Involvement of Bcl-2 family and caspase-3-like protease in NO-mediated neuronal apoptosis

Journal of Neurochemistry

Volumn 71, Issue 4, 1998, Pages 1588-1596

  Tamatani, Michio ^a   Ogawa, Satoshi ^a   Niitsu, Youichirou ^a   Tohyama, Masaya ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Apoptosis; Bax; Bcl 2; Caspase 3; Inducible nitric oxide synthase; Nitric oxide

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; INTERLEUKIN 1BETA; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; PROTEIN BAX; PROTEIN BCL 2; PROTEINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; CELL HYPOXIA; COCULTURE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REOXYGENATION;

ANIMALIA;

EID: 0031666555     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.71041588.x     Document Type: Article

References (51)

1. Banker G. A. (1980) Trophic interactions between astroglial cells and hippocampal neurons in culture. Science 209, 809-810.
2. Bo L., Dawson T. M., Wesselingh S., Mork S., Choi S., Kong P. A., Hanley D., and Trapp B. D. (1994) Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis. Ann. Neurol. 36, 778-786.
3. Bolaños J. P., Almeida A., Stewart V., Peuchen S., Land J. M., Clark J. B., and Heales S. J. (1997) Nitric oxide-mediated mitochondrial damage in the brain: mechanism and implications for neurodegenerative diseases. J. Neurochem. 68, 2227-2240.
4. Buttini M., Sauter A., and Boddeke H. W. (1994) Induction of interleukin-1β mRNA after focal cerebral ischaemia in the rat. Mol. Brain Res. 23, 126-134.
5. Chao C. C., Hu S., Sheng W. S., Bu D., Bukrinski M. I., and Peterson P. K. (1996) Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism. Glia 16, 276-284.
6. Charriaut-Marlangue C., Margaill I., Represa A., Popovici T., Plotkine M., and Ben-Ari Y. (1996) Apoptosis and necrosis after reversible focal ischemia: an in situ DNA fragmentation analysis. J. Cereb. Blood. Flow Metab. 16, 186-194.
7. Chinnaiyan A. M., Orth K., O'Rourke K., Duan H. J., Poirier G. G., and Dixit V. M. (1996) Molecular ordering of cell death pathway: bcl-2 and bcl-xL function upstream of the ced-3-like apoptotic proteases. J. Biol. Chem. 271, 4573-4576.
8. Chomczynski P. and Sacchi N. (1987) Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
9. Chou S. M., Wang H. S., and Taniguchi A. (1996) Role of SOD-1 and nitric oxide/cyclic GMP cascade on neurofilament aggregation in ALS/MND. J. Neurol. Sci. 139 (Suppl.), 16-26.
10. Davies A. M. (1995) The Bcl-2 family of proteins, and the regulation of neuronal survival. Trends Neurosci. 18, 355-358.
11. Dawson V. L., Dawson T. M., Bartley D. A., Uhl G. R., and Snyder S. H. (1993) Mechanism of nitric oxide mediated neurotoxicity in primary brain cultures. J. Neurosci. 13, 2651-2661.
12. Dawson V. L., Brahmbhatt H. P., Mong J. A., and Dawson T. M. (1994) Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. Neuropharmacology 33, 1425-1430.
13. Dawson V. L., Kizushi V. M., Huang P. L., Snyder S. H., and Dawson T. M. (1996) Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice. J. Neurosci. 16, 2479-2487.
14. Dorheim M. A., Tracey W. R., Pollock J. S., and Grammas P. (1994) Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease. Biochem. Biophys. Res. Commun. 205, 659-665.
15. Dugan L. L., Bruno V. M. G., Amagasu S. M., and Giffard R. G. (1995) Glia modulate the response of murine cortical neurons to excitotoxicity: glia exacerbate AMPA neurotoxicity. J. Neurosci. 15, 4545-4555.
16. Enari M., Talanian R. V., Wong W. W., and Nagata S. (1996) Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380, 723-726.
17. Endoh M., Maiese K., and Wagner J. (1994) Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia. Brain Res. 651, 92-100.
18. Fernandes-Alnemri T., Litwack G., and Alnemri E. S. (1994) CPP32, a novel human apoptotic protein homology to Caenorhabditis elegans cell death protein Ced-3 and a mammalian interleukin 1β-converting enzyme. J. Biol. Chem. 269, 30761-30764.
19. Friedlander R. M., Gagliardini V., Hara H., Fink K. B., Li W., MacDonald G., Fishman M. C., Greenberg A. H., Moskowitz M. A., and Yuan J. (1997) Expression of a dominant negative mutant of interleukin-1b converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J. Exp. Med. 185, 933-940.
20. Good P. F., Werner P., Hsu A., Olanow C. W., and Perl D. P. (1996) Evidence of neuronal oxidative damage in Alzheimer's disease. Am. J. Pathol. 149, 21-28.
21. Hara H., Friedlander R. M., Gagliardini V., Ayata C., Fink K. B., Huang Z., Shimizu-Sasamata M., Yuan J., and Moskowitz M. A. (1997) Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc. Natl. Acad. Sci. USA 94, 2007-2012.
22. Hantraye P., Brouillet E., Ferrante R., Palfi S., Dolan R., Matthews T., and Beal M. F. (1996) Inhibition of neuronal nitric oxide synthase prevents MPTP induced parkinsonism in baboons. Nat. Med. 2, 1017-1021.
23. Huang Z., Huang P. L., Panahian N., Dalkara T., Fishman M. C., and Moskowitz M. A. (1994) Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265, 1883-1885.
24. Iadecola C., Xu X., Zhang F., El-Fakahany E. E., and Ross M. E. (1995a) Marked induction of calcium-independent nitric oxide synthase activity after focal cerebral ischemia. J. Cereb. Blood Flow Metab. 15, 52-59.
25. Iadecola C., Zhang F., and Xu X. (1995b) Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am. J. Physiol. 268, R286-R292.
26. Ii M., Sunamoto M., Ohnishi K., and Ichimori Y. (1996) Beta-amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity. Brain Res. 720, 93-100.
27. Kroemer G. (1997) The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat. Med. 3, 614-619.
28. Kumar S. (1995) ICE-like proteases in apoptosis. Trends Biochem. Sci. 20, 198-202.
29. Lee S. C., Dickson D. W., Liu W., and Brosnan C. F. (1993) Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-γ. J. Neuroimmunol. 46, 19-24.
30. Li Y., Chopp M., Jiang N., Yao F., and Zaloga C. (1995) Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J. Cereb. Blood Flow Metab. 15, 389-397.
31. Lorsbach R. B., Murphy W. J., Lowenstein C. J., Snyder S. H., and Russel S. W. (1993) Expression of the nitric oxide gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-γ and lipopolysaccharide. J. Biol. Chem. 268, 1908-1913.
32. Maeda Y., Matsumoto M., Hori O., Kuwabara K., Ogawa S., Yan S. D., Ohtsuki T., Kinoshita T., Kamada T., and Stern D. (1994) Hypoxia/reoxygenation-mediated induction of astrocytic interleukin 6: a paracrine mechanism potentially enhancing neuron survival. J. Exp. Med. 180, 2297-2308.
33. Martin E., Nathan C., and Xie Q. (1994) Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J. Exp. Med. 180, 977-984.
34. McCarthy K. D. and de Vellis J. (1980) Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85, 890-902.
35. Melillo G., Musso T., Sica A., Taylor L. S., Cox G. W., and Varesio L. (1995) A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J. Exp. Med. 182, 1683-1693.
36. Moncada S. and Higgs A. (1993) The L-arginine-nitric oxide pathway. N. Engl J. Med. 329, 2002-2012.
37. Moncada S., Palmer R. M., and Higgs E. A. (1991) Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43, 109-142.
38. Murphy S. (1993) Astrocytes: Pharmacology and Function. Academic Press, San Diego.
39. Murphy S., Simmons M. L., Agullo L., Garcia A., Feinstein D. L., Garcia E., Reis D. J., Minc-Golomb D., and Schwartz J. P. (1993) Synthesis of nitric oxide in CNS glial cells. Trends Neurosci. 16, 323-328.
40. Murphy T. H., Schnaar R. L., and Coyle J. T. (1990) Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibitor of cystine uptake. FASEB J. 4, 1624-1633.
41. Nathan C. (1992) Nitric oxide as a secretory product of mammalian cells. FASEB J. 6, 3051-3064.
42. Ogawa S., Herwig G., Esposito C., Macaulay A. P., Brett J., and Stern D. (1990) Hypoxia modulates the barrier and coagulant function of cultured bovine endothelium. J. Clin. Invest. 85, 1090-1098.
43. Oltvai Z., Milliman C. L., and Korsmeyer S. J. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74, 609-619.
44. Saito K., Suyama K., Nishida K., Sei Y., and Basile A. S. (1996) Early increase in TNFα, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain. Neurosci. Lett. 206, 149-152.
45. Schultz J. B., Matthews R. T., and Beal M. F. (1995) Role of nitric oxide in neurodegenerative diseases. Curr. Opin. Neurol. 8, 480-486.
46. Shimizu S., Eguchi Y., Kamiike W., Matsuda H., and Tsujimoto Y. (1996) Bcl-2 expression prevents activation of the ICE protease cascade. Oncogene 12, 2251-2257.
47. Skaper S. D., Facci L., and Leon A. (1995) Inflammatory mediator stimulation of astrocytes and meningeal fibroblasts induces neuronal degeneration via the nitridergic pathway. J. Neurochem. 64, 266-276.
48. Steller H. (1995) Mechanism and genes of cellular suicide. Science 267, 1445-1449.
49. Xie Q., Cho H. J., Calaycay J., Mumford R. A., Swiderek K. M., Lee T. D., Ding A., Troso T., and Nathan C. (1992) Cloning and characterization of inducible nitric oxide synthase from mouse macrophage. Science 256, 225-228.
50. Xie Q., Whisnant R., and Nathan C. (1994) Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide. J. Exp. Med. 177, 1779-1784.
51. Zhang Z. G., Chopp M., Gautam S., Zaloga C., Zhang R. L., Schmidt H. H., Pollock J. S., and Forstermann U. (1994) Upregulation of neuronal nitric oxide synthase and mRNA, and selective sparing of nitric oxide synthase-containing neurons after focal cerebral ischemia in rat. Brain Res. 654, 85-95.