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Volumn 96, Issue 3, 2005, Pages 143-148

The RET proto-oncogene: A molecular therapeutic target in thyroid cancer

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; 4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ADENOVIRUS VECTOR; ARTEMIN; CEP 2563; CEP 701; CEP 751; CETUXIMAB; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; IMATINIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRINOTECAN; MITOGEN ACTIVATED PROTEIN KINASE P38; MUCIN 1; MUCIN 4; MUCIN 5B; NEURTURIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C GAMMA; PROTEIN BAD; PROTEIN KINASE B; PROTEIN RET; PROTEIN SHC; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RPI 1; STAT3 PROTEIN; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB;

EID: 17744373695     PISSN: 13479032     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2005.00023.x     Document Type: Review
Times cited : (105)

References (47)
  • 1
    • 0022330363 scopus 로고
    • Activation of a novel human transforming gene, ret, by DNA rearrangement
    • Takahashi M, Ritz J, Cooper GM. Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell 1985; 42: 581-8.
    • (1985) Cell , vol.42 , pp. 581-588
    • Takahashi, M.1    Ritz, J.2    Cooper, G.M.3
  • 2
    • 0023158426 scopus 로고
    • Ret transforming gene encodes a fusion protein homologous to tyrosine kinases
    • Takahashi M, Cooper GM. ret transforming gene encodes a fusion protein homologous to tyrosine kinases. Mol Cell Biol 1987; 7: 1378-85.
    • (1987) Mol. Cell Biol. , vol.7 , pp. 1378-1385
    • Takahashi, M.1    Cooper, G.M.2
  • 3
    • 0024208663 scopus 로고
    • Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains
    • Takahashi M, Buma Y, Iwamoto T, Inaguma Y, Ikeda H, Hiai H. Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene 1988; 3: 571-8.
    • (1988) Oncogene , vol.3 , pp. 571-578
    • Takahashi, M.1    Buma, Y.2    Iwamoto, T.3    Inaguma, Y.4    Ikeda, H.5    Hiai, H.6
  • 6
    • 0036581222 scopus 로고    scopus 로고
    • The GDNF family: Signalling, biological functions and therapeutic value
    • Airaksinen MS, Saarma M. The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 2002; 3: 383-94.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 383-394
    • Airaksinen, M.S.1    Saarma, M.2
  • 7
    • 0028174023 scopus 로고
    • Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor
    • Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 1994; 367: 380-3.
    • (1994) Ret. Nature , vol.367 , pp. 380-383
    • Schuchardt, A.1    D'Agati, V.2    Larsson-Blomberg, L.3    Costantini, F.4    Pachnis, V.5
  • 11
    • 0034849573 scopus 로고    scopus 로고
    • The GDNF/RET signaling pathway and human diseases
    • Takahashi M. The GDNF/RET signaling pathway and human diseases. Cytokine Growth Factor Rev 2001; 12: 361-73.
    • (2001) Cytokine Growth Factor Rev. , vol.12 , pp. 361-373
    • Takahashi, M.1
  • 12
    • 0028838086 scopus 로고
    • Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations
    • Asai N, Iwashita T, Matsuyama M, Takahashi M. Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol Cell Biol 1995; 15: 1613-9.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 1613-1619
    • Asai, N.1    Iwashita, T.2    Matsuyama, M.3    Takahashi, M.4
  • 14
    • 0030047832 scopus 로고    scopus 로고
    • Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation
    • Iwashita T, Asai N, Murakami H, Matsuyama M, Takahashi M. Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation. Oncogene 1996; 12: 481-7.
    • (1996) Oncogene , vol.12 , pp. 481-487
    • Iwashita, T.1    Asai, N.2    Murakami, H.3    Matsuyama, M.4    Takahashi, M.5
  • 15
    • 0034693757 scopus 로고    scopus 로고
    • The RET proto-oncogene in human cancers
    • Jhiang SM. The RET proto-oncogene in human cancers. Oncogene 2000; 19: 5590-7.
    • (2000) Oncogene , vol.19 , pp. 5590-5597
    • Jhiang, S.M.1
  • 17
    • 3042749217 scopus 로고    scopus 로고
    • The RET proto-oncogene: A potential target for molecular cancer therapy
    • Putzer BM, Drosten M. The RET proto-oncogene: a potential target for molecular cancer therapy. Trends Mol Med 2004; 10: 351-7.
    • (2004) Trends Mol. Med. , vol.10 , pp. 351-357
    • Putzer, B.M.1    Drosten, M.2
  • 20
    • 0029893933 scopus 로고    scopus 로고
    • A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins
    • Asai N, Murakami H, Iwashita T, Takahashi M. A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins. J Biol Chem 1996; 271: 17644-9.
    • (1996) J. Biol. Chem. , vol.271 , pp. 17644-17649
    • Asai, N.1    Murakami, H.2    Iwashita, T.3    Takahashi, M.4
  • 21
    • 0028982261 scopus 로고
    • The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10
    • Pandey A, Duan H, Di Fiore PP, Dixit VM. The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10. J Biol Chem 1995; 270: 21461-3.
    • (1995) J. Biol. Chem. , vol.270 , pp. 21461-21463
    • Pandey, A.1    Duan, H.2    Di Fiore, P.P.3    Dixit, V.M.4
  • 22
    • 2442492170 scopus 로고    scopus 로고
    • Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival
    • Encinas M, Crowder RJ, Milbrandt J, Johnson EM Jr. Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival. J Biol Chem 2004; 279: 18262-9.
    • (2004) J. Biol. Chem. , vol.279 , pp. 18262-18269
    • Encinas, M.1    Crowder, R.J.2    Milbrandt, J.3    Johnson Jr., E.M.4
  • 25
    • 0033584474 scopus 로고    scopus 로고
    • Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation
    • Murakami H, Iwashita T, Asai N, Shimono Y, Iwata Y, Kawai K, Takahashi M. Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation. Biochem Biophys Res Commun 1999; 262: 68-75.
    • (1999) Biochem. Biophys. Res. Commun. , vol.262 , pp. 68-75
    • Murakami, H.1    Iwashita, T.2    Asai, N.3    Shimono, Y.4    Iwata, Y.5    Kawai, K.6    Takahashi, M.7
  • 26
    • 0034671913 scopus 로고    scopus 로고
    • Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase
    • Besset V, Scott RP, Ibanez CF. Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase. J Biol Chem 2000; 275: 39159-66.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39159-39166
    • Besset, V.1    Scott, R.P.2    Ibanez, C.F.3
  • 30
    • 0034603172 scopus 로고    scopus 로고
    • Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway
    • Segouffin-Cariou C, Billaud M. Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway. J Biol Chem 2000; 275: 3568-76.
    • (2000) J. Biol. Chem. , vol.275 , pp. 3568-3576
    • Segouffin-Cariou, C.1    Billaud, M.2
  • 34
    • 6344276574 scopus 로고    scopus 로고
    • Central role of the threonine residue within the p. +1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells
    • Yuan ZL, Guan YJ, Wang L, Wei W, Kane AB, Chin YE. Central role of the threonine residue within the p. +1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. Mol Cell Biol 2004; 24: 9390-400.
    • (2004) Mol. Cell Biol. , vol.24 , pp. 9390-9400
    • Yuan, Z.L.1    Guan, Y.J.2    Wang, L.3    Wei, W.4    Kane, A.B.5    Chin, Y.E.6
  • 35
    • 1542283574 scopus 로고    scopus 로고
    • Basic science going clinical: Molecularly targeted therapy of chronic myclogenous leukemia
    • Deininger MW. Basic science going clinical: molecularly targeted therapy of chronic myclogenous leukemia. J Cancer Res Clin Oncol 2004; 130: 59-72.
    • (2004) J. Cancer Res. Clin Oncol. , vol.130 , pp. 59-72
    • Deininger, M.W.1
  • 38
  • 40
    • 0037699063 scopus 로고    scopus 로고
    • PP1 inhibitor induces degradation of RET MEN2A and RET MEN2B oncoproteins through proteosomal targeting
    • Carniti C, Perego C, Mondellini P, Pierotti MA, Bongarzone I. PP1 inhibitor induces degradation of RET MEN2A and RET MEN2B oncoproteins through proteosomal targeting. Cancer Res 2003; 63: 2234-43.
    • (2003) Cancer Res. , vol.63 , pp. 2234-2243
    • Carniti, C.1    Perego, C.2    Mondellini, P.3    Pierotti, M.A.4    Bongarzone, I.5
  • 41
    • 4444273158 scopus 로고    scopus 로고
    • Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors
    • Carlomagno F, Guida T, Anaganti S, Vecchio G, Fusco A, Ryan AJ, Billaud M, Santoro M. Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors. Oncogene 2004; 23: 6056-63.
    • (2004) Oncogene , vol.23 , pp. 6056-6063
    • Carlomagno, F.1    Guida, T.2    Anaganti, S.3    Vecchio, G.4    Fusco, A.5    Ryan, A.J.6    Billaud, M.7    Santoro, M.8
  • 44
    • 0036915701 scopus 로고    scopus 로고
    • A new therapeutic approach in medullary thyroid cancer treatment: Inhibition of oneogenic RET signaling by adenoviral vector-mediated expression of a dominant-negative RET mutant
    • discussion 997
    • Drosten M, Frilling A, Stiewe T, Putzer BM. A new therapeutic approach in medullary thyroid cancer treatment: inhibition of oneogenic RET signaling by adenoviral vector-mediated expression of a dominant-negative RET mutant. Surgery 2002; 132: 991-7; discussion 997.
    • (2002) Surgery , vol.132 , pp. 991-997
    • Drosten, M.1    Frilling, A.2    Stiewe, T.3    Putzer, B.M.4
  • 45
    • 0038235732 scopus 로고    scopus 로고
    • Antitumor capacity of a dominant-negative RET proto-oncogene mutant in a medullary thyroid carcinoma model
    • Drosten M, Stiewe T, Putzer BM. Antitumor capacity of a dominant-negative RET proto-oncogene mutant in a medullary thyroid carcinoma model. Hum Gene Ther 2003; 14: 971-82.
    • (2003) Hum. Gene Ther. , vol.14 , pp. 971-982
    • Drosten, M.1    Stiewe, T.2    Putzer, B.M.3
  • 46
    • 2442701289 scopus 로고    scopus 로고
    • The ErbB/HER receptor protein-tyrosine kinases and cancer
    • Roskoski R Jr. The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochem Biophys Res Commun 2004; 319: 1-11.
    • (2004) Biochem. Biophys. Res. Commun. , vol.319 , pp. 1-11
    • Roskoski Jr., R.1


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