Adipose differentiation-related protein has two independent domains for targeting to lipid droplets

Biochemical and Biophysical Research Communications

Volumn 306, Issue 2, 2003, Pages 333-338

  Nakamura, Noriko ^a   Fujimoto, Toyoshi ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Adipose differentiation related protein; GFP; Lipid droplet; Targeting

Indexed keywords

ADIPOPHILIN; AMINO ACID; FAT DROPLET; MUTANT PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CYTOPLASM; EMBRYO; MITOCHONDRION; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN TARGETING; RAT;

EID: 0038546739     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00979-3     Document Type: Article

References (32)

1. Murphy D.J., Vance J. Mechanisms of lipid-body formation. Trends Biol. Sci. 24:1999;109-115.
2. Brown D.A. Lipid droplets: proteins floating on a pool of fat. Curr. Biol. 11:2001;R446-R449.
3. Tauchi-Sato K., Ozeki S., Houjou T., Taguchi R., Fujimoto T. The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition. J. Biol. Chem. 277:2002;44507-44512.
4. Fujimoto T., Kogo H., Ishiguro K., Tauchi K., Nomura R. Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell. J. Cell Biol. 152:2001;1079-1085.
5. Ostermeyer A.G., Paci J.M., Zeng Y., Lublin D.M., Munro S., Brown D.A. Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets. J. Cell Biol. 152:2001;1071-1078.
6. Pol A., Luetterforst R., Lindsay M., Heino S., Ikonen E., Parton R.G. A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance. J. Cell Biol. 152:2001;1057-1070.
7. Parton R.G. Caveolae and caveolins. Curr. Opin. Cell Biol. 8:1996;542-548.
8. van Rooijen G.J., Moloney M.M. Structural requirements of oleosin domains for subcellular targeting to the oil body. Plant Physiol. 109:1995;1353-1361.
9. Hope R.G., Murphy D.J., McLauchlan J. The domains required to direct core proteins of hepatitis C virus and GB virus-B to lipid droplets share common features with plant oleosin proteins. J. Biol. Chem. 277:2002;4261-4270.
10. Jiang H.-P., Serrero G. Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Proc. Natl. Acad. Sci. USA. 89:1992;7856-7860.
11. Heid H.W., Moll R., Schwetlick I., Rackwitz H.-R., Keenan T.W. Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases. Cell Tissue Res. 294:1998;309-321.
12. Imamura M., Inoguchi T., Ikuyama S., Taniguchi S., Kobayashi K., Nakashima N., Nawata H. ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts. Am. J. Physiol. Endocrinol. Metab. 283:2002;E775-E783.
13. Nakamura N., Akashi T., Kikuchi A., Fujimoto T. Targeting mechanism of adipose differentiation-related protein to lipid droplets. Mol. Biol. Cell. 12:2001;474.
14. Targett-Adams P., Chambers D., Gledhill S., Hope G., Coy J.F., Girod A., McLauchlan J. Live cell analysis and targeting of the lipid droplet binding protein ADRP. J. Biol. Chem. 278:2003;15998-16007.
15. McManaman J.L., Zabaronick W., Schaack J., Orlicky D.J. Lipid droplet targeting domains of adipophilin. J. Lipid Res. 44:2003;668-673.
16. Brasaemle D.L., Barber T., Wolins N.E., Serrero G., Blanchette-Mackie E.J., Londos C. Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J. Lipid Res. 38:1997;2249-2263.
17. Greenberg A.S., Egan J.J., Wek S.A., Garty N.B., Blanchette-Mackie E.J., Londos C. Perilipin a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J. Biol. Chem. 266:1991;11341-11346.
18. Wolins N.E., Rubin B., Brasaemle D.L. TIP47 associates with lipid droplets. J. Biol. Chem. 276:2001;5101-5108.
19. Miura S., Gan J.W., Brzostowski J., Parisi M.J., Schultz C.J., Londos C., Oliver B., Kimmel A.R. Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. J. Biol. Chem. 277:2002;32253-32257.
20. Barbero P., Buell E., Zulley S., Pfeffer S.R. TIP47 is not a component of lipid droplets. J. Biol. Chem. 276:2001;24348-24351.
21. Monier S., Parton R.G., Vogel F., Behlke J., Henske A., Kurzchalia T.V. VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro. Mol. Biol. Cell. 6:1995;911-927.
22. Londos C., Brasaemle D.L., Schltz C.J., Segrest J.P., Kimmel A.R. Perilipins, ADRP and other proteins that associate with intracellular neutral lipid droplets in animal cells. Semi. Cell Dev. Biol. 10:1999;51-58.
23. Garcia A., Sekowski A., Subramanian V., Brasaemle D.L. The central domain is required to target and anchor perilipin A to lipid droplets. J. Biol. Chem. 278:2003;625-635.
24. Tansey J.T., Sztalryd C., Gruia-Gray J., Roush D.L., Zee J.V., Gavrilova O., Reitman M.L., Deng C.X., Li C., Kimmel A.R., Londos C. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis enhanced leptin production and resistance to diet-induced obesity. Proc. Natl. Acad. Sci. USA. 98:2001;6494-6499.
25. Fawcett D.W. The Cell. 1981;W.B. Saunders, Philadelphia, PA.
26. Chanderbhan R., Noland B.J., Scallen T.J., Vahouny G.V. Sterol carrier protein2. Delivery of cholesterol from adrenal lipid droplets to mitochondria for pregnenolone synthesis. J. Biol. Chem. 257:1982;8928-8934.
27. Chacinska A., Pfanner N., Meisinger C. How mitochondria import hydrophilic and hydrophobic proteins. Trends Cell Biol. 12:2002;299-303.
28. Gao J., Serrero G. Adipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake. J. Biol. Chem. 274:1999;16825-16830.
29. Gao J., Ye H., Serrero G. Stimulation of adipose differentiation related protein (ADRP) expression in adipocyte precursors by long-chain fatty acids. J. Cell Physiol. 182:2000;297-302.
30. Atshaves B.P., Storey S.M., McIntosh A., Petrescu A.D., Lyuksyutova O.L., Greenberg A.S., Schroeder F. Sterol carrier protein-2 expression modulates protein and lipid composition of lipid droplets. J. Biol. Chem. 276:2001;25324-25335.
31. Serrero G., Frolov A., Schroeder F., Tanaka K., Gelhaar L. Adipose differentiation related protein: expression, purification of recombinant protein in Escherichia coli and characterization of its fatty acid binding properties. Biochim. Biophys. Acta. 1488:2000;245-254.
32. Atshaves B.P., Starodub O., McIntosh A., Petrescu A., Rothus J.B., Kier A.B., Schroeder F. Sterol carrier protein-2 alters high density lipoprotein-mediated cholesterol efflux. J. Biol. Chem. 275:2000;36852-36861.