Adipophilin Enhances Lipid Accumulation and Prevents Lipid Efflux from THP-1 Macrophages: Potential Role in Atherogenesis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 24, Issue 3, 2004, Pages 504-510

  Larigauderie, Guilhem ^a   Furman, Christophe ^a   Jaye, Michael ^b   Lasselin, Catherine ^a   Copin, Corinne ^a   Fruchart, Jean Charles ^a   Castro, Graciela ^a   Rouis, Mustapha ^a  

^a INSTITUT PASTEUR DE LILLE   (France)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Acetylated LDL; Adipophilin; Atherosclerosis; Cholesterol efflux; Macrophage

Indexed keywords

ACETYL LOW DENSITY LIPOPROTEIN; ADIPOPHILIN; CELL PROTEIN; CHOLESTEROL ESTER; LOW DENSITY LIPOPROTEIN RECEPTOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTERY INTIMA; ARTICLE; ATHEROGENESIS; BINDING AFFINITY; CELL LINE; CELL STIMULATION; CHEMICAL MODIFICATION; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIPID STORAGE; LIPID TRANSPORT; MACROPHAGE; PRIORITY JOURNAL; PROTEIN FUNCTION;

APOLIPOPROTEIN A-I; CAROTID ARTERY DISEASES; CELL DIFFERENTIATION; CELL LINE; CHOLESTEROL; CHOLESTEROL ESTERS; DNA, COMPLEMENTARY; ENDARTERECTOMY, CAROTID; FOAM CELLS; GENE SILENCING; HUMANS; LIPID METABOLISM; LIPOPROTEINS, LDL; MACROPHAGES; MONOCYTES; PEPTIDES; RECEPTORS, IMMUNOLOGIC; RECEPTORS, SCAVENGER; RNA, MESSENGER; RNA, SMALL INTERFERING; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION; TRIGLYCERIDES;

EID: 1542373710     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000115638.27381.97     Document Type: Article

References (50)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
2. Erown MS, Goldstein JL. Lipoprotein metabolism in the macrophage: implication for cholesterol deposition in atherosclerosis. Ann Rev Biochem. 1983;52:223-261.
3. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989;320:915-924.
4. Martens JS, Lougheed M, Gomez-Munoz A, Steinbrecher UP. A modification of apolipoprotein B accounts for most of the induction of macrophage growth by oxidized low density lipoprotein. J Biol Chem. 1999;274:10903-10910.
5. Huang Y, Schafer-Elinder L, Wu R, Claesson H, Frostegard J. Lysophosphatidylcholine (LPC) induces proinflammatory cytokines by a platelet-activating factor (PAF) receptor-dependent mechanism. Clin Exp Immunol. 1999;116:326-331.
6. Huang Y, Mironova M, Lopes-Villera M. Oxidized LDL stimulates matrix metalloproteinase-1 expression in human vascular endothelial cells. Arterioscler Thromb Vasc Biol. 1999;19:2640-2647.
7. Huang A, Li C, Kao R, Stone W. Lipid hydroperoxides inhibit nitric oxide production in RAW264.7 macrophages. Free Radic Biol Med. 1999;26:526-537.
8. Jong M, Hendriks W, van Vark L, Dahlmans V, Groener J, Havekes L. Oxidized VLDL induces less triglyceride accumulation in J774 macrophages than native VLDL due to an impaired extracellular lipolysis. Arterioscler Thromb Vasc Biol. 2000;20:144-151.
9. Gomez-Munoz A, Martens J, Steinbrecher U. Stimulation of phospholipase D activity by oxidized LDL in mouse peritoneal macrophages. Arterioscler Thromb Vasc Biol. 2000;20:135-143.
10. Shiffman D, Mikita T, Tai J, Wade D, Porter J, Seilhamer J, Somogyi R, Liang S, Lawn R. Large scale gene expression analysis of cholesterol-loaded macrophages. J Biol Chem. 2000;275:37324-37332.
11. Yachang F, Nanlan L, Lopes-Virella MF, Timothy G. The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages. Atherosclerosis. 2002;165:259-269.
12. Jiang HP, Serrero G. Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Proc Natl Acad Sci USA. 1992;89:7856-7860.
13. Brasaemle DL, Barber T, Wolins NE, Serrero G, Blanchette-Mackie EJ, Londos C. Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J Lipid Res. 1997;38:2249-2263.
14. Heid HW, Moll R, Schwetlick I, Rackwitz HR, Keenan TW. Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases. Cell Tissue Res. 1998;294:309-321.
15. Wang X, Reape TJ, Li X, Rayner K, Webb CL, Burnand KG, Lysko PG. Induced expression of adipophilin mRNA in human macrophages stimulated with oxidized low-density lipoprotein and in atherosclerotic lesions. FEBS Lett. 1999;462:145-150.
16. Buechler C, Ritter M, Duong CQ, Orso E, Kapinsky M, Schmitz G. Adipophilin is a sensitive marker for lipid loading in human blood monocytes. Biochim Biophys Acta. 2001;1532:97-104.
17. Vosper H, Patel L, Graham TL, Khoudoli GA, Hill A, Macphee CH, Pinto I, Smith SA, Suckling KE, Wolf CR, Palmer CN. The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages. J Biol Chem. 2001;276:44258-44265.
18. Lada AT, Rudel LL, St Clair RW. Effects of LDL enriched with different dietary fatty acids on cholesteryl ester accumulation and turnover in THP-1 macrophages. J Lipid Res. 2003;44:770-779.
19. Havel R, Eder H, Bradgon J. The distribution and chemical composition of ultracentrifugally separated lipoprotein in human serum. J. Clin. Invest. 1955;3:1345-1353.
20. Basu SK, Goldstein JL, Anderson RGW, Brown MS. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc Natl Acad Sci USA. 1976;73:3178-3182.
21. Habeeb AF. Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. Anal Biochem. 1966;14:328-336.
22. Goldstein JL, Basu SK, Brown MS. Receptor-mediated endocytosis of low-density lipoprotein in cultured cells. Methods Enzymol. 1983;98:241-260.
23. Kritharides L, Christian A, Stoudt G, Morel D, Rothblat GH. Cholesterol metabolism and efflux in human THP-1 macrophages. Arterioscler Thromb Vasc Biol. 1998;18:1589-1599.
24. Lowry OH, Rosenbrough NJ, Raff AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem. 1951;193:265-275.
25. Legedz L, Randon J, Sessa C, Baguet J-P, Feugier P, Cerutti C, McGregor J, Brica G. Cathepsin G is associated with atheroma formation in human carotid artery. J Hypertens. 2003; in press.
26. Johnson AC, Yabu JM, Hanson S, Shah VO, Zager RA. Experimental glomerulopathy alters renal cortical cholesterol, SR-B1, ABCA1, and HMG CoA reductase expression. Am J Pathol. 2003;162:283-291.
27. Scatchard G. The attraction of proteins for small molecules and ions. Ann N Y Acad Sci. 1949;51:660-672.
28. Greenberg AS, Egan JJ, Wek SA, Garty NB, Blanchette-Mackie EJ, Londos C. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J Biol Chem. 1991;266:11341-11346.
29. Servetnick DA, Brasaemle DL, Gruia-Gray J, Kimmel AR, Wolff J, Londos C. Perilipins are associated with cholesteryl ester droplets in steroidogenic adrenal cortical and Leydig cells. J Biol Chem. 1995;270:16970-16973.
30. de Winther MP, Hofker MH. Scavenging new insights into atherogenesis. J Clin Invest. 2000;105:1039-1041.
31. Chang TY, Chang CC, Cheng D. Acyl-coenzyme A: cholesterol acyltransferase. Annu Rev Biochem. 1997;66:613-638.
32. Okazaki H, Osuga J, Tsukamoto K, Isoo N, Kitamine T, Tamura Y, Tomita S, Sekiya M, Yahagi N, Iizuka Y, Ohashi K, Harada K, Gotoda T, Shimano H, Kimura S, Nagai R, Yamada N, Ishibashi S. Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase. J Biol Chem. 2002;277:31893-31899.
33. Santamarina-Fojo S, Remaley AT, Neufeld EB, Brewer HB, Jr. Regulation and intracellular trafficking of the ABCA1 transporter. J Lipid Res. 2001;42:1339-1345.
34. Leake DS, Rankin SM. The oxidative modification of low-density lipoproteins by macrophages. Biochem J. 1990;270:741-748.
35. Lehmann JM, Kliewer SA, Moore LB, Smith-Oliver TA, Oliver BB, Su JL, Sundseth SS, Winegar DA, Blanchard DE, Spencer TA, Willson TM. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem. 1997;272:3137-3140.
36. Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Kimura S, Ishibashi S, Yamada N. Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. Mol Cell Biol. 2001;21:2991-3000.
37. Joseph SB, Laffitte BA, Patel PH, Watson MA, Matsukuma KE, Walczak R, Collins JL, Osborne TF, Tontonoz P. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J Biol Chem. 2002;277:11019-11025.
38. Mazzone T, Gump H, Diller P, Getz GS. Macrophage free cholesterol content regulates apolipoprotein E synthesis. J Biol Chem. 1987;262:11657-11662.
39. Imamura M, Inoguchi T, Ikuyama S, Taniguchi S, Kobayashi K, Nakashima N, Nawata H. ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts. Am J Physiol Endocrinol Metab. 2002;283:E775-E783.
40. Gao J, Serrero G. Adipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake. J Biol Chem. 1999;274:16825-16830.
41. Brasaemle DL, Rubin B, Harten IA, Gruia-Gray J, Kimmel AR, Londos C. Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis. J Biol Chem. 2000;275:38486-38493.
42. Atshaves BP, Storey SM, McIntosh AL, Petrescu AD, Lyuksyutova OI, Greenberg AS, Schroeder F. Sterol carrier protein-2 expression modulates protein and lipid composition of lipid droplets. J Biol Chem. 2001;276:25324-25335.
43. Londos C, Brasaemle DL, Schultz CJ, Segrest JP, Kimmel AR. Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells. Semin Cell Dev Biol. 1999;10:51-58.
44. Brown DA. Lipid droplets: proteins floating on a pool of fat. Curr Biol. 2001;11:R446-R449.
45. Fujimoto T, Kogo H, Ishiguro K, Tauchi K, Nomura R. Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell. J Cell Biol. 2001;152:1079-1085.
46. Ostermeyer AG, Paci JM, Zeng Y, Lublin DM, Munro S, Brown DA. Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets. J Cell Biol. 2001;152:1071-1078.
47. Pol A, Luetterforst R, Lindsay M, Heino S, Ikonen E, Parton RG. A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance. J Cell Biol. 2001;152:1057-1070.
48. Franke WW, Hergt M, Grund C. Rearrangement of the vimentin cytoskeleton during adipose conversion: formation of an intermediate filament cage around lipid globules. Cell. 1987;49:131-141.
49. Lieber JG, Evans RM. Disruption of the vimentin intermediate filament system during adipose conversion of 3T3-L1 cells inhibits lipid droplet accumulation. J Cell Sci. 1996;109:3047-3058.
50. Tansey JT, Sztalryd C, Gruia-Gray J, Roush DL, Zee JV, Gavrilova O, Reitman ML, Deng CX, Li C, Kimmel AR, Londos C. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci USA. 2001;98:6494-6499.