Oct-4: Control of totipotency and germline determination

Molecular Reproduction and Development

Volumn 55, Issue 4, 2000, Pages 452-457

  Pesce, Maurizio ^a   Schöler, Hans R ^b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; BLASTOCYST; CELL DIFFERENTIATION; DOWN REGULATION; EMBRYO CELL; GASTRULATION; GERM LINE; INNER CELL MASS; PHENOTYPE; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; STEM CELL; TRANSACTIVATION;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; DNA-BINDING PROTEINS; EMBRYO; GERM CELLS; HIGH MOBILITY GROUP PROTEINS; OCTAMER TRANSCRIPTION FACTOR-3; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 0342514498     PISSN: 1040452X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2795(200004)55:4<452::AID-MRD14>3.0.CO;2-S     Document Type: Article

References (42)

1. Ambrosetti DC, Basilico C, Dailey L. 1997. Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites. Mol Cell Biol 17:6321-6329.
2. Ben-Shushan E, Pikarsky E, Klar A, Bergman Y. 1993. Extinction of Oct-3/4 gene expression in embryonal carcinoma x fibroblast somatic cell hybrids is accompanied by changes in the methylation status, chromatin structure, and transcriptional activity of the Oct-3/4 upstream region. Mol Cell Biol 13:891-901.
3. Ben-Shushan E, Thompson JR, Gudas LJ, Bergman Y. 1998. Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site. Mol Cell Biol 18:1866-1878.
4. Botquin V, Hess H, Fuhrmann G, Anastassiadis C, Gross MK, Vriend G, Schöler HR. 1998. New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev 12:2073-2090.
5. Brehm A, Ohbo K, Schöler H. 1997. The carboxy-terminal transactivation domain of Oct-4 acquires cell specificity through the POU domain. Mol Cell Biol 17:154-162.
6. Brehm A, Ohbo K, Zwerschke W, Botquin V, Jansen-Durr P, Schöler HR. 1999. Synergism with germ line transcription factor Oct-4: viral oncoproteins share the ability to mimic a stem cell-specific activity. Mol Cell Biol 19:2635-2643.
7. Chai N, Patel Y, Jacobson K, McMahon J, McMahon A, Rappolee DA. 1998. FGF is an essential regulator of the fifth cell division in preimplantation mouse embryos. Dev Biol 198:105-115.
8. Curatola AM, Basilico C. 1990. Expression of the K-fgf proto oncogene is controlled by 3′ regulatory elements which are specific for embryonal carcinoma cells. Mol Cell Biol 10:2475-2484.
9. Ephrussi A, Lehmann R. 1992. Induction of germ cell formation by oskar. Nature 358:387-392.
10. Ginsburg M, Snow MHL, McLaren A. 1990. Primordial germ cells in the mouse embryo during gastrulation. Development 110:521-528.
11. Herr W, Cleary MA. 1995. The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain. Genes Dev 9:1679-1693.
12. Jaenisch R. 1997. DNA methylation and imprinting: why bother? Trends Genet 13:323-329.
13. Lawson KA, Hage WJ. 1994. Clonal analysis of the origin of primordial germ cells in the mouse. Ciba Found Symp 182:68-84.
14. Lawson KA, Dunn NR, Roelen BA, Zeinstra LM, Davis AM, Wright CV, Korving JP, Hogan BL. 1999. Bmp4 is required for the generation of primordial germ cells in the mouse embryo. Genes Dev 13:424-436.
15. Liu L, Roberts RM. 1996. Silencing of the gene for the beta subunit of human chorionic gonadotropin by the embryonic transcription factor Oct-3/4. J Biol Chem 271:16683-16689.
16. Liu L, Leaman D, Villalta M, Roberts RM. 1997. Silencing of the gene for the alpha-subunit of human chorionic gonadotropin by the embryonic transcription factor Oct-3/4. Mol Endocrinol 11:1651-1658.
17. McLaren A. 1999. Signaling for germ cells. Genes Dev 13:373-376.
18. Mello CC, Schubert C, Draper B, Zhang W, Lobel R, Priess JR. 1996. The PIE-1 protein and germline specification in C. elegans embryos. Nature 382:710-712.
19. Monk M, Boubelik M, Lehnert S. 1987. Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development 99:371-382.
20. Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Schöler H, Smith A. 1998. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct-4. Cell 95:379-391.
21. Nishimoto M, Fukushima A, Okuda A, Muramatsu M. 1999. The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2. Mol Cell Biol 19:5453-5465.
22. Okamoto K, Okazawa H, Okuda A, Sakai M, Muramatsu M, Hamada H. 1990. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 60:461-472.
23. Okuda A, Fukushima A, Nishimoto M, Orimo A, Yamagishi T, Nabeshima Y, Kuro-o M, Nabeshima Y, Boon K, Keaveney M, Stunnenberg HG, Muramatsu M. 1998. UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells. EMBO J 17:2019-2032.
24. Palmieri SL, Peter W, Hess H, Schöler HR. 1994. Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol 166:259-267.
25. Pesce M, Gross MK, Schöler HR. 1998. In line with our ancestors: Oct-4 and the mammalian germ. Bioessays 20:722-732.
26. Pesce M, Anastassiadis K, Schöler HR. 1999. Oct-4: Lessons of totipotency from embryonic stem cells. Cells Tissues Organs 165:144-152.
27. Rosner MH, Vigano MA, Ozato K, Timmons PM, Poirier F, Rigby PW, Staudt LM. 1990. A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 345:686-692.
28. Ryan AK, Rosenfeld MG. 1997. POU domain family values: flexibility, partnerships, and developmental codes. Genes Dev 11:1207-1225.
29. Schöler HR, Ruppert S, Suzuki N, Chowdhury K, Gruss P. 1990. New type of POU domain in germ line-specific protein Oct-4. Nature 344:435-439.
30. Schöler HR, Ciesiolka T, Gruss P. 1991. A nexus between Oct-4 and E1A: implications for gene regulation in embryonic stem cells. Cell 66:291-304.
31. Seydoux G, Mello CC, Petitt J, Wood WB, Priess JR, Fire A. 1996. Repression of gene expression in the embryonic germ lineage of C. elegans. Nature 382:713-716.
32. Shimazaki T, Okazawa H, Fujii H, Ikeda M, Tamai K, McKay RD, Muramatsu M, Hamada H. 1993. Hybrid cell extinction and reexpression of Oct-3 function correlates with differentiation potential. EMBO J. 12:4489-4498.
33. Surani MA. 1998. Imprinting and the initiation of gene silencing in the germ line. Cell 93:309-312.
34. Tarn PP, Zhou SX. 1996. The allocation of epiblast cells to ectodermal and germ-line lineages is influenced by the position of the cells in the gastrulating mouse embryo. Dev Biol 178:124-132.
35. Tanaka S, Kunath T, Hadjantonakis A-K, Nagy A, Rossant J. 1998. Promotion of trophoblast stem cell proliferation by FGF-4. Science 282:2072-2075.
36. van Eijk MJ, van Rooijen MA, Modina S, Scesi L, Folkers G, van Tol HT, Bevers MM, Fisher SR, Lewin HA, Rakacolli D, Galli C, de Vaureix C, Trounson AO, Mummery CL, Gandolfi F. 1999. Molecular cloning, genetic mapping, and developmental expression of bovine POU5F1. Biol Reprod 60:1093-1103.
37. Wegner M, Drolet DW, Rosenfeld MG. 1993. POU-domain proteins: structure and function of developmental regulators. Curr Opin Cell Biol 5:488-498.
38. Wilder PJ, Kelly D, Brigman K, Peterson CL, Nowling T, Gao QS, McComb RD, Capecchi MR, Rizzino A. 1997. Inactivation of the FGF-4 gene in embryonic stem cells alters the growth and/or the survival of their early differentiated progeny. Dev Biol 192:614-629.
39. Winnier G, Blessing M, Labosky PA, Hogan BL, 1995, Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 9:2105-2116.
40. Yeom YI, Fuhrmann G, Ovitt CE, Brehm A, Ohbo K, Gross M, Hübner K, Schöler HR. 1996. Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development 122:881-894.
41. Yuan H, Corbi N, Basilico C, Dailey L. 1995. Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev 9:2635-2645.
42. Zwilling S, König H, Wirth T. 1995. High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors. EMBO J 14:1198-1208.