcription factors regulate the expression of interleukin-8 through the mitogen-activated protein kinase pathways in response to mechanical stretch of human airway smooth muscle cells. J. Biol. Chem. 278 (2003) 18868-18876
143. Kuroyanagi Y., Kaneko Y., Muta K., Park B.S., Moi P., Ausenda S., Cappellini M.D., and Ikuta T. cAMP differentially regulates gamma-globin gene expression in erythroleukemic cells and primary erythroblasts through c-Myb expression. Biochem. Biophys. Res. Commun. 344 (2006) 1038-1047
144. Kwan H.Y., Huang Y., and Yao X. Store-operated calcium entry in vascular endothelial cells is inhibited by cGMP via a protein kinase G-dependent mechanism. J. Biol. Chem. 275 (2000) 6758-6763
145. Kwon N.S., Stuehr D.J., and Nathan C.F. Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. J. Exp. Med. 174 (1991) 761-767
146. Lauer T., Preik M., Rassaf T., Strauer B.E., Deussen A., Feelisch M., and Kelm M. Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action. Proc. Natl. Acad. Sci. USA 98 (2001) 12814-12819
147. Lee T.W., Chen G.G., Xu H., Yip J.H., Chak E.C., Mok T.S., and Yim A.P. Differential expression of inducible nitric oxide synthase and
148. Lell B., May J., Schmidt-Ott R.J., Lehman L.G., Luckner D., Grevem B., Matousek P., Schmid D., Herbich K., Mockenhaupt F.P., Meyer C.G., Bienzle U., et al. The role of red blood cell polymorphisms in resistance and susceptibility to malaria. Clin. Infect. Dis. 28 (1999) 794-799
149. Lepoivre M., Flaman J.M., Bobe P., Lemaire G., and Henry Y. Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Relationship to cytostasis induced in tumor cells by cytotoxic macrophages. J. Biol. Chem. 269 (1994) 21891-21897
150. Liao J.C., Hein T.W., Vaughn M.W., Huang K.T., and Kuo L. Intravascular flow decreases erythrocyte consumption of nitric oxide. Proc. Natl. Acad. Sci. USA 96 (1999) 8757-8761
151. Lin F.K., Suggs S., Lin C.H., Browne J.K., Smailing R., Egric J.C., Chen K.K., Fox G.M., Martin F., and Wasser Z. Cloning and expression of the human erythropoietin gene. Proc. Natl. Acad. Sci. USA 92 (1985) 7850-7884
152. Lin K.T., Xue J.Y., Nomen M., Spur B., and Wong P.Y. Peroxynitrite-induced apoptosis in HL-60 cells. J. Biol. Chem. 270 (1995) 16487-16490
153. Lincoln T.M. Cyclic GMP and mechanisms of vasodilation. Pharmacol. Ther. 41 (1989) 479-502
154. Liu X., Miller M.J., Joshi M.S., Sadowska-Krowicka H., Clark D.A., and Lancaster Jr. J.R. Diffusion-limited reaction of free nitric oxide with erythrocytes. J. Biol. Chem. 273 (1998) 18709-18713
155. Liu X., Miller M.J.S., Joshi M.S., Thomas D.D., and Lancaster J.R. Accelerated reaction of nitric oxide with oxygen within the hydrophobic interior of biological membranes. Proc. Natl. Acad. Sci. USA 95 (1998) 2175-2179
156. Liu X., Liu Q., Gupta E., Zorko N., Brownlee E., and Zweier J.L. Quantitative measurements of NO reaction kinetics with a Clark-type electrode. Nitric Oxide 13 (2005) 68-77
157. Loibl S., Buck A., Strank C., von Minckwitz G., Roller M., Sinn H.P., Schini-Kerth V., Solbach C., Strebhardt K., and Kaufmann M. The role of early expression of inducible nitric oxide synthase in human breast cancer. Eur. J. Cancer 41 (2005) 265-271
158. Long J.H.D., Lira V.A., Soltow Q.A., Betters J.L., Sellman J.E., and Criswell D.S. Arginine supplementation induces myoblast fusion via augmentation of nitric oxide production. J. Muscle Res. Cell. Motil. 27 (2006) 577-584
159. Lopansri B.K., Anstey N.M., Weinberg J.B., Stoddard G.J., Hobbs M.R., Levesque M.C., Mwaikambo E.D., and Granger D.L. Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production. Lancet 361 (2003) 676-678
160. Maciejewski J.P., Selleri C., Sato T., Cho H.J., Keefer L.K., Nathan C.F., and Young N.S. Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha. J. Clin. Invest. 96 (1995) 1085-1092
161. MacMicking J., Xie Q.W., and Nathan C. Nitric oxide and macrophage function. Annu. Rev. Immunol. 15 (1997) 323-350
162. Magill L., Walker B., and Irvine A.E. The proteasome: A novel therapeutic target in haematopoietic malignancy. Hematology 8 (2003) 275-283
163. Majka M., Janowska-Wieczorek A., Ratajczak J., Ehrenman K., Pietrzkowski Z., Kowalska M.A., Gewirtz A.M., Emerson S.G., and Ratajczak M.Z. Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner. Blood 97 (2001) 3075-3085
164. Mamone G., Sannolo N., Malorni A., and Ferranti P. In vitro formation of S-nitrosohemoglobin in red cells by inducible nitric oxide synthase. FEBS Lett. 462 (1999) 241-245
165. Mannick J.B., Asano K., Izumi K., Kieff E., and Stamler J.S. Nitric oxide produced by human B-lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Cel1 79 (1994) 1137-1146
166. Marrero M.B., Venema V.J., Ju H., He H., Liang H., Caldwell R.B., and Venema R.C. Endothelial nitric oxide synthase interactions with G-protein-coupled receptors. Biochem. J. 343 (1999) 335-340
167. Martin J.H., and Edwards S.W. Changes in mechanisms of monocyte/macrophage-mediated cytotoxicity during culture. Reactive oxygen intermediates are involved in monocyte-mediated cytotoxicity, whereas reactive nitrogen intermediates are employed by macrophages in tumor cell killing. J. Immunol. 150 (1993) 3478-3486
168. McDaniel M.L., Corbett J.A., Kwon G., and Hill J.R. A role for nitric oxide and other inflammatory mediators in cytokine-induced pancreatic beta-cell dysfunction and destruction. Adv. Exp. Med. Biol. 426 (1997) 313-319
169. McDevitt M.A., Xie J., Gordeuk V., and Bucala R. The anemia of malaria infection: Role of inflammatory cytokines. Curr. Hematol. Rep. 3 (2004) 97-106
170. Mellion B.T., Ignarro L.J., Ohlstein E.H., Pontecorvo E.G., Hyman A.L., and Kadowitz P.J. Evidence for the inhibitory role of guanosine 3′,5′-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators. Blood 57 (1981) 946-955
171. Messmer U.K., Lapetina E.G., and Brune B. Nitric oxide-induced apoptosis in RAW 264.7 macrophages is antagonized by protein kinase C- and protein kinase A activating compounds. Mol. Pharmacol. 47 (1995) 757-765
172. Metcalf D. Some general aspects of hematopoietic cell development. In: Zon L.I. (Ed). "Hematopoiesis: A Developmental Approach" (2001), Oxford University Press, Oxford, UK 3-14
173. Michaely P., and Bennett V. Mechanism for binding site diversity on ankyrin. Comparison of binding sites on ankyrin for neurofascin and the Cl-/HCO3- anion exchanger. J. Biol. Chem. 270 (1995) 31298-31302
174. Michell B.J., Chen Z., Tiganis T., Stapleton D., Katsis F., Power D.A., Sim A.T., and Kemp B.E. Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J. Biol. Chem. 276 (2001) 17625-17628
175. Minneci P.C., Deans K.J., Huang Z., Yuen P.S.T., Star R.A., Banks S.M., Schechter A.N., Natanson C., Gladwin M.T., and Solomon S.B. Hemolysis associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. J. Clin. Invest. 115 (2005) 3409-3417
176. Minning D.M., Gow A.J., Bonaventura J., Braun R., Dewhirst M., Goldberg D.E., and Stamler J.S. Ascaris haemoglobin is a nitric oxide-activated 'deoxygenase'. Nature 401 (1999) 497-502
177. Mitchell H.H., Shonle H.A., and Grindley H.S. The origin of the nitrates in the urine. J. Biol. Chem. 24 (1916) 461-490
178. Moi P., and Kan Y.W. Synergistic enhancement of globin gene expression by activator protein-1-like proteins. Proc. Natl. Acad. Sci. USA 87 (1990) 9000-9004
179. Morris C.R., Vichinsky E.P., van Warmerdam J., Machado L., Kepka-Lenhart Jr. D., Morris S.M., and Kuypers F.A. Hydroxyurea and arginine therapy: Impact on nitric oxide production in sickle cell disease. J. Pediatr. Hematol. Oncol. 25 (2003) 629-634
180. Morrison S.J., and Weissman I.L. The long-term repopulating subset of haemopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1 (1994) 661-673
181. Mortensen K., Skouv J., Hougaard D.M., and Larsson L.I. Endogenous endothelial cell nitric-oxide synthase modulates apoptosis in cultured breast cancer cells and is transcriptionally regulated by p53. J. Biol. Chem. 274 (1999) 37679-37684
182. Mujais S.K., Bery N., Pullman T.N., and Goldwasser E. Erythropoietin is produced by tubular cells of the rat kidney. Cell Biochem. Biophys. 30 (1999) 153-166
183. Musial A., and Eissa N.T. Inducible nitric-oxide synthase is regulated by the proteasome degradation pathway. J. Biol. Chem. 276 (2001) 24268-24273
184. Nagababu E., Ramasamy S., Abernethy D.R., and Rifkind J.M. Active nitric oxide produced in the red cell under hypoxic conditions by deoxyhemoglobin-mediated nitrite reduction. J. Biol. Chem. 278 (2003) 46349-46356
185. Nahavandi M., Tavakkoli F., Wyche M.Q., Perlin E., Winter W.P., and Castro O. Nitric oxide and cyclic GMP levels in sickle cell patients receiving hydroxyurea. Br. J. Haematol. 119 (2002) 855-857
186. Nahavandi M., Tavakkoli F., Millis R.M., Wyche M.Q., Habib M.J., and Tavakoli N. Effects of hydroxyurea and l-arginine on the production of nitric oxide metabolites in cultures of normal and sickle erythrocytes. Hematology 11 (2006) 291-294
187. Nappi A.J., Vass E., Frey F., and Carton Y. Nitric oxide involvement in Drosophila immunity. Nitric Oxide 4 (2000) 423-430
188. Ohneda O., and Bautch V.L. Murine endothelial cells support fetal liver erythropoiesis and myelopoiesis via distinct interactions. Br. J. Haematol. 98 (1997) 798-808
189. Osti F., Corradini F.G., Hanau S., Matteuzzi M., and Gambari R. Human leukemia K562 cells: Induction to erythroid differentiation by guanine, guanosine and guanine nucleotides. Haematologica 82 (1997) 395-401
190. Pace B.S., Qian X.H., Sangerman J., Ofori-Acquah S.F., Baliga B.S., Han J., and Critz S.D. p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors. Exp. Hematol. 31 (2003) 1089-1096
191. Pai K., Shrivastava A., Kumar R., Khetarpal S., Sarmah B., Gupta P., and Sodhi A. Activation of P388D1 macrophage cell line by chemotherapeutic drugs. Life Sci. 60 (1997) 1239-1248
192. Palmer R.M., Ashton D.S., and Moncada S. Vascular endothelial cells synthesize nitric oxide from l-arginine. Nature 333 (1988) 664-666
193. Paolucci C., Burastero S.E., Rovere-Querini P., De Palma C., Falcone S., Perrotta C., Capobianco A., Manfredi A.A., and Clementi E. Synergism of nitric oxide and maturation signals on human dendritic cells occurs through a cyclic GMP-dependent pathway. J. Leukoc. Biol. 73 (2003) 253-262
194. Papayannopoulou T., Priestley G.V., Bonig H., and Nakamoto B. The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization. Blood 101 (2003) 4739-4747
195. Park J.I., Choi H.S., Jeong J.S., Han J.Y., and Kim I.H. Involvement of p38 kinase in hydroxyurea-induced differentiation of K562 cells. Cell Growth Differ. 12 (2001) 481-486
196. Park S.W., Lee S.G., Song S.H., Heo D.S., Park B.J., Lee D.W., Kim K.H., and Sung M.W. The effect of nitric oxide on cyclooxygenase-2 (COX-2) overexpression in head and neck cancer cell lines. Int. J. Cancer 107 (2003) 729-738
197. Perner A., Andresen L., Normark M., and Rask-Madsen J. Constitutive expression of inducible nitric oxide synthase in the normal human colonic epithelium. Scand. J. Gastroenterol. 37 (2002) 944-948
198. Pluta R.M., Dejam A., Grimes G., Gladwin M.T., and Oldfield E.H. Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage. JAMA 293 (2005) 1477-1484
199. Poderoso J.J., Carreras M.C., Lisdero C., Riobo N., Schopfer F., and Boveris A. Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. Arch. Biochem. Biophys. 328 (1996) 85-92
200. Queen L.R., Xu B., Horinouchi K., Fisher I., and Ferro A. Beta(2)-adrenoceptors activate nitric oxide synthase in human platelets. Circ. Res. 87 (2000) 39-44
201. Rafferty S.P., Domachowske J.B., and Malech H.L. Inhibition of hemoglobin expression by heterologous production of nitric oxide synthase in the K562 erythroleukemic cell line. Blood 88 (1996) 1070-1078
202. Rees D.D., Palmer R.M., and Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc. Natl. Acad. Sci. USA 86 (1989) 3375-3378
203. 2+ release from internal stores in neuronal cell line is enhanced by cyclic AMP. Eur. J. Pharmacol. 227 (1992) 89-93
204. Reiter C.D., Wang X.D., Tanus-Santos J.E., Hogg N., Cannon R.O., Schechter A.N., and Gladwin M.T. Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat. Med. 8 (2002) 1383-1389
205. Robinson L.J., Weremowicz S., Morton C.C., and Michel T. Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene. Genomics 19 (1994) 350-357
206. Rodgers G.P., Dover G.J., Uyesaka N., Noguchi C.T., Schechter A.N., and Nienhuis A.W. Augmentation by erythropoietin of the fetal-hemoglobin response to hydroxyurea in sickle cell disease. N. Engl. J. Med. 328 (1993) 73-80
207. Rood P.M., Gerritsen W.R., Kramer D., Ranzijn C., von dem Borne A.E., and van der Schoot C.E. Adhesion of hematopoietic progenitor cells to human bone marrow or umbilical vein derived endothelial cell lines: A comparison. Exp. Hematol. 27 (1999) 1306-1314
208. Rother R.P., Bell L., Hillmen P., and Gladwin M.T. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin-a novel mechanism of human disease. JAMA 293 (2005) 1653-1662
209. Russwurm M., Behrends S., Harteneck C., and Koesling D. Functional properties of a naturally occurring isoform of soluble guanylyl cyclase. Biochem. J. 335 (1998) 125-130
210. Rybicki A.C., Schwartz R.S., Hustedt E.J., and Cobb C.E. Increased rotational mobility and extractability of band 3 from protein 4.2-deficient erythrocyte membranes: Evidence of a role for protein 4.2 in strengthening the band 3-cytoskeleton linkage. Blood 88 (1996) 2745-2753
211. Safaya S., Ibrahim A., and Rieder R.F. Augmentation of gamma-globin gene promoter activity by carboxylic acids and components of the human beta-globin locus control region. Blood 84 (1994) 3929-3935
212. Sakahira H., Enari M., and Nagata S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391 (1998) 96-99
213. Salgo M.G., Squadrito G.L., and Pryor W.A. Peroxynitrite causes apoptosis in rat thymocytes. Biochem. Biophys. Res. Commun. 215 (1995) 1111-1118
214. Sawada K., Krantz S.B., Dai C.H., Koury S.T., Horn S.T., Glick A.D., and Civin C.I. Purification of human blood burst-forming units-erythroid and demonstration of the evolution of erythropoietin receptor. J. Cell. Physiol. 142 (1990) 219-230
215. Saxena R.K., and Chandrasekhar B. A novel nonphagocytic mechanism of erythrocyte destruction involving direct cell-mediated cytotoxicity. Int. J. Hematol. 71 (2000) 227-237
216. Sessa W.C., Garcia-Gardena G., Liu J., Keh A., Pollock J.S., Bradley J., Thiru S., Braverman I.M., and Desai K.M. The Golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxide. J. Biol. Chem. 270 (1995) 17641-17644
217. Sethi S., and Dikshit M. Modulation of polymorphonuclear leukocytes function by nitric oxide. Thromb. Res. 100 (2000) 223-247
218. Shami P.J., Moore J.O., Gockerman J.P., Hathorn J.W., Misukonis M.A., and Weinberg J.B. Nitric oxide modulation of the growth and differentiation of freshly isolated acute non-lymphocytic leukemia cells. Leuk. Res. 19 (1995) 527-533
219. Shami P.J., and Weinberg J.B. Differential effects of nitric oxide on erythroid and myeloid colony growth from CD34+ human bone marrow cells. Blood 87 (1996) 977-982
220. Shaul P.W., Smart E.J., Robinson L.J., German Z., Yuhanna I.S., Ying Y., Anderson R.G., and Michel T. Acetylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae. J. Biol. Chem. 271 (1996) 6518-6522
221. Stamler J.S., Jia L., Eu J.P., McMahon T.J., Demchenko I.T., Bonaventura J., Gernert K., and Piantadosi C.A. Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science 276 (1997) 2034-2037
222. Stangl V., Lorenz M., Meiners M., Ludwig A., Bartsch C., Moobed M., Vietzke A., Kinkel H.T., Baumann G., and Stangl K. Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway. FASEB J. 18 (2004) 272-279
223. Stevenson M.M., and Riley E.M. Innate immunity to malaria. Nat. Rev. Immunol. 4 (2004) 169-180
224. Stone J.R., and Marletta M.A. Soluble guanylate cyclase from bovine lung: Activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. Biochemistry 33 (1994) 5636-5640
225. Stone J.R., and Marletta M.A. Heme stoichiometry of heterodimeric soluble guanylate cyclase. Biochemistry 34 (1995) 14668-14674
226. Stuehr D. Mammalian nitric oxide synthases. Biochim. Biophys. Acta 1411 (1999) 217-230
227. Swana H.S., Smith S.D., Perrotta P.L., Saito N., Wheeler M.A., and Weiss R.M. Inducible nitric oxide synthase with transitional cell carcinoma of the bladder. J. Urol. 161 (1999) 630-634
228. Tamatani M., Ogawa S., Niitsu Y., and Tohyama M. Involvement of Bcl-2 family and caspase-3-like protease inNO-mediated neuronal apoptosis. J. Neurochem. 71 (1998) 1588-1596
229. Tatoyan A., and Giulivi C. Purification and characterization of a nitric-oxide synthase from rat liver mitochondria. J. Biol. Chem. 273 (1998) 11044-11048
230. Taylor B.S., and Geller D.A. Molecular regulation of the human inducible nitric oxide synthase (iNOS) gene. Shock 13 (2000) 413-424
231. Thomsen L.L., Lawton F.G., Knowles R.G., Beesley J.E., Riveros-Moreno V., and Moncada S. Nitric oxide synthase activity in human gynecological cancer. Cancer Res. 54 (1994) 1352-1354
232. Thomsen L.L., Miles D.W., Happerfield L., Bobrow L.G., Knowles R.G., and Moncada S. Nitric oxide synthase activity in human breast cancer. Br. J. Cancer 72 (1995) 41-44
233. Tournier C., Hess P., Yang D.D., Xu J., Turner T.K., Nimnual A., Bar-Sagi D., Jones S.N., Flavell R.A., and Davis R.J. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288 (2000) 870-874
234. Toyoshima H., Nasa Y., Hashizume Y., Koseki Y., Isayama Y., Kohsaka Y., Yamada T., and Takeo S. Modulation of cAMP-mediated vasorelaxation by endothelial nitric oxide and basal cGMP in vascular smooth muscle. J. Cardiovasc. Pharmacol. 32 (1998) 543-551
235. Tsoukias N.M., and Popel A.S. Erythrocyte consumption of nitric oxide in presence and absence of plasma-based hemoglobin. Am. J. Physiol. Heart Circ. Physiol. 282 (2002) H2265-H2277
236. Urbich C., Fleming I., Förstermann U., Zeiher A.M., and Dimmeler S. Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis. Circ. Res. 91 (2002) 837-844
237. Vaandrager A.B., and de Jonge H.R. Signalling by cGMP-dependent protein kinases. Mol. Cell. Biochem. 157 (1996) 23-30
238. van der Zee R., Murohara T., Luo Z., Zollmann F., Passeri J., Lekutat C., and Isner J.M. Vascular endothelial growth factor/vascular permeability factor augments nitric oxide release from quiescent rabbit and human vascular endothelium. Circulation 95 (1997) 1030-1037
239. Vaughn M.W., Kuo L., and Liao J.C. Effective diffusion distance of nitric oxide in the microcirculation. Am. J. Physiol. 274 (1998) H1705-H1714
240. Vaughn M.W., Huang K.T., Kuo L., and Liao J.C. Erythrocytes possess an intrinsic barrier to nitric oxide consumption. J. Biol. Chem. 275 (2000) 2342-2348
241. Veith R., Galanello R., Papayannopoulou T., and Stamatoyannopoulos G. Stimulation of F-cell production in patients with sickle-cell anemia treated with cytarabine or hydroxyurea. N. Engl. J. Med. 313 (1985) 1571-1575
242. Wang S., Wang W., Wesley R.A., and Danner R.L. A Sp1 binding site of the tumor necrosis factor alpha promoter functions as a nitric oxide response element. J. Biol. Chem. 274 (1999) 33190-33193
243. Wang Y.Z., Cao Y.Q., Wu J.N., Chen M., and Cha X.Y. Expression of nitric oxide synthase in human gastric carcinoma and its relation to p53,PCNA. World J. Gastroenterol. 11 (2005) 46-50
244. Wedel B., Humbert P., Harteneck C., Foerster J., Malkewitz J., Böhme E., Schultz G., and Koesling D. Mutation of His-105 in the β1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclase. Proc. Natl. Acad. Sci. USA 91 (1994) 2592-2596
245. Weninger W., Rendl M., Pammer J., Mildner M., Tschugguel W., Schneeberger C., Sturzl M., and Tschachler E. Nitric oxide synthases in Kaposi sarcoma are expressed predominantly by vessels and tissue macrophages. Lab. Invest. 78 (1998) 949-955
246. Wilson J.G., and Tavassoli M. Microenvironmental factors involved in the establishment of erythropoiesis in bone marrow. Ann. NY Acad. Sci. 718 (1994) 271-283
247. Wilson K.T., Fu S., Ramanujam K.S., and Meltzer S.J. Increased expression of inducible nitric oxide synthase andcyclooxygenase-2 in Barrett s esophagus and associated adenocarcinomas. Cancer Res. 58 (1998) 2929-2934
248. Wu H., Liu X., Jaenisch R., and Lodish H.F. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 83 (1995) 59-67
249. Wu H.M., Wen H.C., and Lin W.W. Proteasome inhibitors stimulate interleukin-8 expression via Ras and apoptosis signal-regulating kinase-dependent extracellular signal-related kinase and c-Jun N-terminal kinase activation. Am. J. Respir. Cell Mol. Biol. 27 (2002) 234-243
250. Xu B., Li J., Gao L., and Ferro A. Nitric oxide-dependent vasodilatation of rabbit femoral artery by beta(2)-adrenergic stimulation or cyclic AMP elevation in vivo. Br. J. Pharmacol. 129 (2000) 969-974
251. Xu X., Cho M., Spencer N.Y., Patel N., Huang Z., Shields H., King S.B., Gladwin M.T., Hogg N., and Kim-Shapiro D.B. Measurements of nitric oxide on the heme iron and beta-93 thiol of human hemoglobin during cycles of oxygenation and deoxygenation. Proc. Natl. Acad. Sci. USA 100 (2003) 11303-11308
252. Yamaguchi H., Ishii E., Saito S., Tashiro K., Fujita I., Yoshidomi S., Ohtubo M., Akazawa K., and Miyazaki S. Umbilical vein endothelial cells are an important source of c-kit and stem cell factor which regulate the proliferation of haemopoietic progenitor cells. Br. J. Haematol. 94 (1996) 606-611
253. Yamaguchi T., Chattopadhyay N., Kifor O., Sanders J.L., and Brown E.M. Activation of p42/44 and p38 mitogen-activated protein kinases by extracellular calcium-sensing receptor agonists induces mitogenic responses in the mouse osteoblastic MC3T3-E1 cell line. Biochem. Biophys. Res. Commun. 279 (2000) 363-368
254. Yang Y.M., Pace B., Kitchens D., Ballas S.K., Shah A., and Baliga B.S. BFU-E colony growth in response to hydroxyurea: Correlation between in vitro and in vivo fetal hemoglobin induction. Am. J. Hematol. 56 (1997) 252-258
255. Yuen P.S., Potter L.R., and Garbers D.L. A new form of guanylyl cyclase is preferentially expressed in rat kidney. Biochemistry 29 (1990) 10872-10878
256. Yui Y., Hattori R., Kosuga K., Eizawa H., Hiki K., and Kawai C. Purification of nitric oxide synthase from rat macrophages. J. Biol. Chem. 266 (1991) 12544-12547
257. Zech B., Kohl R., von Knethen A., and Brune B. Nitric oxide donors inhibit formation of the Apaf-1/caspase-9 apoptosome and activation of caspases. Biochem. J. 371 (2003) 1055-1064
258. Zuhrie S.R., Pearson J.D., and Wickramasinghe S.N. Haemoglobin synthesis in K562 erythroleukaemia cells is affected by intimate contact with monolayers of various human cell types. Leuk. Res. 12 (1988) 567-574