Potent CpG oligonucleotides containing phosphodiester linkages: In vitro and in vivo immunostimulatory properties

Biochemical and Biophysical Research Communications

Volumn 297, Issue 1, 2002, Pages 83-90

  Yu, Dong ^a   Zhu, Fu Gang ^a   Bhagat, Lakshmi ^a   Wang, Hui ^b   Kandimalla, Ekambar R ^a   Zhang, Ruiwen ^b   Agrawal, Sudhir ^a  

^a HYBRIDON INC   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

3 3 linked; Anticancer; CpG DNA; IL 12; IL 6; Immunostimulatory; Oligonucleotides; Phosphodiester; Phosphorothioate

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 6; NUCLEASE; OLIGONUCLEOTIDE; PHOSPHODIESTER DEOXYRIBONUCLEIC ACID; PHOSPHOROTHIOATE DEOXYRIBONUCLEIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CPG ISLAND; CYTOKINE RELEASE; DNA SEQUENCE; DRUG POTENCY; FEMALE; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CPG ISLANDS; CYTOKINES; DEOXYRIBONUCLEASES; ENZYME STABILITY; IMMUNITY, CELLULAR; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NF-KAPPA B; OLIGONUCLEOTIDES; SPLEEN; TUMOR CELLS, CULTURED;

BACTERIA (MICROORGANISMS); BOVINAE; MUS MUSCULUS; VERTEBRATA;

EID: 0036384444     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02127-7     Document Type: Article

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