Numerous growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner

Blood

Volumn 97, Issue 10, 2001, Pages 3075-3085

  Majka, Marcin ^a,b   Janowska Wieczorek, Anna ^a,b   Ratajczak, Janina ^a,b   Ehrenman, Karen ^a,b   Pietrzkowski, Zbigniew ^a,b   Anna Kowalska, M ^a,b   Gewirtz, Alan M ^a,b   Emerson, Stephen G ^a,b   Ratajczak, Mariusz Z ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; FAS LIGAND; FIBROBLAST GROWTH FACTOR 2; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1; INTERLEUKIN 16; INTERLEUKIN 8; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 3; MONOCYTE CHEMOTACTIC PROTEIN 4; RANTES; SCATTER FACTOR; SOMATOMEDIN C; STEM CELL FACTOR; THROMBOCYTE FACTOR 4; THROMBOPOIETIN; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; BURST FORMING UNIT E; CELL COMMUNICATION AND CELL CONTACT; CELL PROLIFERATION; COLONY FORMING UNIT; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; ENDOTHELIUM CELL; ERYTHROBLAST; GENETIC TRANSCRIPTION; HEMATOPOIESIS; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MACROPHAGE; MEGAKARYOBLAST; MYELOBLAST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0035874498     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.10.3075     Document Type: Article

References (65)

1. Verfaille C. Adhesion receptors as regulators of the hematopoietic process. Blood. 1998;92:2609-2612.
2. Taichman RS, Emerson SG. The role of osteoblasts in the hematopoietic microenvironment. Stem Cells. 1998;16:7-15.
3. Ratajczak MZ, Gewirtz AM. The biology of hemopoietic stem cells. Semin Oncol. 1995;22:210-217.
4. Sharkis SJ, Cremo C, Collector MI, Noga SJ, Donnenberg AD. Thymic regulation of hematopoiesis: isolation of helper and suppressor populations using counterflow centrifugal elutriation. Blood. 1986;68:787-789.
5. Zandstra PW, Lauffenburger DA, Eaves CJ. A ligand-receptor signaling threshold model of stem cell differentiation control: a biologically conserved mechanism applicable to hematopoiesis. Blood. 2000;96:1215-1222.
6. - human umbilical cord blood cells reveals their potentiality to engraft adults. Proc Natl Acad Sci U S A. 1993;90:8707-8711.
7. Watari K, Lansdorp PM, Dragowska W, Mayani H, Schrader JW. Expression of interleukin-1β gene in candidate human hematopoietic stem cells. Blood. 1994;84:36-42.
8. Ratajczak MZ, Kuczynski W, Sokol D, Moore J, Pletcher C, Gewirtz AM. Expression and physiologic significance of kit ligand and stem cell tyrosine kinase-1 receptor ligand expression in normal human CD34+, c-Kit R+ marrow cells. Blood. 1995;86:2161-2167.
9. Behringer D, Kresin V, Henschler R, Mertelsmann R, Lindermann A. Cytokine and chemokine production by CD34+ haematopoietic progenitor cells: detection in single cells. Br J Haematol. 1997;97:9-14.
10. Stopka T, Zivny JH, Stopkova P, Prchal JF. Prchal JT. Human hematopoietic progenitors express erythropoietin. Blood. 1998;91:3766-3772.
11. Majka M, Rozmyslowicz T, Lee B, et al. Bone marrow cD34+ cells and megakaryoblasts secrete β-chemokines that block infection of hematopoietic cells by M-tropic R5 HIV. J Clin Invest. 1999;104:1739-1749.
12. + cells from thymus, cord, and peripheral blood and bone marrow is explained by their ability to produce β-chemokines. Exp Hematol. 2000;28:1334-1342.
13. Wickenhauser C, Lorenzen J, Thiele J, et al. Secretion of cytokines (interleukin-1α, -3, and -6 and granulocyte-macrophage colony stimulating factor) by normal human bone marrow megakaryocytes. Blood. 1995;85:685-691.
14. Jiang S, Levine JD, Fu Y, et al. Cytokine production by primary bone marrow megakaryocytes. Blood. 1994;84:4151-4156.
15. Cluitmans FHM, Esendam BHJ, Landegent JE, Willemze R, Flakenburg JHF. Constitutive in vivo cytokine and hematopoietic growth factor gene expression in the bone marrow and peripheral blood of healthy individuals. Blood. 1995;85:2038-2044.
16. Fortunel N, Hatzfeld J, Kisselev S, et al. Release from quiescence of primitive human hematopoietic stem/progenitor cells by blocking their cell-surface TGF-β type II receptor in a short-term in vitro assay. Stem Cells. 2000;18:102-111.
17. Pierelli L, Marone M, Bonanno G, et al. Modulation of bcl-2 and p27 in human primitive proliferating hematopoietic progenitors by autocrine TGF-β1 is a cycle-independent effect and influences their hematopoietic potential. Blood. 2000;95:3001-3010.
18. Phillips RL, Ernst RE, Brunk B, et al. The genetic program of hematopoietic stem cells. Science. 2000;288:1635-1641.
19. Ratajczak J, Zhang Q, Wojczyk S, Pertusini E, Wasik M, Ratajczak MZ. The role of insulin (INS), and insulin-like growth factor-I (IGF-I) in regulating human erythropoiesis: studies in vitro under serum-free conditions-comparison to other cytokines and growth factors. Leukemia. 1998;12:371-381.
20. Ratajczak MZ, Ratajczak J, Machalinski B, et al. 1998. Role of vascular endothelial growth factor (VEGF), placenta derived growth factor (PIGF)/Flt-1 and Flk-1/KDR receptor axes in human adult and fetal hematopoiesis. Br J Haematol. 1998;103:969-979.
21. Ratajczak MZ, Luger SM, DeRiel K, Abraham J, Calabretta B, Gewirtz AM. Role of the KIT protooncogene in normal and malignant human hematopoiesis. Proc Natl Acad Sci U S A. 1992;89:1710-1714.
22. Majka M, Ratajczak J, Lee B, et al. The role of HIV related chemokine receptors and chemokines in human erythropoiesis in vitro. Stem Cells. 2000;18:128-138.
23. + cells and their transmigration through reconstituted basement membrane. Blood. 1999;93:3379-3390.
24. Ratajczak J, Machalinski B, Samuel A, et al. A novel serum free system for cloning human megakaryocytic progenitors (CFU-Meg): the role of thrombopoietin and other cytokines on bone marrow and cord blood CFU-Meg growth under serum free conditions. Folia Histochem Cytobiol. 1998;36:61-66.
25. Ratajczak MZ, Ratajczak J, Marlicz W, et al. Recombinant human thrombopoietin (TPO) stimulates erythropoiesis by inhibiting erythroid progenitor cell apoptosis. Br J Haematol. 1997;98:8-17.
26. Cines DB, Pollak ES, Buck CA, et al. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood. 1998;91:3527-3561.
27. Aiuti A, Turchetto L, Cota M, et al. Human CD34+ cells express CXCR4 and its ligand stromal derived factor-1: implications for infection by T-cell tropic human immunodeficiency virus. Blood. 1999;94:62-73.
28. Maciaszek JW, Parada NA, Cruishank WW, Center DM, Kornfeld H, Viglianti GA. IL-16 represses HIV-1 promoter activity. J Immunol. 1997;158:5-8.
29. Rollins BJ. Chemokines. Blood. 1997;90:909-928.
30. Moses A, Nelson J, Bagby GC. The influence of human immunodeficiency virus-1 on hematopoiesis. Blood. 1998;91:1479-1495.
31. Peichev M, Naiyer AJ, Pereira D, et al. Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors. Blood. 2000;95:952-958.
32. Nagasawa T, Hirota S, Tachibana K, et al. Defects of B-cell lymphopoiesis and bone marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature. 1996;382:635-638.
33. Zou YR, Kottmann AH, Kuroda M, et al. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature. 1998;393:595-598.
34. + progenitors to peripheral blood. J Exp Med. 1997;185:111-120.
35. Browder TM, Dunbar CE, Nienhuis AW. Private and public autocrine loops in neoplastic cells. Cancer Cells. 1989;1:9-17.
36. Jiang X, Lopez A, Holyoake T, Eaves A, Eaves C. Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia. Proc Natl Acad Sci U S A. 1999;96:12804-12809.
37. Rambaldi A, Wakamiya N, Vellenga E, et al. Expression of the macrophage colony-stimulating factor and c-fms genes in human acute myeloblastic leukemia cells. J Clin Invest. 1998;81:1030-1035.
38. Young DC, Griffin JD. Autocrine secretion of GMCSF in acute myeloblastic leukemia. Blood. 1986;68:1178-1181.
39. Young DC, Wagner K, Griffin JD. Constitutive expression of the granulocyte-macrophage colony-stimulating factor gene in acute myeloblastic leukemia. J Clin Invest. 1997;79:100-106.
40. Pech N, Olivier H, Goldwasser E. Further study of internal autocrine regulation of multipotent hematopoietic cells. Blood. 1993;82:1502-1506.
41. Lu L, Heinrich MC, Wang LS, et al. Retroviral-mediated gene transduction of c-kit into single hematopoietic progenitor cells from cord blood enhances erythroid colony formation and decreases sensitivity of inhibition by tumor necrosis factor-α and transforming growth factor-β1. Blood. 1999;94:2319-2332.
42. Schibler KR, Li Y, Ohls RK, et al. Possible mechanisms accounting for the growth factor independence of hematopoietic progenitors from umbilical cord blood. Blood. 1994;84:3679-3684.
43. Soma T, Dunbar CE. In vivo models for studying the role of autocrine or paracrine growth factors in hematologic malignancies. Exp Hematol. 1995;23:385-388.
44. Lee B, Ratajczak J, Doms RW, Gewirtz AM, Ratajczak MZ. Coreceptor/chemokine receptor expression on human hematopoietic cells: biological implications for HIV-1 infection. Blood. 1999;93:1145-1156.
45. Ratajczak MZ, Ratajczak J, Skorska M, et al. Effect of basic (FGF-2) and acidic (FGF-1) fibroblast growth factors on early hematopoietic cell development. Br J Haematol. 1996;93:772-782.
46. Ratajczak MZ, Marlicz W, Ratajczak J, et al. Effect of hepatocyte growth factor (HGF) on human early haematopoietic cell development. Br J Haematol. 1997;99:228-236.
47. Broudy VC, Kaushansky K. Biology of thrombopoietin. Curr Opin Pediatr. 1998;10:60-64.
48. Solar GP, Kerr WC, Zeigler FC, et al. Role of cmpl in early hematopoiesis. Blood. 1998;92:4-10.
49. Rafli S, Mohle R, Shapiro F, Frey BM, Moore MAS. Regulation of hematopoiesis by microvascular endothelium. Leuk Lymphoma. 1997;27:375-386.
50. Rafil S. Circulating endothelial precursors: mystery, reality, and promise. J Clin Invest. 2000;105:71-77.
51. Simmons PJ, Torok-Storb B. CD34 expression by stromal precursors in normal human adult bone marrow. Blood. 1991;78:2848-2853.
52. Krause DS, Fackler MJ, Civin CI, May WS. CD34 structure, biology, and clinical utility. Blood. 1996;88:2358-2361.
53. Veikkola T, Alitalo K. VEGFs, receptors and angiogenesis. Semin Cancer Biol. 1999;9:211-220.
54. Risau W. Mechanisms of angiogenesis. Nature. 1997;386:671-674.
55. Folkman J, D'Amore PA. Blood vessel formation: what is its molecular basis? Cell. 1996;87:1153-1155.
56. Perez-Atayde AR, Sallan SE, Tedrow U, Connors S, Allred E, Folkman J. Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. Am J Pathol. 1997;150:815-821.
57. Yoshida S, Ono M, Shono T, et al. Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis. Mol Cell Biol. 1997;17:4015-4023.
58. Padro T, Ruiz S, Bieker R, et al. Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia. Blood. 2000;95:2637-2644.
59. Fiedler W, Graeven U, Ergun S, et al. Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia. Blood. 1997;89:1870-1875.
60. Oliva A, Kinter AL, Vaccarezza M, et al. Natural killer cells from human immunodeficiency virus (HIV)-infected individuals are an important source of CC chemokines and suppress HIV-1 entry and replication in vitro. J Clin Invest. 1998;102:223-227.
61. Phillips RL, Ernst RE, Brunk B, et al. The genetic program of hematopoietic stem cells. Science. 2000;288:1635-1640.
62. Wagner L, Yang OO, Garcia-Zepeda EA, et al. Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans. Nature. 1998;391:908-911.
63. Peters R, Leyvraz S, Perey L. Apoptotic regulation in primitive hematopoietic precursors. Blood. 1998;92:2041-2052.
64. Morel PA, Oriss TB. Crossregulation between Th1 and Th2 cells. Crit Rev Immunol. 1998;18:275-303.
65. + haematopoietic bone marrow cells in vitro. Blood. 1997;89:1165-1172.