CTLA-4 blockade of antigen-induced cell death

Blood

Volumn 97, Issue 4, 2001, Pages 1134-1137

  Da Rocha Dias, S ^a   Rudd, C E ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS ANTIGEN; INTERLEUKIN 2; LIGAND; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CYTOKINE PRODUCTION; HYBRIDOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0035865522     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.4.1134     Document Type: Article

References (44)

1. The B7 and CD28 receptor families
2. New perspectives of CD28-B7 mediated T cell costimulation
3. The emerging role of CTLA-4 as an immune attenutor
4. CTLA-4 can function as a negative regulator of T cell activation
5. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
6. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
7. CTLA-4 ligation blocks CD28-dependent T cell activation
8. CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction
9. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
10. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
11. CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice
12. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses
13. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
14. Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice
15. Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses
16. Cutting edge: Lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous
17. CTLA-4 regulates tolerance induction and T cell differentiation in vivo
18. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
19. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
20. The role of tyrosine phosphorylation and PTP-1C in CTLA-4 signal transduction
21. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
22. Molecular basis of T cell inactivation by CTLA-4
23. Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation
24. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2
25. Interaction of CTLA-4 with AP-50, a clathrin-coated pit adaptor protein
26. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
27. Cytolytic T lymphocyte-associated antigen-4 and the TCRzeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2
28. Tyrosine phosphatase SHP-2 binding to CTLA-4: Absence of direct YVKM/YFIP motif recognition
29. Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70
30. CTLA-4-mediated inhibition of early events of T cell proliferation
31. CTLA4 ligation attenuates AP-1, NFAT and NF-kappaB activity in activated T cells
32. CTLA-4 ligation suppresses CD28-induced NF-kappaB and AP-1 activity in mouse T cell blasts
33. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
34. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
35. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
36. Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
37. Distinct regulation of T-cell death by CD28 depending on both its aggregation and T-cell receptor triggering: A role for Fas-FasL
38. Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation
39. Requirement of p56lck in T-cell receptor/CD3-mediated apoptosis and Fas-ligand induction in Jurkat cells
40. Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cells
41. Expression of Fas ligand in activated T cells is regulated by c-Myc
42. Sequential involvement of NFAT and Egr transcription factors in FasL regulation
43. Cytotoxic T lymphocyte antigen 4 is induced in the thymus upon in vivo activation and its blockade prevents anti-CD3-mediated depletion of thymocytes
44. Fas-independent death of activated CD4(+) T lymphocytes induced by CTLA-4 cross-linking