Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth

Journal of Biological Chemistry

Volumn 282, Issue 6, 2007, Pages 3428-3432

  Li, Zhe ^a,b   Xu, Mingjiang ^c   Xing, Shu ^a,b   Ho, Wanting Tina ^a   Ishii, Takefumi ^c   Li, Qingshan ^b   Fu, Xueqi ^b   Zhao, Zhizhuang Joe ^a,b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b JILIN UNIVERSITY   (China)

^c UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICANCER DRUG; POLYCYTHEMIA VERA; POTENT INHIBITOR;

BIOASSAY; BIOMEDICAL ENGINEERING; CELL GROWTH; PATIENT TREATMENT; TRANSPLANTS;

ENZYME INHIBITION;

ERLOTINIB; GEFITINIB; IMATINIB; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; GROWTH INHIBITOR; JAK2 PROTEIN, HUMAN; PHENYLALANINE; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; VALINE;

ARTICLE; CELL CULTURE; CELL GROWTH; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; ERYTHROLEUKEMIA CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MYELOPROLIFERATIVE DISORDER; POLYCYTHEMIA VERA; PRIORITY JOURNAL; AMINO ACID SUBSTITUTION; ANIMAL; CELL PROLIFERATION; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; LEUKEMIA CELL LINE; METABOLISM; MOUSE; PATHOLOGY; TUMOR CELL LINE;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DELIVERY SYSTEMS; ENZYME ACTIVATION; GROWTH INHIBITORS; HEMATOPOIETIC STEM CELLS; HUMANS; JANUS KINASE 2; JURKAT CELLS; MICE; PHENYLALANINE; POLYCYTHEMIA VERA; PROTEIN KINASE INHIBITORS; QUINAZOLINES; VALINE;

EID: 33947541141     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C600277200     Document Type: Article

References (26)

1. Blume-Jensen, P., and Hunter, T. (2001) Nature 411, 355-365
2. Druker, B. J. Talpaz, M., Resta, D. J., Peng, B., Buchdunger, E., Ford, J. M., Lydon, N. B., Kantarjian, H., Capdeville, R., Ohno-Jones, S., and Sawyers, C. L. (2001) N. Engl. J. Med. 344, 1031-1037
3. Cools, J., DeAngelo, D. J., Gotlib, J., Stover, E. H., Legare, R. D., Cortes, J., Kutok, J., Clark, J., Galinsky, I., Griffin, J. D., Cross, N. C., Tefferi, A., Malone, J., Alam, R., Schrier, S. L., Schmid, J., Rose, M., Vandenberghe, P., Verhoef, G., Boogaerts, M., Wlodarska, I., Kantarjian, H., Marynen, P., Coutre, S. E., Stone, R., and Gilliland, D. G. (2003) N. Engl. J. Med. 348, 1201-1214
4. Paez, J. G., Janne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., Herman, P., Kaye, F. J., Lindeman, N., Boggon, T. J., Naoki, K., Sasaki, H., Fujii, Y., Eck, M. J., Sellers, W. R., Johnson, G. E., and Meyerson, M. (2004) Science 304, 1497-1500
5. Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., Louis, D. N., Christiani, D. C., Settleman, J., and Haber, D. A. (2004) N. Engl. J. Med. 350, 2129-2139
6. Baxter, E. J., Scott, L. M., Campbell, P. J., East, C., Fourouclas, N., Swanton, S., Vassiliou, G. S., Bench, A. J., Boyd, E. M., Curtin, N., Scott, M. A., Erber, W. N., Green, A. R., and Cancer Genome Project (2005) Lancet 365, 1054-1061
7. Levine, R. L., Wadleigh, M., Cools, J., Ebert, B. L., Wernig, G., Huntly, B. J., Boggon, T. J., Wlodarska, I., Clark, J. J., Moore, S., Adelsperger, J., Koo, S., Lee, J. C., Gabriel, S., Mercher, T., D'Andrea, A., Frohling, S., Dohner, K., Marynen, P., Vandenberghe, P., Mesa, R. A., Tefferi, A., Griffin, J. D., Eck, M. J., Sellers, W. R., Meyerson, M., Golub, T. R., Lee, S. J., and Galliland, D. G. (2005) Cancer Cell 7, 387-397
8. James, C., Ugo, V., Le Couedic, J. P., Staerk, J., Delhommeau, F., Lacout, C., Garcon, L., Raslova, H., Berger, R., Bennaceur-Griscelli, A., Villeval, J. L., Constantinescu, S. N., Casadevall, N., and Vainchenker, W. (2005) Nature 434, 1144-1148
9. Kralovics, R., Passamonti, F., Buser, A. S., Teo, S. S., Tiedt, R., Passweg, J. R., Tichelli, A., Cazzola, M., and Skoda, R. C. (2005) N. Engl. J. Med. 352, 1779-1790
10. Zhao, R., Xing, S., Li, Z., Fu,.X., Li, Q., Krantz, S. B., and Zhao, Z. J. (2005) J. Biol. Chem. 280 22788-22792
11. Steensma, D. P., Dewald, G. W., Lasho, T. L., Powell, H. L., McClure, R. F., Levine, R. L., Gilliland, D. G., and Tefferi, A. (2005) Blood 106, 1207-1209
12. Jones, A. V., Kreil, S., Zoi, K., Waghorn, K., Curtis, C., Zhang, L., Score, J., Seear, R., Chase, A. J., Grand, F. H., White, H., Zoi, C., Loukopoules, D., Terpos, E., Vervessou, E. C., Schultheis, B., Emig, M., Ernst, T., Lengfelder, E., Hehlmann, R., Hochhaus, A., Oscier, D., Silver, R. T., Reiter, A., and Cross, N. C. (2005) Blood 106, 2162-2168
13. Scott, L. M., Campbell, P. J., Baxter, E. J., Todd, T., Stephens. P., Edkins, S., Wooster, R., Stratton, M. R., Futreal, P. A., and Green, A. R. (2005) Blood 106, 2920-2921
14. Jelinek, J., Oki, Y., Gharibyan, V., Bueso-Ramos, C., Prchal, J. T., Verstovsek, S., Beran, M., Estey, E., Kantarjian, H. M., and Issa, J. P. (2005) Blood 106, 3370-3373
15. Levine, R. L., Loriaux, M., Huntly, B. J., Loh, M. L., Beran, M., Stoffregen, E., Berger, R., Clark, J. J., Willis, S. G., Nguyen, K. T., Flores, N. J., Estey, E., Gattermann, N., Armstrong, S., Look, A. T., Griffin, J. D., Bernard, O. A., Heinrich, M. C., Gilliland, D. G., Druker, B., and Deininger, M. W. (2005) Blood 106, 3377-3379
16. Wernig, G., Mercher, T., Okabe, R., Levine, R. L., Lee, B. H., and Gilliland, D. G. (2006) Blood 107, 4274-4281
17. Lacout, C., Pisani, D. F., Tulliez, M., Gachelin, F. M., Vainchenker, W., and Villeval, J. L. (2006) Blood 108, 1652-1660
18. Xu, X., Zhang, Q., Luo, J., Xing, S., Li, Q., Krantz, S. B., Fu, X., and Zhao, Z. J. (2007) Blood 109, 339-342
19. Sandberg, E. M., Ma, X., He, K., Frank, S. J., Ostrov, D. A., and Sayeski, P. P. (2005) J. Med. Chem. 48, 2526-2533
20. Greulich, H., Chen, T. H., Feng, W., Janne, P. A., Alvarez, J. V., Zappaterra, M., Bulmer, S. E., Frank, D. A., Hahn, W. C., Sellers, W. R., and Meyerson, M. (2005) PLoS Med. 2, 1167-1176
21. Druker, B. J., Tamura, S., Buchdunger, E., Ohno, S., Segal, G. M., Fanning, S., Zimmermann, J., and Lydon, N. B. (1996) Nat. Med. 2, 561-566
22. Deininger, M. W., Goldman, J. M., Lydon, N., and Melo, J. V. (1997) Blood 90, 3691-3698
23. Quentmeier, H., MacLeod, R. A., Zaborski, M., and Drexler, H. G. (2006) Leukemia 20, 471-476
24. Oehler, L., Jaeger, E., Eser, A., Sillaber, C., Gisslinger, H., and Geissler, K. (2003) Blood 102, 2240-2242
25. Silver, R. T. (2003) Leukemia 17, 1186-1187
26. Jones, A. V., Silver, R. T., Waghorn, K., Curtis, C., Kreil, S., Zoi, K., Hochhaus, A., Oscier, D., Metzgeroth, G., Lengfelder, E., Reiter, A., Chase, A. J., and Cross, N. C. (2006) Blood 107, 3339-3341