Immunostimulatory properties of phosphorothionate CpG DNA containing both 3′-5′- and 2′-5′-internucleotide linkages

Nucleic Acids Research

Volumn 30, Issue 7, 2002, Pages 1613-1619

  Yu, Dong ^a   Kandimalla, Ekambar R ^a   Zhao, Qiuyan ^a   Cong, Yanping ^a   Agrawal, Sudhir ^a  

^a HYBRIDON INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEOTIDE; DNA; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; NUCLEOTIDE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; CYTOKINE; OLIGONUCLEOTIDE;

ANIMAL CELL; CONTROLLED STUDY; CPG ISLAND; CYTOKINE RELEASE; DNA FLANKING REGION; DNA MODIFICATION; DNA SYNTHESIS; FEMALE; GENE SEQUENCE; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; LINKAGE ANALYSIS; LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CELL DIVISION; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYTOLOGY; DRUG EFFECT; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY; SECRETION; SPLEEN; SPLENOMEGALY;

ANIMALIA; VERTEBRATA;

ANIMALS; CELL DIVISION; CPG ISLANDS; CYTOKINES; DNA; FEMALE; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-6; LYMPHOCYTES; MICE; MICE, INBRED BALB C; OLIGONUCLEOTIDES; SPLEEN; SPLENOMEGALY; THIONUCLEOTIDES;

EID: 0036525602     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (41)

1. Immunology of Bacterial CpG-DNA
2. Immunostimulatory DNA Sequences
3. Antimetastatic effect of CpG DNA mediated by type I IFN
4. NK- and CD8(+) T cell-mediated eradication of established tumors by peritumoral injection of CpG-containing oligodeoxynucleotides
5. Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs
6. Antisense therapeutics: Is it as simple as complementary base recognition?
7. Non-specific antiviral activity of antisense molecules targeted to the E1 region of human papillomavirus
8. Immunization of woodchucks (Marmota monax) with hepatitis delta virus DNA vaccine
9. CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans
10. Vaccination with DNA containing tat coding sequences and unmethylated CpG motifs protects cynomolgus monkeys upon infection with simian/human immunodeficiency virus (SHIV89.6P)
11. Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity
12. Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator
13. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis
14. A Toll-like receptor recognizes bacterial DNA
15. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA
16. Role of Toll-like receptor9 in CpG DNA-induced activation of human cells
17. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
18. Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells
19. CpG motifs in bacterial DNA trigger direct B-cell activation
20. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo
21. Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs
22. Effect of chemical modifications of cytosine and guanine in a CpG-motif of oligonucleotides: Structure-immunostimulatory activity relationships
23. Effect of different chemically modified oligodeoxynucleotides on immune stimulation
24. Site of chemical modifications in CpG containing phosphorothioate oligodeoxynucleotide modulates its immunostimulatory activity
25. Immunostimulatory activity of CpG containing phosphorothioate oligodeoxynucleotide is modulated by modification of a single deoxynucleoside
26. Immunostimulatory activity of CpG oligonucleotides containing non-ionic methylphosphonate linkages
27. Modulation of immunostimulatory activity of CpG oligonucleotides by site-specific deletion of nucleobases
28. Oligoribonucleotides containing 2′,5′-phosphodiester linkages exhibit binding selectivity for 3′,5′-RNA over 3′,5′-ssDNA
29. (2′-5′)-Oligo-3′-deoxynucleotides: Selective binding to single-stranded RNA but not DNA
30. Stereochemistry of 2′,5′ nucleic acids and their constituents
31. NMR structure of a 2′,5′ RNA favors A type duplex with compact C2′ endo nucleotide repeat
32. Mixed backbone antisense oligonucleotides: Design, biochemical and biological properties of oligonucleotides containing 2′-5Pm-ribo- and 3′-5′-deoxyribonucleotide segments
33. 2′,5′-linked oligo-3′-deoxyribonucleoside phosphorothioate chimeras: Thermal stability and antisense inhibition of gene expression
34. Chemistry and biochemistry of 2′,5′-oligoadenylate-based antisense strategy
35. Effects of phosphorothioate oligodeoxyribonucleotide and oligoribonucleotides on human complement and coagulation
36. 3H-1,2-benzodithiole-3-one 1,1-dioxide as an improved sulfurizing reagent in the solid-phase synthesis of oligodeoxyrionucleoside phosphorothioates
37. Pattern and kinetics of cytokine production following administration of phosphorothioate oligonucleotides in mice
38. Immune stimulation by an antisense oligomer complementary to the rev gene of HIV-1
39. Hematopoietic remodeling triggered by CpG DNA
40. Leukocyte stimulation by oligodeoxynucleotides
41. Antisense and/or immunostimulatory oligonucleotide therapeutics