Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity

Journal of Clinical Investigation

Volumn 104, Issue 7, 1999, Pages 937-945

  Gladwin, Mark T ^a   Schechter, Alan N ^b   Shelhamer, James H ^a   Pannell, Lewis K ^b   Conway, Deirdre A ^b   Hrinczenko, Borys W ^b   Nichols, James S ^a   Pease Fye, Margaret E ^a   Noguchi, Constance T ^b   Rodgers, Griffin P ^b   Ognibene, Frederick P ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; HEMOGLOBIN BETA CHAIN; HEMOGLOBIN S; NITRIC OXIDE; OXYGEN;

ADULT; ARTICLE; CELL MEMBRANE TRANSPORT; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; INHALATIONAL DRUG ADMINISTRATION; MALE; OXYGEN AFFINITY; OXYGEN DISSOCIATION CURVE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN MODIFICATION; SICKLE CELL ANEMIA; TISSUE PERFUSION; TREATMENT OUTCOME;

EID: 0032696892     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI7637     Document Type: Article

References (26)

1. Bunn, H.F. 1997. Pathogenesis and treatment of sickle cell disease. N. Engl. J. Med. 337:762-769.
2. Steinberg, M.H. 1999. Management of sickle cell disease. N. Engl. J. Med. 340:1021-1030.
3. Gaston, B., et al. 1993. Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways. Proc. Natl. Acad. Sci. USA. 90:10957-10961.
4. Stamler, J.S., et al. 1992. Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc. Natl. Acad. Sci. USA. 89:7674-7677.
5. +, NO, and NO- donation by S-nitrosothiols: implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation. Arch. Biochem. Biophys. 318:279-285.
6. Jia, L., Bonaventura, C., Bonaventura, J., and Stamler, J.S. 1996. S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature. 380:221-226.
7. Gow, A.J., and Stamler, J.S. 1998. Reactions between nitric oxide and haemoglobin under physiological conditions. Nature. 391:169-173.
8. Stamler, J.S., et al. 1997. Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science. 276:2034-2037.
9. Head, C.A., et al. 1997. Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo. J. Clin. Invest. 100:1193-1198.
10. Guarnone, R., Centenara, E., and Barosi, G. 1995, Performance characteristics of Hemox-Analyzer for assessment of the hemoglobin dissociation curve. Haematologica. 80:426-430.
11. Green, L.C., et al. 1982. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal. Biochem. 126:131-138.
12. Samouilov, A., and Zweier, J.L. 1998. Development of chemiluminescence-based methods for specific quantitation of nitrosylated thiols. Anal. Biochem. 258:322-330.
13. McMahon, T.J., and Stamler, J.S. 1999. Concerted nitric oxide/oxygen delivery by hemoglobin. Methods Enzymol. 301:99-114.
14. Winterbourn, C.C., and Carrell, R.W. 1977. Oxidation of human haemoglobin by copper. Mechanism and suggested role of the thiol group of residue beta-93. Biochem. J. 165:141-148.
15. Patel, R.P., et al. 1999, Biochemical characterization of human S-nitrosohemoglobin. Effects on oxygen binding and transnitrosation, J. Biol. Chem. 274:15487-15492.
16. Garel, M.C., Domenget, C., Galacteros, F., Martin-Caburi, J., and Beuzard, Y. 1984. Inhibition of erythrocyte sickling by thiol reagents. Mol. Pharmacol. 26:559-565.
17. Garel, M.C., et al. 1986. Covalent binding of glutathione to hemoglobin. I. Inhibition of hemoglobin S polymerization. J. Biol. Chem. 261:14704-14709.
18. Pawloski, J.R., Swaminathan, R.V., and Stamler, J.S. 1998. Cell-free and erythrocytic S-nitrosohemoglobin inhibits human platelet aggregation. Circulation. 97:263-267
19. Fox-Robichaud, A., et al. 1998. Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds. J. Clin. Invest. 101:2497-2505.
20. Gladwin, M.T., Schechter, A.N., Shelhamer, J.H., and Ognibene, F.P. 1999. The acute chest syndrome in sickle cell disease. Possible role of nitric oxide in its pathophysiology and treatment. Am. J. Respir. Crit. Care Med. 159:1368-1376.
21. Atz, A.M., and Wessel, D.L. 1997. Inhaled nitric oxide in sickle cell disease with acute chest syndrome. Anesthesiology. 87:988-990.
22. French, J.A., II, et al. 1997. Mechanisms of stroke in sickle cell disease: sickle erythrocytes decrease cerebral blood flow in rats after nitric oxide synthase inhibition. Blood. 89:4591-4599.
23. Funai, E.F., Davidson, A., Seligman, S.P., and Finlay, T.H. 1997. S-nitrosohemoglobin in the fetal circulation may represent a cycle for blood pressure regulation. Biochem. Biophys. Res. Commun. 239:875-877.
24. Takahashi, Y., et al. 1998. Nitrosyl hemoglobin in blood of normoxic and hypoxic sheep during nitric oxide inhalation. Am. J. Physiol. 274:H349-H357.
25. Rodgers, G.P., et al. 1990. Microcirculatory adaptations in sickle cell anemia: reactive hyperemia response. Am. J. Physiol. 258:H113-H120.
26. Lonsdorfer, J., et al. 1983. Cardiorespiratory adjustments in chronic sickle cell anemia. Bull. Eur. Physiopathol. Respir. 19:339-344.