Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids

Journal of the American Chemical Society

Volumn 128, Issue 9, 2006, Pages 2822-2835

  Dursina, Beatrice ^a   Reents, Reinhard ^a,c   Delon, Christine ^a   Wu, Yaowen ^a   Kulharia, Mahesh ^a   Thutewohl, Michael ^a,d   Veligodsky, Alexei ^a,f   Kalinin, Alexandr ^a,e   Evstifeev, Vladimir ^a   Ciobanu, Doina ^a   Szedlacsek, Stefan E ^b   Waldmann, Herbert ^a   Goody, Roger S ^a   Alexandrov, Kirill ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b INSTITUTE OF BIOCHEMISTRY OF THE ROMANIAN ACADEMY   (Romania)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d OREGON STATE UNIVERSITY   (United States)

^e NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^f ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CELLS; CHEMICAL MODIFICATION; DISEASES; ENZYME INHIBITION; LIPIDS; MICROORGANISMS; POLYPEPTIDES;

ISOPRENOIDS; MAMMALIAN CELLS; PEPTIDE SUBSTRATES;

ENZYMES;

ANTINEOPLASTIC AGENT; ANTIPARASITIC AGENT; ANTIVIRUS AGENT; DIMETHYLALLYLTRANSFERASE; ENZYME INHIBITOR; GERANYLGERANYLTRANSFERASE 1; GERANYLTRANSFERASE; GUANOSINE TRIPHOSPHATASE; ISOPRENOID PHOSPHATE; NITROBENZENE DERIVATIVE; PRENYLTRANSFERASE INHIBITOR; PYROPHOSPHORIC ACID DERIVATIVE; RAB GERANYLGERANYLTRANSFERASE; UNCLASSIFIED DRUG; [3,7 DIMETHYL 8 (7 NITROBENZO[1,2,5]OXADIAZOL 4 YLAMINO)OCTA 2,6 DIENE 1]PYROPHOSPHATE; [3,7,11 TRIMETHYL 12 (7 NITROBENZO[1,2,5]OXADIAZOL 4 YLAMINO)DODECA 2,6,10 TRIENE 1]PYROPHOSPHATE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENZYME ASSAY; ENZYME SUBSTRATE; EUKARYOTE; HUMAN; HUMAN CELL; IC 50; ISOPRENYLATION; MAMMAL CELL; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRENYLATION; PROTEIN LIPID INTERACTION; PROTEIN PROCESSING;

EID: 33644947798     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja052196e     Document Type: Article

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