Dual lipolytic control of body fat storage and mobilization in Drosophila

PLoS Biology

Volumn 5, Issue 6, 2007, Pages 1248-1256

  Grönke, Sebastian ^a   Müller, Günter ^b   Hirsch, Jochen ^a   Fellert, Sonja ^a   Andreou, Alexandra ^a   Haase, Tobias ^a,c   Jäckle, Herbert ^a   Kühnlein, Ronald P ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^c TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOKINETIC HORMONE; ADIPOSE TRIGLYCERIDE LIPASE; GONADORELIN RECEPTOR; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ANIMAL; ARTICLE; BODY FAT; CHEMICAL ANALYSIS; CONTROLLED STUDY; DROSOPHILA; ENERGY METABOLISM; GENETIC ANALYSIS; GENETICS; HOMEOSTASIS; IN VIVO STUDY; LIPID METABOLISM; LIPID STORAGE; LIPOLYSIS; METABOLISM; MUTANT; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PHYSIOLOGY;

ANIMALS; DROSOPHILA; ENERGY METABOLISM; GENETICS; HOMEOSTASIS; LIPASE; LIPOLYSIS; METABOLISM; MUTATION; PHYSIOLOGY; RECEPTORS, LHRH;

ANIMALIA; HEXAPODA; MAMMALIA;

EID: 34250306022     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.0050137     Document Type: Article

References (47)

1. Brown DA (2001) Lipid droplets: proteins floating on a pool of fat. Curr Biol 11: R446-449.
2. Martin S, Parton RG (2006) Lipid droplets: A unified view of a dynamic organelle. Nat Rev Mol Cell Biol 7: 373-378.
3. Chanarin I, Patel A, Slavin G, Wills EJ, Andrews TM, et al. (1975) Neutral-lipid storage disease: A new disorder of lipid metabolism. Br Med J 1: 553-555.
4. Dorfman ML, Hershko C, Eisenberg S, Sagher F (1974) Ichthyosiform dermatosis with systemic lipidosis. Arch Dermatol 110: 261-266.
5. Lefevre C, Jobard F, Caux F, Bouadjar B, Karaduman A, et al. (2001) Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/ thioesterase subfamily, in Chanarin-Dorfman syndrome. Am J Hum Genet 69: 1002-1012.
6. Zimmermann R, Strauss JG, Hämmerle G, Schoiswohl G, Birner-Grünberger R, et al. (2004) Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306: 1383-1386.
7. Villena JA, Roy S, Sarkadi-Nagy E, Kim K, Sul H (2004) Desnutrin, an adipocyte gene encoding a novel patatin-domain containing protein, is induced by fasting and glucocorticoids. Ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem 279: 47066-75
8. Jenkins CM, Mancuso DJ, Yan W, Sims HF, Gibson B, et al. (2004) Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 279: 48968-48975.
9. Lass A, Zimmermann R, Hämmerle G, Riederer M, Schoiswohl G, et al. (2006) Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab 3: 309-319.
10. Fischer J, Lefevre C, Morava E, Mussini JM, Laforet P, et al. (2007) The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy. Nat Genet 39: 28-30.
11. Schönborn V, Heid IM, Vollmert C, Lingenhel A, Adams TD, et al. (2006) The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes. Diabetes 55: 1270-1275.
12. Hämmerle G, Lass A, Zimmermann R, Gorkiewicz G, Meyer C, et al. (2006) Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312: 734-737.
13. Zechner R, Strauss JG, Hämmerle G, Lass A, Zimmermann R (2005) Lipolysis: pathway under construction. Curr Opin Lipidol 16: 333-340.
14. Jaworski K, Sarkadi-Nagy E, Duncan R, Ahmadian M, Sul HS (2007) Hormonal regulation of lipolysis in adipose tissue. Am J Physiol Gastrointest Liver Physiol: doi:10.1152/ajpgi.00554.2006
15. Londos C, Sztalryd C, Tansey JT, Kimmel AR (2005) Role of PAT proteins in lipid metabolism. Biochimie 87: 45-49.
16. Subramanian V, Rothenberg A, Gomez C, Cohen AW, Garcia A, et al. (2004) Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes. J Biol Chem 279: 42062-42071.
17. Yamaguchi T, Omatsu N, Matsushita S, Osumi T (2004) CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome. J Biol Chem 279: 30490-30497.
18. Athenstaedt K, Daum G (2005) Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles. J Biol Chem 280: 37301-37309.
19. Kurat CF, Natter K, Petschnigg J, Wolinski H, Scheuringer K, et al. (2006) Obese yeast: Triglyceride lipolysis is functionally conserved from mammals to yeast. J Biol Chem 281: 491-500.
20. Eastmond PJ (2006) SUGAR-DEPENDENT1 encodes a patatin domain triacylglycerol lipase that initiates storage oil breakdown in germinating Arabidopsis seeds. Plant Cell 18: 665-675.
21. Grönke S, Mildner A, Fellert S, Tennagels N, Petry S, et al. (2005) Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Cell Metab 1: 323-330.
22. Van der Horst DJ, Van Marrewijk WJ, Diederen JH (2001) Adipokinetic hormones of insect: release, signal transduction, and responses. Int Rev Cytol 211: 179-240.
23. Gäde G, Auerswald L (2003) Mode of action of neuropeptides from the adipokinetic hormone family. Gen Comp Endocrinol 132: 10-20.
24. Staubli F, Jorgensen TJD, Cazzamali G, Williamson M, Lenz C, et al. (2002) Molecular identification of the insect adipokinetic hormone receptors. Proc Natl Acad Sci U S A 99: 3446-3451.
25. Lee G, Park JH (2004) Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster. Genetics 167: 311-323.
26. Kim SK, Rulifson EJ (2004) Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells. Nature 431: 316-320.
27. Isabel G, Martin JR, Chidami S, Veenstra JA, Rosay P (2005) AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila. Am J Physiol Regul Integr Comp Physiol 288: R531-538.
28. Patel RT, Soulages JL, Hariharasundaram B, Arrese EL (2005) Activation of the lipid droplet controls the rate of lipolysis of triglycerides in the insect fat body. J Biol Chem 280: 22624-22631.
29. Patel RT, Soulages JL, Arrese EL (2006) Adipokinetic hormone-induced mobilization of fat body triglyceride stores in Manduca sexta: Role of TG-lipase and lipid droplets. Arch Insect Biochem Physiol 63: 73-81.
30. Teixeira L, Rabouille C, Rorth P, Ephrussi A, Vanzo NF (2003) Drosophila Perilipin/ADRP homologue Lsd2 regulates lipid metabolism. Mech Dev 120: 1071-1081.
31. Grönke S, Beller M, Fellert S, Ramakrishnan H, Jäckle H, et al. (2003) Control of fat storage by a Drosophila PAT domain protein. Curr Biol 13: 603-606.
32. Arrese EL, Patel RT, Soulages JL (2006) The main triglyceride-lipase from the insect fat body is an active phospholipase A1: Identification and characterization. J Lipid Res 47: 2656-2667.
33. Ziegler R (1991) Changes in lipid and carbohydrate metabolism during starvation in adult Manduca sexta. J Comp Physiol (B) 161: 125-131.
34. Park Y, Kim YJ, Adams ME (2002) Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution. Proc Natl Acad Sci U S A 99: 11423-11428.
35. Hauser F, Sondergaard L, Grimmelikhuijzen CJ (1998) Molecular cloning, genomic organization and developmental regulation of a novel receptor from Drosophila melanogaster structurally related to gonadotropin-releasing hormone receptors for vertebrates. Biochem Biophys Res Commun 249: 822-828.
36. The Flybase Consortium (2003) The FlyBase database of the Drosophila genome projects and community literature. Nucleic Acids Res 31: 172-175.
37. Soni KG, Lehner R, Metalnikov P, O'Donnell P, Semache M, et al. (2004) Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase. J Biol Chem 279: 40683-40689.
38. Pennington JE, Wells MA (2002) Triacylglycerol-rich lipophorins are found in the dipteran infraorder Culicomorpha, not just in mosquitoes. J Insect Sci 2: 15.
39. Lee MJ, Goldsworthy GJ (1995) The preparation and use of dispersed cells from fat body of Locusta migratoria in a filtration plate assay for adipokinetic peptides. Anal Biochem 228: 155-161.
40. Ziegler R (1997) Lipid synthesis by ovaries and fat body of Aedes aegypti (Diptera: Culicidae). Eur J Entomol 94: 385-391.
41. Lorenz MW (2001) Synthesis of lipids in the fat body of Gryllus bimaculatus: Age-dependency and regulation by adipokinetic hormone. Arch Insect Biochem Physiol 47: 198-214.
42. Rorth P (1996) A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. Proc Natl Acad Sci U S A 93: 12418-12422.
43. Beinert N, Werner M, Dowe G, Chung HR, Jäckle H, et al. (2004) Systematic gene targeting on the X chromosome of Drosophila melanogaster. Chromosoma 113: 271-275.
44. Fredrikson G, Tornqvist H, Belfrage P (1986) Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol. Biochim Biophys Acta 876: 288-293.
45. Petry S, Ben Ali Y, Chahinian H, Jordan H, Kleine H, et al. (2005) Sensitive assay for hormone-sensitive lipase using NBD-labeled monoacylglycerol to detect low activities in rat adipocytes. J Lipid Res 46: 603-614.
46. Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, et al. (2002) A Drosophila full-length cDNA resource. Genome Biol 3: RESEARCH0080.
47. Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.