The "Epigenetic Code Replication Machinery", ECREM: A promising drugable target of the epigenetic cell memory

Current Medicinal Chemistry

Volumn 14, Issue 25, 2007, Pages 2629-2641

  Bronner, Christian ^a   Chataigneau, Thierry ^a   Schini Kerth, Valérie B ^a   Landry, Yves ^a  

^a CNRS   (France)

Author keywords

Cancer; DNA methyltransferase; Drug; Epigenetic; Histone acety ltransferases; Histone code; Histone deacetylases; Inhibitors; Neuro degenerative disorders; Sirtuins; Therapy

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; APICIDIN; ARYLBUTYRIC ACID DERIVATIVE; AZACITIDINE; BUTYRIC ACID; CATECHIN; CURCUMIN; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE INHIBITOR; EMBRYONIC ECTODERM DEVELOPMENT PROTEIN; EPICATECHIN; EPIGALLOCATECHIN GALLATE; FISETIN; FR 901228; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HYDRALAZINE; MYRICETIN; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCAINAMIDE; PROCAINE; PROTAMINE KINASE; QUERCETIN; RESVERATROL; TRICHOSTATIN A; UNINDEXED DRUG; VALPROIC ACID; ZEBULARINE;

ALZHEIMER DISEASE; ATHEROSCLEROSIS; BIOTINYLATION; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMICAL MODIFICATION; CHROMOSOMAL INSTABILITY; DEGENERATIVE DISEASE; DEMETHYLATION; DEVELOPMENTAL STAGE; DNA METHYLATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; EMBRYO DEVELOPMENT; EPIGENETICS; GENETIC CODE; GENETIC TRANSCRIPTION; GENOME IMPRINTING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFLAMMATORY DISEASE; LEUKEMIA; LOW DRUG DOSE; MEMORY CELL; MUTAGENESIS; MYELODYSPLASTIC SYNDROME; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PHENOTYPE; PROTEIN PHOSPHORYLATION; REVIEW; SIDE EFFECT; TWINS; UBIQUITINATION; X CHROMOSOME INACTIVATION;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DRUG DESIGN; EPIGENESIS, GENETIC; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; PROTAMINE KINASE; SIRTUINS; UBIQUITINATION;

EID: 35748932923     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986707782023244     Document Type: Review

References (142)

1. Varmuza, S. Genome, 2003, 46, 963.
2. Kornberg, R.D.; Lorch, Y. Cell, 1999, 98, 285.
3. Margueron, R.; Trojer, P.; Reinborg, D. Curr. Opin. Genet. Dev., 2005, 15, 163.
4. Jenuwein, T.; Allis, C.D. Science, 2001, 293, 1074.
5. Shilatifard, A. Annu. Rev. Biochem, 2006, 75, 243.
6. Oommen, A.M.; Griffin, J.B.; Sarath, G.; Zempleni, J. J. Nutr. Biochem., 2005, 16, 74.
7. Jaenisch, R.; Bird, A. Nat. Genet., 2003, 33, 245.
8. Brehm, A.; Ovitt, C.E.; Scholer, H.R. APMIS, 1998, 106, 114.
9. Pesce, M.; Scholer, H.R. Mol. Reprod. Dev., 2000, 55, 452.
10. Nichols, J.; Zevnik, B.; Anastassiadis, K.; Niwa, H.; Klewe-Nebenius, D.; Chambers, I.; Scholer, H.; Smith, A. Cell, 1998, 95, 379.
11. Feldman, N.; Gerson, A.; Fang, J.; Li, E.; Zhang, Y.; Shinkai, Y.; Cedar, H.; Bergman, Y. Nat. Cell Biol., 2006, 8, 188.
12. Jelinic, P.; Shaw, P. J. Pathol., 2007, 11, 261.
13. Heard, E. Curr. Opin. Genet. Dev., 2005, 15, 482.
14. Bird, A. Genes Dev., 2002, 16, 6.
15. Boyes, J.; Bird, A. Cell, 1991, 64, 1123.
16. Bird, A.P.; Wolffe, A.P. Cell, 1999, 99, 451.
17. Wade, P.A. Oncogene, 2001, 20, 3166.
18. Klose, R.J.; Bird, A.P. Trends Biochem. Sci., 2006, 31, 89.
19. Bronner, C.; Chataigneau.; T.; Schini-Kerth, V. B. From the control of cell growth to cancer Chichester.; Ed Giordano, Wiley and Sons publisher, 2007.
20. Fatemi, M.; Wade, P.A. J. Cell Sci., 2006, 119, 3033.
21. Hermann, A.; Gowher, H.; Jeltsch, A. Cell. Mol. Life Sci., 2004, 61, 2571.
22. Hermann, A.; Goyal, R.; Jeltsch, A. J. Biol. Chem., 2004, 279, 48350.
23. Vilkaitis, G.; Suetake, I.; Klimasauskas, S.; Tajima, S. J. Biol. Chem., 2005, 280, 64.
24. Jones, P.A; Baylin, S.B. Nat. Rev. Genet., 2002, 3, 415.
25. Tagami, H.; Ray-Gallet, D.; Almouzni, G.; Nakatani, Y. Cell, 2004, 116, 51.
26. Antczak, A.J.; Tsubota, T.; Kaufman, P.D.; Berger, J.M. BMC Struct. Biol. 2006, 6, 26.
27. Recht, J.; Tsubota, T.; Tanny, J.C.; Diaz, R.L.; Berger, J.M.; Zhang, X.; Garcia, B.A.; Shabanowitz, J.; Burlingame, A.L.; Hunt, D.F.; Kaufman, P.D.; Allis, C.D. Proc. Natl. Acad. Sci. USA, 2006, 103, 6988.
28. Celic, I.; Masumoto, H.; Griffith, W.P.; Meluh, P.; Cotter R.J.; Boeke, J.D.; Verreault, A. Curr. Biol., 2006, 16, 1280.
29. Chow, CM.; Georgiou, A.; Szutorisz, H.; Maia e Silva, A.; Pombo, A.; Barahona, I.; Dargelos, E.; Canzonetta C.; Pillon N. EMBO Rep., 2005, 6, 354.
30. Hake, S.B.; Allis, C.D. Proc. Natl. Acad. Sci. USA, 2006, 103, 6428.
31. de la Cruz, X.; Lois, S.; Sanchez-Molina, S.; Martinez-Balbas, M.A. Bioessays, 2005, 27, 164.
32. Mellor, J. Cell, 2006, 126, 22.
33. Agalioti, T.; Chen, G.; Thanos, D. Cell, 2002, 111, 381.
34. Jacobson, R.H.; Ladurner, A.G.; King, D.S.; Tjian, R. Science, 2000, 288, 1422.
35. Ladumer, A.G.; Inouye, C.; Jain, R.; Tjian, R. Mol. Cell., 2003, 11, 365.
36. Dhalluin, C.; Carlson, J.E.; Zeng, L.; He, C.; Aggarwal, A.K.; Zhou, M.M. Nature, 1999, 399, 491.
37. Ornaghi, P.; Ballario, P.; Lena, A.M.; González, A.; Filetici, P. J. Mol. Biol., 1999, 287, 1.
38. Owen, D.J.; Ornaghi, P.; Yang, J.C.; Lowe, N.; Evans, P.R.; Ballario, P.; Neuhaus, D.; Filetici, P.; Travers, A.A. EMBO J., 2000, 19, 6141.
39. Hudson, B.P.; Martinez-Yamout, M.A.; Dyson, H.J.; Wright, P.E. J. Mol. Biol., 2000, 304, 355.
40. Sims, R.J.; Chen, C.F.; Santos-Rosa, H.; Kouzarides, T.; Patel, S.S.; Reinberg, D. J. Biol. Chem., 2005, 280, 41789.
41. Min, J.; Zhang, Y.; Xu, R.M. Genes Dev., 2003, 17, 1823.
42. Bannister, A.J.; Zegerman, P.; Partridge, J.F.; Miska, E.A.; Thomas, J.O.; Allshire, R.C.; Kouzarides, T. Nature, 2001, 410, 120.
43. Yu, J.; Li, Y.; Ishizuka, T.; Guenther, M.G.; Lazar, M.A. EMBO J., 2003, 22, 3403.
44. Imai, S.; Armstrong, C.M.; Kaeberlein, M.; Guarente, L. Nature, 2000, 403, 795.
45. Carmen, A.A.; Milne, L., Grunstein, M. J. Biol. Chem., 2002, 277, 4778.
46. Chiu, Y.H.; Yu, Q.; Sandmeier, J.J.; Bi, X. Genetics, 2003, 165, 115.
47. Jeanblanc, M.; Mousli, M.; Hopfner, R.; Bathami, K.; Martinet, N.; Abbady, A.Q.; Siffert, J.C.; Mathieu, E.; Muller, C.D.; Bronner, C. Oncogene, 2005, 24, 7337.
48. Hopfner, R.; Mousli, M.; Jeltsch, J.M.; Voulgaris, A.; Lutz, Y.; Marin, C.; Bellocq, J.P.; Oudet P.; Bronner C. Cancer Res., 2000, 60, 121.
49. Hopfner, R.; Mousli, M.; Garnier, J.M.; Redon, R.; du Manoir, S.; Chatton, B.; Ghyselinck, N.; Oudet, P.; Bronner, C. Gene, 2001, 266, 15.
50. Hopfner, R.; Mousli, M.; Oudet, P.; Bronner, C. Anticancer Res., 2002, 22, 3165.
51. Mousli, M.; Hopfner, R.; Abbady, A.Q.; Monté, D.; Jeanblanc, M.; Oudet, P.; Louis, B.; Bronner, C. Br. J. Cancer, 2003, 89, 120.
52. Jenkins, Y.; Markovtsov, V.; Lang, W.; Sharma, P.; Pearsall, D.; Warner, J.; Franci, C.; Huang, B.; Huang, J.; Yam, G.C.; Vistan, J.P.; Pali, E.; Vialard, J.; Janicot, M.; Lorens, J.B.; Payan, D.G.; Hitoshi, Y. Mol. Biol. Cell., 2005, 16, 5621.
53. Citterio, E.; Papait, R.; Nicassio, F.; Vecchi, M.; Gomiero, P.; Mantovani, R.; Di Fiore, PP.; Bonapace I.M. Mol. Cell Biol., 2004, 24, 2526.
54. Achour, M.; Jacq, X.; Rondé, P.; Alhosin, M.; Charlot, C.; Chataigneau, T.; Jeanblanc, M.; Macaluso, M.; Giordano, A.; Hughes, A.D.; Schini-Kerth, V.B.; Bronner, C. Submitted.
55. Macaluso, M.; Montanari, M.; Gregorio, V.; Noto, P.B.; Bronner, C.; Giordano, A. Cancer Res., 2007, in press.
56. Bronner, C.; Achour M.; Arima, Y.; Chataigneau, T.; Saya, H.; Schini-Kerth, V.B. Pharmacol. Ther., in press.
57. Sapountzi, V.; Logan, I.R.; Robson, C.N. Int. J. Biochem. Cell Biol., 2006, 38, 1496.
58. Squatrito, M.; Gorrini, C.; Amati, B. Trends Cell. Biol., 2006, 16, 433.
59. Giacinti, C.; Giordano, A. Oncogene, 2006, 25, 5220.
60. Gabellini, C.; Del Bufalo, D.; Zupi, G. Oncogene, 2006, 25, 5326.
61. Macaluso, M.; Montanari, M.; Giordano, A. Oncogene, 2006, 25, 5263.
62. Jeltsch, A. Curr. Top. Microbiol. Immunol., 2006, 301, 203.
63. Turek-Plewa, J.; Jagodzinski, P.P. Cell. Mol. Biol. Lett., 2005, 10, 631.
64. Goll, M.G.; Kirpekar, F.; Maggert, K.A.; Yoder, J.A.; Hsieh, C.L.; Zhang, X.; Golic, K.G.; Jacobsen, S.E.; Bestor, T.H. Science, 2006, 311, 395.
65. Kuhlmann, M.; Borisova, B.E.; Kaller, M.; Larsson, P.; Stach, D.; Na, J.; Eichinger, L.; Lyko, F.; Ambros, V.; Soderbom, F.; Hammann, C.; Nellen, W. Nucleic Acids Res., 2005, 33, 6405.
66. Kunert, N.; Marhold, J.; Stanke, J.; Stach, D.; Lyko, F. Development, 2003, 130, 5083.
67. Jeltsch, A.; Nellen, W.; Lyko, F. Trends Biochem. Sci., 2006, 31, 306.
68. Okano, M.; Xie, S.; Li, E. Nat. Genet., 1998, 19, 219.
69. Gowher, H.; Jeltsch, A. J. Mol. Biol., 2001, 309, 1201.
70. Huntriss, J.; Hinkins, M.; Oliver, B.; Harris, S.E.; Beazley, J.C.; Rutherford, A.J.; Gosden, R.G.; Lanzendorf, S.E.; Picton, H.M. Mol. Reprod Dev., 2004, 67, 323.
71. Kaneda, M.; Okano, M.; Hata, K.; Sado, T.; Tsujimoto, N.; Li, E.; Sasaki, H. Nature, 2004, 429, 900.
72. Okano, M.; Bell, D.W.; Haber, D.A.; Li, E. Cell, 1999, 99, 247.
73. Xu, G.L.; Bestor, T.H.; Bourc'his, D.; Hsieh, C.L.; Tommerup, N.; Bugge, M.; Hulten, M.; Qu, X.; Russo, J.J.; Viegas-Pequignot, E. Nature, 1999, 402, 187.
74. Spotswood, H.T.; Turner, B.M. J. Clin. Invest., 2002, 110, 577.
75. Santos-Rosa, H.; Caldas C. Eur. J. Cancer, 2005, 41, 2381.
76. Rea, S.; Eisenhaber, F.; O'Carroll, D.; Strahl, B.D.; Sun,Z.W.; Schmid, M.; Opravil, S.; Mechtler, K.; Ponting, C.P., Allis, C.D.; Jenuwein, T. Nature, 2000, 406, 593.
77. Peters, A.H.; O'Carroll, D.; Scherthan, H.; Mechtler, K.; Sauer, S.; Schofer, C.; Weipoltshammer, K.; Pagani, M.; Lachner, M.; Kohlmaier, A.; Opravil, S.; Doyle M.; Sibilia, M.; Jenuwein, T. Cell, 2001, 107, 323.
78. Tachibana, M.; Sugimoto, K.; Fukushima, T.; Shinkai, Y. J. Biol. Chem., 2001, 276, 25309.
79. Schultz, D.C.; Ayyanathan, K.; Negorev, D.; Maul, G.G.; Rauscher, F.J. 3rd. Genes Dev., 2002, 16, 919.
80. Ogawa, H.; Ishiguro, K.; Gaubatz, S.; Livingston, D.M.; Nakatani, Y. Science, 2002, 296, 1132.
81. Beisel, C.; Imhof, A.; Greene, J.; Kremmer, E.; Sauer, F. Nature, 2002, 419, 857.
82. Wu, R.; Terry, A.V.; Singh, P.B.; Gilbert, D.M. Mol. Biol. Cell, 2005, 16, 2872.
83. Rice, J.C.; Briggs, S.D.; Ueberheide, B.; Barber, C.M.; Shabanowitz, J.; Hunt, D.F.; Shinkai, Y.; Allis, C.D. Mol. Cell, 2003, 12, 1591.
84. Noma, K.; Allis, C.D.; Grewal, S.I. Science, 2001, 293, 1150.
85. Litt, M.D.; Simpson, M.; Gaszner, M.; Allis, C.D.; Felsenfeld, G. Science, 2001, 293, 2453.
86. Lachner, M.; O'Carroll, D.; Rea, S.; Mechtler, K.; Jenuwein, T. Nature, 2001, 410, 116.
87. Nakayama, J.; Rice, J.C.; Strahl, B.D.; Allis, C.D.; Grewal, S.I. Science, 2001, 292, 110.
88. Jacobs, S.A.; Khorasanizadeh, S. Science, 2002, 295, 2080.
89. Orlando, V. Cell, 2003, 112, 599.
90. Cao, R.; Wang, L.; Wang, H.; Xia, L.; Erdjument-Bromage, H.; Tempst, P.; Jones, R.S.; Zhang, Y. Science, 2002, 298, 1039.
91. Czermin, B.; Melfi, R.; McCabe, D.; Seitz, V.; Imhof, A.; Pirrotta, V. Cell, 2002, 111, 185.
92. Kuzmichev, A.; Nishioka, K.; Erdjument-Bromage, H.; Tempst, P.; Reinberg, D. Genes Dev., 2002, 16, 2893.
93. Milne, T.A.; Briggs, S.D.; Brock, H.W.; Martin, M.E.; Gibbs, D.; Allis, C.D.; Hess, J.L. Mol. Cell, 2002, 10, 1107.
94. Nakamura, T.; Mori, T.; Tada, S.; Krajewski, W.; Rozovskaia, T.; Wassell, R.; Dubois, G.; Mazo, A.; Croce, C.M.; Canaani, E. Mol. Cell, 2002, 10, 1119.
95. Muller, J.; Hart, C.M.; Francis, N.J.; Vargas, M.L.; Sengupta, A.; Wild, B.; Miller, E.L.; O'Connor, M.B.; Kingston, R.E.; Simon, J.A. Cell, 2002, 111, 197.
96. Shi, Y.; Lan, F.; Matson, C.; Mulligan, P.; Whetstine, J.R.; Cole, P.A.; Casero, R.A.; Shi, Y. Cell, 2004, 119, 941.
97. Shi, Y.J.; Matson, C.; Lan, F.; Iwase, S.; Baba, T.; Shi, Y. Mol. Cell, 2005, 19, 857.
98. Metzger, E.; Wissmann, M.; Yin, N.; Muller, J.M.;, Schneider, R.; Peters, A.H.; Gunther, T.; Buettner, R.; Schule, R. Nature, 2005, 437, 436.
99. Klose, R.J.; Yamane, K.; Bae, Y.; Zhang, D.; Erdjument-Bromage, H.; Tempst, P.; Wong, J.; Zhang, Y. Nature, 2006, 442, 312.
100. Klose, R.J.; Yan, Q.; Tothova, Z.; Yamane, K.; Erdjument-Bromage, H.; Tempst, P.; Gilliland D.G.; Zhang, Y.; Kaelin, W.G Jr. Cell, 2007, 128, 889.
101. Strahl, B.D.; Allis, C.D. Nature, 2000, 403, 41.
102. Turner, B.M. Cell, 2002, 111, 285.
103. Minucci, S.; Pelicci, P.G. Nat. Rev. Cancer, 2006, 6, 38.
104. Lin, H.Y.; Chen, C.S.; Lin, S.P.; Weng, J.R.; Chen, C.S. Med. Res. Rev., 2006, 26, 397.
105. Gray, S.G.; Ekstrom, T.J. Exp. Cell. Res., 2001, 262, 75.
106. Crosio, C.; Fimia, G.M.; Loury, R.; Kimura, M.; Okano, Y.; Zhou, H.; Sen, S.; Allis, C.D.; Sassone-Corsi, P. Mol. Cell. Biol., 2002, 22, 874.
107. Nowak, S.J.; Corces, V.G. Trends Genet., 2004, 20, 214-220.
108. Cheung, W.L.; Turner, F.B.; Krishnamoorthy, T.; Wolner, B.; Ahn, S.H.; Foley, M.; Dorsey, J.A.; Peterson, C.L.; Berger, S.L.; Allis, C.D. Curr. Biol., 2005, 15, 656.
109. Nowak, S.J.; Pai, C.Y.; Corces, V.G. Mol. Cell. Biol., 2003, 23, 6129.
110. Sun, Z.W; Allis, C.D. Nature, 2002, 418, 104.
111. Zhu, B.; Zheng, Y.; Pham, A.D.; Mandal, S.S.; Erdjument-Bromage, H.; Tempst, P.; Reinberg, D. Mol. Cell, 2005, 20, 601.
112. Minsky, N., Oren, M. Mol. Cell, 2004, 16, 631.
113. Buchwald, G.; van der Stoop, P.; Weichenrieder, O.; Perrakis, A.; van Lohuizen, M.; Sixma, T.K. EMBO J., 2006, 25, 2465.
114. Henry, K.W.; Wyce, A.; Lo, W.S.; Duggan, L.J.; Emre, N.C.; Kao, C.F.; Pillus, L.; Shilatifard, A.; Osley, M.A.; Berger, S.L. Genes Dev., 2003, 17, 2648-.
115. Shukla, A.; Stanojevic N.; Duan Z.; Sen P.; Bhaumik S.R. Mol. Cell. Biol., 2006, 26, 3339.
116. Wyce, A.; Henry, K.W.; Berger, S.L. Novartis Found Symp., 2004, 259, 63.
117. Boulikas, T. Int. Rev. Cytol., 1995, 162A, 279.
118. Faraone-Menella, M.R. Biochem. Cell. Biol,. 2005, 83, 396.
119. Chew, YC.; Camporeale, G.; Kothapalli, N.; Sarath, G.; Zempleni, J. J Nutr. Biochem., 2006, 17, 225.
120. Narang, M.A.; Dumas, R.; Ayer, L.M.; Gravel, R.A. Hum. Mol. Genet., 2004, 13, 15-23.
121. Kothapalli, N.; Camporeale, G.; Kueh, A.; Chew, Y.C.; Oommen, A.M.; Griffin, J.B.; Zempleni, J. J. Nutr. Biochem., 2005, 16, 446.
122. Horn, P.J.; Peterson, C.L. Chromosome Res., 2006, 14, 83.
123. Taddei, A.; Roche, D.; Sibarita, J.B.; Turner B.M.; Almouzni G. J. Cell. Biol., 1999, 147, 1153.
124. Papait, R.; Pistore, C.; Negri, D.; Pecoraro,D.; Cantarini, L.; Bonapace, I.M. Mol. Biol. Cell., 2007, 18, 1098.
125. Shibahara, K.; Stillman, B. Cell, 1999, 96, 575.
126. Zhu, W.G.; Otterson, G.A. Curr. Med. Chem. Anticancer Agents, 2003, 3, 187.
127. Suzuki, T.; Miyata, N. Curr. Med. Chem., 2006, 13, 935.
128. Hellebrekers, D.M.; Griffioen, A.W.; van Engeland, M. Biochim. Biophys. Acta, 2007, 1775, 76.
129. Karam, J.A.; Fan, J.; Stanfield, J.; Richer, E.; Benaim, E.A.; Frenkel, E.; Antich, P.; Sagalowsky, A.I.; Mason, R.P.; Hsieh, J.T. Int. J. Cancer, 2007, 120, 1795.
130. Yang, A.S.; Doshi, K.D.; Choi, S.W.; Mason, J.B.; Mannari, R.K.; Gharybian, V.; Luna, R.; Rashid, A.; Shen, L.; Kantarjian, H.M.; Garcia-Manero, G.; Issa, J.P. Cancer Res., 2006, 66, 5495.
131. Rao, S.P.; Rechsteiner, M.P.; Berger, C.; Sigrist, J.A.; Nadal, D.; Bernasconi, M. Mol. Cancer, 2007, 6, 3.
132. Segura-Pacheco, B.; Trejo-Becerril, C.; Perez-Cardenas, E.; Taja-Chayeb, L.; Marisca, I.; Chavez, A.; Acuna, C.; Salazar, A.M.; Lizano, M.; Ducnas-Gonzalez, A. Clin. Cancer Res., 2003, 9, 1596.
133. Lee, W.J.; Shim, J.Y.; Zhu, B.T. Mol. Pharmacol., 2005, 68, 1018.
134. Arts, J.; de Schepper, S.; Van Emelen, K. Curr. Med. Chem., 2003, 10, 2343.
135. Curtin, M.; Glaser, K. Curr. Med. Chem., 2003, 10, 2373.
136. Mai, A.; Massa, S.; Valente, S.; Simeoni S.; Ragno, R.; Bottoni, P.; Scatena, R.; Brosch, G. Chemmedchem., 2006, 1, 225.
137. Remiszewski, S.W. Curr. Med. Chem., 2003, 10, 2393.
138. Porcu, M.; Chiarugi, A. Trends Pharmacol Sci., 2005, 26, 94.
139. Tang, B.L.; Chua CE. Mol. Aspects Med., 2007, in press.
140. Yang, S.R.; Wright, J; Bauter, M.; Sewcryniak, K.; Kode, A.; Rahman, I.; Am. J. Physiol. Lung Cell. Mol. Physiol., 2007, 292, L567.
141. Thangapazham, R.L.; Sharma, A.; Mahcshwari, R.K. AAPS J., 2006, 8, E443.
142. Balasubramanyam, K.; Varier, R.A.; Altaf, M.; Swaminathan, V.; Siddappa, N.B.; Ranga, U.; Kundu, T.K. J. Biol. Chem., 2004, 279, 51163.