Tyrosine-mediated inhibitory signals contribute to CTLA-4 function in vivo

International Immunology

Volumn 16, Issue 4, 2004, Pages 539-547

  Yi, Lou Ann ^a   Hajialiasgar, Soheila ^a   Chuang, Ellen ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Co stimulation; T cell homeostasis; Th1 Th2

Indexed keywords

ADAPTOR PROTEIN; CD28 ANTIGEN; CLATHRIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 4; MITOGENIC AGENT; T LYMPHOCYTE RECEPTOR; TYROSINE; VALINE;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN BINDING; ANTIGEN FUNCTION; ARTICLE; CELL DIVISION; CELL MUTANT; CELL SURFACE; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ENDOCYTOSIS; GENE MUTATION; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; LYMPHADENOPATHY; LYMPHOPROLIFERATIVE DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

AGE FACTORS; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD3; ANTIGENS, CD4; ANTIGENS, CD45; ANTIGENS, DIFFERENTIATION; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CELL COUNT; CELL DIVISION; COCULTURE TECHNIQUES; CROSSES, GENETIC; FEMALE; FLOW CYTOMETRY; INTERFERON TYPE II; INTERLEUKIN-4; L-SELECTIN; LYMPH NODES; LYMPHATIC DISEASES; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; POINT MUTATION; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; TYROSINE;

EID: 1842854703     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxh055     Document Type: Article

References (35)

1. Alegre, M. L., Noel, P. J., Eisfelder, B. J., Chuang, E., Clark, M. R., Reiner, S. L. and Thompson, C. B. 1996. Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J. Immunol. 157:4762.
2. Linsley, P. S., Bradshaw, J., Greene, J., Peach, R., Bennett, K. L. and Mittler, R. S. 1996. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 4:535.
3. Shiratori, T., Miyatake, S., Ohno, H., Nakaseko, C., Isono, K., Bonifacino, J. S. and Saito, T. 1997. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP- 2. Immunity 6:583.
4. Chuang, E., Alegre, M. L., Duckett, C. S., Noel, P. J., Vander Heiden, M. G. and Thompson, C. B. 1997. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J. Immunol. 159:144.
5. Bradshaw, J. D., Lu, P., Leytze, G., Rodgers, J., Schieven, G. L., Bennett, K. L., Linsley, P. S. and Kurtz, S. E. 1997. Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation. Biochemistry 36:15975.
6. Zhang, Y. and Allison, J. P. 1997. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. Proc. Natl Acad. Sci. USA 94:9273.
7. Follows, E. R., McPheat, J. C., Minshull, C., Moore, N. C., Pauptit, R. A., Rowsell, S., Stacey, C. L., Stanway, J. J., Taylor, I. W. and Abbott, W. M. 2001. Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28. Biochem. J. 359:427.
8. Schneider, H., Martin, M., Agarraberes, F. A., Yin, L., Rapoport, I., Kirchhausen, T. and Rudd, C. E. 1999. Cytolytic T lymphocyte-associated antigen-4 and the TCRζ/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. J. Immunol. 163:1868.
9. Schneider, H., Prasad, K. V., Shoelson, S. E. and Rudd, C. E. 1995. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. J. Exp. Med. 181:351.
10. Marengere, L. E., Waterhouse, P., Duncan, G. S., Mittrucker, H. W., Feng, G. S. and Mak, T. W. 1996. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272:1170.
11. Schneider, H., da Rocha Dias, S., Hu, H. and Rudd, C. E. 2001. A regulatory role for cytoplasmic YVKM motif in CTLA-4 inhibition of TCR signaling. Eur. J. Immunol. 31:2042.
12. Nakaseko, C., Miyatake, S., Iida, T., Hara, S., Abe, R., Ohno, H., Saito, Y. and Saito, T. 1999. Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tail. J. Exp. Med. 190:765.
13. Cinek, T., Sadra, A. and Imboden, J. B. 2000. Cutting edge: tyrosine-independent transmission of inhibitory signals by CTLA. J. Immunol. 164:5.
14. Baroja, M. L., Luxenberg, D., Chau, T., Ling, V., Strathdee, C. A., Carreno, B. M. and Madrenas, J. 2000. The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation. J. Immunol. 164:49.
15. Masteller, E. L., Chuang, E., Mullen, A. C., Reiner, S. L. and Thompson, C. B. 2000. Structural analysis of CTLA-4 function in vivo. J. Immunol. 164:5319.
16. Bird, J. J., Brown, D. R., Mullen, A. C., Moskowitz, N. H., Mahowald, M. A., Sider, J. R., Gajewski, T. F., Wang, C. R. and Reiner, S. L. 1998. Helper T cell differentiation is controlled by the cell cycle. Immunity 9:229.
17. Borriello, F., Sethna, M. P., Boyd, S. D., Schweitzer, A. N., Tivol, E. A., Jacoby, D., Strom, T. B., Simpson, E. M., Freeman, G. J. and Sharpe, A. H. 1997. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 6:303.
18. Shahinian, A., Pfeffer, K., Lee, K. P., Kundig, T. M., Kishihara, K., Wakeham, A., Kawai, K., Ohashi, P. S., Thompson, C. B. and Mak, T. W. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261:609.
19. Lane, P., Gerhard, W., Hubele, S., Lanzavecchia, A. and McConnell, F. 1993. Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1. Immunology 80:56.
20. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12:431.
21. h2 responses. J. Immunol. 162:5784.
22. h2 differentiation. J. Immunol. 163:2634-2639.
23. h1 differentiation: IFN-gamma regulates IL-18R alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expression. Nat. Rev. Immunol. 2:389.
24. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL. J. Immunol. 166:3008.
25. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192:303.
26. + regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295.
27. + T cells. Immunity 7:885.
28. Mandelbrot, D. A., McAdam, A. J. and Sharpe, A. H. 1999. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). J. Exp. Med. 189:435.
29. Garside, P. and Mowat, A. M. 2001. Oral tolerance. Semin. Immunol. 13:177.
30. Chambers, C. A., Krummel, M. F., Boitel, B., Hurwitz, A., Sullivan, T. J., Fournier, S., Cassell, D., Brunner, M. and Allison, J. P. 1996. The role of CTLA-4 in the regulation and initiation of T-cell responses. Immunol. Rev. 153:27.
31. Okkenhaug, K., Wu, L., Garza, K. M., La Rose, J., Khoo, W., Odermatt, B., Mak, T. W., Ohashi, P. S. and Rottapel, R. 2001. A point mutation in CD28 distinguishes proliferative signals from survival signals. Nat. Immunol. 2:325.
32. L.J. Immunol. 166:5331.
33. L induction. J. Immunol. 160:12.
34. Chuang, E., Fisher, T. S., Morgan, R. W., Robbins, M. D., Duerr, J. M., Vander Heiden, M. G., Gardner, J. P., Hambor, J. E., Neveu, M. J. and Thompson, C. B. 2000. The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A. Immunity. 13:313.
35. Di Fiore, P. P. and De Camilli, P. 2001. Endocytosis and signaling. an inseparable partnership. Cell 106:1.