Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4

EMBO Journal

Volumn 20, Issue 16, 2001, Pages 4423-4431

  Jäger, Sibylle ^a   Strayle, Jochen ^b   Heinemeyer, Wolfgang ^c   Wolf, Dieter H ^c  

^a BAYER AG   (Germany)

^b MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^c UNIVERSITY OF STUTTGART   (Germany)

Author keywords

Cdc4; Cic1; Proteasome; Protein degradation; SCF

Indexed keywords

ADAPTOR PROTEIN; CELL CYCLE PROTEIN; FUNGAL PROTEIN; PROTEASOME; UBIQUITIN;

ARTICLE; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SACCHAROMYCES CEREVISIAE;

AMINO ACID SEQUENCE; CARRIER PROTEINS; CELL CYCLE PROTEINS; F-BOX PROTEINS; FUNGAL PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE HYDROLASES; PEPTIDE SYNTHASES; PROTEASOME ENDOPEPTIDASE COMPLEX; SACCHAROMYCES CEREVISIAE PROTEINS; SKP CULLIN F-BOX PROTEIN LIGASES; SUBSTRATE SPECIFICITY; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0035882157     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.16.4423     Document Type: Article

References (55)

1. Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation
2. In vivo half-life of a protein is a function of its amino-terminal residue
3. Gene identification using the yeast two-hybrid system
4. The suppressor gene scl1+ of Saccharomyces cerevisiae is essential for growth
5. 1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast
6. The proteasome: Paradigm of a self-compartmentalizing protease
7. The human papillomavirus E7 oncoprotein functionally interacts with the S4 subunit of the 26S proteasome
8. Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly
9. SCF and Cullin/Ring H2-based ubiquitin ligases
10. Epitope-tagged ubiquitin. A new probe for analyzing ubiquitin function
11. Subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope-ER network in yeast
12. Son1p is a component of the 26S proteasome of the yeast Saccharomyces cerevisiae
13. Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism
14. Net results of nucleolar dynamics
15. 2/metaphase
16. The regulatory particle of the Saccharomyces cerevisiae proteasome
17. Structure of 20S proteasome from yeast at 2.4 Å resolution
18. A gated channel into the proteasome core particle
19. Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: Mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival
20. PRE5 and PRE6, the last missing genes encoding 20S proteasome subunits from yeast? Indication for a set of 14 different subunits in the eukaryotic proteasome core
21. The active sites of the eukaryotic 20S proteasome and their involvement in subunit precursor processing
22. The ubiquitin system
23. Proteasomes: Destruction as a programme
24. The PRE4 gene codes for a subunit of the yeast proteasome necessary for peptidylglutamyl-peptide-hydrolyzing activity. Mutations link the proteasome to stress- and ubiquitin-dependent proteolysis
25. In vivo degradation of a transcriptional regulator: The yeast α2 repressor
26. Purification of two high molecular weight proteases from rabbit reticulocyte lysate
27. Proteasome complex as a potential cellular target of hepatitis B virus X protein
28. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
29. A proteolytic pathway that recognizes ubiquitin as a degradation signal
30. Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets
31. The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome
32. Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: Coupling glucose sensing to gene expression and the cell cycle
33. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
34. The abundance of cell cycle regulatory protein Cdc4p is controlled by interactions between its F box and Skp1p
35. Three-dimensional imaging by deconvolution microscopy
36. Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome
37. Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast
38. Combinatorial control in ubiquitin-dependent proteolysis: Don't Skp the F-box hypothesis
39. Immunofluorescence methods for yeast
40. Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly
41. Effects on NF-κB1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome
42. The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair
43. Subcellular localization, stoichiometry and protein levels of 26S proteasome subunits in yeast
44. Rad23 links DNA repair to the ubiquitin/proteasome pathway
45. A yeast nucleolar protein related to mammalian fibrillarin is associated with small nucleolar RNA and is essential for viability
46. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex
47. 1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1
48. The multiubiquitin-chain-binding protein Mcb1 is a component of the 26S proteasome in Saccharomyces cerevisiae and plays a nonessential, substrate-specific role in protein turnover
49. The N-end rule: Functions, mysteries, uses
50. Proteasomal proteomics: Identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes
51. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae
52. Nucleolar Arf sequesters Mdm2 and activates p53
53. Physical association of ubiquitin ligases and the 26S proteasome
54. Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases