Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production

Lancet

Volumn 361, Issue 9358, 2003, Pages 676-678

  Lopansri, Bert K ^a   Anstey, Nicholas M ^b   Weinberg, J Brice ^c   Stoddard, Gregory J ^d   Hobbs, Maurine R ^a   Levesque, Marc C ^c   Mwaikambo, Esther D ^e   Granger, Donald L ^a,f  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^b FLINDERS UNIVERSITY   (Australia)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^e HUBERT KAIRUKI MEMORIAL UNIVERSITY   (Tanzania)

^f Division of Infectious Diseases   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ARTICLE; BIOSYNTHESIS; BLOOD LEVEL; BLOOD SAMPLING; BRAIN MALARIA; CHILD; CONTROLLED STUDY; CRYOPRESERVATION; DOWN REGULATION; FEMALE; HUMAN; HUMAN TISSUE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0037460705     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(03)12564-0     Document Type: Article

References (5)

1. Anstey N.M., Weinberg J.B., Hassanali M.Y., et al. Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J Exp Med. 184:1996;557-567.
2. Wu G., Morris S.M. Jr. Arginine metabolism: nitric oxide and beyond. Biochem J. 336:1998;1-17.
3. Meyer J., Richter N., Hecker M. High-performance liquid chromatographic determination of nitric oxide synthase-related arginine derivatives in vitro and in vivo. Anal Biochem. 247:1997;11-16.
4. Kamada Y., Nagaretani H., Tamura S., et al. Vascular endothelial dysfunction resulting from L-arginine deficiency in a patient with lysinuric protein intolerance. J Clin Invest. 108:2001;717-724.
5. Planche T., Dzeing A., Emmerson A.C., et al. Plasma glutamine and glutamate concentrations in Gabonese children with Plasmodium falciparum infection. Q J Med. 95:2002;89-97.