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Volumn 3, Issue 12, 2007, Pages 827-834

Technology Insight: Small, noncoding RNA molecules as tools to study and treat endocrine diseases

Author keywords

Endocrine disease; miRNA; Novel targets; RNA interference; Therapeutic potential

Indexed keywords

MICRORNA; SMALL INTERFERING RNA; UNTRANSLATED RNA;

EID: 36349007520     PISSN: 17458366     EISSN: 17458374     Source Type: Journal    
DOI: 10.1038/ncpendmet0674     Document Type: Review
Times cited : (9)

References (83)
  • 1
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A et al. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1
  • 2
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM et al. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1
  • 3
    • 3142615372 scopus 로고    scopus 로고
    • The RNAi revolution
    • Novina CD and Sharp PA (2004) The RNAi revolution. Nature 430: 161-164
    • (2004) Nature , vol.430 , pp. 161-164
    • Novina, C.D.1    Sharp, P.A.2
  • 4
    • 9344235449 scopus 로고    scopus 로고
    • Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs
    • Cai X et al. (2004) Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 10: 1957-1966
    • (2004) RNA , vol.10 , pp. 1957-1966
    • Cai, X.1
  • 5
    • 8144225486 scopus 로고    scopus 로고
    • MicroRNA genes are transcribed by RNA polymerase II
    • Lee Y et al. (2004) MicroRNA genes are transcribed by RNA polymerase II. EMBO J 23: 4051-4060
    • (2004) EMBO J , vol.23 , pp. 4051-4060
    • Lee, Y.1
  • 6
    • 0141843656 scopus 로고    scopus 로고
    • The nuclear RNase III Drosha initiates microRNA processing
    • Lee Y et al. (2003) The nuclear RNase III Drosha initiates microRNA processing. Nature 425: 415-419
    • (2003) Nature , vol.425 , pp. 415-419
    • Lee, Y.1
  • 7
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
    • Yi R et al. (2003) Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 17: 3011-3016
    • (2003) Genes Dev , vol.17 , pp. 3011-3016
    • Yi, R.1
  • 8
    • 0347988235 scopus 로고    scopus 로고
    • Nuclear export of microRNA precursors
    • Lund E et al. (2004) Nuclear export of microRNA precursors. Science 303: 95-98
    • (2004) Science , vol.303 , pp. 95-98
    • Lund, E.1
  • 9
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros V (2004) The functions of animal microRNAs. Nature 431: 350-355
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 10
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 11
    • 23944514849 scopus 로고    scopus 로고
    • Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation
    • Bagga S et al. (2005) Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 122: 553-563
    • (2005) Cell , vol.122 , pp. 553-563
    • Bagga, S.1
  • 12
    • 33645119514 scopus 로고    scopus 로고
    • MicroRNAs direct rapid deadenylation of mRNA
    • Wu L et al. (2006) MicroRNAs direct rapid deadenylation of mRNA. Proc Natl Acad Sci U S A 103: 4034-4039
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 4034-4039
    • Wu, L.1
  • 13
    • 1642374097 scopus 로고    scopus 로고
    • Specificity of microRNA target selection in translational repression
    • Doench JG and Sharp PA (2004) Specificity of microRNA target selection in translational repression. Genes Dev 18: 504-511
    • (2004) Genes Dev , vol.18 , pp. 504-511
    • Doench, J.G.1    Sharp, P.A.2
  • 14
    • 32444436121 scopus 로고    scopus 로고
    • Short RNAs repress translation after initiation in mammalian cells
    • Petersen CP et al. (2006) Short RNAs repress translation after initiation in mammalian cells. Mol Cell 21: 533-542
    • (2006) Mol Cell , vol.21 , pp. 533-542
    • Petersen, C.P.1
  • 15
    • 33846277696 scopus 로고    scopus 로고
    • Repression of protein synthesis by miRNAs: How many mechanisms?
    • Pillai RS et al. (2007) Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol 17: 118-126
    • (2007) Trends Cell Biol , vol.17 , pp. 118-126
    • Pillai, R.S.1
  • 16
    • 34547944309 scopus 로고    scopus 로고
    • MicroRNA inhibition of translation initiation in vitro by targeting the Cap-binding complex eIF4F
    • Mathonnet G et al. (2007) MicroRNA inhibition of translation initiation in vitro by targeting the Cap-binding complex eIF4F. Science 317: 1764-1767
    • (2007) Science , vol.317 , pp. 1764-1767
    • Mathonnet, G.1
  • 17
    • 13444252847 scopus 로고    scopus 로고
    • Rfam: Annotating noncoding RNAs in complete genomes
    • Griffiths-Jones S et al. (2005) Rfam: annotating noncoding RNAs in complete genomes. Nucleic Acids Res 33: D121-D124
    • (2005) Nucleic Acids Res , vol.33
    • Griffiths-Jones, S.1
  • 18
    • 16844379687 scopus 로고    scopus 로고
    • The role of small RNAs in human diseases: Potential troublemaker and therapeutic tools
    • Gong H et al. (2005) The role of small RNAs in human diseases: potential troublemaker and therapeutic tools. Med Res Rev 25: 361-381
    • (2005) Med Res Rev , vol.25 , pp. 361-381
    • Gong, H.1
  • 19
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • Lu J et al. (2005) MicroRNA expression profiles classify human cancers. Nature 435: 834-838
    • (2005) Nature , vol.435 , pp. 834-838
    • Lu, J.1
  • 20
    • 33646056975 scopus 로고    scopus 로고
    • A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors
    • Voorhoeve PM et al. (2006) A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 124: 1169-1181
    • (2006) Cell , vol.124 , pp. 1169-1181
    • Voorhoeve, P.M.1
  • 21
    • 18844459384 scopus 로고    scopus 로고
    • miR-15a and miR-16-1 downregulation in pituitary adenomas
    • Bottoni A et al. (2005) miR-15a and miR-16-1 downregulation in pituitary adenomas. J Cell Physiol 204: 280-285
    • (2005) J Cell Physiol , vol.204 , pp. 280-285
    • Bottoni, A.1
  • 22
    • 0035878534 scopus 로고    scopus 로고
    • Gain of chromosome 3 and loss of 13q are frequent alterations in pituitary adenomas
    • Fan X et al. (2001) Gain of chromosome 3 and loss of 13q are frequent alterations in pituitary adenomas. Cancer Genet Cytogenet 128: 97-103
    • (2001) Cancer Genet Cytogenet , vol.128 , pp. 97-103
    • Fan, X.1
  • 23
    • 33750600178 scopus 로고    scopus 로고
    • MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior
    • Roldo C et al. (2006) MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior. J Clin Oncol 24: 4677-4684
    • (2006) J Clin Oncol , vol.24 , pp. 4677-4684
    • Roldo, C.1
  • 24
    • 30044436911 scopus 로고    scopus 로고
    • The role of microRNA genes in papillary thyroid carcinoma
    • He H et al. (2005) The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci U S A 102: 19075-19080
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 19075-19080
    • He, H.1
  • 25
    • 12144257058 scopus 로고    scopus 로고
    • Kit as a human oncogenic tyrosine kinase
    • Kitamura Y and Hirotab S (2004) Kit as a human oncogenic tyrosine kinase. Cell Mol Life Sci 61: 2924-2931
    • (2004) Cell Mol Life Sci , vol.61 , pp. 2924-2931
    • Kitamura, Y.1    Hirotab, S.2
  • 26
    • 10344243662 scopus 로고    scopus 로고
    • MicroRNA-143 regulates adipocyte differentiation
    • Esau C et al. (2004) MicroRNA-143 regulates adipocyte differentiation. J Biol Chem 279: 52361-52365
    • (2004) J Biol Chem , vol.279 , pp. 52361-52365
    • Esau, C.1
  • 27
    • 9144270691 scopus 로고    scopus 로고
    • A pancreatic islet-specific microRNA regulates insulin secretion
    • Poy MN et al. (2004) A pancreatic islet-specific microRNA regulates insulin secretion. Nature 432: 226-230
    • (2004) Nature , vol.432 , pp. 226-230
    • Poy, M.N.1
  • 28
    • 33748749597 scopus 로고    scopus 로고
    • MicroRNA-9 controls the expression of granuphilin/Slp4 and the secretory response of insulin-producing cells
    • Plaisance V et al. (2006) MicroRNA-9 controls the expression of granuphilin/Slp4 and the secretory response of insulin-producing cells. J Biol Chem 281: 26932-26942
    • (2006) J Biol Chem , vol.281 , pp. 26932-26942
    • Plaisance, V.1
  • 29
    • 34547126004 scopus 로고    scopus 로고
    • MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic β-cell lines
    • Baroukh N et al. (2007) MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic β-cell lines. J Biol Chem 282: 19575-19588
    • (2007) J Biol Chem , vol.282 , pp. 19575-19588
    • Baroukh, N.1
  • 30
    • 35649011441 scopus 로고    scopus 로고
    • Over-expression of miR-29, highly upregulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes
    • doi: 10.1210/me.2007-0167
    • He A et al. (2007) Over-expression of miR-29, highly upregulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. Mol Endocrinol [doi: 10.1210/me.2007-0167]
    • (2007) Mol Endocrinol
    • He, A.1
  • 31
    • 33645075443 scopus 로고    scopus 로고
    • miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
    • Esau C et al. (2006) miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab 3: 87-98
    • (2006) Cell Metab , vol.3 , pp. 87-98
    • Esau, C.1
  • 32
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • Xing M (2005) BRAF mutation in thyroid cancer. Endocr Relat Cancer 12: 245-262
    • (2005) Endocr Relat Cancer , vol.12 , pp. 245-262
    • Xing, M.1
  • 33
    • 33645069923 scopus 로고    scopus 로고
    • BRAF is a therapeutic target in aggressive thyroid carcinoma
    • Salvatore G et al. (2006) BRAF is a therapeutic target in aggressive thyroid carcinoma. Clin Cancer Res 12: 1623-1629
    • (2006) Clin Cancer Res , vol.12 , pp. 1623-1629
    • Salvatore, G.1
  • 34
    • 17744373695 scopus 로고    scopus 로고
    • The RET proto-oncogene: A molecular therapeutic target in thyroid cancer
    • Kodama Y et al. (2005) The RET proto-oncogene: a molecular therapeutic target in thyroid cancer. Cancer Sci 96: 143-148
    • (2005) Cancer Sci , vol.96 , pp. 143-148
    • Kodama, Y.1
  • 35
    • 12144289681 scopus 로고    scopus 로고
    • A large-scale RNAi screen in human cells identifies new components of the p53 pathway
    • Berns K et al. (2004) A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428: 431-437
    • (2004) Nature , vol.428 , pp. 431-437
    • Berns, K.1
  • 36
    • 12144288006 scopus 로고    scopus 로고
    • A resource for large-scale RNA-interference-based screens in mammals
    • Paddison PJ et al. (2004) A resource for large-scale RNA-interference-based screens in mammals. Nature 428: 427-431
    • (2004) Nature , vol.428 , pp. 427-431
    • Paddison, P.J.1
  • 37
    • 20444426889 scopus 로고    scopus 로고
    • A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity
    • Kolfschoten IG et al. (2005) A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. Cell 121: 849-858
    • (2005) Cell , vol.121 , pp. 849-858
    • Kolfschoten, I.G.1
  • 38
    • 20444376939 scopus 로고    scopus 로고
    • A genetic screen for candidate tumor suppressors identifies REST
    • Westbrook TF et al. (2005) A genetic screen for candidate tumor suppressors identifies REST. Cell 121: 837-848
    • (2005) Cell , vol.121 , pp. 837-848
    • Westbrook, T.F.1
  • 39
    • 33144463713 scopus 로고    scopus 로고
    • An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARγ, adipogenesis, and insulin-responsive hexose transport
    • Tang X et al. (2006) An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARγ, adipogenesis, and insulin-responsive hexose transport. Proc Natl Acad Sci U S A 103: 2087-2092
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2087-2092
    • Tang, X.1
  • 40
    • 0035825643 scopus 로고    scopus 로고
    • Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
    • Abel ED et al. (2001) Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409: 729-733
    • (2001) Nature , vol.409 , pp. 729-733
    • Abel, E.D.1
  • 41
    • 14644426519 scopus 로고    scopus 로고
    • Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism
    • Taniguchi CM et al. (2005) Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism. J Clin Invest 115: 718-727
    • (2005) J Clin Invest , vol.115 , pp. 718-727
    • Taniguchi, C.M.1
  • 42
    • 2442701392 scopus 로고    scopus 로고
    • PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3
    • Koo SH et al. (2004) PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3. Nat Med 10: 530-534
    • (2004) Nat Med , vol.10 , pp. 530-534
    • Koo, S.H.1
  • 43
    • 33748331432 scopus 로고    scopus 로고
    • Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling
    • Cho CY et al. (2006) Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. Cell Metab 3: 367-378
    • (2006) Cell Metab , vol.3 , pp. 367-378
    • Cho, C.Y.1
  • 44
    • 0037348329 scopus 로고    scopus 로고
    • RNA interference targeting Fas protects mice from fulminant hepatitis
    • Song E et al. (2003) RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 9: 347-351
    • (2003) Nat Med , vol.9 , pp. 347-351
    • Song, E.1
  • 45
    • 6944238701 scopus 로고    scopus 로고
    • Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury
    • Hamar P et al. (2004) Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proc Natl Acad Sci U S A 101: 14883-14888
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 14883-14888
    • Hamar, P.1
  • 46
    • 27644485522 scopus 로고    scopus 로고
    • Gene silencing in the endocrine pancreas mediated by short-interfering RNA
    • Bradley SP et al. (2005) Gene silencing in the endocrine pancreas mediated by short-interfering RNA. Pancreas 31: 373-379
    • (2005) Pancreas , vol.31 , pp. 373-379
    • Bradley, S.P.1
  • 47
    • 23444445660 scopus 로고    scopus 로고
    • Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
    • Morrissey DV et al. (2005) Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat Biotechnol 23: 1002-1007
    • (2005) Nat Biotechnol , vol.23 , pp. 1002-1007
    • Morrissey, D.V.1
  • 48
    • 15444373116 scopus 로고    scopus 로고
    • RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
    • Urban-Klein B et al. (2005) RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther 12: 461-466
    • (2005) Gene Ther , vol.12 , pp. 461-466
    • Urban-Klein, B.1
  • 49
    • 25444482607 scopus 로고    scopus 로고
    • Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
    • Hu-Lieskovan S et al. (2005) Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res 65: 8984-8992
    • (2005) Cancer Res , vol.65 , pp. 8984-8992
    • Hu-Lieskovan, S.1
  • 50
    • 9144247189 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
    • Soutschek J et al. (2004) Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432: 173-178
    • (2004) Nature , vol.432 , pp. 173-178
    • Soutschek, J.1
  • 51
    • 33646185371 scopus 로고    scopus 로고
    • RNAi-mediated gene silencing in non-human primates
    • Zimmermann TS et al. (2006) RNAi-mediated gene silencing in non-human primates. Nature 441: 111-114
    • (2006) Nature , vol.441 , pp. 111-114
    • Zimmermann, T.S.1
  • 52
    • 34447114618 scopus 로고    scopus 로고
    • Transvascular delivery of small interfering RNA to the central nervous system
    • Kumar P et al. (2007) Transvascular delivery of small interfering RNA to the central nervous system. Nature 448: 39-43
    • (2007) Nature , vol.448 , pp. 39-43
    • Kumar, P.1
  • 53
    • 23844474160 scopus 로고    scopus 로고
    • Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
    • Song E et al. (2005) Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol 23: 709-717
    • (2005) Nat Biotechnol , vol.23 , pp. 709-717
    • Song, E.1
  • 54
    • 0033230617 scopus 로고    scopus 로고
    • PKR; a sentinel kinase for cellular stress
    • Williams BR (1999) PKR; a sentinel kinase for cellular stress. Oncogene 18: 6112-6120
    • (1999) Oncogene , vol.18 , pp. 6112-6120
    • Williams, B.R.1
  • 55
    • 0042972933 scopus 로고    scopus 로고
    • Activation of the interferon system by short-interfering RNAs
    • Sledz CA et al. (2003) Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 5: 834-839
    • (2003) Nat Cell Biol , vol.5 , pp. 834-839
    • Sledz, C.A.1
  • 56
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge AD et al. (2005) Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol 23: 457-462
    • (2005) Nat Biotechnol , vol.23 , pp. 457-462
    • Judge, A.D.1
  • 57
    • 20144389695 scopus 로고    scopus 로고
    • Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7
    • Hornung V et al. (2005) Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med 11: 263-270
    • (2005) Nat Med , vol.11 , pp. 263-270
    • Hornung, V.1
  • 58
    • 1542306855 scopus 로고    scopus 로고
    • Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase
    • Kim DH et al. (2004) Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat Biotechnol 22: 321-325
    • (2004) Nat Biotechnol , vol.22 , pp. 321-325
    • Kim, D.H.1
  • 59
    • 0347623204 scopus 로고    scopus 로고
    • Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs)
    • Persengiev SP et al. (2004) Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). RNA 10: 12-18
    • (2004) RNA , vol.10 , pp. 12-18
    • Persengiev, S.P.1
  • 60
    • 16244362066 scopus 로고    scopus 로고
    • Cationic lipids enhance siRNA-mediated interferon response in mice
    • Ma Z et al. (2005) Cationic lipids enhance siRNA-mediated interferon response in mice. Biochem Biophys Res Commun 330: 755-759
    • (2005) Biochem Biophys Res Commun , vol.330 , pp. 755-759
    • Ma, Z.1
  • 61
    • 0142173075 scopus 로고    scopus 로고
    • Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells
    • Saxena S et al. (2003) Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells. J Biol Chem 278: 44312-44319
    • (2003) J Biol Chem , vol.278 , pp. 44312-44319
    • Saxena, S.1
  • 62
    • 19344378192 scopus 로고    scopus 로고
    • Sequence-specific inhibition of small RNA function
    • Hutvagner G et al. (2004) Sequence-specific inhibition of small RNA function. PLoS Biol 2: e98
    • (2004) PLoS Biol , vol.2
    • Hutvagner, G.1
  • 63
    • 1242318826 scopus 로고    scopus 로고
    • Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing
    • Meister G et al. (2004) Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA 10: 544-550
    • (2004) RNA , vol.10 , pp. 544-550
    • Meister, G.1
  • 64
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with 'antagomirs'
    • Krutzfeldt J et al. (2005) Silencing of microRNAs in vivo with 'antagomirs'. Nature 438: 685-689
    • (2005) Nature , vol.438 , pp. 685-689
    • Krutzfeldt, J.1
  • 65
    • 16244377103 scopus 로고    scopus 로고
    • A crucial test
    • Check E (2005) A crucial test. Nat Med 11: 243-244
    • (2005) Nat Med , vol.11 , pp. 243-244
    • Check, E.1
  • 66
    • 3142668312 scopus 로고    scopus 로고
    • Gene therapy for proliferative ocular diseases
    • McFarland TJ et al. (2004) Gene therapy for proliferative ocular diseases. Expert Opin Biol Ther 4: 1053-1058
    • (2004) Expert Opin Biol Ther , vol.4 , pp. 1053-1058
    • McFarland, T.J.1
  • 67
    • 13444262170 scopus 로고    scopus 로고
    • Inhibition of respiratory viruses by nasally administered siRNA
    • Bitko V et al. (2005) Inhibition of respiratory viruses by nasally administered siRNA. Nat Med 11: 50-55
    • (2005) Nat Med , vol.11 , pp. 50-55
    • Bitko, V.1
  • 68
    • 34249660144 scopus 로고    scopus 로고
    • TXNIP regulates peripheral glucose metabolism in humans
    • Parikh H et al. (2007) TXNIP regulates peripheral glucose metabolism in humans. PLoS Med 4: e158
    • (2007) PLoS Med , vol.4
    • Parikh, H.1
  • 69
    • 33645112623 scopus 로고    scopus 로고
    • PKCθ is a key player in the development of insulin resistance
    • Haasch D et al. (2006) PKCθ is a key player in the development of insulin resistance. Biochem Biophys Res Commun 343: 361-368
    • (2006) Biochem Biophys Res Commun , vol.343 , pp. 361-368
    • Haasch, D.1
  • 70
    • 33745198007 scopus 로고    scopus 로고
    • Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport
    • Sajan MP et al. (2006) Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport. J Biol Chem 281: 17466-17473
    • (2006) J Biol Chem , vol.281 , pp. 17466-17473
    • Sajan, M.P.1
  • 71
    • 33644875891 scopus 로고    scopus 로고
    • Tmem27: A cleaved and shed plasma membrane protein that stimulates pancreatic β cell proliferation
    • Akpinar P et al. (2005) Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic β cell proliferation. Cell Metab 2: 385-397
    • (2005) Cell Metab , vol.2 , pp. 385-397
    • Akpinar, P.1
  • 72
    • 21044433282 scopus 로고    scopus 로고
    • The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet β cells
    • Schisler JC et al. (2005) The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet β cells. Proc Natl Acad Sci U S A 102: 7297-7302
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 7297-7302
    • Schisler, J.C.1
  • 73
    • 23844485708 scopus 로고    scopus 로고
    • Differential gene expression between Zucker fatty rats and Zucker diabetic fatty rats: A potential role for the immediate-early gene Egr-1 in regulation of β cell proliferation
    • Garnett KE et al. (2005) Differential gene expression between Zucker fatty rats and Zucker diabetic fatty rats: a potential role for the immediate-early gene Egr-1 in regulation of β cell proliferation. J Mol Endocrinol 35: 13-25
    • (2005) J Mol Endocrinol , vol.35 , pp. 13-25
    • Garnett, K.E.1
  • 74
    • 10744229064 scopus 로고    scopus 로고
    • RNA interfering approach for clarifying the PPARγ pathway using lentiviral vector expressing short hairpin RNA
    • Katayama K et al. (2004) RNA interfering approach for clarifying the PPARγ pathway using lentiviral vector expressing short hairpin RNA. FEBS Lett 560: 178-182
    • (2004) FEBS Lett , vol.560 , pp. 178-182
    • Katayama, K.1
  • 75
    • 8744305112 scopus 로고    scopus 로고
    • Analysis of insulin signalling by RNAi-based gene silencing
    • Zhou QL et al. (2004) Analysis of insulin signalling by RNAi-based gene silencing. Biochem Soc Trans 32: 817-821
    • (2004) Biochem Soc Trans , vol.32 , pp. 817-821
    • Zhou, Q.L.1
  • 76
    • 3943097347 scopus 로고    scopus 로고
    • RNA-mediated interference indicates that SEL1L plays a role in pancreatic β-cell growth
    • Diaferia G et al. (2004) RNA-mediated interference indicates that SEL1L plays a role in pancreatic β-cell growth. DNA Cell Biol 23: 510-518
    • (2004) DNA Cell Biol , vol.23 , pp. 510-518
    • Diaferia, G.1
  • 77
    • 0037934650 scopus 로고    scopus 로고
    • Insulin signaling through Akt/ protein kinase B analyzed by small interfering RNA-mediated gene silencing
    • Jiang ZY et al. (2003) Insulin signaling through Akt/ protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci USA 100: 7569-7574
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7569-7574
    • Jiang, Z.Y.1
  • 78
    • 0141764778 scopus 로고    scopus 로고
    • Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis
    • Waselle L et al. (2003) Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis. Mol Biol Cell 14: 4103-4113
    • (2003) Mol Biol Cell , vol.14 , pp. 4103-4113
    • Waselle, L.1
  • 79
    • 0041381430 scopus 로고    scopus 로고
    • Transcription regulation of the multiple endocrine neoplasia type 1 gene in human and mouse
    • Zablewska B et al. (2003) Transcription regulation of the multiple endocrine neoplasia type 1 gene in human and mouse. J Clin Endocrinol Metab 88: 3845-3851
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3845-3851
    • Zablewska, B.1
  • 80
    • 20344391925 scopus 로고    scopus 로고
    • The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II
    • Yart A et al. (2005) The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II. Mol Cell Biol 25: 5052-5060
    • (2005) Mol Cell Biol , vol.25 , pp. 5052-5060
    • Yart, A.1
  • 81
    • 0038713461 scopus 로고    scopus 로고
    • Differential expression of galectin-3 in pituitary tumors
    • Riss D et al. (2003) Differential expression of galectin-3 in pituitary tumors. Cancer Res 63: 2251-2255
    • (2003) Cancer Res , vol.63 , pp. 2251-2255
    • Riss, D.1
  • 82
    • 33744954161 scopus 로고    scopus 로고
    • Ribonucleic acid interference targeting S100A4 (Mts1) suppresses tumor growth and metastasis of anaplastic thyroid carcinoma in a mouse model
    • Shi Y et al. (2006) Ribonucleic acid interference targeting S100A4 (Mts1) suppresses tumor growth and metastasis of anaplastic thyroid carcinoma in a mouse model. J Clin Endocrinol Metab 91: 2373-2379
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2373-2379
    • Shi, Y.1
  • 83
    • 20044390030 scopus 로고    scopus 로고
    • Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation
    • Sorrentino R et al. (2005) Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation. J Clin Endocrinol Metab 90: 928-935
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 928-935
    • Sorrentino, R.1


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