Effect of aging and dietary restriction on hepatocyte proliferation and death in male F344 rats

Cell and Tissue Research

Volumn 288, Issue 1, 1997, Pages 69-77

  Higami, Yoshikazu ^a   Shimokawa, Isao ^a   Okimoto, Tomoaki ^a   Tomita, Masato ^a   Yuo, Takane ^a   Ikeda, Takayoshi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

Aging; Cell death; Cell proliferation; Dietary restriction; Hepatocytes; Proliferating cell nuclear antigen; Rat (Fischer 344); Terminal dUTP nick end labeling (TUNEL)

Indexed keywords

CYCLINE; DNA NUCLEOTIDYLEXOTRANSFERASE;

AGING; ANIMAL TISSUE; ARTICLE; CELL CYCLE S PHASE; CELL DEATH; CELL PROLIFERATION; DIET RESTRICTION; IMMUNOCYTOCHEMISTRY; LEUKEMIA CELL; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

AGING; ANIMALS; APOPTOSIS; CELL DIVISION; DEOXYURACIL NUCLEOTIDES; IMMUNOENZYME TECHNIQUES; LIVER; MALE; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, INBRED F344;

ANIMALIA;

EID: 0030944390     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410050793     Document Type: Article

References (36)

1. Bralet M-P, Branchereau S, Brechot C, Ferry N (1994) Cell lineage study in the liver using retroviral mediated gene transfer. Am J Pathol 144:896-905
2. Bucher NLR, Swaffield MN, DiTroia JF (1964) The influence of age upon the incorporation of thymidine 2-C14 into the DNA of regenerating rat liver. Cancer Res 24:509-512
3. Celis JE, Celis A (1985) Cell cycle-dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cell: subdivision of S phase. Proc Natl Acad Sci USA 82:3262-3266
4. Chetsanga CJ, Boyd V, Peterson L, Rusholow K (1975) Single-strand regions in DNA of old Mice. Nature 1975; 253:130-131
5. Childs GV, Lloyd JM, Unabia G, Gharib SD, Wierman ME, Chin WM (1987) Detection of luteinizing hormone β messenger ribonucleic acid (RNA) in individual gonadotropes after castration: use of a new in situ hybridization method with photobiotinylated complementary RNA probe. Mol Endocrinol 1:926-932
6. El-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, Wiman KG, Mercer WE, Kastan MB, Kohn KW, Elledge SJ, Kinzler KW, Vogelstain B (1994) Waf1/Cip1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 54:1169-1174
7. Feuers RJ, Weindruch R, Hart RW (1993) Caloric restriction, aging and antioxidant enzymes. Mutat Res 295:191-200
8. Foley J, Ton T, Maronpot R, Butterworth B, Goldsworthy TL (1993) Comparison of proliferating cell nuclear antigen to tritiated thymidine as a marker of proliferating hepatocytes in rats. Environ Health Perspect 101 (Suppl 5): 199-206
9. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 119:493-501
10. Grisham JW (1994) Migration of hepatocytes along hepatic plates and stem cell-fed hepatocyte lineage. Am J Pathol 144:849-854
11. Haley-Zitlin V, Richardson A (1993) Effect of dietary restriction on DNA repair and DNA damage. Mutat Res 295:237-245
12. Harman D (1956) Aging: a theory based on free radical and radiation biology. J Gerontol 11:298-300
13. Hayflick L (1965) The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37:614-636
14. Higami Y, Shimokawa I, Okimoto T, Ikeda T (1994a) An age-related increase in the basal level of DNA damage and DNA vulnerability to oxygen radicals in the individual hepatocytes of male F344 rats. Mutat Res 316:59-67
15. Higami Y, Shimokawa I, Okimoto T, Ikeda T (1994b) Vulnerability to oxygen radicals is more important than impaired repair in hepatocytic deoxyribonucleic acid damage in aging. Lab Invest 71:650-656
16. Higami Y, Shimokawa I, Okimoto T, Tomita T, Yuo T, Ikeda T (1996) Susceptibility of hepatocytes to cell death induced by single administration of cycloheximide in young and old F344 rats. Effect of dietary restriction. Mutat Res 357:225-230
17. Holmes GE, Bernstein C, Bernstein H (1992) Oxidative and other DNA damages as the basis of aging: a review. Mutat Res 275:305-315
18. Ishigami A, Reed TD, Roth GS (1993) Effect of aging on EGF stimulated DNA synthesis and EGF receptor levels in primary cultured rat hepatocytes. Biochem Biophys Res Commun 196:181-186
19. Ishigami A, Roth GS (1994) Age-related changes in DNA synthesis stimulated by epinephrine and isoproterenol in primary cultured rat hepatocytes. J Cell Physiol 158:231-236
20. Laganiere S, Yu BP (1987) Anti-lipoperoxidation action of food restriction. Biochem Biophys Res Commun 145:1185-1191
21. Ledda-Columbano GM, Coni P, Faa G, Manenti G, Columbano A (1992) Rapid induction of apoptosis in rat liver by cycloheximide. Am J Pathol 140:545-549
22. Maeda H, Gleiser CA, Masoro EJ, Murata I, McMahan CA, Yu BP (1985) Nutritional influences on aging of Fischer 344 rats: II. Pathology. J Gerontol 40:671-688
23. McConkey DJ, Hartzell P, Nicotera P, Wyllie AH, Orrenius S (1988) Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress. Toxicol Lett 42:123-130
24. Mercer WE, Shields MT, Lin D, Appella E, Ullrich SJ (1991) Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression. Proc Natl Acad Sci USA 88:1958-1962
25. Muskhelishvili L, Hart RW, Turturro A, James SJ (1995) Age-related changes in the intrinsic rate of apoptosis in livers of diet-restricted and ad libitum-fed B6C3F1 mice. Am J Pathol 147:20-24
26. Oberhammer FA, Pavelka M, Sharma S, Tiefenbacher R, Purchio A, Bursch W, Schulte-Hermann R (1992) Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor-β1. Proc Natl Acad Sci USA 89:5408-5412
27. Pacifici RE, Davies KJA (1991) Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited. Gerontology 37:166-180
28. Raff MC (1992) Social controls on cell survival and cell death. Nature 356:397-400
29. Rappaport AM, Borowy AJ, Lougheed WM, Lotto WN (1954) Subdivision of hexagonal liver lobules into a structural and functional unit. Anat Rec 119:11-13
30. Sawada N, Ishikawa T (1988) Reduction of potential for replicative but not unscheduled DNA synthesis in hepatocytes isolated from aged as compared to young rats. Cancer Res 48:1618-1622
31. Shay JW, Pereira-Smith OM, Wright WE (1991) A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res 196:33-39
32. Shinagawa T, Yoshioka K, Kakumu S, Wakita T, Ishikawa T, Itoh Y, Takayanagi M (1991) Apoptosis in cultured rat hepatocytes: the effects of tumour necrosis factor a and interferon γ. J Pathol 165:247-253
33. Stefanski SA, Elwell MR, Stranberg PC (1990) Spleen, lymph nodes and thymus. In: Boorman GA, Eustis SL, Elwell MR, Montgomery CA Jr, MacKenzie WF (eds) Pathology of the Fischer rat. Academic Press, San Diego, pp 369-393
34. sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts. Oncogene 10:835-840
35. Yu BP, Masoro EJ, McMahan CA (1985) Nutritional influences on aging of Fischer 344 rats. I. Physical, metabolic and longevity characteristics. J Gerontol 40:657-670
36. Zajicek G, Oren R, Weinred M Jr (1985) The streaming liver. Liver 5:293-300