The role of immunomodulatory oligonucleotides in prevention of OVA-induced Eustachian tube dysfunction

International Journal of Pediatric Otorhinolaryngology

Volumn 70, Issue 12, 2006, Pages 2019-2026

  Ebert Jr , Charles S ^a   Rose, Austin S ^a   Patel, Mihir R ^a   Hardy, Stuart M ^a   Kandimalla, Ekambar R ^b   Agrawal, Sudhir ^b   Prazma, Jiri ^a   Pillsbury III, Harold C ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b HYBRIDON INC   (United States)

Author keywords

Allergy; Eustachian tube dysfunction; Oligonucleotide; Otitis media; Transtympanic

Indexed keywords

OLIGONUCLEOTIDE; OVALBUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDITORY TUBE DYSFUNCTION; CONTROLLED STUDY; DRUG POTENCY; FUNCTION TEST; IMMUNOMODULATION; MALE; MIDDLE EAR; MUCOCILIARY TRANSPORT; NONHUMAN; PRESSURE MEASUREMENT; PRIORITY JOURNAL; PROPHYLAXIS; PROVOCATION TEST; RANDOMIZATION; RAT; SENSITIZATION;

ANIMALS; DISEASE MODELS, ANIMAL; EUSTACHIAN TUBE; IMMUNOLOGIC FACTORS; INJECTIONS, SUBCUTANEOUS; MALE; OLIGONUCLEOTIDES; OTITIS MEDIA WITH EFFUSION; OVALBUMIN; RANDOM ALLOCATION; RATS; RATS, INBRED BN;

EID: 33750828452     PISSN: 01655876     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijporl.2006.07.016     Document Type: Article

References (40)

1. Shekelle P., Takata G., Chan L.S., et al. Diagnosis, natural history, and late effects of otitis media with effusion. Evid. Rep. Technol. Assess. (Summ.) 55 (2002) 1-5
2. Stool S.E., Berg A.O., Berman S., et al. Otitis media with effusion in young children. Clincal Practice Guideline, Number 12 Agency for Health Care Policy Research (1994), Public Health Service, US Department of Health and Human Services, Rockville, MD
3. Daly K.A., Hunter L.L., and Giebink G.S. Chronic otitis media with effusion. Pediatr. Rev. 20 3 (1999) 85-93 quiz 4
4. Rosenfeld R.M., Culpepper L., Doyle K.J., et al. Clinical practice guideline: otitis media with effusion. Otolaryngol. Head Neck Surg. 130 5 Suppl. (2004) S95-S118
5. Bondy J., Berman S., Glazner J., and Lezotte D. Direct expenditures related to otitis media diagnoses: extrapolations from a pediatric medicaid cohort. Pediatrics 105 6 (2000) E72
6. Rovers M.M., Schilder A.G., Zielhuis G.A., and Rosenfeld R.M. Otitis media. Lancet 363 9407 (2004) 465-473
7. Casselbrant M.L. Epidemiology. In: Rosenfeld R.M., and Bluestone C.D. (Eds). Evidence-based Otitis Media. 2nd ed. (2003), BC Decker Inc., Hamilton, Ontario 147-162
8. Tos M. Epidemiology and natural history of secretory otitis. Am. J. Otol. 5 6 (1984) 459-462
9. Williamson I.G., Dunleavey J., Bain J., and Robinson D. The natural history of otitis media with effusion-a three-year study of the incidence and prevalence of abnormal tympanograms in four South West Hampshire infant and first schools. J. Laryngol. Otol. 108 11 (1994) 930-934
10. Bernstein J.M. Role of allergy in Eustachian tube blockage and otitis media with effusion: a review. Otolaryngol. Head Neck Surg. 114 4 (1996) 562-568
11. Daly K.A., Rovers M.M., Hoffman H.J., et al. Recent advances in otitis media. 1. Epidemiology, natural history, and risk factors. Ann. Otol. Rhinol. Laryngol. Suppl. 194 (2005) 8-15
12. Bluestone C.D., and Doyle W.J. Anatomy and physiology of Eustachian tube and middle ear related to otitis media. J. Allergy Clin. Immunol. 81 5 Pt 2 (1988) 997-1003
13. Alho O.P., Oja H., Koivu M., and Sorri M. Risk factors for chronic otitis media with effusion in infancy. Each acute otitis media episode induces a high but transient risk. Arch. Otolaryngol. Head Neck Surg. 121 8 (1995) 839-843
14. Doyle W.J. The link between allergic rhinitis and otitis media. Curr. Opin. Allergy Clin. Immunol. 2 1 (2002) 21-25
15. Hunt C.E., Lesko S.M., Vezina R.M., et al. Infant sleep position and associated health outcomes. Arch. Pediatr. Adolesc. Med. 157 5 (2003) 469-474
16. Barenkamp S.J., Kurono Y., Ogra P.L., et al. Recent advances in otitis media. 5. Microbiology and immunology. Ann. Otol. Rhinol. Laryngol. Suppl. 194 (2005) 60-85
17. Bluestone C.D. Epidemiology and pathogenesis of chronic suppurative otitis media: implications for prevention and treatment. Int. J. Pediatr. Otorhinolaryngol. 42 3 (1998) 207-223
18. Hardy S.M., Heavner S.B., White D.R., McQueen C.T., Prazma J., and Pillsbury H.C. Late-phase allergy and Eustachian tube dysfunction. Otolaryngol. Head Neck Surg. 125 4 (2001) 339-345
19. Downs B.W., Butehorn III H.F., Prazma J., Rose A.S., Stamat J.C., and Pillsbury III H.C. Action of histamine on Eustachian tube function. Otolaryngol. Head Neck Surg. 124 4 (2001) 414-420
20. Hurst D.S., Amin K., Seveus L., and Venge P. Evidence of mast cell activity in the middle ears of children with otitis media with effusion. Laryngoscope 109 3 (1999) 471-477
21. Irander K., Borres M.P., and Bjorksten B. Middle ear diseases in relation to atopy and nasal metachromatic cells in infancy. Int. J. Pediatr. Otorhinolaryngol. 26 1 (1993) 1-9
22. Sobol S.E., Taha R., Schloss M.D., et al. T(H)2 cytokine expression in atopic children with otitis media with effusion. J. Allergy Clin. Immunol. 110 1 (2002) 125-130
23. Kandimalla E.R., and Agrawal S. Agonists of toll-like receptor 9: modulation of host immune responses with synthetic oligodeoxynucleotides. In: Rich T. (Ed). Toll and Toll-like Receptors: An Immunological Perspective (2005), Kluwer Academic/Plenum Publishers, New York 181-212
24. Klinman D.M. Use of CpG oligodeoxynucleotides as immunoprotective agents. Expert Opin. Biol. Ther. 4 6 (2004) 937-946
25. Agrawal D.K., Edwan J., Kandimalla E.R., et al. Novel immunomodulatory oligonucleotides prevent development of allergic airway inflammation and airway hyperresponsiveness in asthma. Int. Immunopharmacol. 4 1 (2004) 127-138
26. Zhu F.G., Kandimalla E.R., Yu D., Tang J.X., et al. Modulation of ovalbumin-induced Th2 responses by second-generation immunomodulatory oligonucleotides in mice. Int. Immunopharmacol. 4 7 (2004) 851-862
27. Kandimalla E.R., Bhagat L., Wang D., Yu D., et al. Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles. Nucleic Acids Res. 31 9 (2003) 2393-2400
28. Ebert Jr. C.S., Pollock H.W., Dubin M.G., et al. Effect of intranasal histamine challenge on Eustachian tube function. Int. J. Pediatr. Otorhinolaryngol. 63 3 (2002) 189-198
29. Flisberg K., Ingelstedt S., and Ortegren U. The valve and "locking" mechanisms of the Eustachian tube. Acta Otolaryngol. Suppl. 182 (1963) 57-68
30. Takahashi H., Hayashi M., Sato H., and Honjo I. Primary deficits in Eustachian tube function in patients with otitis media with effusion. Arch. Otolaryngol. Head Neck Surg. 115 5 (1989) 581-584
31. Miller Jr. G.F. Eustachian tubal function in normal and diseased ears. Arch. Otolaryngol. 81 (1965) 41-48
32. White D.R., Heavner S.B., Hardy S.M., and Prazma J. Gastroesophageal reflux and Eustachian tube dysfunction in an animal model. Laryngoscope 112 6 (2002) 955-961
33. Gossett P., Tillie-Leblond I., Malaquin F., et al. Interleukin-8 secretion in patients with allergic rhinits after an allergen challenge: interleukin-8 is not the main chemotactic factor present in nasal lavages. Clin. Exp. Allergy 27 4 (1997) 379-388
34. Jero J., Virlainen A., Virtanen M., Eskola J., et al. Factors predicting poor outcome of acute otitis media in children. In: Lim D.J., Bluestone C.D., Casselbrant M., Klein J.O., and Ogra P.L. (Eds). Proceedings of the Sixth International Symposium on Recent Advances in Otitis Media (1996), BC Decker, Hamilton, Canada 78-80
35. Hurst D.S., and Venge P. Levels of eosinophil cationic protein and myeloperoxidase from chronic middle ear effusion in patients with allergy and/or acute infection. Otolaryngol. Head Neck Surg. 114 4 (1996) 531-544
36. Wright E.D., Husrt D., Miotto D., Giguere C., et al. Increased expression of major basic protein (MBP) and interleukin-5 (IL-5) in middle ear biopsy specimens from atopic patients with persistent otitis media with effusion. Otolaryngol. Head Neck Surg. 123 5 (2000) 533-538
37. Hurst D.S., and Venge P. Evidence of eosinophil, neutrophil, and mast-cell mediators in the effusion of OME patients with and without atopy. Allergy 55 5 (2000) 435-441
38. Li Y., Kandimalla E.R., and Agrawal S. Oligodeoxynucleotides containing synthetic immunostimulatory motifs augment potent Th1 immune responses to HBsAg in mice. Int. Immunopharmacol. 5 (2005) 981-991
39. Passalacqua G., and Canonica G.W. Treating the allergic patient: think globally, treat globally. Allergy 57 10 (2002) 876-883
40. Johansson S.G., Hourihane J.O., Bousquet J., et al. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 56 9 (2001) 813-824