Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient

Science

Volumn 276, Issue 5321, 1997, Pages 2034-2037

  Stamler, Jonathan S ^a   Jia, Li ^a   Eu, Jerry P ^a   McMahon, Timothy J ^a   Demchenko, Ivan T ^a   Bonaventura, Joseph ^a   Gernert, Kim ^a   Piantadosi, Claude A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN;

ARTICLE; BLOOD FLOW; HEMODYNAMICS; OXYGEN SATURATION; PRIORITY JOURNAL; REGULATORY MECHANISM;

ANIMALS; BLOOD PRESSURE; CEREBROVASCULAR CIRCULATION; CYSTEINE; HEMODYNAMIC PROCESSES; HEMOGLOBINS; MERCAPTOETHANOL; MODELS, MOLECULAR; NITRIC OXIDE; NITROSO COMPOUNDS; OXYGEN; OXYHEMOGLOBINS; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; S-NITROSOTHIOLS;

EID: 0030791742     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.276.5321.2034     Document Type: Article

References (34)

1. L. Stryer, in Biochemistry, L. Stryer, Ed. (Freeman, San Francisco, CA, 1981), pp. 43-82; A. C. Guyton, in Textbook of Medical Physiology (Saunders, Philadelphia, PA, 1981), pp. 208-215, 224-225, 230-245, and 344-355.
2. L. Stryer, in Biochemistry, L. Stryer, Ed. (Freeman, San Francisco, CA, 1981), pp. 43-82; A. C. Guyton, in Textbook of Medical Physiology (Saunders, Philadelphia, PA, 1981), pp. 208-215, 224-225, 230-245, and 344-355.
3. B. Duling and R. M. Berne, Circ. Res. 27, 669 (1970); A. S. Popel, R. N. Pittman, L. Ellsworth [erratum, Am. J. Physiol. 261 (September 1991)] ibid. 256, H921 (1989); D. P. Swain and R. N. Pittman, ibid., p. H247; I. Torres Filho, H. Kerger, M. Intaglietta, Microvasc. Res. 51, 202 (1996); D. Buerk, R. Shonat, C. Riva, S. Cranstoun, ibid. 45, 134 (1993).
4. B. Duling and R. M. Berne, Circ. Res. 27, 669 (1970); A. S. Popel, R. N. Pittman, L. Ellsworth [erratum, Am. J. Physiol. 261 (September 1991)] ibid. 256, H921 (1989); D. P. Swain and R. N. Pittman, ibid., p. H247; I. Torres Filho, H. Kerger, M. Intaglietta, Microvasc. Res. 51, 202 (1996); D. Buerk, R. Shonat, C. Riva, S. Cranstoun, ibid. 45, 134 (1993).
5. B. Duling and R. M. Berne, Circ. Res. 27, 669 (1970); A. S. Popel, R. N. Pittman, L. Ellsworth [erratum, Am. J. Physiol. 261 (September 1991)] ibid. 256, H921 (1989); D. P. Swain and R. N. Pittman, ibid., p. H247; I. Torres Filho, H. Kerger, M. Intaglietta, Microvasc. Res. 51, 202 (1996); D. Buerk, R. Shonat, C. Riva, S. Cranstoun, ibid. 45, 134 (1993).
6. B. Duling and R. M. Berne, Circ. Res. 27, 669 (1970); A. S. Popel, R. N. Pittman, L. Ellsworth [erratum, Am. J. Physiol. 261 (September 1991)] ibid. 256, H921 (1989); D. P. Swain and R. N. Pittman, ibid., p. H247; I. Torres Filho, H. Kerger, M. Intaglietta, Microvasc. Res. 51, 202 (1996); D. Buerk, R. Shonat, C. Riva, S. Cranstoun, ibid. 45, 134 (1993).
7. B. Duling and R. M. Berne, Circ. Res. 27, 669 (1970); A. S. Popel, R. N. Pittman, L. Ellsworth [erratum, Am. J. Physiol. 261 (September 1991)] ibid. 256, H921 (1989); D. P. Swain and R. N. Pittman, ibid., p. H247; I. Torres Filho, H. Kerger, M. Intaglietta, Microvasc. Res. 51, 202 (1996); D. Buerk, R. Shonat, C. Riva, S. Cranstoun, ibid. 45, 134 (1993).
8. M. Intaglietta, P. Johnson, R. Winslow, Cardiovasc. Res. 32, 632 (1996); E. Braunwald, Ed., Heart Disease: A Textbook of Cardiovascular Medicine (Saunders, Philadelphia, PA, 1988); E. Antonini and M. Brunori, Hemoglobin and Myoglobin in Their Reactions with Ligands (Elsevier, New York, 1971).
9. M. Intaglietta, P. Johnson, R. Winslow, Cardiovasc. Res. 32, 632 (1996); E. Braunwald, Ed., Heart Disease: A Textbook of Cardiovascular Medicine (Saunders, Philadelphia, PA, 1988); E. Antonini and M. Brunori, Hemoglobin and Myoglobin in Their Reactions with Ligands (Elsevier, New York, 1971).
10. M. Intaglietta, P. Johnson, R. Winslow, Cardiovasc. Res. 32, 632 (1996); E. Braunwald, Ed., Heart Disease: A Textbook of Cardiovascular Medicine (Saunders, Philadelphia, PA, 1988); E. Antonini and M. Brunori, Hemoglobin and Myoglobin in Their Reactions with Ligands (Elsevier, New York, 1971).
11. M. F. Perutz, in Molecular Basis of Blood Diseases, G. Stammatayanopoulos, Ed. (Saunders, Philadelphia, PA, 1987), pp. 127-178; D. Voet and J. G. Voet, (Wiley, New York, 1995), pp. 215-235.
12. M. F. Perutz, in Molecular Basis of Blood Diseases, G. Stammatayanopoulos, Ed. (Saunders, Philadelphia, PA, 1987), pp. 127-178; D. Voet and J. G. Voet, (Wiley, New York, 1995), pp. 215-235.
13. L. Jia, C. Bonaventura, J. Bonaventura, J. S. Stamler, Nature 380, 221 (1996).
14. A. C. Guyton, in Textbook of Medical Physiology (Saunders, Philadelphia, PA, 1981), pp. 504-513.
15. 2) and GSNO preparations were synthesized and quantified as described in (5).
16. J. S. Stamler et al., data not shown.
17. 2; P < 0.05).
18. Protein modeling was done with SYBYL software from TRIPOS Inc. (St. Louis, MO). Hemoglobin coordinates came from the Brookhaven Protein Data Bank (PDB): In oxy Hb, 1HCO and other PDB coordinate files; in deoxy Hb, 3HHB and other PDB files. NO was modeled onto oxy Hb and deoxy Hb with the use of the bond distances and angles recorded in S. Oae and K. Shinhama [Org. Prep. Proc. Int. 15, 165 (1983)] with rotational freedom about the Cα-Cβ, Cβ, Cβ-Cβ, Sγ-Nδ bonds. Figures were prepared with the program VIEW (L. Bergman, University of North Carolina).
19. 2 tracings were recorded with PC WINDAQ (software, DI-200 AC; DATA Q Instruments, OH). Cerebral blood flow was calculated with the initial slope method [W. D. Heiss and H. Traupe, Stroke 12, 161 (1981); W. Young, ibid. 11, 552 (1980)]. Regional blood flow was monitored for 30 min before and after drug administration (time 0).
20. 2 tracings were recorded with PC WINDAQ (software, DI-200 AC; DATA Q Instruments, OH). Cerebral blood flow was calculated with the initial slope method [W. D. Heiss and H. Traupe, Stroke 12, 161 (1981); W. Young, ibid. 11, 552 (1980)]. Regional blood flow was monitored for 30 min before and after drug administration (time 0).
21. 2 tracings were recorded with PC WINDAQ (software, DI-200 AC; DATA Q Instruments, OH). Cerebral blood flow was calculated with the initial slope method [W. D. Heiss and H. Traupe, Stroke 12, 161 (1981); W. Young, ibid. 11, 552 (1980)]. Regional blood flow was monitored for 30 min before and after drug administration (time 0).
22. P. M. Tibbles and J. S. Edelsberg, N. Engl. J. Med. 334, 1642 (1996).
23. Approximately 0.1 μM SNO-RBCs lowered blood pressure by 7 ± 1 mmHg and ∼0.5 μM SNO-RBCs lowered blood pressure by 16 ± 2 mmHg (n = 8; P < 0.001 versus baseline).
24. M. W. Dewhirst, T. W. Secomb, E. T. Ong, R. Hsu, J. F. Gross, Cancer Res. 54, 3333 (1994); H. Kerger, I. Torres Filho, M. Rivas, R. Winslow, M. Intaglietta, Am. J. Physiol. 268, H802 (1995).
25. M. W. Dewhirst, T. W. Secomb, E. T. Ong, R. Hsu, J. F. Gross, Cancer Res. 54, 3333 (1994); H. Kerger, I. Torres Filho, M. Rivas, R. Winslow, M. Intaglietta, Am. J. Physiol. 268, H802 (1995).
26. K. H. Park, L. E. Rubin, S. S. Gross, R. Levi, Circ. Res. 71, 992 (1992); V. Hampl, S. L. Archer, D. P. Nelson, E. K. Weir, J. Appl. Physiol. 75, 1748 (1993).
27. K. H. Park, L. E. Rubin, S. S. Gross, R. Levi, Circ. Res. 71, 992 (1992); V. Hampl, S. L. Archer, D. P. Nelson, E. K. Weir, J. Appl. Physiol. 75, 1748 (1993).
28. M. Casadevall et al., Gastroenterology 110, 1156 (1996); S.-M. Kasper et al., Anesth. Analg. 83, 921 (1996); J. S. Stamler, Nature 380, 108 (1996); M. G. Persson, L. E. Gustafsson, N. P. Wiklund, P. Hedqvist, S. Moncada, Br. J. Pharmacol. 100, 463 (1990); D. Mitchell and K. Tyml, Am. J. Physiol. 270 (Heart Circ. Physiol. 39), H1696 (1996); C. E. King et al., J. Appl. Physiol. 76, 1166 (1994).
29. M. Casadevall et al., Gastroenterology 110, 1156 (1996); S.-M. Kasper et al., Anesth. Analg. 83, 921 (1996); J. S. Stamler, Nature 380, 108 (1996); M. G. Persson, L. E. Gustafsson, N. P. Wiklund, P. Hedqvist, S. Moncada, Br. J. Pharmacol. 100, 463 (1990); D. Mitchell and K. Tyml, Am. J. Physiol. 270 (Heart Circ. Physiol. 39), H1696 (1996); C. E. King et al., J. Appl. Physiol. 76, 1166 (1994).
30. M. Casadevall et al., Gastroenterology 110, 1156 (1996); S.-M. Kasper et al., Anesth. Analg. 83, 921 (1996); J. S. Stamler, Nature 380, 108 (1996); M. G. Persson, L. E. Gustafsson, N. P. Wiklund, P. Hedqvist, S. Moncada, Br. J. Pharmacol. 100, 463 (1990); D. Mitchell and K. Tyml, Am. J. Physiol. 270 (Heart Circ. Physiol. 39), H1696 (1996); C. E. King et al., J. Appl. Physiol. 76, 1166 (1994).
31. M. Casadevall et al., Gastroenterology 110, 1156 (1996); S.-M. Kasper et al., Anesth. Analg. 83, 921 (1996); J. S. Stamler, Nature 380, 108 (1996); M. G. Persson, L. E. Gustafsson, N. P. Wiklund, P. Hedqvist, S. Moncada, Br. J. Pharmacol. 100, 463 (1990); D. Mitchell and K. Tyml, Am. J. Physiol. 270 (Heart Circ. Physiol. 39), H1696 (1996); C. E. King et al., J. Appl. Physiol. 76, 1166 (1994).
32. M. Casadevall et al., Gastroenterology 110, 1156 (1996); S.-M. Kasper et al., Anesth. Analg. 83, 921 (1996); J. S. Stamler, Nature 380, 108 (1996); M. G. Persson, L. E. Gustafsson, N. P. Wiklund, P. Hedqvist, S. Moncada, Br. J. Pharmacol. 100, 463 (1990); D. Mitchell and K. Tyml, Am. J. Physiol. 270 (Heart Circ. Physiol. 39), H1696 (1996); C. E. King et al., J. Appl. Physiol. 76, 1166 (1994).
33. M. Casadevall et al., Gastroenterology 110, 1156 (1996); S.-M. Kasper et al., Anesth. Analg. 83, 921 (1996); J. S. Stamler, Nature 380, 108 (1996); M. G. Persson, L. E. Gustafsson, N. P. Wiklund, P. Hedqvist, S. Moncada, Br. J. Pharmacol. 100, 463 (1990); D. Mitchell and K. Tyml, Am. J. Physiol. 270 (Heart Circ. Physiol. 39), H1696 (1996); C. E. King et al., J. Appl. Physiol. 76, 1166 (1994).
34. We are indebted to W. Dewhirst for his insight. J.S.S. is a Pew scholar in the biomedical sciences and the recipient of grants from the National Heart, Lung, and Blood Institute (NHLBI) (HL 52529 and HR59130). C.A.P. is funded by the NHLBI.