Critical evaluation of the free radical theory of aging: A proposal for the oxidative stress hypothesis

Annals of the New York Academy of Sciences

Volumn 786, Issue , 1996, Pages 1-11

  Yu, Byung Pal ^a   Yang, Ryung ^b  

^a University of Texas Health Science Center ^*  (United States)

^b Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; FREE RADICAL; SUPEROXIDE;

AGING; CONFERENCE PAPER; DIET RESTRICTION; METABOLIC RATE; MITOCHONDRION; OXIDATIVE STRESS;

EID: 0029785583     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb39047.x     Document Type: Review

References (44)

1. DICE, J. F. 1993. Cellular and molecular mechanisms of aging. Physiol. Rev. 73: 149-159.
2. MASORO, E. J. 1995. Aging: current concepts. In Handbook of Physiology. Sect 11. Aging. E. J. Masoro, Ed. 3-21. Oxford University Press. New York.
3. HARMAN, D. 1981. The aging process. Proc. Natl. Acad. Sci. USA 78: 7124-7128.
4. BUETTNER, G. R. 1993. The pecking order of free radicals and oxidants: lipid peroxidation, a-tocopherol, and ascorbate. Arch. Biochem. Biophys. 300: 535:543.
5. HARMAN, D. 1972. The biologic clock: the mitochondria? J. Am. Geriatr. Soc. 20: 145-147.
6. BANDY, B. & A. J. DAVISON. 1990. Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging? Free Rad. Biol. Med. 8: 523-539.
7. YU, B. P. 1993. Need the free radical theory of aging be linked to the metabolic rate theory? Aging Clin. Exp. Res. 5: 243-244.
8. CHEN, J. J. & B. P. YU. 1994. Alterations in mitochondrial membrane fluidity by lipid peroxidation products. Free Radical Biol. Med. 17: 411-418.
9. SOHAL, R. S. 1993. The free radical hypothesis of aging: an appraisal of the current status. Aging Clin. Exp. Res. 5: 3-17.
10. HOLMES, D. J. & S. N. AUSTAD. 1995. Birds as animal models for the comparative biology of aging: a prospectus. J. Gerontol. 50A: B59-B66.
11. MASORO, E. J., B. P. YU & H. A. BERTRAND. 1982. Action of food restriction in delaying the aging process. Proc. Natl. Acad. Sci. USA 79: 4239-4241.
12. ENESCO, H. E., A. MCTAVISH & R. GARBERI. 1990. Spontaneous activity level and lifespan in rotifers: lack of support for the rate of living theory. Gerontology 3: 256-261.
13. MCCARTER, R. J., E. J. MASORO & B. P. YU. 1985. Does food restriction retard aging reducing metabolic rate? Am. J. Physiol. 248: E488-E490.
14. LANE, M. A., D. J. BAER, E. M. TILMONT, V. W. RUMPLER, D. K. INGRAM, G. S. ROTH & R. G. CUTLER. Energy balance in Rhesus monkeys (Macaca mulatta) subjected to long-term dietary restriction. J. Gerontol. In press.
15. 2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds. Free Radical Res. 21: 317-328.
16. WALLACE, D. C. 1992. Mitochondrial genetics: a paradigm for aging and degenerative disease. Science 256: 628-632.
17. MIGUEL, J. 1992. An update on the mitochondrial DNA mutation hypothesis of cell aging. Mutat. Res. 275: 209-216.
18. HEGNER, D. 1980. Age-dependence of molecular and functional changes in biological properties. Mech. Ageing Dev. 14: 101-118.
19. ESTERBAUER, H., R. J. SCHAUR & H. ZOLLNER. 1991. Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes. Free Radical Biol. Med. 11: 81-128.
20. WOLFF, S. P. & R. T. DEAN. 1992. Glucose autoxidation and protein modification. Biochem. J. 245: 243-250.
21. MATSUO, M., F. GOMI, K. KURAMOTO & M. SAGAL 1993. Food restriction suppresses age-dependent increases in the respired rates of hydrocarbons from rat. J. Gerontol. 48: 133-138.
22. SAWADA, M., U. SESTER & J. C. CARLSON. 1992. Superoxide radical formation and associated biochemical alterations in the plasma membrane of brain, heart, and liver during the lifetime of the rat. J. Cell. Biochem. 48: 296-304.
23. ZAHN, H. C., C. P. SUN, C. G. LIU & J. H. ZHOU. 1992. Age-related change of free radical generation in liver and sex glands of rats. Mech. Ageing Dev. 62: 111-116.
24. YU, B. P. 1994. Cellular defenses against damage from reactive oxygen Physiol. Rev. 74: 139-163.
25. SCHMIDT, H. H. H. W. & U. WALTER. 1994. NO at work. Cell 78: 919-925.
26. LAI, C. C., P. K. ANDRUS & T. H. CHIU. 1994. Hydroxyl radical generation and nitric oxide synthases activity in Fisher 344 X Brown-Norway F1 rat brain. Neurosci. Let. 179: 37-40.
27. SNYDER, S. H. 1992. Nitric oxide: first in a new class of neurotransmitters? Science 257: 494-496.
28. LAGANIERE, S. & B. P. YU. 1993. Modulation of membrane phospholipid fatty acid composition by age and food restriction. Gerontology 39: 7-18.
29. CHOUDHARY, A. K., M. NOKUBO, G. R. REDDY, S. N. YOOLA, J. D. MORROW, I. A. BLAIR & L. J. MARNETT. 1994. Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver. Science 265: 1580-1582.
30. CHOE, M., C. JACKSON & B. P. YU. 1995. Lipid peroxidation contributes to age-related membrane rigidity. Free Radical Biol. Med 18: 977-984.
31. YU, B. P. 1995. Modulation of oxidative stress as a means of life-prolonging action of dietary restriction. In Oxidative Stress and Aging. R. G. Cutler, L. Parker, J. Bertram & A. Mori, Eds. 331-342. Birkhäuser Verlag. Basel.
32. TAPPEL, A. L. 1977. Protection against free radical lipid peroxidation reactions. In Pharmacological Intervention in the Aging Process. J. Roberts, R. C. Adelman & V. Cristofalo, Eds. 111-131. Plenum. New York.
33. JACOB, R. A. 1995. The integrated antoxidant system. Nutr. Rev. 15: 755-766.
34. LÓPEZ-TORRES, M. R. PEREZ-COMPO, C. ROJAS, S. CADENAS & G. BARJA. 1993. Simultaneous induction of SOD, glutathione reductase, GSH, and ascorbate in liver and kidney correlates with survival during aging. Free Radical Biol. Med. 15: 133-142.
35. LAHERA, V. & A. K. KHRAIBI. 1994. Nitric oxide inhibition in hypertension. New Physiol. Sci. 9: 268-271.
36. REITER, R. J., D. MELCHIORRI, E. SEWERYNEK, B. POEGGELER, L. BARLOW-WALDEN, J. CHUANG, G. G. ORTIZ & A. ACUÑA-CASTROVIEJO. 1995. A review of the evidence supporting melatonin's role as an antioxidant. J. Pineal Res. 18: 1-11.
37. KOIZUMI, A., R. WEINDRUCH & R. WALFORD. 1987. Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice. J. Nutr. 117: 361-367.
38. LUHTALA, T. A., E. B. ROECKER, T. PUGH, R. J. FEURES & R. WEINDRUCH. 1994. Dietary restriction attenuates age-related increases in rat skeletal muscle antioxidant enzyme activities. J. Gerontol. 49: 13231-13238.
39. LEE, D. W. & B. P. YU. 1990. Modulation of free radicals and superoxide dismutase by age and dietary restriction. Aging Clin. Exp. Res. 2: 357-362.
40. KIM, J. D., B. P. YU, R. J. MCCARTER, S. Y. LEE & J. H. HERLIHY. 1995. Exercise and diet modulated cardiac lipid peroxidation and anti-oxidant defences. Free Radical Biol. Med. In press.
41. CHOI, J. H. & B. P. YU. 1995. Brain synaptosomal aging: free radicals and membrane fluidity. Free Radical Biol. Med. 18(2): 133-139.
42. CHOI, J. H. & B. P. YU. 1994. Modulation of age-related alterations of iron, ferritin and lipid peroxidation in rat serum. Age 17: 93-97.
43. KRISTAL, B. & B. P. YU. 1992. An emerging hypothesis: synergistic induction of aging by free radicals and Maillard reactions. J. Gerontol. 47: B107-B114.
44. YAMAZAKI, I. 1987. Free radical mechanisms in enzyme reactions. Free Radical Biol. Med. 3: 397-404.