BRL 49653 blocks the lipolytic actions of tumor necrosis factor-α: A potential new insulin-sensitizing mechanism for thiazolidinediones

Diabetes

Volumn 47, Issue 4, 1998, Pages 691-695

  Souza, Sandra C ^a   Yamamoto, Mia T ^a   Franciosa, Mark D ^a   Lien, Ping ^a   Greenberg, Andrew S ^a,b  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; FATTY ACID; GLYCEROL; ISOPRENALINE; PROSTAGLANDIN J2; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; ROSIGLITAZONE; TRIACYLGLYCEROL LIPASE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; DRUG ANTAGONISM; FATTY ACID SYNTHESIS; LIPOLYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

3T3 CELLS; ADIPOCYTES; ANIMALS; CHOLESTEROL ESTERASE; FATTY ACIDS, NONESTERIFIED; GLYCEROL; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; LIPOLYSIS; MICE; PHOSPHOPROTEINS; PROSTAGLANDIN D2; THIAZOLES; THIAZOLIDINEDIONES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031948947     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.4.691     Document Type: Article

References (36)

1. Saltiel A, Olefsky, JM: Thiazolidinediones in the treatment of insulin resistance and type 2 diabetes. Diabetes 45:1661-1669, 1996
2. Oakes ND, Kennedy CJ, Jenkins AB, Laybutt DR, Chisholm DJ, Kraegen EW: A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat. Diabetes 43:1203-1210, 1994
3. Chaiken R, Eckert-Norton M, Pasmantier R, Boden G, Ryan I, Gelfand RA, Lebovitz HE: Metabolic effects of darglitazone, an insulin sensitizer, in NIDDM subjects. Diabetologia 38:1307-1312, 1995
4. Coppack S, Jensen M, Miles J: In vivo regulation of lipolysis in humans. J Lipid Res 35:177-193, 1994
5. Boden G: Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46:3-10, 1997
6. Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB: The expression of tumor necrosis factor in human adipose tissue: regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 95:2111-2119, 1995
7. Hotamisligil GS, Shargill NS, Spiegelman BM: Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259:87-91, 1993
8. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM: Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J Clin Invest 95:2409-2415, 1995
9. Feingold KR, Doerrler W, Dinarello CA, Fiers W, Grunfeld C: Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked by inhibition of prostaglandin synthesis. Endocrinology 130:10-16, 1992
10. Hauner H. Petruschke T, Russ M, Rohrig K, Eckel J: Effects of tumor necrosis factor alpha (TNFα) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture. Diabetologia 38:764-771, 1995
11. Ohsumi J, Skakibara S, Yamaguchi J, Miyadi K, Yoshioka S, Fujiwara T, Horikoshi H, Serizawa N: Troglitazone prevents the inhibitory effects of inflammatory cytokines on insulin-induced adipocyte differentiation in 3T3-L1 cells. Endocrinology 135:2279-2282, 1994
12. Szalkowski D, White-Carrington S, Berger J, Zhang B: Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor-α on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3-L1 cells. Endocrinology 136:1474-1481, 1995
13. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA: An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ. J Biol Chem. 270:12953-12956, 1995
14. 2 is a ligand for the adipocyte determination factor PPARγ. Cell 83:803-812, 1995
15. 2 metabolite binds peroxisome proliferator-activated receptor γ. Cell 83:813-819, 1995
16. Greenberg AS, Egan JJ, Wek SA, Garty NB, Blanchette-Mackie EJ, Londos C: Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of the lipid storage droplets. J Biol Chem 266:11341-11346, 1991
17. Stralfors PF, Olsson H, Belfrage P: Hormone-sensitive lipase. In The Enzymes XVII, Boyer PD, Krebs EG, Eds. Academic, San Diego, CA, 1987, p. 147-177
18. Greenberg AS, Egan JJ, Wek S, Moos MC Jr, Londos C, Kimmel AR: Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Proc Natl Acad Sci USA 90:12035-12039, 1993
19. Kohanski R, Frost S, Lane M: Insulin-dependent phosphorylation of the insulin receptor-protein kinase and activation of glucose transport in 3T3-L1 adipocytes. J Biol Chem 261:12272-12281, 1986
20. Arner P: Regulation of adipocyte lipolysis. Diabetes Reviews 4:450-463, 1996
21. Blanchette-Mackie EJ, Dwyer NK, Barber T, Coxey RA, Takeda T, Rondonine CM, Theodorakias JL, Greenberg AS, Londos C: Perilipin is located on the surface layer of the intracellular lipid droplets in adipocytes. J Lipid Res 36:1211-1226, 1995
22. Londos C: Hormone-sensitive lipase and the control of lipolysis in adipocytes. In Diabetes Mellitus: A Fundamental and Clinical Text. LeRoith D, Taylor SI, Olefsky JM, Eds. Philadelphia, Lippincott-Raven, 1996, p. 223-227
23. Rosenbaum SE, Greenberg AS: Tumor Necrosis Factor-α and the thiazolidinedione BRL 49653 differentially regulate gene expression in 3T3-L1 adipocytes (Abstract). FASEB J 3 (Suppl. II):A437, 1996
24. Souza S, Yamamato M, Greenberg A: Overexpression of the perilipins block the ability of tumor necrosis factor to increase adipocyte lipolysis (Abstract). Adipose Cell, Keystone Symposia, 1997
25. Stralfors P, Bjorgell P, Belfrage P: Hormonal regulation of hormone-sensitive lipase in intact adipocytes: identification of phosphorylated sites and effects on the phosphorylation by lipolytic hormones and insulin. Proc Natl Acad Sci USA 81:3317-3321, 1984
26. Egan JJ, Greenberg AS, Chang M-K, Wek SA, Moos MC Jr, Londos C: Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet. Proc Natl Acad Sci USA 89:8537-8541, 1992
27. Lehmann J, Lenhard J, Oliver B, Ringold G, Kliewer S: Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272:3406-3410, 1997
28. Hardardottir I, Doerrier W, Feingold KR, Grunfeld C: Cytokines stimulate lipolysis and decrease lipoprotein lipase activity by a prostaglandin independent mechanism. Biochem Biophys Res Comm 1:237-243, 1992
29. Peraldi P, Xu M, Spiegelman B: Thiazolidiediones block tumor necrosis factor-α-inhibition of insulin signaling. J Clin Invest 100:1863-1869, 1997
30. Miles PDG, Romeo OM, Higo K, Cohen A, Rafaat K, Olefsky JM: TNF-α-induced insulin resistance in vivo and its prevention by troglitazone. Diabetes 46:1678-1683, 1997
31. Randle PJ, Garland PB, Hales CN, Newsholme EA: The glucose-fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet i:174-189, 1963
32. Ferrannini E, Barrett EJ, Bevilacqua S, DeFronzo RA: Effect of fatty acids on glucose production and utilization in man. J Clin Invest 72:1737-1747, 1983
33. Pei D, Chen Y-D, Hollenbeck C, Bhargava R, Reaven G: Relationship between insulin-mediated glucose disposal by muscle and adipose tissue lipolysis in healthy volunteers. J Clin Endocrinol Metab 80:3368-3372, 1995
34. Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, Shulman GI: Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 97:2859-2865, 1996
35. Hotamisligil GS, Budavari A, Murray D, Spiegelman BM: Reduced tyrosine kinase activity of the insulin receptor in obese-diabetes: central role of tumor necrosis factor-α. J Clin Invest 94:1543-1549, 1994
36. Uysal K, Wiesbrock S, Marino M, Hotamisligil GS: Protection from obesity-linked insulin resistance in mice lacking TNF-α function. Nature 389:610-614, 1997