Vesicular acetylcholine transporter can be a morphological marker for the reinnervation to muscle of regenerating motor axons

Neuroscience Research

Volumn 48, Issue 3, 2004, Pages 305-314

  Maeda, Mitsuyo ^a   Ohba, Norihiro ^a   Nakagomi, Saya ^a   Suzuki, Yasuhiro ^a   Kiryu Seo, Sumiko ^a   Namikawa, Kazuhiko ^a   Kondoh, Wataru ^a   Tanaka, Akemi ^a   Kiyama, Hiroshi ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Axotomy; Biotin dextran; Electron microscopy; Fluoro Gold; Hypoglossal nerve; Immunocytochemistry; Neuromuscular junction; Rat

Indexed keywords

ACETYLCHOLINE; BIOTIN DERIVATIVE; DEXTRAN; FLUOROGOLD; MARKER; TRACER; VESICULAR ACETYLCHOLINE TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; HYPOGLOSSAL NERVE; IMMUNOCOMPETENT CELL; IMMUNOCYTOCHEMISTRY; MALE; MOTOR NERVE; MUSCLE REINNERVATION; NERVE CRUSH; NERVE ENDING; NERVE FIBER; NERVE FIBER GROWTH; NERVE FIBER TRANSECTION; NERVE REGENERATION; NEUROMUSCULAR SYNAPSE; NONHUMAN; POSTOPERATIVE PERIOD; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYNAPSE VESICLE; TONGUE;

EID: 1242338818     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2003.11.008     Document Type: Article

References (22)

1. Arvidsson U., Riedl M., Elde R., Meister B. Vesicular acetylcholine transporter (VAChT) protein: a novel and unique marker for cholinergic neurons in the central and peripheral nervous systems. J. Comp. Neurol. 378:1997;454-467.
2. Cajal, R.Y., 1928. Degeneration and Regeneration of the Nervous Sysytem. Oxford University Press, London.
3. Erickson J.D., Varoqui H., Schafer M.K., Modi W., Diebler M.F., Weihe E., Rand J., Eiden L.E., Bonner T.I., Usdin T.B. Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locus. J. Biol. Chem. 269:1994;21929-21932.
4. Fernandes K.J., Fan D.P., Tsui B.J., Cassar S.L., Tetzlaff W. Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: differential regulation of GAP-43, tubulins, and neurofilament-M. J. Comp. Neurol. 414:1999;495-510.
5. Gilmor M.L., Nash N.R., Roghani A., Edwards R.H., Yi H., Hersch S.M., Levey A.I. Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles. J. Neurosci. 16:1996;2179-2190.
6. Hirota H., Kiyama H., Kishimoto T., Taga T. Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma. J. Exp. Med. 183:1996;2627-2634.
7. Ichikawa T., Ajiki K., Matsuura J., Misawa H. Localization of two cholinergic markers, choline acetyltransferase and vesicular acetylcholine transporter in the central nervous system of the rat: in situ hybridization histochemistry and immunohistochemistry. J. Chem. Neuroanat. 13:1997;23-39.
8. Laurence K.M. Prenatal detection and prevention of neural tube defects in South Wales. J. R. Soc. Health. 106:1986;153-160.
9. Li J.Y., Dahlstrom A.M., Hersh L.B., Dahlstrom A. Fast axonal transport of the vesicular acetylcholine transporter (VAChT) in cholinergic neurons in the rat sciatic nerve. Neurochem. Int. 32:1998;457-467.
10. Namikawa K., Honma M., Abe K., Takeda M., Mansur K., Obata T., Miwa A., Okado H., Kiyama H. Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration. J. Neurosci. 20:2000;2875-2886.
11. Nguyen Q.T., Sanes J.R., Lichtman J.W. Pre-existing pathways promote precise projection patterns. Nat. Neurosci. 5:2002;861-867.
12. Novikova L., Novikov L., Kellerth J.O. Persistent neuronal labeling by retrograde fluorescent tracers: a comparison between Fast Blue, Fluoro-Gold and various dextran conjugates. J. Neurosci. Methods. 74:1997;9-15.
13. Phanithi P.B., Yoshida Y., Santana A., Su M., Kawamura S., Yasui N. Mild hypothermia mitigates post-ischemic neuronal death following focal cerebral ischemia in rat brain: immunohistochemical study of Fas, caspase-3 and TUNEL. Neuropathology. 20:2000;273-282.
14. Rajakumar N., Elisevich K., Flumerfelt B.A. Biotinylated dextran: a versatile anterograde and retrograde neuronal tracer. Brain Res. 607:1993;47-53.
15. Roghani A., Shirzadi A., Kohan S.A., Edwards R.H., Butcher L.L. Differential distribution of the putative vesicular transporter for acetylcholine in the rat central nervous system. Brain Res. Mol. Brain Res. 43:1996;65-76.
16. Schafer M.K., Weihe E., Varoqui H., Eiden L.E., Erickson J.D. Distribution of the vesicular acetylcholine transporter (VAChT) in the central and peripheral nervous systems of the rat. J. Mol. Neurosci. 5:1994;1-26.
17. Schmued L.C., Fallon J.H. Fluoro-Gold: a new fluorescent retrograde axonal tracer with numerous unique properties. Brain Res. 377:1986;147-154.
18. Shu S.Y., Ju G., Fan L.Z. The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system. Neurosci. Lett. 85:1988;169-171.
19. Usdin T.B., Eiden L.E., Bonner T.I., Erickson J.D. Molecular biology of the vesicular ACh transporter. Trends Neurosci. 18:1995;218-224.
20. Wang W., Salvaterra P.M., Loera S., Chiu A.Y. Brain-derived neurotrophic factor spares choline acetyltransferase mRNA following axotomy of motor neurons in vivo. J. Neurosci. Res. 47:1997;134-143.
21. Weihe E., Tao-Cheng J.H., Schafer M.K., Erickson J.D., Eiden L.E. Visualization of the vesicular acetylcholine transporter in cholinergic nerve terminals and its targeting to a specific population of small synaptic vesicles. Proc. Natl. Acad. Sci. U.S.A. 93:1996;3547-3552.
22. Zhang L., McClellan A.D. Fluorescent tracers as potential candidates for double labeling of descending brain neurons in larval lamprey. J. Neurosci. Methods. 85:1998;51-62.