The murine perilipin gene: The lipid droplet-associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin

Mammalian Genome

Volumn 12, Issue 9, 2001, Pages 741-749

  Lu, Xinyue ^a   Gruia Gray, Jasmine ^a   Copeland, Neal G ^b   Gilbert, Debra J ^b   Jenkins, Nancy A ^b   Londos, Constantine ^a   Kimmel, Alan R ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; FAT DROPLET; GENE PRODUCT; MESSENGER RNA; PERILIPIN; UNCLASSIFIED DRUG;

ADIPOCYTE; ARTICLE; CHROMOSOMAL LOCALIZATION; DICTYOSTELIUM; DROSOPHILA; HORMONAL REGULATION; HYDROLYSIS; LIPID STORAGE; MULTIGENE FAMILY; NONHUMAN; POLYADENYLATION; RNA SPLICING; SEQUENCE ANALYSIS;

5' UNTRANSLATED REGIONS; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DICTYOSTELIUM; DNA PRIMERS; DNA, COMPLEMENTARY; DROSOPHILA; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; POLYADENYLATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID;

DICTYOSTELIUM; INVERTEBRATA; MAMMALIA; MURINAE; VERTEBRATA;

EID: 0034861995     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00335-01-2055-5     Document Type: Article

References (46)

1. Basic local alignment search tool
2. Gapped BLAST and PSI-BLAST, a new generation of protein database search programs
3. Central role of the adipocyte in insulin resistance
4. Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes
5. Post-translational regulation of perilipin expression, stabilization by stored, intracellular neutral lipids
6. Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein
7. The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets
8. Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis
9. The DPE, a conserved downstream core promoter element that is functionally analogous to the TATA box
10. Fatvg encodes a new localized RNA that uses a 25-nucleotide element (FVLE1) to localize to the vegetal cortex of Xenopus oocytes
11. Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes
12. Development and applications of a molecular genetic linkage map of the mouse genome
13. TIP47, a cargo selection device for mannose 6-phosphate receptor trafficking
14. Interaction of furin in immature secretory granules from neuroendocrine cells with the AP-1 adaptor complex is modulated by casein kinase II phosphorylation
15. Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation
16. Mechanism of hormone-stimulated lipolysis in adipocytes, translocation of hormone-sensitive lipase to the lipid storage droplet
17. Structure of the gene encoding mouse adipose differentiation-related protein (ADRP)
18. A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus
19. Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens
20. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets
21. Isolation of cDNAs for perilipins A and B, sequence and expression of lipid droplet-associated proteins of adipocytes
22. Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases
23. Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus
24. Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein
25. Novel regulatory factors interacting with the promoter of the gene encoding the mRNA cap binding protein (elF4E) and their function in growth regulation
26. Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail
27. On the control of tipolysis in adipocytes
28. Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells
29. Genomic mapping of murine Zp-2 and Zp-3, two oocyte-specific loci encoding zona pellucida proteins
30. Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus, IDDM4, IDDM5 and IDDM8
31. Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice
32. A casein kinase II phosphorylation site in the cytoplasmic domain of the cation-dependent mannose-6-phosphate receptor determines the high affinity interaction of the AP-1 Golgi assembly proteins with membranes
33. The mammary fat pad
34. Isolation of adipophilin and butyrophilin from bovine milk and characterization of a cDNA encoding adipophilin
35. Isolation and chromosomal mapping of the human homolog of perilipia, a rat adipose tissue-specific gene, by differential display method
36. Mechanism of free fatty-acid induced insulin resistance in humans
37. Cloning of cell-specific secreted and surface proteins by subtractive antibody screening
38. Perilipins are associated with cholesteryl ester droplets in steroidogenic adrenal cortical and Leydig cells
39. The initiator element, a paradigm for core promoter heterogeneity within metazoan protein-coding genes
40. The gene-finder computer tools for analysis of human and model organisms genome sequences
41. Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes
42. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity
43. Blast 2 sequences - A new tool for comparing protein and nucleotide sequences
44. Cloning and sequence analysis of cDNAs encoding human placental tissue protein 17 (PP17) variants
45. TIP47 associates with lipid droplets
46. Linkage of type I diabetes to 15q26 (IDDM3) in the Danish population