A role for nitric oxide and other inflammatory mediators in cytokine-induced pancreatic β-cell dysfunction and destruction

Advances in Experimental Medicine and Biology

Volumn 426, Issue , 1997, Pages 313-319

  McDaniel, M L ^a   Corbett, J A ^a   Kwon, G ^a   Hill, J R ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001462775     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4899-1819-2_41     Document Type: Article

References (16)

1. J.A. Corbett, and M.L. McDaniel, Perspectives in Diabetes: Does nitric oxide mediate autoimmune destruction of β-cells? Possible therapeutic interventions in IDDM, Diabetes 41:897 (1992).
2. T. Mandrup-Poulsen, S. Helqvist, L.D. Wogensen, J. Molvig, F. Pociot, J. Johannesen, and J. Nerup, Cytokines and free radicals as effector molecules in the destruction of pancreatic beta cells, Curr. Top. Microbiol. Immunol. 164:169 (1990).
3. A. Rabinovitch, Roles of cytokines in IDDM pathogenesis and islet β-cell destruction, Diabetes Rev. 1: 215 (1993).
4. J.H. Hughes, J.R. Colca, R.A. Easom, J. Turk, and M.L. McDaniel, Interleukin-1 inhibits insulin secretion from isolated rat pancreatic islets by a process that requires gene transcription and mRNA translation, J Clin Invest 86:856 (1990).
5. U. Forstermann, H.H.H.W. Schmidt, J.S. Pollock, H. Sheng, J.A. Mitchell, T.D. Warner, M. Nakane, and F. Murad, Isoforms of nitric oxide synthase, Biochem. Pharmacol. 42:1849 (1991).
6. J.A. Corbett, J.L. Wang, T.P. Misko, W. Zhao, W. Hickey, and M.L. McDaniel, Nitric oxide mediates IL-1β-induced islet dysfunction and destruction: Prevention by dexamethasone, Autoimmunity 15:145 (1993).
7. C. Nathan, Nitric oxide as a secretory product of mammalian cells, FASEB J. 6:3051 (1992).
8. C. Southern, D. Schulster, and I.C. Green, Inhibition of insulin secretion by interleukin-1β and tumor necrosis factor α via an L-arginine-dependent nitric oxide generation mechanism, FEBS Lett. 276:42 (1990).
9. N. Welsh, D.L. Eizirik, K. Bendtzen, and S. Sandler, Interleukin-1β induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of Krebs cycle enzyme aconitase, Endocrinol. 129:3167 (1991).
10. J.A. Corbett, J.R. Lancaster, M.A. Sweetland, and M.L. McDaniel ML, Interleukin 1 induced inhibition of glucose stimulated insulin secretion and the formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans, J. Biol .Chem. 266:21351 (1991).
11. J.A. Corbett, J.L. Wang, J.H. Hughes, B.A. Wolf, M. Sweetland, J.R. Lancaster, and M.L. McDaniel, Nitric oxide and cGMP formation induced by interleukin-1β in islets of Langerhans: Evidence for an effector role of nitric oxide in islet dysfunction, Biochem. J. 287:229 (1992).
12. J.A. Corbett JA, J.L. Wang, M.A. Sweetland, J.R. Lancaster, and M.L. McDaniel, IL-1β induces the formation of nitric oxide by β-cells purified from rodent islets of Langerhans: Evidence for the β-cell as a source and site of action of nitric oxide, J. Clin. Invest. 90:2384 (1992).
13. J.A. Corbett, G. Kwon, T.P. Misko, C.P. Rodi, and M.L. McDaniel, Tyrosine kinase involvement in IL-1β expression of iNOS by β-cells purified from islets of Langerhans, Am. J. Physiol. 267:(Cell Physiol. 36) C48 (1994).
14. J.A. Corbett, M.A. Sweetland, J.R. Lancaster, and M.L. McDaniel, A 1 hour pulse with IL-1β induces the formation of nitric oxide and inhibits insulin secretion by rat islets of Langerhans: Evidence for a tyrosine kinase signaling mechanism, FASEB J. 7:369 (1993).
15. J.A. Corbett, G. Kwon, J. Turk, and M.L. McDaniel, IL-1β induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: Activation of cyclooxygenase by nitric oxide, Biochemistry 32:13767 (1993).
16. 2+ in glucose-induced insulin release by islets, Progress in Lipid Research, 26:125 (1987).