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Volumn 13, Issue 6, 2000, Pages 413-424

Molecular regulation of the human inducible nitric oxide synthase (iNOS) gene

Author keywords

Gene expression; Heat shock; I B; Inducible nitric oxide synthase (iNOS); Inflammation; Nitric oxide (NO); Nuclear factor kappa B (NF B); P53; Transcription

Indexed keywords

GROWTH PROMOTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, MOUSE; NOS2A PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034199889     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200006000-00001     Document Type: Review
Times cited : (156)

References (105)
  • 1
    • 0025784834 scopus 로고
    • Endogenous nitric oxide: Physiology, pathology and clinical relevance
    • Moncada S, Higgs EA: Endogenous nitric oxide: physiology, pathology and clinical relevance. Eur J Clin Invest 21:361-374, 1991
    • (1991) Eur J Clin Invest , vol.21 , pp. 361-374
    • Moncada, S.1    Higgs, E.A.2
  • 2
    • 0025802065 scopus 로고
    • Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
    • Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH: Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 351:714-718, 1991
    • (1991) Nature , vol.351 , pp. 714-718
    • Bredt, D.S.1    Hwang, P.M.2    Glatt, C.E.3    Lowenstein, C.4    Reed, R.R.5    Snyder, S.H.6
  • 6
    • 0028492503 scopus 로고
    • Invited opinion: Role of nitric oxide in hemorrhagic, traumatic, and anaphylactic shock and thermal injury
    • Szabo C, Thiemermann C: Invited opinion: role of nitric oxide in hemorrhagic, traumatic, and anaphylactic shock and thermal injury. Shock 2:145-155, 1994
    • (1994) Shock , vol.2 , pp. 145-155
    • Szabo, C.1    Thiemermann, C.2
  • 7
    • 0029864356 scopus 로고    scopus 로고
    • Nitric oxide and septic shock
    • Cobb JP, Danner RL: Nitric oxide and septic shock. JAMA 275:1192-1196, 1996.
    • (1996) JAMA , vol.275 , pp. 1192-1196
    • Cobb, J.P.1    Danner, R.L.2
  • 8
    • 0025195627 scopus 로고
    • G-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide
    • G-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide. Proc Natl Acad Sci USA 87:3629-3632, 1990.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 3629-3632
    • Kilbourn, R.G.1    Gross, S.S.2    Jubran, A.3
  • 11
    • 0031306612 scopus 로고    scopus 로고
    • Inhibition of nitric oxide synthesis during severe shock but not after resuscitation increases hepatic injury and neutrophil accumulation in hemorrhaged rats
    • Harbrecht BG, Wu B, Watkins SC, Billiar TR, Peitzman AB: Inhibition of nitric oxide synthesis during severe shock but not after resuscitation increases hepatic injury and neutrophil accumulation in hemorrhaged rats. Shock :425-421, 1997.
    • (1997) Shock , pp. 425-1421
    • Harbrecht, B.G.1    Wu, B.2    Watkins, S.C.3    Billiar, T.R.4    Peitzman, A.B.5
  • 12
    • 0031112190 scopus 로고    scopus 로고
    • Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: Lessons learned from experimental and clinical studies
    • Kilbourn RG, Szabo C, Traber DL: Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: lessons learned from experimental and clinical studies. Shock 7:235-246, 1997
    • (1997) Shock , vol.7 , pp. 235-246
    • Kilbourn, R.G.1    Szabo, C.2    Traber, D.L.3
  • 14
    • 0031901747 scopus 로고    scopus 로고
    • Molecular biology of inducible nitric oxide synthase
    • Geller DA, Billiar TR: Molecular biology of inducible nitric oxide synthase. Cancer Mutat Res 17:7-23, 1997
    • (1997) Cancer Mutat Res , vol.17 , pp. 7-23
    • Geller, D.A.1    Billiar, T.R.2
  • 15
    • 0032111014 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase in the liver: Regulation and function
    • Moscow
    • Taylor BS, Alarcon LH, Billiar TR: Inducible nitric oxide synthase in the liver: regulation and function. Biochemistry (Moscow) 63:766-781, 1998
    • (1998) Biochemistry , vol.63 , pp. 766-781
    • Taylor, B.S.1    Alarcon, L.H.2    Billiar, T.R.3
  • 18
    • 0026764084 scopus 로고
    • Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase
    • Janssens SP, Shimouchi A, Quertermous T, Bloch DB: Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem 267:14519-14522, 1992
    • (1992) J Biol Chem , vol.267 , pp. 14519-14522
    • Janssens, S.P.1    Shimouchi, A.2    Quertermous, T.3    Bloch, D.B.4
  • 19
    • 0027473029 scopus 로고
    • Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle
    • Nakane M, Schmidt HHHW, Pollock JS, Forstermann U, Murad F: Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS Lett 316:175-180, 1993
    • (1993) FEBS Lett , vol.316 , pp. 175-180
    • Nakane, M.1    Schmidt, H.H.H.W.2    Pollock, J.S.3    Forstermann, U.4    Murad, F.5
  • 21
    • 0028113983 scopus 로고
    • Inducible nitric oxide synthase from articular human chondrocytes: cDNA, cloning and analysis of mrna expression
    • Maier R, Bilbe G, Rediske J, Cotz M: Inducible nitric oxide synthase from articular human chondrocytes: cDNA, cloning and analysis of mRNA expression. Biochem Biophys Acta 1208:145-150, 1994
    • (1994) Biochem Biophys Acta , vol.1208 , pp. 145-150
    • Maier, R.1    Bilbe, G.2    Rediske, J.3    Cotz, M.4
  • 22
    • 0027372580 scopus 로고
    • Purification and cDNA sequence of an inducible nitric oxide synthase (NOS) from a human tumor cell line
    • Sherman PA, Laubach VE, Reep BR, Wood ER: Purification and cDNA sequence of an inducible nitric oxide synthase (NOS) from a human tumor cell line. Biochemistry 32:11600-11605, 1993
    • (1993) Biochemistry , vol.32 , pp. 11600-11605
    • Sherman, P.A.1    Laubach, V.E.2    Reep, B.R.3    Wood, E.R.4
  • 23
    • 0028016430 scopus 로고
    • Cloning and functional expression of human inducible nitric oxide synthase (NOS) from a glioblastoma cell line A-172
    • Hokari A, Zeniya M, Esumi H: Cloning and functional expression of human inducible nitric oxide synthase (NOS) from a glioblastoma cell line A-172. J Biochem 116:575-581, 1994
    • (1994) J Biochem , vol.116 , pp. 575-581
    • Hokari, A.1    Zeniya, M.2    Esumi, H.3
  • 26
    • 0027183208 scopus 로고
    • Structural and chromosomal localization of the human constituitive endothelial nitric oxide synthase
    • Marsden PA, Heab HHQ, Scherer SW, Stewart RJ, Hall AV, et al: Structural and chromosomal localization of the human constituitive endothelial nitric oxide synthase. J Biol Chem 268:17478-17488, 1993
    • (1993) J Biol Chem , vol.268 , pp. 17478-17488
    • Marsden, P.A.1    Heab, H.H.Q.2    Scherer, S.W.3    Stewart, R.J.4    Hall, A.V.5
  • 27
    • 0026574761 scopus 로고
    • Localization of brain nitric oxide synthase (NOS) to human chromosome 12
    • Kishimoto J, Spurr N, Liao M, Lizhi L, Emsonp Xu W: Localization of brain nitric oxide synthase (NOS) to human chromosome 12. Genomics 14:802-804, 1992
    • (1992) Genomics , vol.14 , pp. 802-804
    • Kishimoto, J.1    Spurr, N.2    Liao, M.3    Lizhi, L.4    Emsonp, Xu.W.5
  • 28
    • 0028972555 scopus 로고
    • A central role for interleukin-1b in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase
    • Geller DA, de Vera ME, Russell DA, Shapiro RA, Nussler AK, Simmons RL, Billiar TR: A central role for interleukin-1b in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase. J Immunol 155: 4890-4898, 1995
    • (1995) J Immunol , vol.155 , pp. 4890-4898
    • Geller, D.A.1    De Vera, M.E.2    Russell, D.A.3    Shapiro, R.A.4    Nussler, A.K.5    Simmons, R.L.6    Billiar, T.R.7
  • 29
    • 0029940198 scopus 로고    scopus 로고
    • Regulation of inducible nitric oxide synthase mRNA levels by differentiation and cytokines in human keratinocytes
    • Arany I, Brysk MM, Brysk H, Tyring SK: Regulation of inducible nitric oxide synthase mRNA levels by differentiation and cytokines in human keratinocytes. Biochem Biophys Res Commun 220:618-622, 1996
    • (1996) Biochem Biophys Res Commun , vol.220 , pp. 618-622
    • Arany, I.1    Brysk, M.M.2    Brysk, H.3    Tyring, S.K.4
  • 30
    • 0029881475 scopus 로고    scopus 로고
    • Induction and activity of nitric oxide synthase in cultured human intestinal epithelial monolayers
    • Salzman AL, Denenberg AG, Ueta I, O'Connor M, Linn SC, Szabo C: Induction and activity of nitric oxide synthase in cultured human intestinal epithelial monolayers. Am J Physiol 270:G565-G573, 1996.
    • (1996) Am J Physiol , vol.270
    • Salzman, A.L.1    Denenberg, A.G.2    Ueta, I.3    O'Connor, M.4    Linn, S.C.5    Szabo, C.6
  • 34
    • 0027255749 scopus 로고
    • Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-γ and bacterial LPS
    • Xie QW, Whisnant R, Nathan C: Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-γ and bacterial LPS. J Exp Med 177:1779-1785, 1993.
    • (1993) J Exp Med , vol.177 , pp. 1779-1785
    • Xie, Q.W.1    Whisnant, R.2    Nathan, C.3
  • 36
    • 0030887752 scopus 로고    scopus 로고
    • Analysis of expression and promoter function of the human inducible nitric oxide synthase gene in DLD-1 cells and monkey hepatocytes
    • Laubach, VE, Zhang CX, Russell SW, Murphy WJ, Sherman PA: Analysis of expression and promoter function of the human inducible nitric oxide synthase gene in DLD-1 cells and monkey hepatocytes. Biochimica et Biophysica Acta 1351:287-295, 1997
    • (1997) Biochimica et Biophysica Acta , vol.1351 , pp. 287-295
    • Laubach, V.E.1    Zhang, C.X.2    Russell, S.W.3    Murphy, W.J.4    Sherman, P.A.5
  • 37
    • 0032575626 scopus 로고    scopus 로고
    • Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor-κB-binding sites
    • Marks-Konczalik J, Chu SC, Moss J: Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor-κB-binding sites. J Biol Chem 273:22201-22208, 1998
    • (1998) J Biol Chem , vol.273 , pp. 22201-22208
    • Marks-Konczalik, J.1    Chu, S.C.2    Moss, J.3
  • 38
    • 0029941097 scopus 로고    scopus 로고
    • Transcriptional regulation of the human iNOS gene in vascular-smooth-muscle cells and macrophages: Evidence for tissue specificity
    • Kolyada AY, Savikovsky N, Madias NE: Transcriptional regulation of the human iNOS gene in vascular-smooth-muscle cells and macrophages: evidence for tissue specificity. Biochem Biophys Res Commun 220:600-605, 1996.
    • (1996) Biochem Biophys Res Commun , vol.220 , pp. 600-605
    • Kolyada, A.Y.1    Savikovsky, N.2    Madias, N.E.3
  • 39
    • 0030860442 scopus 로고    scopus 로고
    • Transcriptional regulation of human inducible nitric oxide synthase in an intestinal epithelial cell line
    • Linn, SC, Morelli PJ, Edry I, Cottongim SE, Szabo C, Salzman AL: Transcriptional regulation of human inducible nitric oxide synthase in an intestinal epithelial cell line. Am J Physiol 35:G1499-G1508, 1997
    • (1997) Am J Physiol , vol.35
    • Linn, S.C.1    Morelli, P.J.2    Edry, I.3    Cottongim, S.E.4    Szabo, C.5    Salzman, A.L.6
  • 40
    • 0030741468 scopus 로고    scopus 로고
    • Human-and mouse-inducible nitric oxide synthase gene promoters require activation of phosphatidylcholine-specific phospholipase C and NF-κB
    • Spitsin SV, Farber JL, Bertovich M, Moehren G, Koprowski H, Michaels FH: Human-and mouse-inducible nitric oxide synthase gene promoters require activation of phosphatidylcholine-specific phospholipase C and NF-κB. Mol Med 3:315-326, 1997
    • (1997) Mol Med , vol.3 , pp. 315-326
    • Spitsin, S.V.1    Farber, J.L.2    Bertovich, M.3    Moehren, G.4    Koprowski, H.5    Michaels, F.H.6
  • 41
    • 0032816421 scopus 로고    scopus 로고
    • Inhibition of cytokine-induced nitric oxide synthase (iNOS) expression by gene transfer of adenoviral IκBα
    • Taylor, BS, Shao, LF, Gambotto, A, Ganster, RW, Geller, DA. Inhibition of cytokine-induced nitric oxide synthase (iNOS) expression by gene transfer of adenoviral IκBα. Surgery 126:142-147, 1999.
    • (1999) Surgery , vol.126 , pp. 142-147
    • Taylor, B.S.1    Shao, L.F.2    Gambotto, A.3    Ganster, R.W.4    Geller, D.A.5
  • 43
    • 0026490278 scopus 로고
    • Functional analysis of the human vascular cell adhesion molecule 1 promoter
    • Neish AS, Williams AJ, Palmer HJ, Whitley MZ, Collins T: Functional analysis of the human vascular cell adhesion molecule 1 promoter. J Exp Med 176:1583-1593, 1992
    • (1992) J Exp Med , vol.176 , pp. 1583-1593
    • Neish, A.S.1    Williams, A.J.2    Palmer, H.J.3    Whitley, M.Z.4    Collins, T.5
  • 44
    • 0026052725 scopus 로고
    • Cloning of the human gene for intracellular adhesion molecule 1 and analysis of its 5′-regulatory region. Induction by cytokines and phobol ester
    • Voraberger G, Schafer R, Stratowa, C: Cloning of the human gene for intracellular adhesion molecule 1 and analysis of its 5′-regulatory region. Induction by cytokines and phobol ester. J Immunol 147:2777-2786, 1991
    • (1991) J Immunol , vol.147 , pp. 2777-2786
    • Voraberger, G.1    Schafer, R.2    Stratowa, C.3
  • 45
    • 0025601628 scopus 로고
    • Cooperative interaction of nuclear factor-kappa B-and cis regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines
    • Mukaida N, Mahe Y, Matsushima K. Cooperative interaction of nuclear factor-kappa B-and cis regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines. J Biol Chem 265:21128-21133, 1990
    • (1990) J Biol Chem , vol.265 , pp. 21128-21133
    • Mukaida, N.1    Mahe, Y.2    Matsushima, K.3
  • 46
    • 0028179929 scopus 로고
    • NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a non-consensus CRE-like site
    • Cogswell JP, Godlevski MM, Wisely GB, Clay WC, Leesnitzer LM, Ways JP, Gray JG: NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a non-consensus CRE-like site. J Immunol 153:712-723, 1994
    • (1994) J Immunol , vol.153 , pp. 712-723
    • Cogswell, J.P.1    Godlevski, M.M.2    Wisely, G.B.3    Clay, W.C.4    Leesnitzer, L.M.5    Ways, J.P.6    Gray, J.G.7
  • 47
    • 0028068807 scopus 로고
    • Positive and negative regulation of IL-2 gene expression: Role of multiple regulatory sites
    • Zhang L, Nabel GJ: Positive and negative regulation of IL-2 gene expression: role of multiple regulatory sites. Cytokines 6:221-228, 1994
    • (1994) Cytokines , vol.6 , pp. 221-228
    • Zhang, L.1    Nabel, G.J.2
  • 48
    • 0031005027 scopus 로고    scopus 로고
    • Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB
    • Ohmori Y, Schreiber RD, Hamilton TA: Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB. J Biol Chem 272:14899-14907, 1997
    • (1997) J Biol Chem , vol.272 , pp. 14899-14907
    • Ohmori, Y.1    Schreiber, R.D.2    Hamilton, T.A.3
  • 49
    • 0001378811 scopus 로고    scopus 로고
    • Autocrine/paracrine IFNalpha-beta mediates lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: Pivotal role of Stat1alpha induction of the inducible nitric oxide synthase gene
    • Gao JJ, Filla MB, Fultz MJ, Vogel SN, Russell SW, Murphy WJ: Autocrine/paracrine IFNalpha-beta mediates lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha induction of the inducible nitric oxide synthase gene. J Immunol 161:4803-4810, 1998
    • (1998) J Immunol , vol.161 , pp. 4803-4810
    • Gao, J.J.1    Filla, M.B.2    Fultz, M.J.3    Vogel, S.N.4    Russell, S.W.5    Murphy, W.J.6
  • 50
    • 0031679445 scopus 로고    scopus 로고
    • Cytokine induction of NO synthase II in human DLD-1 cells: Roles of the JAK-STAT, AP-1, and NF-κB-signaling pathways
    • Kleinert H, Wallerath T, Fritz G, Ihrig-Biedert I, Geller D, Forstermann U: Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1, and NF-κB-signaling pathways. Br J Pharmacol 125;1:193-201, 1998
    • (1998) Br J Pharmacol , vol.125 , Issue.1 , pp. 193-201
    • Kleinert, H.1    Wallerath, T.2    Fritz, G.3    Ihrig-Biedert, I.4    Geller, D.5    Forstermann, U.6
  • 52
    • 0001153209 scopus 로고    scopus 로고
    • Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria
    • Kun JF, Mordmuller B, Lell B, Lehman LG, Luckner D, Kremsner PG: Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria. Lancet 351:265-266, 1998.
    • (1998) Lancet , vol.351 , pp. 265-266
    • Kun, J.F.1    Mordmuller, B.2    Lell, B.3    Lehman, L.G.4    Luckner, D.5    Kremsner, P.G.6
  • 54
    • 0027939931 scopus 로고
    • Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase
    • Xie Q-W, Kashiwabara Y, Nathan C: Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem 269: 4705-4708, 1994
    • (1994) J Biol Chem , vol.269 , pp. 4705-4708
    • Xie, Q.-W.1    Kashiwabara, Y.2    Nathan, C.3
  • 55
    • 0031006431 scopus 로고    scopus 로고
    • A novel lipopolysaccharide-response element contributes to induction of nitric oxide synthase
    • Xie Q-W: A novel lipopolysaccharide-response element contributes to induction of nitric oxide synthase. J Biol Chem 272:14867-14872,1997
    • (1997) J Biol Chem , vol.272 , pp. 14867-14872
    • Xie, Q.-W.1
  • 56
    • 0029997562 scopus 로고    scopus 로고
    • In vivo footprinting of the mouse inducible nitric oxide synthase gene: Inducible protein occupation of numerous sites including Oct and NF-IL6
    • Goldring CE, Reveneau S, Algarte M, Jeannin JF: In vivo footprinting of the mouse inducible nitric oxide synthase gene: inducible protein occupation of numerous sites including Oct and NF-IL6. Nucl Acids Res 24:1682-1687, 1996
    • (1996) Nucl Acids Res , vol.24 , pp. 1682-1687
    • Goldring, C.E.1    Reveneau, S.2    Algarte, M.3    Jeannin, J.F.4
  • 57
    • 0031160086 scopus 로고    scopus 로고
    • IL-6 induction of protein-DNA complexes via a novel regulatory region of the inducible nitric oxide synthase gene promoter: Role of octamer binding proteins
    • Sawada T, Falk LA, Padmini R, Murphy WJ, Pluznik DV: IL-6 induction of protein-DNA complexes via a novel regulatory region of the inducible nitric oxide synthase gene promoter: role of octamer binding proteins. J Immunol 158:5267-5276, 1997
    • (1997) J Immunol , vol.158 , pp. 5267-5276
    • Sawada, T.1    Falk, L.A.2    Padmini, R.3    Murphy, W.J.4    Pluznik, D.V.5
  • 58
    • 0032559035 scopus 로고    scopus 로고
    • Activation of the iNOS gene promoter by Brn-3 POU family transcription factors is dependent upon the octamer motif in the promoter
    • Gay RD, Dawson SJ, Murphy WJ, Russell SW, Latchman DS: Activation of the iNOS gene promoter by Brn-3 POU family transcription factors is dependent upon the octamer motif in the promoter. Biochem Biophys Acta 1443:315-322, 1998
    • (1998) Biochem Biophys Acta , vol.1443 , pp. 315-322
    • Gay, R.D.1    Dawson, S.J.2    Murphy, W.J.3    Russell, S.W.4    Latchman, D.S.5
  • 59
    • 0033563095 scopus 로고    scopus 로고
    • Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible nitric oxide synthase expression
    • Dlaska M, Weiss G: Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible nitric oxide synthase expression. J Immunol 162:6171-6177, 1999
    • (1999) J Immunol , vol.162 , pp. 6171-6177
    • Dlaska, M.1    Weiss, G.2
  • 60
    • 0028106830 scopus 로고
    • Role of interferon regulatory factor 1 in inducton of nitric oxide synthase
    • Martin E, Nathan C, Xie QW: Role of interferon regulatory factor 1 in inducton of nitric oxide synthase. J Exp Med 180:977-984, 1994
    • (1994) J Exp Med , vol.180 , pp. 977-984
    • Martin, E.1    Nathan, C.2    Xie, Q.W.3
  • 61
    • 0031022516 scopus 로고    scopus 로고
    • An interferon-g-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-γ and LPS
    • Gao J, Morrison DC, Parmely TJ, Russell SW, Murphy WJ: An interferon-g-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-γ and LPS. J Biol. Chem 272:1226-1230, 1997
    • (1997) J Biol. Chem , vol.272 , pp. 1226-1230
    • Gao, J.1    Morrison, D.C.2    Parmely, T.J.3    Russell, S.W.4    Murphy, W.J.5
  • 62
    • 0001378811 scopus 로고    scopus 로고
    • Autocrine/paracrine IFN-αβ mediates the lipopolysaccharide-induced activation of transcription factor Stat1a in mouse macrophages: Pivotal role of Stat1a in induction of the inducible nitric oxide synthase gene
    • Gao JJ, Filla MB, Fultz MJ, Vogel SN, Russell SW, Murphy WJ: Autocrine/paracrine IFN-αβ mediates the lipopolysaccharide-induced activation of transcription factor Stat1a in mouse macrophages: Pivotal role of Stat1a in induction of the inducible nitric oxide synthase gene. J Immunol 161:4803-4810, 1998
    • (1998) J Immunol , vol.161 , pp. 4803-4810
    • Gao, J.J.1    Filla, M.B.2    Fultz, M.J.3    Vogel, S.N.4    Russell, S.W.5    Murphy, W.J.6
  • 63
    • 0029773746 scopus 로고    scopus 로고
    • Both basal and enhancer elements are required for full induction of the mouse inducible nitric oxide synthase gene
    • Murphy WJ, Muroi M, Zhang CX, Suzuki T, Russell SW: Both basal and enhancer elements are required for full induction of the mouse inducible nitric oxide synthase gene. J Endotoxin Res 3:381-393, 1996
    • (1996) J Endotoxin Res , vol.3 , pp. 381-393
    • Murphy, W.J.1    Muroi, M.2    Zhang, C.X.3    Suzuki, T.4    Russell, S.W.5
  • 64
    • 0028850008 scopus 로고
    • The cytokine responsive vascular smooth musle cell enhancer of inducible nitric oxide synthase
    • Spink, J, Cohen J, Evans TJ: The cytokine responsive vascular smooth musle cell enhancer of inducible nitric oxide synthase. J Biol Chem 270:29541-29547, 1995
    • (1995) J Biol Chem , vol.270 , pp. 29541-29547
    • Spink, J.1    Cohen, J.2    Evans, T.J.3
  • 65
    • 0028786601 scopus 로고
    • A hypoxia responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • Melillo G, Musso T, Sica A, Taylor LS, Cox GW, Varesio L: A hypoxia responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med 182:1683-1693, 1995
    • (1995) J Exp Med , vol.182 , pp. 1683-1693
    • Melillo, G.1    Musso, T.2    Sica, A.3    Taylor, L.S.4    Cox, G.W.5    Varesio, L.6
  • 66
    • 0029886747 scopus 로고    scopus 로고
    • Transcriptional basis for hyporepsonsiveness of human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-g
    • Zhang X, Laubach VE, Alley EW, Edwards KA, Sherman PA, Russell SW, Murphy WJ: Transcriptional basis for hyporepsonsiveness of human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-g. J Leukocyte Biol 59:575-585,1996
    • (1996) J Leukocyte Biol , vol.59 , pp. 575-585
    • Zhang, X.1    Laubach, V.E.2    Alley, E.W.3    Edwards, K.A.4    Sherman, P.A.5    Russell, S.W.6    Murphy, W.J.7
  • 67
    • 0032926256 scopus 로고    scopus 로고
    • Expression of the induciible nitric oxide synthase in human monocytic U937 cells allows high output nitric oxide production
    • Bertholet S, Tzeng E, Felley-Bosco E, Mauel J: Expression of the induciible nitric oxide synthase in human monocytic U937 cells allows high output nitric oxide production. J Leukoc Biol 65:50-58, 1999
    • (1999) J Leukoc Biol , vol.65 , pp. 50-58
    • Bertholet, S.1    Tzeng, E.2    Felley-Bosco, E.3    Mauel, J.4
  • 68
    • 0031784643 scopus 로고    scopus 로고
    • Nitric oxide production and nitric oxide synthase type 2 expression by human mononuclear phagocytes: A review
    • Weinberg JB. Nitric oxide production and nitric oxide synthase type 2 expression by human mononuclear phagocytes: a review. [Review] Mol Med 4:557-591, 1998.
    • (1998) Mol Med , vol.4 , pp. 557-591
    • Weinberg, J.B.1
  • 69
    • 0023058975 scopus 로고
    • A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
    • Shaw G, Kamen R: A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46:659-667, 1986
    • (1986) Cell , vol.46 , pp. 659-667
    • Shaw, G.1    Kamen, R.2
  • 70
    • 0000370303 scopus 로고
    • Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators
    • Caput D, Beutler B, Hartog K, Thayer R, Brown-Shimer S, Serami A: Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators. Proc Natl Acad Sci USA 83:1670-1674, 1986
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 1670-1674
    • Caput, D.1    Beutler, B.2    Hartog, K.3    Thayer, R.4    Brown-Shimer, S.5    Serami, A.6
  • 71
    • 0025098538 scopus 로고
    • Endotoxin-reponsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level
    • Han J, Brown T, Beutler B: Endotoxin-reponsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. J Exp Med 171:465-475, 1990
    • (1990) J Exp Med , vol.171 , pp. 465-475
    • Han, J.1    Brown, T.2    Beutler, B.3
  • 72
    • 0030583120 scopus 로고    scopus 로고
    • Expression of human inducible nitric oxide synthase is regulated by both promoter and 3′-regions
    • Nunokawa Y, Oikawa S, Tanaka S: Expression of human inducible nitric oxide synthase is regulated by both promoter and 3′-regions. Biochem Biophys Res Commun 223:347-352, 1996
    • (1996) Biochem Biophys Res Commun , vol.223 , pp. 347-352
    • Nunokawa, Y.1    Oikawa, S.2    Tanaka, S.3
  • 73
    • 0028917561 scopus 로고
    • Structural diversity in the 5′-untranslated region of cytokine-stimulated human inducible nitric oxide synthase mRNA
    • Chu SC, Wu HP, Banks TC, Eissa NT, Moss J: Structural diversity in the 5′-untranslated region of cytokine-stimulated human inducible nitric oxide synthase mRNA. J Biol Chem 270:10625-10630, 1995
    • (1995) J Biol Chem , vol.270 , pp. 10625-10630
    • Chu, S.C.1    Wu, H.P.2    Banks, T.C.3    Eissa, N.T.4    Moss, J.5
  • 74
    • 0343116848 scopus 로고    scopus 로고
    • Alternative splicing of human inducible nitric oxide synthase mRNA: Tissue specific regulation and induction by cytokines
    • Eissa NT, Strauss AJ, Haggerty CM, Choo EK, Chu SC, Moss J: Alternative splicing of human inducible nitric oxide synthase mRNA: tissue specific regulation and induction by cytokines. J Biol Chem 271:27184-27187, 1996
    • (1996) J Biol Chem , vol.271 , pp. 27184-27187
    • Eissa, N.T.1    Strauss, A.J.2    Haggerty, C.M.3    Choo, E.K.4    Chu, S.C.5    Moss, J.6
  • 75
    • 0032560499 scopus 로고    scopus 로고
    • Cloning and characterizaion of human inducible nitric oxide synthase splic variant: A domain, encoded by exons 8 and 9, is critical for dimerization
    • Eissa NT, Yuan JW, Haggerty CM, Choo EK, Palmer CD, Moss J: Cloning and characterizaion of human inducible nitric oxide synthase splic variant: a domain, encoded by exons 8 and 9, is critical for dimerization. Proc Natl Acad Sci USA 95:7625-7630, 1998
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7625-7630
    • Eissa, N.T.1    Yuan, J.W.2    Haggerty, C.M.3    Choo, E.K.4    Palmer, C.D.5    Moss, J.6
  • 76
    • 0029785475 scopus 로고    scopus 로고
    • Competition for tetrahydrobiopterin between phenylalanine hydroxylase and nitric oxide synthase in rat liver
    • Pastor CM, Williams D, Yoneyama T, Hatakeyama K, Singleton, Naylor E, Billiar TR: Competition for tetrahydrobiopterin between phenylalanine hydroxylase and nitric oxide synthase in rat liver. J Biol Chem 271:24534-24538, 1996
    • (1996) J Biol Chem , vol.271 , pp. 24534-24538
    • Pastor, C.M.1    Williams, D.2    Yoneyama, T.3    Hatakeyama, K.4    Naylor, E.5    Billiar, T.R.6
  • 77
    • 0027251094 scopus 로고
    • Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity
    • Harada T, Kagamiyama H, Hatakeyama K: Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity. Science 260: 1507-1510, 1993
    • (1993) Science , vol.260 , pp. 1507-1510
    • Harada, T.1    Kagamiyama, H.2    Hatakeyama, K.3
  • 78
    • 0032929055 scopus 로고    scopus 로고
    • The role protein of phosphatases in the expression of inducible nitric oxide synthase in the rat hepatocyte
    • Taylor BS, Liu S, Villavicencio RT, Ganster RW, Geller DA. The role protein of phosphatases in the expression of inducible nitric oxide synthase in the rat hepatocyte. Hepatology 29:1199-1207, 1999
    • (1999) Hepatology , vol.29 , pp. 1199-1207
    • Taylor, B.S.1    Liu, S.2    Villavicencio, R.T.3    Ganster, R.W.4    Geller, D.A.5
  • 79
    • 0025201481 scopus 로고
    • Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase
    • Knowles RG, Salter M, Brooks SL, Moncada S: Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase. Biochem Biophys Res Commun 172:1042-1048, 1990
    • (1990) Biochem Biophys Res Commun , vol.172 , pp. 1042-1048
    • Knowles, R.G.1    Salter, M.2    Brooks, S.L.3    Moncada, S.4
  • 81
    • 0030060927 scopus 로고    scopus 로고
    • Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor NF-κB
    • Kleinert H, Euchenhofer C, Ihrig-Biedert I, Forstermann U: Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor NF-κB. Mol Pharmacol 1996;49:15-21, 1996
    • (1996) Mol Pharmacol , vol.1996 , Issue.49 , pp. 15-21
    • Kleinert, H.1    Euchenhofer, C.2    Ihrig-Biedert, I.3    Forstermann, U.4
  • 82
    • 0031416497 scopus 로고    scopus 로고
    • Dexamethasone suppresses inducible nitric oxide synthase gene expression by upregulating I-κBα and inhibiting NF-κB
    • de Vera ME, Taylor BS, Wang Q, Shapiro RA, Billiar TR, Geller DA. dexamethasone suppresses inducible nitric oxide synthase gene expression by upregulating I-κBα and Inhibiting NF-κB. Am J Phys 273:G1290-G1296, 1997
    • (1997) Am J Phys , vol.273
    • De Vera Me1    Taylor, B.S.2    Wang, Q.3    Shapiro, R.A.4    Billiar, T.R.5    Geller, D.A.6
  • 83
    • 0028176028 scopus 로고
    • Transforming growth factor-β1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1β in rat smooth muscle cells
    • Perrella MA, Yoshizumi M, Fen Z, Tsai J-C, Hsieh C-M, Kourembanas S, Lee M-E: Transforming growth factor-β1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1β in rat smooth muscle cells. J Biol Chem 269:14595-14600, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 14595-14600
    • Perrella, M.A.1    Yoshizumi, M.2    Fen, Z.3    Tsai, J.-C.4    Hsieh, C.-M.5    Kourembanas, S.6    Lee, M.-E.7
  • 84
    • 0030070297 scopus 로고    scopus 로고
    • Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1ß-stimulated mesangial cells: Evidence for the involvement of transcriptional and posttranscriptional regulation
    • Kunz D, Walker G, Eberhardt W, Pfeilschifter J: Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1ß-stimulated mesangial cells: evidence for the involvement of transcriptional and posttranscriptional regulation. Proc Natl Acad Sci USA 93:255-259, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 255-259
    • Kunz, D.1    Walker, G.2    Eberhardt, W.3    Pfeilschifter, J.4
  • 85
    • 0030658979 scopus 로고    scopus 로고
    • Nitric oxide down-regulates hepatocyte-inducible nitric oxide synthase gene expression
    • Taylor BS, Kim YM, Wang Q, Shapiro RA, Billiar TR, Geller DA. Nitric oxide down-regulates hepatocyte-inducible nitric oxide synthase gene expression. Arch Surg 132:1177-1183, 1997
    • (1997) Arch Surg , vol.132 , pp. 1177-1183
    • Taylor, B.S.1    Kim, Y.M.2    Wang, Q.3    Shapiro, R.A.4    Billiar, T.R.5    Geller, D.A.6
  • 86
    • 0031059681 scopus 로고    scopus 로고
    • Nitric oxide regulates nitric oxide syntase-2 gene expression by inhibiting NF-κB binding to DNA
    • Park SK, Lin HL, Murphy S: Nitric oxide regulates nitric oxide syntase-2 gene expression by inhibiting NF-κB binding to DNA. Biochem J 322: 609-613, 1997
    • (1997) Biochem J , vol.322 , pp. 609-613
    • Park, S.K.1    Lin, H.L.2    Murphy, S.3
  • 87
    • 0027374973 scopus 로고
    • Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide
    • Griscavage JM, Rogers NE, Sherman MP, Ignarro LJ: Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide. J Immunol 151:6329-6337, 1993
    • (1993) J Immunol , vol.151 , pp. 6329-6337
    • Griscavage, J.M.1    Rogers, N.E.2    Sherman, M.P.3    Ignarro, L.J.4
  • 89
    • 0030986262 scopus 로고    scopus 로고
    • Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression
    • Ambs S, Hussain SP, Harris C: Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression. FASEB J 11:443-448, 1997
    • (1997) FASEB J , vol.11 , pp. 443-448
    • Ambs, S.1    Hussain, S.P.2    Harris, C.3
  • 92
    • 0029819656 scopus 로고    scopus 로고
    • Cytokine-induced nitric oxide synthesis in human liver cells is inhibited by the heat shock response
    • de Vera ME, Wong J, Zhou JY, Tzeng E, Wong H, Billiar TR, Geller DA: Cytokine-induced nitric oxide synthesis in human liver cells is inhibited by the heat shock response. Surgery 120:144-149, 1996
    • (1996) Surgery , vol.120 , pp. 144-149
    • De Vera, M.E.1    Wong, J.2    Zhou, J.Y.3    Tzeng, E.4    Wong, H.5    Billiar, T.R.6    Geller, D.A.7
  • 93
    • 0029954682 scopus 로고    scopus 로고
    • Heat shock protein 70 suppresses astroglial-inducible nitric oxide synthase expression by decreasing NF-κB activation
    • Feinstein DL, Galca E, Aquino DA, Li GC, Xu H, Reis DJ. Heat shock protein 70 suppresses astroglial-inducible nitric oxide synthase expression by decreasing NF-κB activation. J Biol Chem 271:17724-17732, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 17724-17732
    • Feinstein, D.L.1    Galca, E.2    Aquino, D.A.3    Li, G.C.4    Xu, H.5    Reis, D.J.6
  • 94
    • 0031031148 scopus 로고    scopus 로고
    • Nitric oxide protects cultured rat hepatocytes from TNFα-induced apoptsosis by inducing heat shock protein 70 expression
    • Kim YM, de Vera ME Watkins SC, Billiar TR: Nitric oxide protects cultured rat hepatocytes from TNFα-induced apoptsosis by inducing heat shock protein 70 expression. J Biol Chem 272:1402-1411, 1997
    • (1997) J Biol Chem , vol.272 , pp. 1402-1411
    • Kim, Y.M.1    De Vera, M.E.2    Watkins, S.C.3    Billiar, T.R.4
  • 95
    • 0025311615 scopus 로고
    • Macrophage deactivating factor and transforming growth factors-b1, -b2, and -b3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-γ
    • Ding A, Nathan CF, Graycar J, Derynck R, Stuehr DJ, Srimal S: Macrophage deactivating factor and transforming growth factors-b1, -b2, and -b3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-γ. J Immunol 145:940-946, 1990.
    • (1990) J Immunol , vol.145 , pp. 940-946
    • Ding, A.1    Nathan, C.F.2    Graycar, J.3    Derynck, R.4    Stuehr, D.J.5    Srimal, S.6
  • 96
    • 0025821493 scopus 로고
    • Transforming growth factor-b2 inihibits interleukin-1β and tumor necrosis factor-α induction of nitric oxide synthase in rat renal mesangial cells
    • Pfeilschifter J, Vosbeck K: Transforming growth factor-b2 inihibits interleukin-1β and tumor necrosis factor-α induction of nitric oxide synthase in rat renal mesangial cells. Biochem Biophys Res Commun 175: 372-375, 1991
    • (1991) Biochem Biophys Res Commun , vol.175 , pp. 372-375
    • Pfeilschifter, J.1    Vosbeck, K.2
  • 97
    • 0026462916 scopus 로고
    • Role of nitric oxide in antagonists effects of transforming growth factor-b and interleukin-1b on the beating rate of cultured cardiac myocytes
    • Roberts AB, Vodovotz Y, Roche NS, Sporn MB, Nathan CF: Role of nitric oxide in antagonists effects of transforming growth factor-b and interleukin-1b on the beating rate of cultured cardiac myocytes. Mol Endocrinol 6:1921-1928, 1992
    • (1992) Mol Endocrinol , vol.6 , pp. 1921-1928
    • Roberts, A.B.1    Vodovotz, Y.2    Roche, N.S.3    Sporn, M.B.4    Nathan, C.F.5
  • 98
    • 0028176028 scopus 로고
    • Transforming growth factor-b1, but not dexamethasone, down regulates nitric oxide synthase mRNA after its induction by interleukin-1b in rat smooth muscle cells
    • Perrella MA, Yoshizumi M, Fen Z, Tsai JC, Hseih CM, Kourembanas S, Lee ME: Transforming growth factor-b1, but not dexamethasone, down regulates nitric oxide synthase mRNA after its induction by interleukin-1b in rat smooth muscle cells. J Biol Chem 269:14595-14600, 1994
    • (1994) J Biol Chem , vol.269 , pp. 14595-14600
    • Perrella, M.A.1    Yoshizumi, M.2    Fen, Z.3    Tsai, J.C.4    Hseih, C.M.5    Kourembanas, S.6    Lee, M.E.7
  • 99
    • 0029666268 scopus 로고    scopus 로고
    • Suppression of interleukin 1-b induced nitric oxide synthase promoter/enhancer activity by transforming growth-b in vascular smooth muscle cells
    • Perrella MA, Patterson C, Tan L, Yet SF, Hseih CM, Yoshizumi M , Lee ME: Suppression of interleukin 1-b induced nitric oxide synthase promoter/enhancer activity by transforming growth-b in vascular smooth muscle cells. J Biol Chem 271:13776-13780, 1996
    • (1996) J Biol Chem , vol.271 , pp. 13776-13780
    • Perrella, M.A.1    Patterson, C.2    Tan, L.3    Yet, S.F.4    Hseih, C.M.5    Yoshizumi, M.6    Lee, M.E.7
  • 100
    • 0027203305 scopus 로고
    • Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor-b
    • Vodovotz Y, Bogdan C, Paik J, Xie QW, Nathan C: Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor-b. J Exp Med 178:605-613, 1993
    • (1993) J Exp Med , vol.178 , pp. 605-613
    • Vodovotz, Y.1    Bogdan, C.2    Paik, J.3    Xie, Q.W.4    Nathan, C.5
  • 102
    • 0027272971 scopus 로고
    • Transforming growth factor beta differentially modulates the inducible nitric oxide synthase gene in distinct cell types
    • Gilbert RS, Herschman HR: Transforming growth factor beta differentially modulates the inducible nitric oxide synthase gene in distinct cell types. Biochem Biophys Res Commun 195:380-384, 1993
    • (1993) Biochem Biophys Res Commun , vol.195 , pp. 380-384
    • Gilbert, R.S.1    Herschman, H.R.2
  • 103
    • 0029962931 scopus 로고    scopus 로고
    • In murine 3T3 fibroblasts, different second messenger pathways resulting in the induction of NO synthase II (iNOS) converge in the activation of transcription factor NF-kappaB
    • Kleinert, H, Euchenhofer C, Ihrig-Biedert I, Forstermann U: In murine 3T3 fibroblasts, different second messenger pathways resulting in the induction of NO synthase II (iNOS) converge in the activation of transcription factor NF-kappaB. J Biol Chem 271:6039-6044, 1996
    • (1996) J Biol Chem , vol.271 , pp. 6039-6044
    • Kleinert, H.1    Euchenhofer, C.2    Ihrig-Biedert, I.3    Forstermann, U.4
  • 105
    • 0002024207 scopus 로고    scopus 로고
    • Transcriptional regulation of the gene encoding nitric oxide synthase
    • Laskin JL, Laskin DL (eds): New York: Marcel Dekker
    • Murphy, WJ. Transcriptional regulation of the gene encoding nitric oxide synthase. In: Laskin JL, Laskin DL (eds): Cellular and Molecular Biology of Nitric Oxide. New York: Marcel Dekker, 1999, pp 1-57.
    • (1999) Cellular and Molecular Biology of Nitric Oxide , pp. 1-57
    • Murphy, W.J.1


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