Knockdown of hypoxia-inducible factor-1α in breast carcinoma MCF-7 cells results in reduced tumor growth and increased sensitivity to methotrexate

Biochemical and Biophysical Research Communications

Volumn 342, Issue 4, 2006, Pages 1341-1351

  Li, Jing ^a   Shi, Mingxia ^a   Cao, Ying ^a   Yuan, Wensu ^b   Pang, Tianxiang ^b   Li, Bingzong ^a   Sun, Zhao ^a   Chen, Lei ^b   Zhao, Robert Chunhua ^a,b  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

Author keywords

Angiogenesis; Glycolysis; HIF 1 ; MCF 7; Methotrexate; RNA interference; Tumor growth; Xenograft

Indexed keywords

GLUCOSE TRANSPORTER 1; GLYCOPROTEIN P; HYPOXIA INDUCIBLE FACTOR 1ALPHA; METHOTREXATE; PHOSPHOGLYCERATE KINASE; SHORT HAIRPIN RNA; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST ADENOCARCINOMA; BREAST CARCINOMA; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG SENSITIVITY; FEMALE; GENE TARGETING; GENETIC TRANSFECTION; GROWTH RATE; HUMAN; HUMAN CELL; HYPOXIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE SECTION; TUMOR GROWTH; XENOGRAFT;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE SILENCING; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; METHOTREXATE;

ANIMALIA; MINK CELL FOCUS-FORMING VIRUS;

EID: 33644911773     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.02.094     Document Type: Article

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