Selective modification of CaaX peptides with ortho-substituted anilinogeranyl lipids by protein farnesyl transferase: Competitive substrates and potent inhibitors from a library of farnesyl diphosphate analogues

Biochemistry

Volumn 46, Issue 40, 2007, Pages 11310-11321

  Troutman, Jerry M ^a   Subramanian, Thangaiah ^a   Andres, Douglas A ^a   Spielmann, H Peter ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL MODIFICATION; ENZYMES; ISOMERS; KINETICS; LIPIDS; SUBSTITUTION REACTIONS; SUBSTRATES;

FARNESYL DIPHOSPHATES; FARNESYL TRANSFERASE INHIBITOR (FTI);

PEPTIDES;

AMINO ACID; ANILINE DERIVATIVE; CYSTEINE; FARNESYL DIPHOSPHATE; GERANYLTRANSFERASE; GLUTAMINE; LIPID; METHIONINE; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; SERINE; SYNTHETIC PEPTIDE; TETRAPEPTIDE;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; KINETICS; PRIORITY JOURNAL; PROTEIN BINDING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEADY STATE; X RAY CRYSTALLOGRAPHY;

ALKYL AND ARYL TRANSFERASES; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; KINETICS; MODELS, BIOLOGICAL; OLIGOPEPTIDES; PEPTIDES; POLYISOPRENYL PHOSPHATES; SESQUITERPENES; SUBSTRATE SPECIFICITY; TERPENES;

EID: 35048858252     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700516m     Document Type: Article

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